九州大学大学院医学研究院
幹細胞再生修復医学分野

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英文原著

20252報
  1. Acute myeloid leukemia stem cells remodel the bone marrow niche via TGF-β-activated Alcam+ bone lining cells, creating a self-sustaining environment
    Nguyen NTK, Yao H, Hosokawa K, Esaki Y, Yuta R, Adachi S & Arai F. — Leukemia (2025)
    doi:10.1038/s41375-025-02640-4
  2. TP-0903 Suppresses Aurora A-PLK1 Signaling to Inhibit Proliferation of a Myelodysplastic Syndrome-Derived Cell Line.
    Kimura-Hyoda T, Ryu M, Yuta R, Fukumoto S, Hosokawa K, Yao H, Yasuda Y, Miura K, Tohyama K, Arai F, Uchiumi T. — Cancer Sci. 2025 Oct;116(10):2831-2845. (Epub 2025 Jul 28)
    doi:10.1111/cas.70151PMID: 40722126
20235報
  1. Loss of endothelial membrane KIT ligand affects systemic KIT ligand levels but not bone marrow hematopoietic stem cells
    Matsuoka S, Facchini R, Luis TC, Carrelha J, Woll PS, Mizukami T, Wu B, Boukarabila H, Buono M, Norfo R, Arai F, Suda T, Mead AJ, Nerlov C, Jacobsen SEW. — Blood 142(19):1622-1632 (2023) ※journal cover image
    doi:10.1182/blood.2022019018
  2. POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis
    Nakashima K, Kunisaki Y, Hosokawa K, Gotoh K, Yao H, Yuta R, Semba Y, Nogami J, Kikushige Y, Stumpf PS, MacArthur BD, Kang D, Akashi K, Ohga S, Arai F. — Commun Biol 6(1):996 (2023)
    doi:10.1038/s42003-023-05374-0
  3. MBTD1 preserves adult hematopoietic stem cell pool size and function
    Takubo K, Htun PW, Ueda T, Sera Y, Iwasaki M, Koizumi M, Shiroshita K, Kobayashi H, Haraguchi M, Watanuki S, Honda ZI, Yamasaki N, Nakamura-Ishizu A, Arai F, Motoyama N, Hatta T, Natsume T, Suda T, Honda H. — PNAS 120(32):e2206860120 (2023)
    doi:10.1073/pnas.2206860120
  4. Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis
    Nakajima-Takagi Y, Oshima M, Takano J, Koide S, Itokawa N, Uemura S, Yamashita M, Andoh S, Aoyama K, Isshiki Y, Shinoda D, Saraya A, Arai F, Yamaguchi K, Furukawa Y, Koseki H, Ikawa T, Iwama A. — eLife 12:e83004 (2023)
    doi:10.7554/eLife.83004
  5. Generation of functional oocytes from male mice in vitro
    Murakami K, Hamazaki N, Hamada N, Nagamatsu G, Okamoto I, Ohta H, Nosaka Y, Ishikura Y, Kitajima TS, Semba Y, Kunisaki Y, Arai F, Akashi K, Saitou M, Kato K, Hayashi K. — Nature 615(7954):900-906 (2023)
    doi:10.1038/s41586-023-05834-x
20221報
  1. MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis
    Hayashi Y, Kawabata KC, Tanaka Y, Uehara Y, Mabuchi Y, Murakami K, Nishiyama A, Kiryu S, Yoshioka Y, Ota Y, Sugiyama T, Mikami K, Tamura M, Fukushima T, Asada S, Takeda R, Kunisaki Y, Fukuyama T, Yokoyama K, Uchida T, Hagihara M, Ohno N, Usuki K, Tojo A, Katayama Y, Goyama S, Arai F, Tamura T, Nagasawa T, Ochiya T, Inoue D, Kitamura T. — Cell Rep 39(6):110805 (2022)
    doi:10.1016/j.celrep.2022.110805
20211報
  1. Modeling Stem Cell Fates using Non-Markov Processes
    Stumpf PS, Arai F, MacArthur BD. — Cell Stem Cell 28(2):187-190 (2021)
    doi:10.1016/j.stem.2021.01.009
20205報
  1. Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal
    Arai F, Stumpf PS, Ikushima YM, Hosokawa K, Roch A, Lutolf MP, Suda T, MacArthur BD. — Cell Systems 11(6):640-652.e5 (2020)
    doi:10.1016/j.cels.2020.11.004
