論文実績

主要業績

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

Shuhei Tsujino, Masumi Tsuda, Sayaka Deguchi, Jumpei Ito, Taha Y. Taha, Hesham Nasser, Lei Wang, Julia Rosecrans, Rigel Suzuki, Saori Suzuki, Kumiko Yoshimatsu, Melanie Ott, Terumasa Ikeda, Kei Sato, Kazuo Takayama, Shinya Tanaka, Tomokazu Tamura, Takasuke Fukuhara

Nature Communications, 17(1), 735. https://doi.org/10.1038/s41467-025-67455-4

NEDD4-binding protein 1 suppresses hepatitis B virus replication by regulating viral RNAs

Nobuhiro Kobayashi, Saori Suzuki, Yuki Sakamoto, Rigel Suzuki, Kento Mori, Yume Kosugi, Tomoya Saito, Yuan Ma, Lihan Liang, Takuma Izumi, Kisho Noda, Daisuke Okuzaki, Yumi Kanegae, Sanae Hayashi, Yasuhito Tanaka, Atsuya Yamashita, Kohji Moriishi, Yoshiharu Matsuura, Osamu Takeuchi, Tomokazu Tamura, Akinobu Taketomi, Takasuke Fukuhara

The Journal of General Virology, 106(3), 002082. https://doi.org/10.1099/jgv.0.002082

Generation of recombinant viruses directly from clinical specimens of COVID-19 patients

Hirotaka Yamamoto, Tomokazu Tamura, Takaya Ichikawa, Yudai Taguchi, Kento Mori, Satoshi Oguri, Rigel Suzuki, Saori Suzuki, Takanori Teshima, Takasuke Fukuhara

Journal of Clinical Microbiology, 62(7), e0004224. https://doi.org/10.1128/jcm.00042-24

Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection

Tomokazu Tamura, Hayato Ito, Shiho Torii, Lei Wang, Rigel Suzuki, Shuhei Tsujino, Akifumi Kamiyama, Yoshitaka Oda, Masumi Tsuda, Yuhei Morioka, Saori Suzuki, Kotaro Shirakawa, Kei Sato, Kumiko Yoshimatsu, Yoshiharu Matsuura, Satoshi Iwano, Shinya Tanaka, Takasuke Fukuhara

iScience, 27(5), 109647. https://doi.org/10.1016/j.isci.2024.109647

A rapid and versatile reverse genetics approach for generating recombinant positive-strand RNA viruses that use IRES-mediated translation

Tomokazu Tamura, Hirotaka Yamamoto, Saho Ogino, Yuhei Morioka, Shuhei Tsujino, Rigel Suzuki, Takahiro Hiono, Saori Suzuki, Norikazu Isoda, Yoshihiro Sakoda, Takasuke Fukuhara

Journal of Virology, 98(3), e0163823. https://doi.org/10.1128/jvi.01638-23

Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

Tomokazu Tamura, Takashi Irie, Sayaka Deguchi, Hisano Yajima, Masumi Tsuda, Hesham Nasser, Keita Mizuma, Arnon Plianchaisuk, Saori Suzuki, Keiya Uriu, Mst Monira Begum, Ryo Shimizu, Michael Jonathan, Rigel Suzuki, Takashi Kondo, Hayato Ito, Akifumi Kamiyama, Kumiko Yoshimatsu, Maya Shofa, Rina Hashimoto, Yuki Anraku, Kanako Terakado Kimura, Shunsuke Kita, Jiei Sasaki, Kaori Sasaki-Tabata, Katsumi Maenaka, Naganori Nao, Lei Wang, Yoshitaka Oda, Genotype to Phenotype Japan (G2P-Japan) Consortium, Terumasa Ikeda, Akatsuki Saito, Keita Matsuno, Jumpei Ito, Shinya Tanaka, Kei Sato, Takao Hashiguchi, Kazuo Takayama, Takasuke Fukuhara

Nature Communications, 15(1), 1176. https://doi.org/10.1038/s41467-024-45274-3

Prolonged shedding of viable SARS-CoV-2 in immunocompromised patients with haematological malignancies: A prospective study

Takaya Ichikawa, Tomokazu Tamura, Mutsumi Takahata, Takashi Ishio, Makoto Ibata, Ikumi Kasahara, Koichiro Minauchi, Satoshi Yamamoto, Takanori Teshima, Takasuke Fukuhara

British Journal of Haematology, 204(3), 815–820. https://doi.org/10.1111/bjh.19143

Increased flexibility of the SARS-CoV-2 RNA-binding site causes resistance to remdesivir

