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Loss of endothelial membrane KIT ligand affects systemic KIT ligand levels but not bone marrow hematopoietic stem cells

Matsuoka S, Facchini R, Luis TC, Carrelha J, Woll PS, Mizukami T, Wu B,
Boukarabila H, Buono M, Norfo R, Arai F, Suda T, Mead AJ, Nerlov C,
Jacobsen SEW.
Blood 142(19):1622-1632, 2023
doi: 10.1182/blood.2022019018.
*This work selected as journal cover image

POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis

Nakashima K, Kunisaki Y, Hosokawa K, Gotoh K, Yao H, Yuta R, Semba Y,
Nogami J, Kikushige Y, Stumpf PS, MacArthur BD, Kang D, Akashi K,
Ohga S, Arai F.
Commun Biol 6(1):996, 2023
doi: 10.1038/s42003-023-05374-0.

MBTD1 preserves adult hematopoietic stem cell pool size and function

Takubo K, Htun PW, Ueda T, Sera Y, Iwasaki M, Koizumi M, Shiroshita K,
Kobayashi H, Haraguchi M, Watanuki S, Honda ZI, Yamasaki N, Nakamura-Ishizu A,
Arai F, Motoyama N, Hatta T, Natsume T, Suda T, Honda H.
Proc Natl Acad Sci U S A. 120(32):e2206860120, 2023
doi: 10.1073/pnas.2206860120.

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

Nakajima-Takagi Y, Oshima M, Takano J, Koide S, Itokawa N, Uemura S,
Yamashita M, Andoh S, Aoyama K, Isshiki Y, Shinoda D, Saraya A, Arai F,
Yamaguchi K, Furukawa Y, Koseki H, Ikawa T, Iwama A.
Elife. 12:e83004, 2023.
doi: 10.7554/eLife.83004

Generation of functional oocytes from male mice in vitro

Murakami K, Hamazaki N, Hamada N, Nagamatsu G, Okamoto I, Ohta H,
Nosaka Y, Ishikura Y, Kitajima TS, Semba Y, Kunisaki Y, Arai F, Akashi K,
Saitou M, Kato K, Hayashi K.
Nature. 615(7954):900-906, 2023
doi: 10.1038/s41586-023-05834-x

MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis

Hayashi Y, Kawabata KC, Tanaka Y,Uehara Y, Mabuchi Y, Murakami K,
Nishiyama A, Kiryu S,Yoshioka Y, Ota Y, Sugiyama T, Mikami K,
Tamura M, Fukushima T, Asada S, Takeda R, Kunisaki Y, Fukuyama T,
Yokoyama K, Uchida T, Hagihara M, Ohno N, Usuki K, Tojo A, Katayama Y,
Goyama S, Arai F, Tamura T, Nagasawa T, Ochiya T, Inoue D, Kitamura T.
Cell Rep. 10;39(6):110805., 2022
doi: 10.1016/j.celrep.2022.110805.

Modeling Stem Cell Fates using Non-Markov Processes

Stumpf PS, Arai F, , MacArthur BD.
Cell Stem Cell. 28(2):187-190, 2021
doi: 10.1016/j.stem.2021.01.009

Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal

Arai F, Stumpf PS, Ikushima YM, Hosokawa K, Roch A, Lutolf MP, Suda T,
MacArthur BD.
Cell Systems., 11(6):640-652.e5, 2020.
doi: 10.1016/j.cels.2020.11.004

Transfer learning efficiently maps bone marrow cell types from mouse to human using single-cell RNA sequencing

Stumpf PS, Du X, Imanishi H, Kunisaki Y, Semba Y, Noble T, Smith RCG,
Zerili MR, West JJ, Oreffo ROC, Farrahi K, Niranjan M, Akashi K,
Arai F, MacArthur BD.
Commun Biol. 3(1):736, 2020.
doi: 10.1038/s42003-020-01463-6.

Heterogeneity and ‘memory’ in stem cell populations

Patrick S.Stumpf, Fumio Arai, Ben D.MacArthur.
Phys Biol. 17(6):065013, 2020.
doi: 10.1088/1478-3975/abba85

Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45 – TER119 – Erythroid and Lymphoid Progenitors

Gotoh K, Kunisaki Y, Mizuguchi S, Setoyama D, Hosokawa K, Yao H,
Nakashima Y, Yagi M, Uchiumi T, Semba Y, Nogami J, Akashi K, Arai F, Kang D.
iScience. 23(11):101654, 2020
doi: 10.1016/j.isci.2020.101654

A novel method to purify neutrophils enables functional analysis of zebrafish hematopoiesis

Konno K, Kulkeaw K, Sasada M, Nii T, Kaneyuki A, Ishitani T, Arai F, Sugiyama D.
Genes Cells., 2020
doi: 10.1111/gtc.12810

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi H, Morikawa T, Okinaga A, Hamano F, Hashidate-Yoshida T,
Watanuki S,Hishikawa D, Shindou H, Arai F, Kabe Y, Suematsu M,
Shimizu T, Takubo K.
Cell Rep. 28(1):145-158.e9, 2019
doi: 10.1016/j.celrep.2019.06.008

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H,
Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N.
Nat Commun. 10(1):1072, 2019
doi: 10.1038/s41467-019-09028-w.