  2. Transfer learning efficiently maps bone marrow cell types from mouse to human using single-cell RNA sequencing
    Stumpf PS, Du X, Imanishi H, Kunisaki Y, Semba Y, Noble T, Smith RCG, Zerili MR, West JJ, Oreffo ROC, Farrahi K, Niranjan M, Akashi K, Arai F, MacArthur BD. — Commun Biol 3(1):736 (2020)
    doi:10.1038/s42003-020-01463-6
  3. Heterogeneity and ‘memory’ in stem cell populations
    Stumpf PS, Arai F, MacArthur BD. — Phys Biol 17(6):065013 (2020)
    doi:10.1088/1478-3975/abba85
  4. Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45–TER119– Erythroid and Lymphoid Progenitors
    Gotoh K, Kunisaki Y, Mizuguchi S, Setoyama D, Hosokawa K, Yao H, Nakashima Y, Yagi M, Uchiumi T, Semba Y, Nogami J, Akashi K, Arai F, Kang D. — iScience 23(11):101654 (2020)
    doi:10.1016/j.isci.2020.101654
  5. A novel method to purify neutrophils enables functional analysis of zebrafish hematopoiesis
    Konno K, Kulkeaw K, Sasada M, Nii T, Kaneyuki A, Ishitani T, Arai F, Sugiyama D. — Genes Cells (2020)
    doi:10.1111/gtc.12810
20193報
  1. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo
    Kobayashi H, Morikawa T, Okinaga A, Hamano F, Hashidate-Yoshida T, Watanuki S, Hishikawa D, Shindou H, Arai F, Kabe Y, Suematsu M, Shimizu T, Takubo K. — Cell Rep 28(1):145-158.e9 (2019)
    doi:10.1016/j.celrep.2019.06.008
  2. Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis
    Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N. — Nat Commun 10(1):1072 (2019)
    doi:10.1038/s41467-019-09028-w
  3. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth
    Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y, Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N, Aikawa Y, Oishi S, Nonami A, Arai F, Hagihara S, Yamaguchi J, Tama F, Kunisaki Y, Yagita K, Ikeda M, Kinoshita T, Kay SA, Itami K, Hirota T. — Sci Adv 5(1):eaau9060 (2019)
    doi:10.1126/sciadv.aau9060
20183報
  1. Leukaemia hijacks a neural mechanism to invade the central nervous system
    Yao H, Price TT, Cantelli G, Ngo B, Warner MJ, Olivere L, Ridge SM, Jablonski EM, Therrien J, Tannheimer S, McCall CM, Chenn A, Sipkins DA. — Nature 560(7716):55-60 (2018)
    doi:10.1038/s41586-018-0342-5
  2. Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
    Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A. — Cell Stem Cell 22(5):713-725.e8 (2018)
    doi:10.1016/j.stem.2018.04.002
  3. Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.
    Yamauchi T, Masuda T, Canver MC, Seiler M, Semba Y, Shboul M, Al-Raqad M, Maeda M, Schoonenberg VAC, Cole MA, Macias-Trevino C, Ishikawa Y, Yao Q, Nakano M, Arai F, Orkin SH, Reversade B, Buonamici S, Pinello L, Akashi K, Bauer DE, Maeda T. — Cancer Cell 33(3):386-400.e5 (2018)
    doi:10.1016/j.ccell.2018.01.012
20175報
  1. The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
    Hosokawa K, MacArthur BD, Ikushima YM, Toyama H, Masuhiro Y, Hanazawa S, Suda T, Arai F — Nat Commun 8:804 (2017)
    doi:10.1038/s41467-017-00935-4
  2. Stem Cell Differentiation as a Non-Markov Stochastic Process.
    Stumpf PS, Smith RCG, Lenz M, Schuppert A, Muller FJ, Babtie A, Chan TE, Stumpf MPH, Please CP, Howison SD, Arai F, MacArthur BD. — Cell Systems 5(3):268-282.e7 (2017)
    doi:10.1016/j.cels.2017.08.009
  3. Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression.