Shiho Torii, Kwang Su Kim, Jun Koseki, Rigel Suzuki, Shoya Iwanami, Yasuhisa Fujita, Yong Dam Jeong, Jumpei Ito, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Genotype to Phenotype Japan (G2P-Japan) Consortium, Kei Sato, Yoshiharu Matsuura, Teppei Shimamura, Shingo Iwami, Takasuke Fukuhara

PLoS Pathogens, 19(3), e1011231. https://doi.org/10.1371/journal.ppat.1011231

Secretory glycoprotein NS1 plays a crucial role in the particle formation of flaviviruses

Tomokazu Tamura, Shiho Torii, Kentaro Kajiwara, Itsuki Anzai, Yoichiro Fujioka, Kisho Noda, Shuhei Taguwa, Yuhei Morioka, Rigel Suzuki, Yuzy Fauzyah, Chikako Ono, Yusuke Ohba, Masato Okada, Takasuke Fukuhara, Yoshiharu Matsuura

PLoS Pathogens, 18(6), e1010593. https://doi.org/10.1371/journal.ppat.1010593

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

Rigel Suzuki, Daichi Yamasoba, Izumi Kimura, Lei Wang, Mai Kishimoto, Jumpei Ito, Yuhei Morioka, Naganori Nao, Hesham Nasser, Keiya Uriu, Yusuke Kosugi, Masumi Tsuda, Yasuko Orba, Michihito Sasaki, Ryo Shimizu, Ryoko Kawabata, Kumiko Yoshimatsu, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Genotype to Phenotype Japan (G2P-Japan) Consortium, Hirofumi Sawa, Terumasa Ikeda, Takashi Irie, Keita Matsuno, Shinya Tanaka, Takasuke Fukuhara, Kei Sato

Nature, 603(7902), 700–705. https://doi.org/10.1038/s41586-022-04462-1

Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction

Shiho Torii, Chikako Ono, Rigel Suzuki, Yuhei Morioka, Itsuki Anzai, Yuzy Fauzyah, Yusuke Maeda, Wataru Kamitani, Takasuke Fukuhara, Yoshiharu Matsuura

Cell Reports, 35(3), 109014. https://doi.org/10.1016/j.celrep.2021.109014

In vivo dynamics of reporter Flaviviridae viruses

Tomokazu Tamura, Manabu Igarashi, Bazarragchaa Enkhbold, Tatsuya Suzuki, Masatoshi Okamatsu, Chikako Ono, Hiroyuki Mori, Takuma Izumi, Asuka Sato, Yuzy Fauzyah, Toru Okamoto, Yoshihiro Sakoda, Takasuke Fukuhara, Yoshiharu Matsuura

Journal of Virology, 93(22), e01191-19. https://doi.org/10.1128/JVI.01191-19

Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9

Takeshi Kurihara, Takasuke Fukuhara, Chikako Ono, Satomi Yamamoto, Kentaro Uemura, Toru Okamoto, Masaya Sugiyama, Daisuke Motooka, Shota Nakamura, Masato Ikawa, Masashi Mizokami, Yoshihiko Maehara, Yoshiharu Matsuura

Scientific Reports, 7(1), 6122. https://doi.org/10.1038/s41598-017-05905-w

Host-derived apolipoproteins play comparable roles with viral secretory proteins Erns and NS1 in the infectious particle formation of Flaviviridae

Takasuke Fukuhara, Tomokazu Tamura, Chikako Ono, Mai Shiokawa, Hiroyuki Mori, Kentaro Uemura, Satomi Yamamoto, Takeshi Kurihara, Toru Okamoto, Ryosuke Suzuki, Kentaro Yoshii, Takeshi Kurosu, Manabu Igarashi, Hiroshi Aoki, Yoshihiro Sakoda, Yoshiharu Matsuura

PLoS Pathogens, 13(6), e1006475. https://doi.org/10.1371/journal.ppat.1006475

Amphipathic a-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles

Takasuke Fukuhara, Masami Wada, Shota Nakamura, Chikako Ono, Mai Shiokawa, Satomi Yamamoto, Takashi Motomura, Toru Okamoto, Daisuke Okuzaki, Masahiro Yamamoto, Izumu Saito, Takaji Wakita, Kazuhiko Koike, Yoshiharu Matsuura

PLoS Pathogens, 10(12), e1004534. https://doi.org/10.1371/journal.ppat.1004534

Variants in IL28B in liver recipients and donors correlate with response to peg-interferon and ribavirin therapy for recurrent hepatitis C

Takasuke Fukuhara, Akinobu Taketomi, Takashi Motomura, Shinji Okano, Akinori Ninomiya, Takayuki Abe, Hideaki Uchiyama, Yuji Soejima, Ken Shirabe, Yoshiharu Matsuura, Yoshihiko Maehara

