原著論文
2023年
Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke
Takashi Irie, Taito Matsuda ,Yoshinori Hayashi and Kinichi Nakashima
PNAS.,2023;vol.120, No.42 プレリリース
Reduced neuroinflammation via astrocytes and neutrophils promotes regeneration after spinal cord injury in neonatal mice
Kazuki Kitade, Kazu Kobayakawa, Hirokazu Saiwai, Yoshihiro Matsumoto, Kenichi Kawaguchi, Keiichiro Iida, Ken Kijima, Hirotaka Iura, Tetsuya Tamaru, Yohei Haruta, Gentaro Ono, Daijiro Konno, Takeshi Maeda, Seiji Okada, Kinichi Nakashima, Yasuharu Nakashima
J Neurotrauma.,2023;vol.0,No.ja
C4orf47 contributes to the dormancy of pancreatic cancer under hypoxic conditions
Shinjiro Nagao, Hideya Onishi, Makoto Kawamoto, Shogo Masuda, Lin Na, Shinji Morisaki, Naoya Iwamoto, Yutaka Yamada, Satoko Koga, Shu Ichimiya, Kazunori Nakayama, Akira Imaizumi, Kinichi Nakashima, Yoshinao Oda, Masafumi Nakamura
J Cancer.,2023;14(2):306-317
Lineage tracing identifies in vitro microglia-to-neuron conversion by NeuroD1 expression
Takashi Irie*, Kanae Matsuda-Ito*, Taito Matsuda#, Takahiro Masuda, Marco Prinz, Noriko Isobe, Kinichi Nakashima
Genes Cells.,2023;1-9
2022年
Expression level of the reprogramming factor NeuroD1 is critical for neuronal conversion efficiency from different cell types
Kanae Matsuda-Ito*, Taito Matsuda*#, and Kinichi Nakashima#
Scientific Reports.2022;12:17980
2021年
Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration
Takahiro Wakizono, Hideyuki Nakashima, Tetsuro Yasui, Teppei Noda, Kei Aoyagi, Kanako Okada, Yasuhiro Yamada, Takashi Nakagawa, and Kinichi Nakashima
JCI Insight. 2021;6(22):e139171., 2021 プレスリリース
SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia
Jun Takouda, Sayako Katada, Takuya Imamura, Tsukasa Sanosaka, Kinichi Nakashima
Pharmacol. Res. Perspect., 9(6):e00749., 2021
Neural stem/precursor cells dynamically change their epigenetic landscape
to differentially respond to BMP signaling for fate switching during brain development
Sayako Katada, Jun Takouda, Takumi Nakagawa, Mizuki Honda, Katsuhide Igarashi, Takuya Imamura, Yasuyuki Ohkawa, Shoko Sato, Hitoshi Kurumizaka, and Kinichi Nakashima
Genes Dev.,35(21-22):1431-1444., 2021 プレスリリース
2021年11月号のCover Article に選ばれました。
Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation
Tomonori KAMEDA, Hideyuki NAKASHIMA, Takumi TAKIZAWA, Fumihito MIURA, Takashi ITO, Kinichi NAKASHIMA, Takuya IMAMURA
J Reprod Dev., 2021, 67(6):369-379
Early-life midazolam exposure persistently changes chromatin accessibility to impair adult hippocampal neurogenesis and cognition
Hiroyoshi Doi*, Taito Matsuda*#, Atsuhiko Sakai, Shuzo Matsubara, Sumio Hoka, Ken Yamaura, and Kinichi Nakashima#
Proc Natl Acad Sci USA, 118(38):e2107596118., 2021 プレスリリース
scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse
Marie-Theres Wittmann, Sayako Katada, Elisabeth Sock, Philipp Kirchner, Arif B Ekici, Michael Wegner, Kinichi Nakashima, Dieter Chichung Lie, André Reis
Development, 15;148(14):dev196022, 2021
Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice
Bijay Parajuli, Hiroki Saito, Youichi Shinozaki, Eiji Shigetomi, Hiroto Miwa, Sosuke Yoneda, Miki Tanimura, Shigeki Omachi, Toshiyuki Asaki, Koji Takahashi, Masahide Fujita, Kinichi Nakashima, Schuichi Koizumi
Glia, 69(10), 2332-2348, 2021 プレスリリース
Generation of ovarian follicles from mouse pluripotent stem cells
