Department of Developmental Neurophysiology │Imai Lab – A Systems and Developmental Neuroscience Lab @ Kyushu University

Welcome

Welcome to the website for the Imai lab (Department of Developmental Neurophysiology, Graduate School of Medical Sciences, Kyushu University). We study neuroscience, in particular neural development from functional and anatomical aspects. We also teach in a physiology class for undergrad medical students.

What we’re interested in

The vast majority of human mental activity is located in the brain. Unsurprisingly, it is a complex network of approximately 100 billion neurons, which form about 100 trillion connections (synapses). Uncovering the principles how these networks are constructed and operate will not only help us combat neurological disorders, but also can develop our understanding of how neural activity can translate into human cognition. We believe that studying the development of neural circuits offers a particularly good strategy to improve our understanding of the brain.

Our lab aims are to understand the development and function of neural circuits using three approaches: circuit mechanisms, circuit structure, and developmental mechanisms. In particular, we focus on the mouse olfactory system as a model to understand the basis of sensory information processing and, the developmental mechanisms on a systems, cellular, and molecular level. We also seek to shed new light on the function of neural circuits as well as pathological conditions, by developing novel imaging techniques such as brain clearing and developing new image analysis methods.

Available Positions

Our lab is currently recruiting graduate students and post-docs (People of all nationalities are welcome). We are also open to short term residences/internships of undergraduates and overseas students/researchers. As neuroscience is a multi-disciplinary field we welcome applicants from a variety of scientific backgrounds. Particularly those with a background in neurophysiology, molecular/cell biology, or mathematics /information science. If you are interested, please see this page and contact me by email.

Circuit bases for sensory information processing in the brain

The mammalian nervous system is composed of enormous numbers of neurons, but how do these cells take on diverse fates and organize and array themselves during development? How is a functional circuit formed during? We study neural circuits for olfaction (see our recent review), somatosensation, audition, and interoception (gut chemical senses) as model systems.

We use in vivo two-photon calcium imaging to study the dynamics of sensory information processing (see a press release and a blog post on our recent paper). We also employ mathematical simulation to understand the circuit dynamics. Circuit bases are now being studied by the light microscopy-based connectomic approaches, incorporating tissue clearing techniques developed recently in our laboratory (e.g., SeeDB, SeeDB2). Our goal is to understand the developmental mechanisms of the functional neuronal circuitry.

Apart from biology, we are also trying to develop new tools in neuroscinece, particularly in connectomics. We believe that new tools reveal new questions and new fields in biology. We have previously developed tissue clearing methods enabling large-scale 3D analyses of neuronal circuits. We are trying to develop new strategies in light microscopy-based connectomics.