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y,
Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N,
Aikawa Y, Oishi S, Nonami A, Arai F, Hagihara S, Yamaguchi J, Tama F,
Kunisaki Y, Yagita K,
Ikeda M, Kinoshita T, Kay SA, Itami K, Hirota T.
Sci Adv. 5(1):eaau9060, 2019
doi: 10.1126/sciadv.aau9060

Leukaemia hijacks a neural mechanism to invade the central nervous system

Yao H, Price TT, Cantelli G, Ngo B, Warner MJ, Olivere L, Ridge SM,
Jablonski EM, Therrien J, Tannheimer S, McCall CM, Chenn A, Sipkins DA.
Nature. 560(7716):55-60, 2018
doi: 10.1038/s41586-018-0342-5

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.

Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M,
Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F,
Yoshimura A, Nakauchi H, Hirao A.
Cell Stem Cell. 22(5):713-725.e8, 2018
doi: 10.1016/j.stem.2018.04.002

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

Yamauchi T, Masuda T, Canver MC, Seiler M, Semba Y, Shboul M,
Al-Raqad M, Maeda M, Schoonenberg VAC, Cole MA, Macias-Trevino C,
Ishikawa Y, Yao Q, Nakano M, Arai F, Orkin SH, Reversade B,
Buonamici S, Pinello L, Akashi K, Bauer DE, Maeda T.
Cancer Cell. 33(3): 386-400.e5., 2018
doi: 10.1016/j.ccell.2018.01.012.

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

Hosokawa K, MacArthur BD, Ikushima YM, Toyama H, Masuhiro Y,
Hanazawa S, Suda T, Arai F
Nature Communications 8(804), 2017.
doi: 10.1038/s41467-017-00935-4

Stem Cell Differentiation as a Non-Markov Stochastic Process.

Stumpf PS, Smith RCG, Lenz M, Schuppert A, Muller FJ, Babtie A, Chan TE,
Stumpf MPH, Please CP, Howison SD, Arai F, MacArthur BD.
Cell Systems. 5(3):268-282.e7, 2017
doi: 10.1016/j.cels.2017.08.009

Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression.

Ali MAE, Fuse K, Tadokoro Y, Hoshii T, Ueno M, Kobayashi M, Nomura N,
Vu HT, Peng H, Hegazy AM, Masuko M, Sone H, Arai F, Tajima A, Hirao A.
Scientific Reports. 7(1):11442, 2017.
doi: 10.1038/s41598-017-11909-3.

Identification of unipotent megakaryocyte progenitors in human hematopoiesis.

Miyawaki K, Iwasaki H, Jiromaru T, Kusumoto H, Yurino A, Sugio T, Uehara Y,
Odawara J, Daitoku S, Kunisaki Y, Mori Y, Arinobu Y, Tsuzuki H, Kikushige Y,
Iino T, Kato K, Takenaka K, Miyamoto T, Maeda T, Akashi K.
Blood. 129(25):3332-3343, 2017.
doi: 10.1182/blood-2016-09-741611.

Differential cytokine contributions of perivascular haematopoietic stem cell niches.

Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez NF, Birbrair A,
Ma’ayan A, Frenette PS.
Nature Cell Biology 19(3):214-223, 2017
doi: 10.1038/ncb3475.

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.

Ito K, Turcotte R, Cui J, Zimmerman SE, Pinho S, Mizoguchi T, Arai F,
Runnels JM, Alt C, Teruya-Feldstein J, Mar JC, Singh R, Suda T,
Lin CP, Frenette PS, Ito K.
Science. 354(6316):1156-1160, 2016.
doi: 10.1126/science.aaf5530

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.

Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K,
Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y,
Kimura H, Nakauchi H, Suda T, Shinkai Y, Iwama A.
Blood. 128(5):638-49, 2016.
doi: 10.1182/blood-2016-01-694810

Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes.