Takashi Yoshino1, Takahiro Suzuki, Go Nagamatsu, Haruka Yabukami, Mika Ikegaya, Mami Kishima, Haruka Kita, Takuya Imamura, Kinichi Nakashima, Ryuichi Nishinakamura, Makoto Tachibana, Miki Inoue, Yuichi Shima, Ken-ichirou Morohashi, Katsuhiko Hayashi
Science, 373, 298, 2021
CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Acting in cis
Yuta Shirogane, Ryuichi Takemoto, Tateki Suzuki, Tomonori Kameda, Kinichi Nakashima, Takao Hashiguchi, and Yusuke Yanagi
J Virol, 24;95(14):e0052821, 2021
MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP–Smad signaling
Hideyuki Nakashima, Keita Tsujimura, Koichiro Irie, Takuya Imamura, Cleber A. Trujillo, Masataka Ishizu, Masahiro Uesaka, Miao Pan, Hirofumi Noguchi, Kanako Okada, Kei Aoyagi, Tomoko Andoh-Noda, Hideyuki Okano, Alysson R. Muotri, Kinichi Nakashima
Cell Reports, 35, 109124, 2021 プレスリリース¹、プレスリリース² 、プレスリリース³
Combinatrial treatment of anti-High Mobility Group Box-1 monoclonal antibody and epothilone B improves functional recovery after spinal cord contusion injury
Yicheng Zhu, Naohiro Uezono, Tetsuro Yasui, Masahide Nakajo, Tatsuya Nagai, Dengli Wang, Masahiro Nishibori, KinichiNakashima
Neurosci Res, 172, 17-25, 2021
Reconstitution of the oocyte transcriptional network with transcription factors
Nobuhiko Hamazaki, Hirohisa Kyogoku, Hiromitsu Araki, Fumihito Miura, Chisako Horikawa, Norio Hamada, So Shimamoto, Orie Hikabe, Kinichi Nakashima, Tomoya S. Kitajima, Takashi Ito, Harry G. Leitch & Katsuhiko Hayashi
Nature, 589(7841):264-269, 2021
2020年
NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytes
Kazunori Nakayama, Hideya Onishi, Akiko Fujimura, Akira Imaizumi, Makoto Kawamoto, Yasuhiro Oyama, Shu Ichimiya, Satoko Koga, Yuichi Fujimoto, Kinichi Nakashima, Masafumi Nakamura
Cell Immunol, 358:104237, 2020
Identification of Qk as a glial precursor cell marker that governs the fate specification of neural stem cells to a glial cell lineage.
Takeuchi A., Takahashi Y., Iida K., Hosokawa M., Irie K., Ito M., Brown BJ., Ohno K., Nakashima K. & Hagiwara M.
Stem Cell Rep,15(4):883-897
Modeling of early neural development in vitro by direct neurosphere formation culture of chimpanzee induced pluripotent stem cells.
Kitajima R., Nakai R., Imamura T., Kameda T., Kozuka D., Hirai H., Ito H., Imai H., Imamura M.
Stem Cell Rep, 44: 101749, 2020
Enhanced processivity of Dnmt1 by monoubiquitinated Histone H3.
Mishima Y.,Brueckner L., Takahashi S., Kawakami T., Otani J., Shinohara A., Takeshita K.,Garvilles RG., Watanabe M., Sakai N., Takeshima H., Nachtegael C., Nishiyama A.,Nakanishi M., Arita K., Nakashima K., Hojo H., Suetake I.
Genes Cells, 25: 22-32, 2020
2019年
Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice.
Saito H., Hara K., Tominaga T., Nakashima K. & Tanemura K.
J Appl Toxicol, 39:1651-1662, 2019
Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells.
Noguchi H., Castillo J.G., Nakashima K. & Pleasure S.J.
eLIFE, 8:e42918, 2019
Pioneer factor NeuroD1 rearranges transcriptional and epigenetic profiles to execute microglia-neuron conversion.
#Matsuda T.，Irie T.，Katsurabayashi S.，Hayashi T.，Nagai T.，Hamazaki N.，Adefuin AM.，Miura F.，Ito T.，Kimura H.，Shirahige K.，Takeda T.，Iwasaki K.，Imamura T. & #Nakashima K.
Neuron, 101, 472-485, 2019
Nox4 promotes neural stem/precursor cell proliferation and neurogenesis in the hippocampus and restores memory function following trimethyltin-induced Injury.
Yoshikawa Y.，*Ago T.，Kuroda J.，Wakisaka Y.，Tachibana M.，Komori M.，Shibahara T.，Nakashima H.，Nakashima K. & Kitazono T.