    Ali MAE, Fuse K, Tadokoro Y, Hoshii T, Ueno M, Kobayashi M, Nomura N, Vu HT, Peng H, Hegazy AM, Masuko M, Sone H, Arai F, Tajima A, Hirao A. — Sci Rep 7(1):11442 (2017)
    doi:10.1038/s41598-017-11909-3
  4. Identification of unipotent megakaryocyte progenitors in human hematopoiesis.
    Miyawaki K, Iwasaki H, Jiromaru T, Kusumoto H, Yurino A, Sugio T, Uehara Y, Odawara J, Daitoku S, Kunisaki Y, Mori Y, Arinobu Y, Tsuzuki H, Kikushige Y, Iino T, Kato K, Takenaka K, Miyamoto T, Maeda T, Akashi K. — Blood 129(25):3332-3343 (2017)
    doi:10.1182/blood-2016-09-741611
  5. Differential cytokine contributions of perivascular haematopoietic stem cell niches.
    Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez NF, Birbrair A, Ma’ayan A, Frenette PS. — Nat Cell Biol 19(3):214-223 (2017)
    doi:10.1038/ncb3475
2016–1998（原文体裁のまま）
  1. Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.
    Ito K, Turcotte R, Cui J, Zimmerman SE, Pinho S, Mizoguchi T, Arai F, Runnels JM, Alt C, Teruya-Feldstein J, Mar JC, Singh R, Suda T, Lin CP, Frenette PS, Ito K. — Science 354(6316):1156-1160 (2016)
    doi:10.1126/science.aaf5530
  2. Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.
    Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y, Iwama A. — Blood 128(5):638-49 (2016)
    doi:10.1182/blood-2016-01-694810
  3. Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes.
    Sakamoto H, Takeda N, Arai F, Hosokawa K, Garcia P, Suda T, Frampton J, Ogawa M. — Stem Cells 33(2):479-490 (2015)
    doi:10.1002/stem.1855
  4. Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression
    Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa K, Doi Y, Ninomiya T, Horiguchi H, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K, Takeya M, Hao H, Hirose N, Minami T, Suda T, Kiyohara Y, Ogawa H, Kaikita K, Oike Y. — Arterioscler Thromb Vasc Biol 34(4):790-800 (2014)
    doi:10.1161/ATVBAHA.113.303116
  5. Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells.
    Yamashita M, Nitta E, Nagamatsu G, Ikushima YM, Hosokawa K, Arai F, Suda T. — Biochem Biophys Res Commun 441(1):196-201 (2013)
    doi:10.1016/j.bbrc.2013.10.032
  6. OP9 bone marrow stroma cells differentiate into megakaryocytes and platelets.
    Matsubara Y, Ono Y, Suzuki H, Arai F, Suda T, Murata M, Ikeda Y. — PLoS One 8(3):e58123 (2013)
    doi:10.1371/journal.pone.0058123
  7. Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.
    Ikushima YM, Arai F, Hosokawa K, Toyama H, Takubo K, Furuyashiki T, Narumiya S, Suda T. — Blood 121(11):1995-2007 (2013)
    doi:10.1182/blood-2012-06-437889
  8. Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells.
    Ikushima YM, Arai F, Nakamura Y, Hosokawa K, Kubota Y, Hirashima M, Toyama H, Suda T. — Biochem Biophys Res Commun 430(1):20-25 (2013)
    doi:10.1016/j.bbrc.2012.11.002
  9. N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs.
    Toyama H, Arai F, Hosokawa K, Ikushima YM, Suda T. — Biochem Biophys Res Commun 428(3):354-359 (2012)
    doi:10.1016/j.bbrc.2012.10.058
  10. A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
    Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, Pandolfi PP. — Nat Med 18(9):1350-1358 (2012)
    doi:10.1038/nm.2882
  11. Noncanonical wnt signaling maintains hematopoietic stem cells in the niche.
    Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T, Li L. — Cell 150(2):351-365 (2012)
    doi:10.1016/j.cell.2012.05.041
  12. Impact of gene dosage, loss of wild type allele and FLT3 ligand on Flt3-ITD induced myeloproliferation.
    Kharazi S, Mead AJ, Mansour A, Hultquist A, Böiers C, Luc S, Buza-Vidas N, Ma Z, Ferry H, Atkinson D, Reckzeh K, Masson K, Cammenga J, Rönnstrand L, Arai F, Suda T, Nerlov C, Sitnicka E, Jacobsen SE. — Blood 118(13):3613-3621 (2011)
    doi:10.1182/blood-2010-06-289207
  13. Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere independent mechanism.