Sakamoto H, Takeda N, Arai F, Hosokawa K, Garcia P, Suda T,
Frampton J, Ogawa M.
Stem Cells. 33 (2): 479-490, 2015.
doi: 10.1002/stem.1855

Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression

Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa K, Doi Y, Ninomiya T,
Horiguchi H, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K,
Takeya M, Hao H, Hirose N, Minami T, Suda T, Kiyohara Y, Ogawa H,
Kaikita K, Oike Y.
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):790-800.
doi: 10.1161/ATVBAHA.113.303116.

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells.

Yamashita M, Nitta E, Nagamatsu G, Ikushima YM, Hosokawa K, Arai F, Suda T.
Biochem Biophys Res Commun. 441 (1): 196-201, 2013.
doi: 10.1016/j.bbrc.2013.10.032

OP9 bone marrow stroma cells differentiate into megakaryocytes and platelets.

Matsubara Y, Ono Y, Suzuki H, Arai F, Suda T, Murata M, Ikeda Y.
PLoS One. 8 (3): e58123, 2013.

Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.

Ikushima YM, Arai F, Hosokawa K, Toyama H, Takubo K, Furuyashiki T, Narumiya S, Suda T.
Blood. 121 (11): 1995-2007, 2013.

Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells.

Ikushima YM, Arai F, Nakamura Y, Hosokawa K, Kubota Y, Hirashima M, Toyama H, Suda T.
Biochem Biophys Res Commun. 430 (1): 20-25, 2013.

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs.

Toyama H, Arai F, Hosokawa K, Ikushima YM, Suda T.
Biochem Biophys Res Commun. 428 (3): 354-359, 2012.

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.

Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, Pandolfi PP.
Nat Med. 18 (9): 1350-1358, 2012.

Noncanonical wnt signaling maintains hematopoietic stem cells in the niche.

Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T, Li L.
Cell 150 (2): 351-365, 2012.

Impact of gene dosage, loss of wild type allele and FLT3 ligand on Flt3-ITD induced myeloproliferation.

Kharazi S, Mead AJ, Mansour A, Hultquist A, Böiers C, Luc S, Buza-Vidas N, Ma Z, Ferry H, Atkinson D, Reckzeh K, Masson K, Cammenga J, Rönnstrand L, Arai F, Suda T, Nerlov C, Sitnicka E, Jacobsen SE.
Blood 118 (13): 3613-3621, 2011

Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere independent mechanism.

Nitta E, Yamashita M, Hosokawa K, Xian M, Takubo K, Arai F, Nakada S, Suda T.
Blood 117 (16): 4169-80. 2011.

Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation.

Shima H, Takubo K, Tago N, Iwasaki H, Arai F, Takahashi T, Suda T.
Exp Hematol 38 (12): 1231-1240, 2010

TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool.

Nakajima H, Ito M, Smookler DS, Shibata F, Fukuchi Y, Morikawa Y, Ikeda Y, Arai F, Suda T, Khokha R, Kitamura T.
Blood 116 (22): 4474-4482, 2010

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells.

Nakamura Y, Arai F*†, Iwasaki H, Hosokawa K, Kobayashi I, Gomei Y, Matsumoto Y, Yoshihara H, Suda T.
Blood 116 (9): 1422-1432, 2010. (*equally contributed, †corresponding author)

Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver.

Iwasaki H, Arai F, Kubota Y, Dahl M, Suda T.
Blood 116 (4): 544-553, 2010

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells.

Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Nakamura Y, Gomei Y, Suda T.
Blood 116 (4): 554-563, 2010. (*equally contributed, †corresponding author)

Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow.

Hosokawa K, Arai F*†, Yoshihara H, Iwasaki H, Hembree M, Yin T, Nakamura N, Gomei Y, Takubo K, Shiama H, Matsuoka S, Li L, Suda T.
Cell Stem Cell 6 (3): 194-198, 2010. (*equally contributed, †corresponding author)

Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells.

Gomei Y, Nakamura Y, Yoshihara H, Hosokawa K, Iwasaki H, Suda T, Arai F†.
Exp Hematol 38 (2): 82-89 2009. (†corresponding author)

IRF-2 protects quiescent HSCs from type-I interferon-dependent exhaustion.

Sato T, Onai N, Yoshihara H, Arai F, Suda T, Ohteki T.
Nat Med 15 (6): 696-700, 2009.

Angiopoietins contribute to lung development by regulating pulmonary vascular network formation.

Hato T, Kimura Y, Morisada T, Koh GY, Miyata K, Tabata M, Kadomatsu T, Endo M, Urano T, Arai F, Araki K, Suda T, Kobayashi K, Oike Y.
Biochem Biophys Res Commun 381 (2): 218-223, 2009

Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice.