Neuroscience, 398, 193-205, 2019
2018年
Canonical TGF-β signaling negatively regulates neuronal morphogenesis through TGIF/Smad complex-mediated CRMP2 suppression
Nakashima H., Tsujimura K.*, Irie K., Ishizu M., Pan M., Kameda T. & Nakashima K.*
J Neurosci, 38: 4791-4810, 2018
Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain
Murao N., Matsubara S., Matsuda T., Noguchi H., Mutoh T., Mutoh M., Koseki H., Namihira M. & Nakashima K.*
Neurosci Res, Epub ahead of print, May 31, 2018
Ectopic neurogenesis induced by prenatal antiepileptic drug exposure augments seizure susceptibility in adult mice
Sakai A., Matsuda T., Doi H., Nagaishi Y., Kato K. & Nakashima K.*
Proc Natl Acad Sci USA, Epub ahead of print, Apr 2, 2018 プレスリリースはこちら
Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury
Nakajo M., Uezono N., Nakashima H., Wake H., Komiya S., Nishibori M. & Nakashima K.*
Neurosci Res, Epub ahead of print, Mar 28, 2018
Prior treatment with anti-High Mobility Group Box-1 antibody boosts human neural stem cell transplantation-mediated functional recovery after spinal cord injury
Uezono N., Zhu Y., Fujimoto Y., Yasui T., Matsuda T., Nakajo M., Abematsu M., Setoguchi T., Mori S., Takahashi H.K., Komiya S., Nishibori M. & Nakashima K.*
Stem Cells, 36, 737-750, 2018 プレスリリースはこちら
HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells
Kimura A., Matsuda T.*, Sakai A., Murao N. & Nakashima K.* (*Corresponding authors)
Dev Dyn, 247, 229-238, 2018
2017年
Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain
Kawamura Y., Katada S., Noguchi H., Yamamoto H., Sanosaka T., Iihara K. & Nakashima K.*
FEBS Lett, 591, 3709-3720
DNA methylome analysis identifies transcription factor-based epigenomic signatures of multilineage competence in neural stem/progenitor cells
Sanosaka T.◊*, Imamura T.◊*, Hamazaki N., Chai M.C., Igarashi K., Ideta-Otsuka M., Miura F., Ito T., Fujii N., Ikeo K. & Nakashima K.* (◊Co-first authors, *Co-corresponding authors)
Cell Reports, 20, 2992–3003, 2017 プレスリリースはこちら
PRMT1 regulates astrocytic differentiation of embryonic neural stem/precursor cells
Honda M., Nakashima K. & Katada S.*
J Neurochem, 142, 901-907, 2017
Hypoxia epigenetically confers astrocytic differentiation potential on human pluripotent cell-derived neural precursor cells
Yasui T., Uezono N., Nakashima H, Noguchi H., Matsuda T., Noda-Andoh T., Okano H. & Nakashima K.*
Stem Cell Reports, 8, 1743–1756, 2017 プレスリリースはこちら
NEUROD1 instructs neuronal conversion in non-reactive astrocytes
Brulet R., Matsuda T., Zhang L., Miranda C., Giacca M., Kaspar B.K., Nakashima K. & Hsieh J.*
Stem Cell Reports, 8, 1506–1515, 2017
Evolutionary acquisition of promoter-associated non-coding RNA (pancRNA) repertoires diversifies species-dependent gene activation mechanisms in mammals
Uesaka M., Agata K., Oishi T., Nakashima K. & Imamura T.*
BMC Genomics, 18, 285, 2017
2016年
Prenatal deletion of DNA methyltransferase 1 in neural stem cells impairs neurogenesis and causes anxiety-like behavior in adulthood
Noguchi H., Kimura A., Murao N., Namihira M. & Nakashima K.*
Neurogenesis, 3, 2016
Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–tet1 catalytic domain fusions
Morita S., Noguchi H., Horii T., Nakabayashi K., Kimura M., Okamura K., Sakai A., Nakashima H., Hata K., Nakashima K. & Hatada I.*
Nat Biotechnol, 34, 1060–1065, 2016
MicroRNA-214 promotes dendritic development by targeting the schizophrenia-associated gene Quaking (Qki)
Irie K., Tsujimura K.*, Nakashima H. & Nakashima K.* (*Corresponding authors)
J Biol Chem, 291, 13891–13904, 2016
DNA methyltransferase 1 is indispensable for development of the hippocampal dentate gyrus
Noguchi H., Murao N., Kimura A., Matsuda T., Namihira M. & Nakashima K.*
J Neurosci, 36, 6050–6068, 2016
Cover Article に選ばれました。
Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation
Ito K., Sanosaka T., Igarashi K., Otsuka I.M., Aizawa A., Uosaki Y., Noguchi A., Arakawa H., Nakashima K. & Takizawa T.*
Sci Rep, 6, 23903, 2016
Bidirectional promoters link cAMP signaling with irreversible differentiation through promoter-associated non-coding RNA (pancRNA) expression in PC12 cells
Yamamoto N., Agata K., Nakashima K. & Imamura T.*
2015年
Reduced adult hippocampal neurogenesis and cognitive impairments following prenatal treatment of the antiepileptic drug valproic acid
Juliandi B.◊, Tanemura K.◊, Igarashi K., Tominaga T., Furukawa Y., Otsuka M., Moriyama N., Ikegami D., Abematsu M., Sanosaka T., Tsujimura K., Narita M., Kanno J. & Nakashima K.* (◊Co-first authors)
Stem Cell Reports, 5, 1-14, 2015 プレスリリースはこちら
miR-199a links MeCP2 with mTOR signaling and its dysregulation leads to Rett Syndrome phenotypes
Tsujimura K., Irie K., Nakashima H., Egashira Y., Fukao Y., Fujiwara M., Itoh M., Uesaka M., Imamura T., Nakahata Y., Yamashita Y., Abe T., Takamori S. & Nakashima K.*