Gastroenterology, 139(5), 1577–1585.e15853. https://doi.org/10.1053/j.gastro.2010.07.058

2026

Analysis of HBV Genome Integration in Patients With HBV-Previously Infected NBNC-HCC

Tomoya Saito, Rigel Suzuki, Akhinur Rahman, Kento Mori, Samiul Alam Rajib, Nobuhiro Kobayashi, Yoichi Yamamoto, Sharmin Nahar Sithi, Takaya Ichikawa, Tatsuya Orimo, Tatsuhiko Kakisaka, Lihan Liang, Naganori Nao, Saori Suzuki, Tomokazu Tamura, Yorifumi Satou, Akinobu Taketomi, Takasuke Fukuhara

Hepatology Research, https://doi.org/10.1111/hepr.70163

Rapid immunization and antibody redesign platform discovers broadly neutralizing antibodies against non-immunized SARS-CoV-2 variant

Shusei Hamamichi, Narumi Uno, Kazuto Shimoya, Takato Fukushima, Marina Abe, Arata Watanabe, Mizuho Ito, Yuko Wakasa, Yuko Yajima, Rio Suzuki, Natsumi Miyazaki, Akifumi Kamiyama, Kana Uno, Masaharu Hiratsuka, Takashi Moriwaki, Tomokazu Tamura, Kyosuke Kanai, Satoshi Abe, Takasuke Fukuhara, Seiji Kageyama, Masayuki Su’etsugu, Yasuhiro Kazuki, Kazuma Tomizuka

Molecular Therapy, 34(1), 620–638. https://doi.org/10.1016/j.ymthe.2025.10.020

2025

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

Nature Communications, 17(1), 735. https://doi.org/10.1038/s41467-025-67455-4

Noncompetitive fluorescence polarization aptamer assay for detecting SARS-CoV-2 variants

Chang Yu-Ting, Rigel Suzuki, Yoichiro Fujioka, Akihiko Ishida, Ayuko Imai, Mao Fukuyama, Motohiro Kasuya, Yusuke Ohba, Takasuke Fukuhara, Koji Shigemura, Akihide Hibara, Masatoshi Maeki, Manabu Tokeshi

ACS Omega, 10(43), 51228–51235.　https://doi.org/10.1021/acsomega.5c06304

First versatile reverse genetics system for DNA viruses using circular polymerase extension reaction

Hirotaka Yamamoto, Tomokazu Tamura, Rigel Suzuki, Saori Suzuki, Takasuke Fukuhara

Microbiology and Immunology, 69(12), 619-622. https://doi.org/10.1111/1348-0421.70016

Evolution of BA.2.86 to JN.1 reveals functional changes in non-structural viral proteins are required for fitness of SARS-CoV-2

Shuhei Tsujino, Masumi Tsuda, Naganori Nao, Kaho Okumura, Lei Wang, Yoshitaka Oda, Yume Mimura, Jingshu Li, Rina Hashimoto, Yasufumi Matsumura, Rigel Suzuki, Saori Suzuki, Kumiko Yoshimatsu, Miki Nagao, Jumpei Ito, Kazuo Takayama, Kei Sato, Keita Matsuno, Tomokazu Tamura, Shinya Tanaka, Takasuke Fukuhara

Journal of Virology, 99(10), e00908-25. https://doi.org/10.1128/jvi.00908-25

Longitudinal antibody titers measured after COVID-19 mRNA vaccination can identify individuals at risk for subsequent infection

Hyeongki Park, Naotoshi Nakamura, Sho Miyamoto, Yoshitaka Sato, Kwang Su Kim, Kosaku Kitagawa, Yurie Kobashi, Yuta Tani, Yuzo Shimazu, Tianchen Zhao, Yoshitaka Nishikawa, Fumiya Omata, Moe Kawashima, Toshiki Abe, Yoshika Saito, Saori Nonaka, Morihito Takita, Chika Yamamoto, Hiroshi Morioka, Katsuhiro Kato, Ken Sagou, Tetsuya Yagi, Takeshi Kawamura, Akira Sugiyama, Aya Nakayama, Yudai Kaneko, Risa Yokokawa Shibata, Kazuyuki Aihara, Tatsuhiko Kodama, Akifumi Kamiyama, Tomokazu Tamura, Takasuke Fukuhara, Kenji Shibuya, Tadaki Suzuki, Shingo Iwami, Masaharu Tsubokura

Science Translational Medicine, 17(816), eadv4214. https://doi.org/10.1126/scitranslmed.adv4214

Characterization of remdesivir resistance mutations in COVID-19 patients with various immunosuppressive diseases