Shima H, Takubo K, Iwasaki H, Yoshihara H, Gomei Y, Hosokawa K, Arai F, Takahashi T, Suda T.
Biochem Biophys Res Commun 378 (3): 467-472, 2009

Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity.

Ohmura M, Naka K, Hoshii T, Muraguchi T, Shugo H, Tamase A, Uema N, Ooshio T, Arai F, Takubo K, Nagamatsu G, Hamaguchi I, Takagi M, Ishihara M, Sakurada K, Miyaji H, Suda T, Hirao A.
Stem Cells 26(12): 3237-3246, 2008

Fbxw7 acts as a critical failsafe against premature loss of hematopoietic stem cells and development of T-ALL.

Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T.
Genes Dev 22 (8): 986-991, 2008

Stem Cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell cycle arrest.

Takubo K, Ohmura M, Azuma M, Nagamatsu G, Yamada W, Arai F, Hirao A, Suda T.
Cell Stem Cell 2 (2): 170-182, 2008

Thrombopoietin/Mpl signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.

Yoshihara H, Arai F*†, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, Miyazaki H, Takahashi T, Suda T.
Cell Stem Cell 1 (6): 685-697, 2007 (*equally contributed, †corresponding author)

Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction.

Hosokawa K, Arai F*, Yoshihara H, Nakamura Y, Gomei Y, Iwasaki H, Miyamoto K, Shima H, Ito K, Suda T.
Biochem Biophys Res Commun 363 (3): 578-583, 2007 (*equally contributed)

Foxo3a is essential for maintenance of hematopoietic stem cell pool.

Miyamoto K, Araki K, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama K-I, Harada M, Motoyama N, Suda T, Hirao A.
Cell Stem Cell 1 (1): 101-112, 2007

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double strand breaks in lymphocytes.

Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A.
J Immunol 178 (1): 103-110, 2007

Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice.

Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T.
Leukemia 21 (1): 136-142, 2007

Premeiotic germ cell defect in seminiferous tubules of Atm-null testis.

Takubo K, Hirao A, Ohmura M, Azuma M, Arai F, Nagamatsu G, Suda T.
Biochem Biophys Res Commun 351 (4): 993-998, 2006

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.

Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y and Suda T.
Nat Med 12 (4): 446-451, 2006

Regulation of oxidative stress by ATM is required for the self-renewal of haematopoietic stem cells.

Ito K, Hirao A, Arai F, Matsuoka S, Takubo K, Hamaguchi I, Nomiyama K, Hosokawa K, Sakurada K, Nakagata N, Ikeda Y, Mak TW, Suda T.
Nature 431 (7011): 997-1002, 2004

Tie2/Angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.

Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Ito K, Takubo K, Koh GY and Suda T.
Cell 118 (2): 149-161, 2004

A novel angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling and regeneration.

Oike Y, Yasunaga K, Ito Y, Matsumoto S, Maekawa H, Morisada T, Arai F, Nakagata N, Takeya M, Masuho Y, and Suda T.
Proc Natl Acad Sci USA 100 (16): 9494-9499, 2003

Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells.

Oike Y, Hamada K, Ito Y, Zhang XQ, Miyata K, Arai F, Inada T, Nakagata N, Takeya M, Gale NW, and Suda T.
Blood 100 (4): 1326-1333, 2002

Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in endochondral ossification.

Arai F, Ohneda O, Miyamoto T, Zhang XQ, and Suda T.
J Exp Med 195 (12): 1549-1563, 2002

Bifurcation of osteoclasts and dendritic cells from common progenitors.

Miyamoto T, Ohneda O, Arai F, Iwamoto K, Okada S, Takagi K, Anderson DM, and Suda T.
Blood 98 (8): 2544-2554, 2001

ALCAM (CD166): its role in hematopoietic and endothelial development.

Ohneda O, Ohneda K, Arai F, Lee J, Miyamoto T, Fukushima Y, Dowbenko D, Lasky LA, and Suda T.
Blood 98 (7): 2134-2142, 2001

An adherent condition is required for formation of multinuclear osteoclasts in the presence of macrophage colony-stimulating factor and receptor activator of nuclear factor kappa B ligand.

Miyamoto T, Arai F, Ohneda O, Takagi K, Anderson DM, Suda T.
Blood 96 (13): 4335-4343, 2000

WECHE: a novel hematopoietic regulatory factor.

Ohneda O, Ohneda K, Nomiyama H, Zheng Z, Gold SA, Arai F, Miyamoto T, Taillon BE, McIndoe RA, Shimkets RA, Lewin DA, Suda T, Lasky LA.
Immunity 12 (2): 141-150, 2000

Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors.

