ケンブリッジ大学のElisa Galliano博士をお招きしてセミナーを開催致します。嗅球神経回路の可塑性の仕組みについてお話し頂きます。
演者： Elisa Galliano 博士
所属： Department of Physiology, Development and Neuroscience, University of Cambridge, UK
タイトル： Not all dopaminergic neurons are created equal: heterogeneity and plasticity in the olfactory bulb
日時： 2021年4月22日（木）17:00～18:00 (JST)
場所： Zoom（URLは学内メールで配信します。九大病院キャンパス以外から視聴を希望する場合はこちらから参加登録をお願いします。）
Abstract:
Dopaminergic (DA) inhibitory interneurons in the olfactory bulb (OB) act at a crucial point in the early olfactory pathway, modulating transmission in OB glomeruli and helping set the gain of incoming inputs. DA neurons are extremely plastic cells, capable of regulating their dopamine production levels in an activity-dependent manner, of undergoing structural plasticity of their dendrites, and even of regenerating throughout life. Long-believed to be a homogeneous population, this talk will explore how recent evidence has instead uncovered a striking heterogeneity in their shape, function and developmental profile – including their ability to undergo adult neurogenesis. Moreover, only a subclass of non-regenerating DA cells has been shown to respond to brief sensory deprivation by implementing structural and intrinsic plastic changes that result in decreased excitability. By specifically acting on one specialised dopaminergic subpopulation, experience-dependent plasticity might act to fine-tune sensory processing in the face of continually fluctuating input.
世話人： 医学研究院・疾患情報研究分野 今井 猛
#第15回疾患情報研究分野主催（第19回今井研主催）公開セミナー