Takaya Ichikawa, Tomokazu Tamura, Naganori Nao, Hikoyu Suzuki, Shuhei Maruyama, Daiki Wada, Shuhei Tsujino, Noriyoshi Yoshinaga, Kohsuke Asagoe, Mutsumi Takahata, Takashi Ishio, Makoto Ibata, Tanino Yoko, Yasutaka Kakinoki, Kazuhiro Okubo, Rigel Suzuki, Saori Suzuki, Yasushi Nakamori, Takanori Teshima, Takasuke Fukuhara

Antiviral Research, 106264. https://doi.org/10.1016/j.antiviral.2025.106264

The crucial role of intercellular calcium wave propagation triggered by influenza A virus in promoting infection

Fumiya Kozawa, Tomokazu Tamura, Naoki Takahashi, Taishi Kakizuka, Taro Ichimura, Rumi Shimada, Yasuyuki Hashimoto, Hironoshin Onizuska, Sayaka Kashiwagi, Tomoko Kamasaki, Maho Amano, Takeharu Nagai, Takasuke Fukuhara, Yoichiro Fujioka, Yusuke Ohba

Cell Communication and Signaling, 23(1), 361. https://doi.org/10.1186/s12964-025-02357-y

ウイルスは細胞同士の「会話」を乗っ取り感染を広げる～インフルエンザの新たな感染メカニズムを発見、治療薬開発に期待～

Enhanced SARS-CoV-2 BA.2.86 neutralization after BA.5 infection in vaccinated kidney transplant recipients

Keita Kawashiro, Kiyohiko Hotta, Rigel Suzuki, Naoya Iwahara, Takayuki Hirose, Shuhei Tsujino, Takasuke Fukuhara, Nobuo Shinohara

Transplantation Proceedings, 57(6), 1013–1017. https://doi.org/10.1016/j.transproceed.2025.05.021

Reverse genetics system for Tick-borne encephalitis virus using Circular Polymerase Extension Reaction

Saki Mitsunaga, Tomokazu Tamura, Samuel Nyampong, Takasuke Fukuhara, Hiroshi Shimoda, Daisuke Hayasaka

Infection, Genetics and Evolution, 132, 105776. https://doi.org/10.1016/j.meegid.2025.105776

Determinants of susceptibility to SARS-CoV-2 infection in murine ACE2

Takashi Kondo, Rigel Suzuki, Hisano Yajima, Sachiho Kawahara, Kodai Yamaya, Takaya Ichikawa, Shuhei Tsujino, Saori Suzuki, Tomokazu Tamura, Takao Hashiguchi, Takasuke Fukuhara

Journal of Virology, 99(6), e0054325. https://doi.org/10.1128/jvi.00543-25

Rapid plasmid-free generation of recombinant positive-strand RNA viruses that use IRES-mediated translation using an expansion of the circular polymerase extension reaction (CPER)

Hirotaka Yamamoto, Tomokazu Tamura, Takausuke Fukuhara

bio-protocol, 15(8), e5275. https://doi.org/10.21769/BioProtoc.5275

NEDD4-binding protein 1 suppresses hepatitis B virus replication by regulating viral RNAs

The Journal of General Virology, 106(3), 002082. https://doi.org/10.1099/jgv.0.002082

Clinical and molecular landscape of prolonged SARS-CoV-2 infection with resistance to remdesivir in immunocompromised patients

Chisako Iriyama, Takaya Ichikawa, Tomokazu Tamura, Mutsumi Takahata, Takashi Ishio, Makoto Ibata, Ryuji Kawai, Mitsunaga Iwata, Masahiro Suzuki, Hirokazu Adachi, Naganori Nao, Hikoyu Suzuki, Akito Kawai, Akifumi Kamiyama, Tadaki Suzuki, Yuichiro Hirata, Shun Iida, Harutaka Katano, Yasushi Ishii, Takahiro Tsuji, Yoshitaka Oda, Shinya Tanaka, Nanase Okazaki, Yuko Katayama, Shimpei Nakagawa, Tetsuya Tsukamoto, Yohei Doi, Takasuke Fukuhara, Takayuki Murata, Akihiro Tomita

PNAS Nexus, 4(4), pgaf085. https://doi.org/10.1093/pnasnexus/pgaf085

Application of versatile reverse genetics system for feline coronavirus

Izumi Kida, Tomokazu Tamura, Yudai Kuroda, Takasuke Fukuhara, Ken Maeda, Keita Matsuno

Microbiology Spectrum, 13(4), e0269224. https://doi.org/10.1128/spectrum.02692-24

M49L and other drug resistance mutations emerging in individuals after administration of ensitrelvir in Japanese clinical settings