Cell Rep, 12, 1-15, 2015 プレスリリースはこちら
Recommended by Faculty of 1000
Low-cost three-dimensional gait analysis system for mice with an infrared depth sensor
Nakamura A., Funaya H., Uezono N., Nakashima K., Ishida Y., Suzuki T., Wakana S. & Shibata T.*
Neurosci Res, 100, 55-62, 2015
Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage
Andoh-Noda T., Akamatsu W., Miyake K., Matsumoto T., Yamaguchi R., Sanosaka T., Okada Y., Kobayashi T., Ohyama M., Nakashima K., Kurosawa H., Kubota T. & Okano H.*
Mol Brain, 8, 2015
TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus
Matsuda T., Murao N., Katano Y., Juliandi B., Kohyama J., Akira S., Kawai T. & Nakashima K.*
Nat commun, 6, 6514, 2015 プレスリリースはこちら
Recommended by Faculty of 1000
Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus
Noguchi H., Kimura A., Murao N., Matsuda T., Namihira M. & Nakashima K.*
Neurosci Res, 95, 1-11, 2015
Gene activation-associated long noncoding RNAs function in mouse preimplantation development
Hamazaki N., Uesaka M., Nakashima K., Agata K. & Imamura T.*
Development, 142, 910-920, 2015 プレスリリースはこちら
2014年
Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem/precursor cells
Murao N., Matsuda T., Noguchi H., Koseki H., Namihira M*. & Nakashima K*. (*Co-corresponding authors)
Neurogenesis, 1, 1-11, 2014
VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome
Guo W◊., Tsujimura K◊., Otsuka I.M., Irie K., Igarashi K*., Nakashima K*. & Zhao X*. (◊Co-first authors, *Co-corresponding authors)
PLoS ONE, 9, e100215, 2014
Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation
Yi S.H., He X.B., Rhee Y.H., Park C.H., Takizawa T., Nakashima K. & Lee S.H.*
Development, 141, 761-772, 2014
Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals
Uesaka M., Nishimura O., Go Y., Nakashima K., Agata K. & Imamura T.*
BMC Genomics, 15, 35, 2014
2013年
Prenatal exposure to suberoylanilide hydroxamic acid perturbs corticogenesis
Yuniarti N., Juliandi B., Muhchyi C., Noguchi H., Sanosaka T. & Nakashima K.
Neurosci Res, 77, 42-49, 2013
Chromatin accessibility at a STAT3 target site is altered prior to astrocyte differentiation
Urayama S., Semi K., Sanosaka T., Hori Y., Namihira M., Kohyama J., Takizawa T. & Nakashima K.
Cell Struct Func, 38, 55-66, 2013
2012年
Unfolded protein response activated by OASIS family transcription factors promotes astrocyte differentiation
Saito A., Kanemoto S., Kawasaki N., Asada R., Iwamoto H., Oki M., Miyagi H., Izumi S., Sanosaka T., Nakashima K. & Imaizumi K.
Nat Commun, 3, 967, 2012
Treatment of a mouse model of spinal cord injury by transplantation of human iPS cell-derived long-term self-renewing neuroepithelial-like stem cells
Fujimoto Y., Abematsu M., Falk A., Tsujimura K., Sanosaka T., Juliandi B., Semi K., Namihira M., Komiya S., Smith A., & Nakashima K.
Stem Cells, 30, 1163-1173, 2012
Oxygen Levels Epigenetically Regulate Fate Switching of Neural Precursor Cells via Hypoxia-Inducible Factor 1alpha-Notch Signal Interaction in the Developing Brain
Mutoh T., Sanosaka T., Ito K. & Nakashima K.
Stem Cells, 30, 561-569, 2012.
Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid
Juliandi B., Abematsu M., Sanosaka T., Tsujimura K., Smith A. & Nakashima K.
Neurosci Res, 72, 23-31, 2012
2011年
Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb
Kuwabara T., Kagalwala M.N., Onuma Y., Ito Y., Warashina M., Terashima K., Sanosaka T., Nakashima K., Gage F.H. & Asashima M.
EMBO Mol Med, 3, 742-754, 2011
Role of GLI2 in the growth of human osteosarcoma
Nagao H., Ijiri K., Hirotsu M., Ishidou Y., Yamamoto T., Nagano S., Takizawa T., Nakashima K., Komiya S. & Setoguchi T.
J Pathol, 224, 169-179, 2011
2010年
Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury
Abematsu M., Tsujimura K., Yamano M., Saito M., Kohno K., Kohyama J., Namihira M., Komiya S. & Nakashima K.
J Clin Invest, 120, 3255-3266, 2010
BMP-induced REST regulates the establishment and maintenance of astrocytic identity
Kohyama J., Sanosaka T., Tokunaga A., Takatsuka E., Tsujimura K., Okano H. & Nakashima K.
J Cell Biol, 189, 159-170, 2010
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus
Mira H., Andreu Z., Suh H., Lie D.C., Jessberger S., Consiglio A., San Emeterio J., Hortiguela R., Marques-Torrejon M.A., Nakashima K., Colak D., Gotz M., Farinas I. & Gage F.H.
Cell Stem Cell, 7, 78-89, 2010
L1 retrotransposition in neurons is modulated by MeCP2
Muotri A.R., Marchetto M.C., Coufal N.G., Oefner R., Yeo G., Nakashima K. & Gage F.H.
Nature, 468, 443-446, 2010
2009年
Astrocyte Differentiation of Neural Precursor Cells is Enhanced by Retinoic Acid Through a Change in Epigenetic Modification
Asano H., Aonuma M., Sanosaka T., Kohyama J., Namihira M. & Nakashima K.