    Nitta E, Yamashita M, Hosokawa K, Xian M, Takubo K, Arai F, Nakada S, Suda T. — Blood 117(16):4169-80 (2011)
    doi:10.1182/blood-2010-08-297390
  14. Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation.
    Shima H, Takubo K, Tago N, Iwasaki H, Arai F, Takahashi T, Suda T. — Exp Hematol 38(12):1231-1240 (2010)
    doi:10.1016/j.exphem.2010.08.004
  15. TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool.
    Nakajima H, Ito M, Smookler DS, Shibata F, Fukuchi Y, Morikawa Y, Ikeda Y, Arai F, Suda T, Khokha R, Kitamura T. — Blood 116(22):4474-4482 (2010)
    doi:10.1182/blood-2010-01-266528
  16. Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells.
    Nakamura Y, Arai F*†, Iwasaki H, Hosokawa K, Kobayashi I, Gomei Y, Matsumoto Y, Yoshihara H, Suda T. — Blood 116(9):1422-1432 (2010)
    doi:10.1182/blood-2009-08-239194
  17. Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver.
    Iwasaki H, Arai F, Kubota Y, Dahl M, Suda T. — Blood 116(4):544-553 (2010)
    doi:10.1182/blood-2009-08-240903
  18. Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells.
    Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Nakamura Y, Gomei Y, Suda T. — Blood 116(4):554-563 (2010)
    doi:10.1182/blood-2009-05-224857
  19. Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow.
    Hosokawa K, Arai F*†, Yoshihara H, Iwasaki H, Hembree M, Yin T, Nakamura N, Gomei Y, Takubo K, Shiama H, Matsuoka S, Li L, Suda T. — Cell Stem Cell 6(3):194-198 (2010)
    doi:10.1016/j.stem.2009.04.013
  20. Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells.
    Gomei Y, Nakamura Y, Yoshihara H, Hosokawa K, Iwasaki H, Suda T, Arai F†. — Exp Hematol 38(2):82-89 (2009)
    doi:10.1016/j.exphem.2009.11.007
  21. IRF-2 protects quiescent HSCs from type-I interferon-dependent exhaustion.
    Sato T, Onai N, Yoshihara H, Arai F, Suda T, Ohteki T. — Nat Med 15(6):696-700 (2009)
    doi:10.1038/nm.1973
  22. Angiopoietins contribute to lung development by regulating pulmonary vascular network formation.
    Hato T, Kimura Y, Morisada T, Koh GY, Miyata K, Tabata M, Kadomatsu T, Endo M, Urano T, Arai F, Araki K, Suda T, Kobayashi K, Oike Y. — Biochem Biophys Res Commun 381(2):218-223 (2009)
    doi:10.1016/j.bbrc.2009.02.030
  23. Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice.
    Shima H, Takubo K, Iwasaki H, Yoshihara H, Gomei Y, Hosokawa K, Arai F, Takahashi T, Suda T. — Biochem Biophys Res Commun 378(3):467-472 (2009)
    doi:10.1016/j.bbrc.2008.11.056
  24. Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity.
    Ohmura M, Naka K, Hoshii T, Muraguchi T, Shugo H, Tamase A, Uema N, Ooshio T, Arai F, Takubo K, Nagamatsu G, Hamaguchi I, Takagi M, Ishihara M, Sakurada K, Miyaji H, Suda T, Hirao A. — Stem Cells 26(12):3237-3246 (2008)
    doi:10.1634/stemcells.2008-0506
  25. Fbxw7 acts as a critical failsafe against premature loss of hematopoietic stem cells and development of T-ALL.
    Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, NakayamaKI, Suda T. — Genes Dev 22(8):986-991 (2008)
    doi:10.1101/gad.1621808
  26. Stem Cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell cycle arrest.
    Takubo K, Ohmura M, Azuma M, Nagamatsu G, Yamada W, Arai F, Hirao A, Suda T. — Cell Stem Cell 2(2):170-182 (2008)
    doi:10.1016/j.stem.2007.10.023
  27. Thrombopoietin/Mpl signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.
    Yoshihara H, Arai F*†, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, Miyazaki H, Takahashi T, Suda T. — Cell Stem Cell 1(6):685-697 (2007)
    doi:10.1016/j.stem.2007.10.020
  28. Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction.