Akira Inoue, Takaya Ichikawa, Daiki Wada, Shuhei Maruyama, Haruka Shimazu, Masami Kashihara, Kazuyuki Okuda, Fukuki Saito, Takasuke Fukuhara, Yasushi Nakamori

Antiviral Research, 106118. https://doi.org/10.1016/j.antiviral.2025.106118

2024

A micro-disc-based multiplex method for monitoring emerging SARS-CoV-2 variants using the molecular diagnostic tool Intelli-OVI

Md Belal Hossain , Yoshikazu Uchiyama, Samiul Alam Rajib, Akhinur Rahman, Mitsuyoshi Takatori, Benjy Jek Yang Tan, Kenji Sugata, Mami Nagashima, Mamiyo Kawakami, Hitoshi Ito, Ryota Kumagai, Kenji Sadamasu, Yasuhiro Ogi, Tatsuya Kawaguchi, Tomokazu Tamura, Takasuke Fukuhara, Masahiro Ono, Kazuhisa Yoshimura, Yorifumi Satou

Communications Medicine, 4(1), 161. https://doi.org/10.1038/s43856-024-00582-z

Virological characteristcs of the SARS-CoV-2 Omicron EG.5.1 variant

Shuhei Tsujino, Sayaka Deguchi, Tomo Nomai, Miguel Padilla-Blanco, Arnon Plianchaisuk, Lei Wang, MST Monira Begum, Keiya Uriu, Keita Mizuma, Naganori Nao, Isshu Kojima, Tomoya Tsubo, Jingshu Li, Yasufumi Matsumura, Miki Nagao, Yoshitaka Oda, Masumi Tsuda, Yuki Anraku, Shunsuke Kita, Hisano Yajima, Kaori Sasaki-Tabata, Ziyi Guo, Alfredo A. Hinay Jr., Kumiko Yoshimatsu, Yuki Yamamoto, Tetsuharu Nagamoto, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Hesham Nasser, Michael Jonathan, Olivia Putri, Yoonjin Kim, Luo Chen, Rigel Suzuki, Tomokazu Tamura, Katsumi Maenaka, Takashi Irie, Keita Matsuno, Shinya Tanaka, Jumpei Ito, Terumasa Ikeda, Kazuo Takayama, Jiri Zahradnik, Takao Hashiguchi, Takasuke Fukuhara, Kei Sato

Microbiology and Immunology, 68(9), 305–330. https://doi.org/10.1111/1348-0421.13165

Generation of recombinant viruses directly from clinical specimens of COVID-19 patients

Hirotaka Yamamoto, Tomokazu Tamura, Takaya Ichikawa, Yudai Taguchi, Kento Mori, Satoshi Oguri, Rigel Suzuki, Saori Suzuki, Takanori Teshima, Takasuke Fukuhara

Journal of Clinical Microbiology, 62(7), e0004224. https://doi.org/10.1128/jcm.00042-24

Involvement of SARS-CoV-2 accessory proteins in immunopathogenesis

Hayato Ito, Tomokazu Tamura, Lei Wang, Kento Mori, Masumi Tsuda, Rigel Suzuki, Saori Suzuki, Kumiko Yoshimatsu, Shinya Tanaka, Takasuke Fukuhara

Microbiology and Immunology, 68(7), 237–247. https://doi.org/10.1111/1348-0421.13157

Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236

Shigeru Fujita, Arnon Plianchaisuk, Sayaka Deguchi, Hayato Ito, Naganori Nao, Lei Wang, Hesham Nasser, Tomokazu Tamura, Izumi Kimura, Yukie Kashima, Rigel Suzuki, Saori Suzuki, Izumi Kida, Masumi Tsuda, Yoshitaka Oda, Rina Hashimoto, Yukio Watanabe, Keiya Uriu, Daichi Yamasoba, Ziyi Guo, Alfredo A Hinay Jr, Yusuke Kosugi, Luo Chen, Lin Pan, Yu Kaku, Hin Chu, Flora Donati, Sarah Temmam, Marc Eloit, Yuki Yamamoto, Tetsuharu Nagamoto, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Yutaka Suzuki, Genotype to Phenotype Japan (G2P-Japan) Consortium, Jumpei Ito, Terumasa Ikeda, Shinya Tanaka, Keita Matsuno, Takasuke Fukuhara, Kazuo Takayama, Kei Sato

eBioMedicine, 104, 105181. https://doi.org/10.1016/j.ebiom.2024.105181

Neutralizing antibody responses and cellular responses against SARS-CoV-2 Omicron subvariants after mRNA SARS-CoV-2 vaccination in kidney transplant recipients