Stem Cells, 27, 2744-2752, 2009
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis
Kuwabara T., Hsieh J., Muotri A., Yeo G., Warashina M., Lie D.C., Moore L., Nakashima K., Asashima M. & Gage F.H.
Nat Neurosci, 12, 1097-1105, 2009
Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells
Namihira M., Kohyama J., Semi K., Sanosaka T., Deneen B., Taga T. & Nakashima K.
Dev Cell, 16, 245-255, 2009
Periventricular notch activation and asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cells
Ochiai W., Nakatani S., Takahara T., Kainuma M., Masaoka M., Minobe S., Namihira M., Nakashima K., Sakakibara A., Ogawa M. & Miyata T.
Mol Cell Neurosci, 40, 225-233, 2009
Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2
Tsujimura K., Abematsu M., Kohyama J., Namihira M. & Nakashima K.
Exp Neurol, 219, 104-111, 2009
2008年
Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation
Hatada I., Namihira M., Morita S., Kimura M., Horii T. & Nakashima K.
PLoS ONE. 3, e3189, 2008
Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain
Kohyama J., Kojima T., Takatsuka E., Yamashita T., Namiki J., Hsieh J., Gage F.H., Namihira M., Okano H., Sawamoto K. & Nakashima K.
Proc Natl Acad Sci USA, 105, 18012-18017, 2008
Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain
Li W., Sun G., Yang S., Qu Q., Nakashima K. & Shi Y.
Mol Endocrinol, 22, 56-64, 2008
Identification of genes that restrict astrocyte differentiation of midgestational neural precursor cells
Sanosaka T., Namihira M., Asano H., Kohyama J., Aisaki K., Igarashi K., Kanno J. & Nakashima K.
Neuroscience, 155, 780-788, 2008
2007年
Bcl-XL/Bax Proteins Direct the Fate of Embryonic Cortical Precursor Cells
Chang M.Y., Sun W., Ochiai W., Nakashima K., Kim S.Y., Park C.H., Kang J.S., Shim J.W., Jo A.Y., Kang C.S., Lee Y.S., Kim J.S. & Lee S.H.
Mol Cell Biol, 27, 4293-4305, 2007
Potentiation of astrogliogenesis by STAT3-mediated activation of bone morphogenetic protein-Smad signaling in neural stem cells
Fukuda S., Abematsu M., Mori H., Yanagisawa M., Kagawa T., Nakashima K., Yoshimura A. & Taga T.
Mol Cell Biol, 27, 4931-4937, 2007
Epigenetic modulation of seizure-induced neurogenesis and cognitive decline
Jessberger S., Nakashima K., Clemenson G.D., Jr., Mejia E., Mathews E., Ure K., Ogawa S., Sinton C.M., Gage F.H. & Hsieh J.
J Neurosci, 27, 5967-5975, 2007
2006年
Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation
Barkho B.Z., Song H., Aimone J.B., Smrt R.D., Kuwabara T., Nakashima K., Gage F.H. & Zhao X.
Stem Cells Dev, 15, 407-421, 2006
Conversion of mammalian Muller glial cells into a neuronal lineage by in vitro aggregate-culture
Kubota A., Nishida K., Nakashima K. & Tano Y.
Biochem Biophys Res Commun, 351, 514-520, 2006
Neuropoietin induces neuroepithelial cells to differentiate into astrocytes via activation of STAT3
Ohno M., Kohyama J., Namihira M., Sanosaka T., Takahashi J.A., Hashimoto N. & Nakashima K.
Cytokine, 36, 17-22, 2006
Methyl-CpG binding proteins are involved in restricting differentiation plasticity in neurons
Setoguchi H., Namihira M., Kohyama J., Asano H., Sanosaka T. & Nakashima K.
J Neurosci Res, 84, 969-979, 2006
Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification
Suzuki A., Raya A., Kawakami Y., Morita M., Matsui T., Nakashima K., Gage F.H., Rodriguez-Esteban C. & Belmonte J.C.
Nat Clin Pract Cardiovasc Med, 3 Suppl 1, S114-S122, 2006
Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells
Suzuki A., Raya A., Kawakami Y., Morita M., Matsui T., Nakashima K., Gage F.H., Rodriguez-Esteban C. & Izpisua Belmonte J.C.
Proc Natl Acad Sci USA, 103, 10294-10299, 2006
2005年
Development of functional human embryonic stem cell-derived neurons in mouse brain
Muotri A.R., Nakashima K., Toni N., Sandler V.M. & Gage F.H.
Proc Natl Acad Sci USA, 102, 18644-18648, 2005
Stage- and site-specific DNA demethylation during neural cell development from embryonic stem cells
Shimozaki K., Namihira M., Nakashima K. & Taga T.
J Neurochem, 93, 432-439, 2005
Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture.
Yanagisawa M., Nakashima K., Ochiai W., Takizawa T., Setoguchi T., Uemura A., Takizawa M., Nobuhisa I. & Taga T.
Neurosci Res, 53, 176-182, 2005
2004年
IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes
Hsieh J., Aimone J.B., Kaspar B.K., Kuwabara T., Nakashima K. & Gage F.H.
J Cell Biol, 164, 111-122, 2004
Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells
Hsieh J., Nakashima K., Kuwabara T., Mejia E. & Gage F.H.
