第２５回　生命医科学セミナー（Biomedical Science Seminar）

演題：Double-strand break repair and genomic integrity

in mammalian cells

演者：Dr. Maria Jasin

所属：Memorial Sloan-Kettering Cancer Center, New York, U.S.A.

日時：平成２０年４月２１日（月）　１９：００～２０：００

場所：病院地区総合研究棟、１階１０２講義室

［セミナー内容の紹介］

Gross chromosomal rearrangements are the hallmark of tumor cells and form by the inappropriate breakage and reunion of DNA. Complex pathways have evolved to respond to DNA double-strand breaks in mammalian cells, including multiple repair pathways. Moreover, robust double-strand break repair is critical for embryonic and germ cell development. Various aspects of DNA double-strand break repair will be discussed, such as modelling oncogenic translocations, the role of the breast cancer tumor suppressor BRCA2 in homologous recombination, and meiotic double-strand break repair.

Ref: Weinstock, DM, Brunet, E, Jasin M (2007) Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70. Nat. Cell. Biol. 9, 978-81.

　今回、共同研究討議並びにAtaxia-Telangiectasia Workshop 2008（April 22-26, Ohtsu Prince Hotel at Lake Biwa）での講演のために来日されます。

　多くの方の参加を歓迎致します。

（共催：福岡医学会、消化器・総合外科学分野　前原喜彦教授）