Keita Kawashiro, Rigel Suzuki, Takuto Nogimori, Shuhei Tsujino, Naoya Iwahara, Takayuki Hirose, Kazufumi Okada, Takuya Yamamoto, Takasuke Fukuhara, Kiyohiko Hotta, Nobuo Shinohara

Scientific Reports, 14(1), 12176. https://doi.org/10.1038/s41598-024-63147-z

Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection

iScience, 27(5), 109647. https://doi.org/10.1016/j.isci.2024.109647

Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1

Tatsuhiko Ozawa, Yoshiki Ikeda, Liuan Chen, Rigel Suzuki, Atsushi Hoshino, Akira Noguchi, Shunsuke Kita, Yuki Anraku, Emiko Igarashi, Yumiko Saga, Noriko Inasaki, Shunta Taminishi, Jiei Sasaki, Yuhei Kirita, Hideo Fukuhara, Katsumi Maenaka, Takao Hashiguchi, Takasuke Fukuhara, Kenichi Hirabayashi, Hideki Tani, Hiroyuki Kishi, Hideki Niimi

Structure, 32(3), 263–272.e7. https://doi.org/10.1016/j.str.2023.12.013

Virological characteristics of the SARS-CoV-2 BA.2.86 variant

Tomokazu Tamura, Keita Mizuma, Hesham Nasser, Sayaka Deguchi, Miguel Padilla-Blanco, Yoshitaka Oda, Keiya Uriu, Jarel E M Tolentino, Shuhei Tsujino, Rigel Suzuki, Isshu Kojima, Naganori Nao, Ryo Shimizu, Lei Wang, Masumi Tsuda, Michael Jonathan, Yusuke Kosugi, Ziyi Guo, Alfredo A Hinay Jr, Olivia Putri, Yoonjin Kim, Yuri L Tanaka, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Genotype to Phenotype Japan (G2P-Japan) Consortium, Akatsuki Saito, Jumpei Ito, Takashi Irie, Shinya Tanaka, Jiri Zahradnik, Terumasa Ikeda, Kazuo Takayama, Keita Matsuno, Takasuke Fukuhara, Kei Sato

Cell Host & Microbe, 32(2), 170–180.e12. https://doi.org/10.1016/j.chom.2024.01.001

A rapid and versatile reverse genetics approach for generating recombinant positive-strand RNA viruses that use IRES-mediated translation

Tomokazu Tamura, Hirotaka Yamamoto, Saho Ogino, Yuhei Morioka, Shuhei Tsujino, Rigel Suzuki, Takahiro Hiono, Saori Suzuki, Norikazu Isoda, Yoshihiro Sakoda, Takasuke Fukuhara

Journal of Virology, 98(3), e0163823. https://doi.org/10.1128/jvi.01638-23

The development of a rapid, high-throughput neutralization assay using a SARS-CoV-2 reporter

Rigel Suzuki, Akifumi Kamiyama, Hayato Ito, Keita Kawashiro, Takahiro Tomiyama, Tomokazu Tamura, Saori Suzuki, Tomoharu Yoshizumi, Kiyohiko Hotta, Takasuke Fukuhara

Journal of Virological Methods, 326, 114894. https://doi.org/10.1016/j.jviromet.2024.114894

Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

Nature Communications, 15(1), 1176. https://doi.org/10.1038/s41467-024-45274-3

2023

High-precision rapid testing of omicron SARS-CoV-2 variants in clinical samples using AI-nanopore

Kaoru Murakami, Shimpei I Kubota, Kumiko Tanaka, Hiroki Tanaka, Keiichiroh Akabane, Rigel Suzuki, Yuta Shinohara, Hiroyasu Takei, Shigeru Hashimoto, Yuki Tanaka, Shintaro Hojyo, Osamu Sakamoto, Norihiko Naono, Takayui Takaai, Kazuki Sato, Yuichi Kojima, Toshiyuki Harada, Takeshi Hattori, Satoshi Fuke, Isao Yokota, Satoshi Konno, Takashi Washio, Takasuke Fukuhara, Takanori Teshima, Masateru Taniguchi, Masaaki Murakami

Lab on a Chip, 23(22), 4909–4918. https://doi.org/10.1039/d3lc00572k

Prolonged shedding of viable SARS-CoV-2 in immunocompromised patients with haematological malignancies: A prospective study

Takaya Ichikawa, Tomokazu Tamura, Mutsumi Takahata, Takashi Ishio, Makoto Ibata, Ikumi Kasahara, Koichiro Minauchi, Satoshi Yamamoto, Takanori Teshima, Takasuke Fukuhara

British Journal of Haematology, 204(3), 815–820. https://doi.org/10.1111/bjh.19143

Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics

Izumi Kimura, Daichi Yamasoba, Hesham Nasser, Hayato Ito, Jiri Zahradnik, Jiaqi Wu, Shigeru Fujita, Keiya Uriu, Jiei Sasaki, Tomokazu Tamura, Rigel Suzuki, Sayaka Deguchi, Arnon Plianchaisuk, Kumiko Yoshimatsu, Yasuhiro Kazuma, Shuya Mitoma, Gideon Schreiber, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Akifumi Takaori-Kondo, Genotype to Phenotype Japan (G2P-Japan) Consortium, Jumpei Ito, Kotaro Shirakawa, Kazuo Takayama, Takashi Irie, Takao Hashiguchi, So Nakagawa, Takasuke Fukuhara, Akatsuki Saito, Terumasa Ikeda, Kei Sato

Journal of Virology, 97(10), e0101123. https://doi.org/10.1128/jvi.01011-23

Safety and immunogenicity of SARS-CoV-2 self-amplifying RNA vaccine expressing an anchored RBD: A randomized, observer-blind phase 1 study

Wataru Akahata, Takashi Sekida, Takuto Nogimori, Hirotaka Ode, Tomokazu Tamura, Kaoru Kono, Yoko Kazami, Ayaka Washizaki, Yuji Masuta, Rigel Suzuki, Kenta Matsuda, Mai Komori, Amber L Morey, Keiko Ishimoto, Misako Nakata, Tomoko Hasunuma, Takasuke Fukuhara, Yasumasa Iwatani, Takuya Yamamoto, Jonathan F Smith, Nobuaki Sato

Cell Reports Medicine, 4(8), 101134. https://doi.org/10.1016/j.xcrm.2023.101134

Inhibitors of cannabinoid receptor 1 suppress the cellular entry of Lujo virus

Miyuki Kimura, Risa Matsuoka, Satoshi Taniguchi, Junki Maruyama, Slobodan Paessler, Saori Oka, Atsushi Yamashita, Takasuke Fukuhara, Yoshiharu Matsuura, Hideki Tani

Virology, 587, 109867. https://doi.org/10.1016/j.virol.2023.109867

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

Tomokazu Tamura, Daichi Yamasoba, Yoshitaka Oda, Jumpei Ito, Tomoko Kamasaki, Naganori Nao, Rina Hashimoto, Yoichiro Fujioka, Rigel Suzuki, Lei Wang, Hayato Ito, Yukie Kashima, Izumi Kimura, Mai Kishimoto, Masumi Tsuda, Hirofumi Sawa, Kumiko Yoshimatsu, Yuki Yamamoto, Tetsuharu Nagamoto, Jun Kanamune, Yutaka Suzuki, Yusuke Ohba, Genotype to Phenotype Japan (G2P-Japan) Consortium, Isao Yokota, Keita Matsuno, Kazuo Takayama, Shinya Tanaka, Kei Sato, Takasuke Fukuhara

Communications Biology, 6(1), 772. https://doi.org/10.1038/s42003-023-05081-w

Impact of imprinted immunity induced by mRNA vaccination in an experimental animal model

Shigeru Fujita, Keiya Uriu, Lin Pan, Naganori Nao, Koshiro Tabata, Mai Kishimoto, Yukari Itakura, Hirofumi Sawa, Izumi Kida, Tomokazu Tamura, Genotype to Phenotype Japan (G2P-Japan) Consortium, Takasuke Fukuhara, Jumpei Ito, Keita Matsuno, Kei Sato

The Journal of Infectious Diseases, 228(8), 1060–1065. https://doi.org/10.1093/infdis/jiad230

saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity against SARS-CoV-2 variants of concern

Mai Komori, Takuto Nogimori, Amber L Morey, Takashi Sekida, Keiko Ishimoto, Matthew R Hassett, Yuji Masuta, Hirotaka Ode, Tomokazu Tamura, Rigel Suzuki, Jeff Alexander, Yasutoshi Kido, Kenta Matsuda, Takasuke Fukuhara, Yasumasa Iwatani, Takuya Yamamoto, Jonathan F Smith, Wataru Akahata

Nature Communications, 14(1), 2810. https://doi.org/10.1038/s41467-023-38457-x

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

Tomokazu Tamura, Jumpei Ito, Keiya Uriu, Jiri Zahradnik, Izumi Kida, Yuki Anraku, Hesham Nasser, Maya Shofa, Yoshitaka Oda, Spyros Lytras, Naganori Nao, Yukari Itakura, Sayaka Deguchi, Rigel Suzuki, Lei Wang, Mst Monira Begum, Shunsuke Kita, Hisano Yajima, Jiei Sasaki, Kaori Sasaki-Tabata, Ryo Shimizu, Masumi Tsuda, Yusuke Kosugi, Shigeru Fujita, Lin Pan, Daniel Sauter, Kumiko Yoshimatsu, Saori Suzuki, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Yuki Yamamoto, Tetsuharu Nagamoto, Gideon Schreiber, Katsumi Maenaka, Genotype to Phenotype Japan (G2P-Japan) Consortium,Takao Hashiguchi, Terumasa Ikeda, Takasuke Fukuhara, Akatsuki Saito, Shinya Tanaka, Keita Matsuno, Kazuo Takayama, Kei Satoo K.