Proc Natl Acad Sci USA, 101, 16659-16664, 2004
A small modulatory dsRNA specifies the fate of adult neural stem cells
Kuwabara T., Hsieh J., Nakashima K., Taira K. & Gage F.H.
Cell, 116, 779-793, 2004
Developmental stage dependent regulation of DNA methylation and chromatin modification in a immature astrocyte specific gene promoter
Namihira M., Nakashima K. & Taga T.
FEBS Lett, 572, 184-188, 2004
Treatment of spinal cord injury by transplantation of fetal neural precursor cells engineered to express BMP inhibitor
Setoguchi T., Nakashima K., Takizawa T., Yanagisawa M., Ochiai W., Okabe M., Yone K., Komiya S. & Taga T.
Exp Neurol, 189, 33-44, 2004
Expression and function of orphan nuclear receptor TLX in adult neural stem cells
Shi Y., Chichung Lie D., Taupin P., Nakashima K., Ray J., Yu R.T., Gage F.H. & Evans R.M.
Nature, 427, 78-83, 2004
Cell fusion-independent differentiation of neural stem cells to the endothelial lineage
Wurmser A.E., Nakashima K., Summers R.G., Toni N., D’Amour K.A., Lie D.C. & Gage F.H.
Nature, 430, 350-356, 2004
2003年
Interisland evolution of Trimeresurus flavoviridis venom phospholipase A2 isozymes
Chijiwa T., Yamaguchi Y., Ogawa T., Deshimaru M., Nobuhisa I., Nakashima K., Oda-Ueda N., Fukumaki Y., Hattori S. & Ohno M.
J Mol Evol, 56, 286-293, 2003
Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures
Shimozaki K., Nakashima K., Niwa H. & Taga T.
Development, 130, 2505-2512, 2003
Requirement of gp130 signaling for the AGM hematopoiesis
Takizawa M., Nobuhisa I., Igarashi K., Ueno M., Nakashima K., Kitamura T. & Taga T.
Exp Hematol, 31, 283-289, 2003
Enhanced gene activation by Notch and BMP signaling cross-talk
Takizawa T., Ochiai W., Nakashima K. & Taga T.
Nucleic Acids Res, 31, 5723-5731, 2003
Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function
Zhao X., Ueba T., Christie B.R., Barkho B., McConnell M.J., Nakashima K., Lein E.S., Eadie B.D., Willhoite A.R., Muotri A.R., Summers R.G., Chun J., Lee K.F. & Gage F.H.
Proc Natl Acad Sci USA, 100, 6777-6782, 2003
2002年
The Role of gp130 in Cerebral Cortical Development: In Vivo Functional Analysis in a Mouse Exo Utero System
Hatta T., Moriyama K., Nakashima K., Taga T. & Otani H.
J Neurosci, 22, 5516-5524, 2002
Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues
Kimura N., Takizawa M., Okita K., Natori O., Igarashi K., Ueno M., Nakashima K., Nobuhisa I. & Taga T.
Genes Cells, 7, 435-446, 2002
Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of stat3
Uemura A., Takizawa T., Ochiai W., Yanagisawa M., Nakashima K. & Taga T.
Cytokine, 18, 1-7, 2002
2001年
Ligand recognition by the vitamin D receptor.
Choi M., Yamamoto K., Masuno H., Nakashima K., Taga T. & Yamada S.
Bioorg Med Chem, 9, 1721-1730, 2001
Brain from bone: efficient “meta-differentiation” of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent
Kohyama J., Abe H., Shimazaki T., Koizumi A., Nakashima K., Gojo S., Taga T., Okano H., Hata J. & Umezawa A.
Differentiation, 68, 235-244, 2001
A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody
Matsuo R., Ochiai W., Nakashima K. & Taga T.
J Immunol Methods, 247, 141-151, 2001
BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis
Nakashima K., Takizawa T., Ochiai W., Yanagisawa M., Hisatsune T., Nakafuku M., Miyazono K., Kishimoto T., Kageyama R. & Taga T.
Proc Natl Acad Sci USA, 98, 5868-5873, 2001
Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3
Ochiai W., Yanagisawa M., Takizawa T., Nakashima K. & Taga T.
Cytokine, 14, 264-271, 2001
Traumatic injury-induced BMP7 expression in the adult rat spinal cord
Setoguchi T., Yone K., Matsuoka E., Takenouchi H., Nakashima K., Sakou T., Komiya S. & Izumo S
Brain Res, 921, 219-225, 2001.
DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain
Takizawa T., Nakashima K., Namihira M., Ochiai W., Uemura A., Yanagisawa M., Fujita N., Nakao M. & Taga T
Dev Cell, 1, 749-758, 2001.
Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3
Takizawa T., Yanagisawa M., Ochiai W., Yasukawa K., Ishiguro T., Nakashima K. & Taga T.
Cytokine, 13, 272-279, 2001
Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion
Ueno M., Igarashi K., Kimura N., Okita K., Takizawa M., Nobuhisa I., Kojima T., Kitamura T., Samulowitz U., Vestweber D., Shimomura T., Suda T., Nakashima K. & Taga T.