    Hosokawa K, Arai F*, Yoshihara H, Nakamura Y, Gomei Y, Iwasaki H, Miyamoto K, Shima H, Ito K, Suda T. — Biochem Biophys Res Commun 363(3):578-583 (2007)
    doi:10.1016/j.bbrc.2007.09.014
  29. Foxo3a is essential for maintenance of hematopoietic stem cell pool.
    Miyamoto K, Araki K, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama K-I, Harada M, Motoyama N, Suda T, Hirao A. — Cell Stem Cell 1(1):101-112 (2007)
    doi:10.1016/j.stem.2007.02.001
  30. Regulation of reactive oxygen species by Atm is essential for proper response to DNA double strand breaks in lymphocytes.
    Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A. — J Immunol 178(1):103-110 (2007)
    doi:10.4049/jimmunol.178.1.103
  31. Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice.
    Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T. — Leukemia 21(1):136-142 (2007)
    doi:10.1038/sj.leu.2404432
  32. Premeiotic germ cell defect in seminiferous tubules of Atm-null testis.
    Takubo K, Hirao A, Ohmura M, Azuma M, Arai F, Nagamatsu G, Suda T. — Biochem Biophys Res Commun 351(4):993-998 (2006)
    doi:10.1016/j.bbrc.2006.10.145
  33. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.
    Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y and Suda T. — Nat Med 12(4):446-451 (2006)
    doi:10.1038/nm1388
  34. Regulation of oxidative stress by ATM is required for the self-renewal of haematopoietic stem cells.
    Ito K, Hirao A, Arai F, Matsuoka S, Takubo K, Hamaguchi I, Nomiyama K, Hosokawa K, Sakurada K, Nakagata N, Ikeda Y, Mak TW, Suda T. — Nature 431(7011):997-1002 (2004)
    doi:10.1038/nature02989
  35. Tie2/Angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.
    Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Ito K, Takubo K, Koh GY and Suda T. — Cell 118(2):149-161 (2004)
    doi:10.1016/j.cell.2004.07.004
  36. A novel angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling and regeneration.
    Oike Y, Yasunaga K, Ito Y, Matsumoto S, Maekawa H, Morisada T, Arai F, Nakagata N, Takeya M, Masuho Y, and Suda T. — PNAS 100(16):9494-9499 (2003)
    doi:10.1073/pnas.1531901100
  37. Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells.
    Oike Y, Hamada K, Ito Y, Zhang XQ, Miyata K, Arai F, Inada T, Nakagata N, Takeya M, Gale NW, and Suda T. — Blood 100(4):1326-1333 (2002)
    doi:10.1182/blood.V100.4.1326.h81602001326_1326_1333
  38. Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in endochondral ossification.
    Arai F, Ohneda O, Miyamoto T, Zhang XQ, and Suda T. — J Exp Med 195(12):1549-1563 (2002)
    doi:10.1084/jem.20011700
  39. Bifurcation of osteoclasts and dendritic cells from common progenitors.
    Miyamoto T, Ohneda O, Arai F, Iwamoto K, Okada S, Takagi K, Anderson DM, and Suda T. — Blood 98(8):2544-2554 (2001)
    doi:10.1182/blood.V98.8.2544
  40. ALCAM (CD166): its role in hematopoietic and endothelial development.
    Ohneda O, Ohneda K, Arai F, Lee J, Miyamoto T, Fukushima Y, Dowbenko D, Lasky LA, and Suda T. — Blood 98(7):2134-2142 (2001)
    doi:10.1182/blood.V98.7.2134
  41. An adherent condition is required for formation of multinuclear osteoclasts in the presence of macrophage colony-stimulating factor and receptor activator of nuclear factor kappa B ligand.
    Miyamoto T, Arai F, Ohneda O, Takagi K, Anderson DM, Suda T. — Blood 96(13):4335-4343 (2000)
    doi:10.1182/blood.V96.13.4335
  42. WECHE: a novel hematopoietic regulatory factor.
    Ohneda O, Ohneda K, Nomiyama H, Zheng Z, Gold SA, Arai F, Miyamoto T, Taillon BE, McIndoe RA, Shimkets RA, Lewin DA, Suda T, Lasky LA. — Immunity 12(2):141-150 (2000)
    doi:10.1016/S1074-7613(00)80167-3
  43. Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors.
