研究業績
論文
Modeling early stages of endoderm development in epiblast stem cell aggregates with supply of extracellular matrices.
Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.
Saba R, Kitajima K, Rainbow L, Engert S, Uemura M, Ishida H, Kokkinopoulos I, Shintani Y, Miyagawa S, Kanai Y, Kanai-Azuma M, Koopman P, Meno C, Kenny J, Lickert H, Saga Y, Suzuki K, Sawa Y, Yashiro K.
ChIP-Atlas: a data-mining suite powered by full integration of public ChIP-seq data.
Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters.
Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells.
Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins.
Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2.
Hyperglycemia impairs left-right axis formation and thereby disturbs heart morphogenesis in mouse embryos.
SraTailor: graphical user interface software for processing and visualizing ChIP-seq data.
Epiblast ground state is controlled by canonical Wnt/beta-catenin signaling in the postimplantation mouse embryo and epiblast stem cells.
T. Sumi, S. Oki, K. Kitajima and C. Meno
Wnt signaling regulates left-right axis formation in the node of mouse embryos.
K. Kitajima, S. Oki, Y. Ohkawa, T. Sumi and C. Meno
The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node.
J. M. Inacio, S. Marques, T. Nakamura, K. Shinohara, C. Meno, H. Hamada and J. A. Belo
Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo.
T. Noda, S. Oki, K. Kitajima, T. Harada, S. Komune and C. Meno
DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.
F. Sanematsu, M. Hirashima, M. Laurin, R. Takii, A. Nishikimi, K. Kitajima, G. Ding, M. Noda, Y. Murata, Y. Tanaka, S. Masuko, T. Suda, C. Meno, J. F. Cote, T. Nagasawa and Y. Fukui
Dissecting the role of Fgf signaling during gastrulation and left-right axis formation in mouse embryos using chemical inhibitors.
S. Oki, K. Kitajima and C. Meno
Planar polarization of node cells determines the rotational axis of node cilia.
M. Hashimoto, K. Shinohara, J. Wang, S. Ikeuchi, S. Yoshiba, C. Meno, S. Nonaka, S. Takada, K. Hatta, A. Wynshaw-Boris and H. Hamada
Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo.
M. Yamamoto, H. Beppu, K. Takaoka, C. Meno, E. Li, K. Miyazono and H. Hamada
Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos.
S. Oki, K. Kitajima, S. Marques, J. A. Belo, T. Yokoyama, H. Hamada and C. Meno
The mouse embryo autonomously acquires anterior-posterior polarity at implantation.
K. Takaoka, M. Yamamoto, H. Shiratori, C. Meno, J. Rossant, Y. Saijoh and H. Hamada
Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system.
T. Nakamura, N. Mine, E. Nakaguchi, A. Mochizuki, M. Yamamoto, K. Yashiro, C. Meno and H. Hamada
Basement membrane fragility underlies embryonic lethality in fukutin-null mice.
H. Kurahashi, M. Taniguchi, C. Meno, Y. Taniguchi, S. Takeda, M. Horie, H. Otani and T. Toda
Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo.
M. Yamamoto, Y. Saijoh, A. Perea-Gomez, W. Shawlot, R. R. Behringer, S. L. Ang, H. Hamada and C. Meno
Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate.
M. Yamamoto, N. Mine, K. Mochida, Y. Sakai, Y. Saijoh, C. Meno and H. Hamada
Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion.
R. Sakuma, Y. Ohnishi Yi, C. Meno, H. Fujii, H. Juan, J. Takeuchi, T. Ogura, E. Li, K. Miyazono and H. Hamada
Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.
A. Perea-Gomez, F. D. Vella, W. Shawlot, M. Oulad-Abdelghani, C. Chazaud, C. Meno, V. Pfister, L. Chen, E. Robertson, H. Hamada, R. R. Behringer and S. L. Ang
Establishment of vertebrate left-right asymmetry.
H. Hamada, C. Meno, D. Watanabe and Y. Saijoh
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse.
M. Yamamoto, C. Meno, Y. Sakai, H. Shiratori, K. Mochida, Y. Ikawa, Y. Saijoh and H. Hamada
The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo.
Y. Sakai, C. Meno, H. Fujii, J. Nishino, H. Shiratori, Y. Saijoh, J. Rossant and H. Hamada
Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.
C. Meno, J. Takeuchi, R. Sakuma, K. Koshiba-Takeuchi, S. Ohishi, Y. Saijoh, J. Miyazaki, P. ten Dijke, T. Ogura and H. Hamada
GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion.
J. Nishino, K. Mochida, Y. Ohfuji, T. Shimazaki, C. Meno, S. Ohishi, Y. Matsuda, H. Fujii, Y. Saijoh and H. Hamada
Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.
C. Meno, K. Gritsman, S. Ohishi, Y. Ohfuji, E. Heckscher, K. Mochida, A. Shimono, H. Kondoh, W. S. Talbot, E. J. Robertson, A. F. Schier and H. Hamada
Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry.
H. Yoshioka, C. Meno, K. Koshiba, M. Sugihara, H. Itoh, Y. Ishimaru, T. Inoue, H. Ohuchi, E. V. Semina, J. C. Murray, H. Hamada and S. Noj
lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.
C. Meno, A. Shimono, Y. Saijoh, K. Yashiro, K. Mochida, S. Ohishi, S. Noji, H. Kondoh and H. Hamada
Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.
C. Meno, Y. Ito, Y. Saijoh, Y. Matsuda, K. Tashiro, S. Kuhara and H. Hamada
Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor.
Y. Saijoh, H. Fujii, C. Meno, M. Sato, Y. Hirota, S. Nagamatsu, M. Ikeda and H. Hamada
Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.
C. Meno, Y. Saijoh, H. Fujii, M. Ikeda, T. Yokoyama, M. Yokoyama, Y. Toyoda and H. Hamada
Synchronous sperm penetration of zona-free mouse eggs in vitro.
Y. Takahashi, C. Meno, E. Sato and Y. Toyoda