Biochem Biophys Res Commun, 287, 501-506, 2001
Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7
Yanagisawa M., Nakashima K., Takeda K., Ochiai W., Takizawa T., Ueno M., Takizawa M., Shibuya H. & Taga T.
Genes Cells, 6, 1091-1099, 2001
Signaling crosstalk underlying synergistic induction of astrocyte differentiation by BMPs and IL-6 family of cytokines
Yanagisawa M., Nakashima K., Takizawa T., Ochiai W., Arakawa H. & Taga T.
FEBS Lett, 489, 139-143, 2001
Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins
Yanagisawa M., Takizawa T., Ochiai W., Uemura A., Nakashima K. & Taga T.
Neurosci Res, 41, 391-396, 2001
2000年
Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan
Chijiwa T., Deshimaru M., Nobuhisa I., Nakai M., Ogawa T., Oda N., Nakashima K., Fukumaki Y., Shimohigashi Y., Hattori S. & Ohno M.
Biochem J, 347, 491-499, 2000
Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons
Kato H., Chen S., Kiyama H., Ikeda K., Kimura N., Nakashima K. & Taga T.
J Biochem, 128, 923-932, 2000
BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6
Kimura N., Matsuo R., Shibuya H., Nakashima K. & Taga T.
J Biol Chem, 275, 17647-17652, 2000
Cell density-dependent regulation of hepatic development by a gp130-independent pathway
Kojima N., Kinoshita T., Kamiya A., Nakamura K., Nakashima K., Taga T., Miyajima A..
Biochem Biophys Res Commun, 277, 152-158, 2000
Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1
Ueno M., Kimura N., Nakashima K., Saito-Ohara F., Inazawa J. & Taga T.
Gene, 254, 29-35, 2000
Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain
Yamamoto K., Masuno H., Choi M., Nakashima K., Taga T., Ooizumi H., Umesono K., Sicinska W., VanHooke J., DeLuca H.F. & Yamada S.
Proc Natl Acad Sci USA, 97, 1467-1472, 2000
Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3
Yanagisawa M., Nakashima K., Arakawa H., Ikenaka K., Yoshida K., Kishimoto T., Hisatsune T. & Taga T.
J Neurochem, 74, 1498-1504, 2000
1999年
Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer.
Kamiya A., Kinoshita T., Ito Y., Matsui T., Morikawa Y., Senba E., Nakashima K., Taga T., Yoshida K., Kishimoto T. & Miyajima A.
EMBO J, 18, 2127-2136, 1999
A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain
Kimura N., Nakashima K., Ueno M., Kiyama H. & Taga T.
Brain Res Dev Brain Res, 115, 183-193, 1999
A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains
Kimura N., Ueno M., Nakashima K. & Taga T.
J Biochem, 126, 180-187, 1999
Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300
Nakashima K., Yanagisawa M., Arakawa H., Kimura N., Hisatsune T., Kawabata M., Miyazono K. & Taga T.
Science, 284, 479-482, 1999
Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation
Nakashima K., Wiese S., Yanagisawa M., Arakawa H., Kimura N., Hisatsune T., Yoshida K., Kishimoto T., Sendtner M. & Taga T.
J Neurosci, 19, 5429-5434, 1999
Astrocyte differentiation mediated by LIF in cooperation with BMP2
Nakashima K., Yanagisawa M., Arakawa H. & Taga T.
FEBS Lett, 457, 43-46, 1999
STAT3-mediated astrocyte differentiation from mouse fetal neuroepithelial cells by mouse oncostatin M
Yanagisawa M., Nakashima K. & Taga T.
Neurosci Lett, 269, 169-172, 1999
1998年
Molecular cloning of mouse choline kinase and choline/ethanolamine kinase: their sequence comparison to the respective rat homologs
Aoyama C., Nakashima K. & Ishidate K.
Biochim Biophys Acta, 1393, 179-185, 1998
Complementary DNA sequence for a 42 kDa rat kidney choline/ethanolamine kinase
Aoyama C., Nakashima K., Matsui M. & Ishidate K.
Biochim Biophys Acta, 1390, 1-7, 1998
Retrotransposable CR1-like elements in crotalinae snake genomes
Nobuhisa I., Ogawa T., Deshimaru M., Chijiwa T., Nakashima K.I., Chuman Y., Shimohigashi Y., Fukumaki Y., Hattori S. & Ohno M.
Toxicon, 36, 915-920, 1998
1997年
Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130
Nakashima K., Narazaki M. & Taga T.
FEBS Lett, 403, 79-82, 1997
Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130
Nakashima K., Narazaki M. & Taga T.
FEBS Lett, 401, 49-52, 1997
Structures of genes encoding phospholipase A2 inhibitors from the serum of Trimeresurus flavoviridis snake
Nobuhisa I., Deshimaru M., Chijiwa T., Nakashima K., Ogawa T., Shimohigashi Y., Fukumaki Y., Hattori S., Kihara H. & Ohno M.
Gene, 191, 31-37, 1997
1996年
Accelerated evolution of crotalinae snake venom gland serine proteases
Deshimaru M., Ogawa T., Nakashima K., Nobuhisa I., Chijiwa T., Shimohigashi Y., Fukumaki Y., Niwa M., Yamashina I., Hattori S. & Ohno M.