    Arai F, Miyamoto T, Ohneda O, Inada T, Sudo T, Brasel K, Miyata T, Anderson DM, Suda T. — J Exp Med 190(12):1741-1754 (1999)
    doi:10.1084/jem.190.12.1741
  44. The N-terminal fragment of osteocalcin is released during osteoclastic bone resorption.
    Kurihara N, Hosoda K, Tatsumi J, Yamaji T, Hoshihara E, Arai F, and Ikeda K. — J Bone Miner Metab 16:11-16 (1998)
    doi:10.1007/s007740050022
  45. 23(S)25(R)-1,25-Dihydroxyvitamin D3-lactone, a naturally occurring metabolite of 1,25-dihydroxyvitamin D3, inhibits osteoclast-like cell formation in human bone marrow cultures.
    Kurihara N, Ishizuka S, Tatsumi J, Kumegawa M, Arai F, Ikeda K, and Roodman GD. — J Bone Miner Metab 16:5-10 (1998)
    doi:10.1007/s007740050021

英文総説

  1. The role of telomere binding molecules for normal and abnormal hematopoiesis.
    Hosokawa K, Arai F — Int J Hematol (2018)
    doi:10.1007/s12185-018-2432-4
  2. Wnt signaling in the niche.
    Suda T, Arai F. — Cell 132(5):729-730 (2008) Invited Review
  3. Role of stem cell niche in the maintenance of hematopoietic stem cells.
    Arai F†, Suda T. — Inflammation and Regeneration 27(2):117-123 (2007)
  4. Regulation of hematopoietic stem cell and its interaction with stem cell niche.
    Arai F†. — J Oral Biosci 48(1):22-29 (2006)
  5. Regulation of the hematopoiesis and its interaction with stem cell niche.
    Arai F†, Hirao A, Suda T. — Int J Hematol 82(5):371-376 (2005)
  6. Regulation of stem cells in the niche.
    Suda T, Arai F, Shimmura S. — Cornea 24(8 Suppl):S12-S17 (2005)
  7. Hematopoietic stem cells and their niche.
    Suda T, Arai F, Hirao A. — Trends Immunol 26(8):426-433 (2005)
  8. Regulation of hematopoietic stem cells by the niche.
    Arai F†, Hirao A, Suda T. — Trends Cardiovasc Med 15(2):75-79 (2005)
  9. Regulation of cell cycle in hematopoietic stem cells by the niche.
    Hirao A, Arai F, Suda T. — Cell Cycle 3(12):1481-1483 (2004)

英文著書

  1. Hematopoietic Cell Isolation by Antibody-Free Flow Cytometry in the Zebrafish Embryo
    Konno K, Kobayashi-Sun J, Arai F, Kobayashi I, Sugiyama D. — Methods Mol Biol 2520:171-180 (2022)
    doi:10.1007/7651_2021_459
  2. The role of N-cadherin-mediated cell adhesion in the regulation of hematopoietic stem/progenitor cell activities in the bone marrow niche.
    Arai F, Hosokawa K, Toyama H, Matsumoto Y, Suda T. — Ann N Y Acad Sci 1266(1):72-77 (2012)
    doi:10.1111/j.1749-6632.2012.06576.x
  3. Gene expression profiling and regulatory networks in single cell.
    Arai F, Hosokawa K, Matsumoto Y, Toyama H, Suda T. — Network analysis in systems biology (Springer), pp.1-13 (2012)
  4. Niche regulation of hematopoietic stem cells in the endosteum.
    Arai F, Yoshihara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Suda T. — Ann N Y Acad Sci 1176:36-46 (2009)
  5. Quiescent stem cells in the niche.
    Arai F, Suda T. — StemBook (Published July 11, 2008)
  6. Regulation of hematopoietic stem cells in the osteoblastic niche.
    Arai F†, Suda T. — Osteoimmunology (Adv Exp Med Biol 602:61-67) (2007)
  7. Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Hematopoietic Stem Cells VI.
    Arai F†, Suda T. — Ann N Y Acad Sci 1106:41-53 (2007)
  8. Endothelial and hematopoietic cells in the intraembryonic compartment.
    Arai F, Suda T. — In Hematopoietic Stem Cell Development (pp.92-107) (2006)