Arai F, Miyamoto T, Ohneda O, Inada T, Sudo T, Brasel K, Miyata T, Anderson DM, Suda T.
J Exp Med 190 (12): 1741-1754, 1999

Macrophage-stimulating protein and its receptor, RON, stimulate human osteoclast activity but not proliferation: effect of MSP distinct from that of hepatocyte growth factor.

Kurihara N, Tatsumi J, Arai F, Iwama A, and Suda T.
Exp Hematol 26 (11): 1080-1085, 1998

The N-terminal fragment of osteocalcin is released during osteoclastic bone resorption.

Kurihara N, Hosoda K, Tatsumi J, Yamaji T, Hoshihara E, Arai F, and Ikeda K.

J Bone Miner Metab 16: 11-16, 1998

23(S)25(R)-1,25-Dihydroxyvitamin D3-lactone, a naturally occurring metabolite of 1,25-dihydroxyvitamin D3, inhibits osteoclast-like cell formation in human bone marrow cultures.

Kurihara N, Ishizuka S, Tatsumi J, Kumegawa M, Arai F, Ikeda K, and Roodman GD.
J Bone Miner Metab 16: 5-10, 1998

英文総説


The role of telomere binding molecules for normal and abnormal hematopoiesis.

Hosokawa K, Arai F
Int J Hematol. 2018
doi: 10.1007/s12185-018-2432-4. 

Wnt signaling in the niche.

Suda, T., and Arai, F.
Cell 132 (5): 729-730, 2008 (Invited Review)

Role of stem cell niche in the maintenance of hematopoietic stem cells.

Arai F†, Suda T.
Inflammation and Regeneration 27 (2): 117-123, 2007 (†corresponding author)

Regulation of hematopoietic stem cell and its interaction with stem cell niche.

Arai F†.
J Oral Biosci 48 (1): 22-29, 2006 (†corresponding author)

Regulation of the hematopoiesis and its interaction with stem cell niche.

Arai F†, Hirao A, Suda T.
Int J Hematol 82 (5): 371-376, 2005 (†corresponding author)

Regulation of stem cells in the niche.

Suda T, Arai F, Shimmura S.
Cornea 24 (8 Suppl): S12-S17, 2005

Hematopoietic stem cells and their niche.

Suda T, Arai F, Hirao A.
Trends Immunol 26 (8): 426-433, 2005

Regulation of hematopoietic stem cells by the niche.

Arai F†, Hirao A, Suda T.
Trends Cardiovasc Med 15 (2): 75-79, 2005 (†corresponding author)

Regulation of cell cycle in hematopoietic stem cells by the niche.

Hirao A, Arai F, Suda T.
Cell Cycle 3 (12): 1481-1483, 2004

英文著書


Hematopoietic Cell Isolation by Antibody-Free Flow Cytometry in the Zebrafish Embryo

Katsuhiro Konno # , Jingjing Kobayashi-Sun # , Fumio Arai , Isao Kobayashi , Daisuke Sugiyama
Methods Mol Biol 2520:171-180, 2022
doi: 10.1007/7651_2021_459.

The role of N-cadherin-mediated cell adhesion in the regulation of hematopoietic stem/progenitor cell activities in the bone marrow niche.

Arai F, Hosokawa K, Toyama H, Matsumoto Y, Suda T.
Ann N Y Acad Sci. 1266 (1): 72-77, 2012.
doi: 10.1111/j.1749-6632.2012.06576.x

Gene expression profiling and regulatory networks in single cell.

Arai F, Hosokawa K, Matsumoto Y, Toyama H, Suda T.
Network analysis in systems biology. (Edited by Avi Ma’ayan and Ben D. Macarthur), Springer, pp. 1-13, 2012.

Niche regulation of hematopoietic stem cells in the endosteum.

Arai F, Yoshihara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Suda T.
Ann N Y Acad Sci 1176, 36-46, 2009.

Quiescent stem cells in the niche.

Arai F, Suda T.
StemBook, ed. (Edited by: Gilliland G) The Stem Cell Research Community, StemBook, http://www.stembook.org. (Published July 11, 2008)

Regulation of hematopoietic stem cells in the osteoblastic niche.

Arai F†, Suda T.
Osteoimmunology: Interactions of the Immune and Skeletal System (Choi Y, edited), Adv Exp Med Biol. 602: 61-67, 2007 (†Corresponding author)

Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Hematopoietic Stem Cells VI.

Arai F†, Suda T.
Ann N Y Acad Sci, 1106:41-53, 2007. (†corresponding author)

Endothelial and hematopoietic cells in the intraembryonic compartment.

Arai F, Suda T.
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