FEBS Lett, 397, 83-88, 1996
Roles of lysine-69 in dimerization and activity of Trimeresurus flavoviridis venom aspartate-49-phospholipase A2
Nakamura S., Nakai M., Nakashima K., Ogawa T., Shimohigashi Y., Ohno M., Kihara H., Yamane T. & Ashida T.
J Mol Recognit, 9, 23-30, 1996
Accelerated evolution of Trimeresurus okinavensis venom gland phospholipase A2 isozyme-encoding genes
Nobuhisa I., Nakashima K., Deshimaru M., Ogawa T., Shimohigashi Y., Fukumaki Y., Sakaki Y., Hattori S., Kihara H. & Ohno M.
Gene, 172, 267-272, 1996
Accelerated evolution of snake venom phospholipase A2 isozymes for acquisition of diverse physiological functions
Ogawa T., Nakashima K., Nobuhisa I., Deshimaru M., Shimohigashi Y., Fukumaki Y., Sakaki Y., Hattori S. & Ohno M.
Toxicon, 34, 1229-1236, 1996
1995年
Purification and primary structure of a myotoxic lysine-49 phospholipase A2 with low lipolytic activity from Trimeresurus gramineus venom
Nakai M., Nakashima K.I., Ogawa T., Shimohigashi Y., Hattori S., Chang C.C. & Ohno M.
Toxicon, 33, 1469-1478, 1995
Accelerated evolution in the protein-coding regions is universal in crotalinae snake venom gland phospholipase A2 isozyme genes
Nakashima K., Nobuhisa I., Deshimaru M., Nakai M., Ogawa T., Shimohigashi Y., Fukumaki Y., Hattori M., Sakaki Y., Hattori S. & Ohno M.
Proc Natl Acad Sci USA, 92, 5605-5609, 1995
Structures of genes encoding TATA box-binding proteins from Trimeresurus gramineus and T. flavoviridis snakes
Nakashima K., Nobuhisa I., Deshimaru M., Ogawa T., Shimohigashi Y., Fukumaki Y., Hattori M., Sakaki Y., Hattori S. & Ohno M.
Gene, 152, 209-213, 1995
Molecular evolution of group II phospholipases A2
Ogawa T., Kitajima M., Nakashima K., Sakaki Y. & Ohno M.
J Mol Evol, 41, 867-877, 1995
Trimeresurus flavoviridis venom gland phospholipase A2 isozymes genes have evolved via accelerated substitutions
Ogawa T., Nakashima K., Oda N., Shimohigashi Y., Ohno M., Hattori S., Hattori M., Sakaki Y. & Kihara H.
J Mol Recognit, 8, 40-46 1995
Lysine-49-Phospholipase A2 from Trimeresurus flavoviridis venom are membrane-acting enzymes
Shimohigashi Y., Tani A., Matsumoto H., Nakashima K., Yamaguchi Y., Oda N., Takano Y., Kamiya H., Kishino J., Arita H. & Ohno M.
J Biochem, 118, 1037-1044, 1995
1994年
Polymorphisms of Trimeresurus flavoviridis venom gland phospholipase A2 isozyme genes
Nakashima K., Nobuhisa I., Ogawa T., Hattori M., Sakaki Y., Kihara H. & Ohno M
Biosci Biotechnol Biochem, 58, 1510-1511, 1994.
Darwinian evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes
Nakashima K., Ogawa T., Oda N., Shimohigashi Y., Hattori M., Sakaki Y., Kihara H. & Ohno M.
Pure & Appl Chem, 66, 715-720, 1994
1993年
Purification, sequencing and characterization of single amino acid-substituted phospholipase A2 isozymes from Trimeresurus gramineus (green habu snake) venom
Fukagawa T., Nose T., Shimohigashi Y., Ogawa T., Oda N., Nakashima K., Chang C.C. & Ohno M.
Toxicon, 31, 957-967, 1993
Accelerated evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes
Nakashima K., Ogawa T., Oda N., Hattori M., Sakaki Y., Kihara H. & Ohno M.
Proc Natl Acad Sci USA, 90, 5964-5968, 1993
Chymotrypsin inhibitory conformation of dipeptides constructed by side chain-side chain hydrophobic interactions
Sakamoto H., Shimohigashi Y., Maeda I., Nose T., Nakashima K., Nakamura I., Ogawa T., Kawano K. & Ohno M.
Mol Recognit, 6, 95-100, 1993
1992年
Refolding of Trimeresurus flavoviridis phospholipase A2
Tsuno S., Ogawa T., Nakashima K., Oda N., Lee S., Shimohigashi Y., Aoyagi H. & Ohno M.
Bull Chem Soc Jpn, 65, 2655-2659 1992
Unusually high conservation of untranslated sequences in cDNAs for Trimeresurus flavoviridis phospholipase A2 isozymes
Ogawa T., Oda N., Nakashima K., Sasaki H., Hattori M., Sakaki Y., Kihara H. & Ohno M.
Proc Natl Acad Sci USA, 89, 8557-8561, 1992