Nature Communications, 14(1), 2800. https://doi.org/10.1038/s41467-023-38435-3

A third dose of the BNT162b2 mRNA vaccine sufficiently improves the neutralizing activity against SARS-CoV-2 variants in liver transplant recipients

Takahiro Tomiyama, Rigel Suzuki, Noboru Harada, Tomokazu Tamura, Katsuya Toshida, Yukiko- Kosai-Fujimoto, Takahiro Tomino, Shohei Yoshiya, Yoshihiro Nagao, Kazuki Takeishi, Shinji Itoh, Nobuhiro Kobayashi, Hayato Ito, Sachiyo Yoshio, Tatsuya Kanto, Tomoharu Yoshizumi, Takasuke Fukuhara

Frontiers in Cellular and Infection Microbiology, 13, 1197349. https://doi.org/10.3389/fcimb.2023.1197349

Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

Jumpei Ito, Rigel Suzuki, Keiya Uriu, Yukari Itakura, Jiri Zahradnik, Kanako Terakado Kimura, Sayaka Deguchi, Lei Wang, Spyros Lytras, Tomokazu Tamura, Izumi Kida, Hesham Nasser, Maya Shofa, Mst Monira Begum, Masumi Tsuda, Yoshitaka Oda, Tateki Suzuki, Jiei Sasaki, Kaori Sasaki-Tabata, Shigeru Fujita, Kumiko Yoshimatsu, Hayato Ito, Naganori Nao, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Yuki Yamamoto, Tetsuharu Nagamoto, Jin Kuramochi, Gideon Schreiber, Genotype to Phenotype Japan (G2P-Japan) Consortium, Akatsuki Saito, Keita Matsuno, Kazuo Takayama, Takao Hashiguchi, Shinya Tanaka, Takasuke Fukuhara, Terumasa Ikeda, Kei Sato

Nature Communications, 14(1), 2671. https://doi.org/10.1038/s41467-023-38188-z

Increased flexibility of the SARS-CoV-2 RNA-binding site causes resistance to remdesivir

PLoS Pathogens, 19(3), e1011231. https://doi.org/10.1371/journal.ppat.1011231

Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids

Rina Hashimoto, Tomokazu Tamura, Yukio Watanabe, Ayaka Sakamoto, Naoko Yasuhara, Hayato Ito, Masahiro Nakano, Hiromitsu Fuse, Akira Ohta, Takeshi Noda, Yasufumi Matsumura, Miki Nagao, Takuya Yamamoto, Takasuke Fukuhara, Kazuo Takayama

Molecular Pharmaceutics, 20(4), 2276–2287. https://doi.org/10.1021/acs.molpharmaceut.3c00114

Antiviral Activity of Micafungin and Its Derivatives against SARS-CoV-2 RNA Replication

Shogo Nakajima, Hirofumi Ohashi, Daisuke Akazawa, Shiho Torii, Rigel Suzuki, Takasuke Fukuhara, Koichi Watashi

Viruses, 15(2), 452. https://doi.org/10.3390/v15020452

2022

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant

Akatsuki Saito, Tomokazu Tamura, Jiri Zahradnik, Sayaka Deguchi, Koshiro Tabata, Yuki Anraku, Izumi Kimura, Jumpei Ito, Daichi Yamasoba, Hesham Nasser, Mako Toyoda, Kayoko Nagata, Keiya Uriu, Yusuke Kosugi, Shigeru Fujita, Maya Shofa, Mst Monira Begum, Ryo Shimizu, Yoshitaka Oda, Rigel Suzuki, Hayato Ito, Naganori Nao, Lei Wang, Masumi Tsuda, Kumiko Yoshimatsu, Jin Kuramochi, Shunsuke Kita, Kaori Sasaki-Tabata, Hideo Fukuhara, Katsumi Maenaka, Yuki Yamamoto, Tetsuharu Nagamoto, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Takamasa Ueno, Gideon Schreiber, Akifumi Takaori-Kondo, Genotype to Phenotype Japan (G2P-Japan) Consortium, Kotaro Shirakawa, Hirofumi Sawa, Takashi Irie, Takao Hashiguchi, Kazuo Takayama, Keita Matsuno, Shinya Tanaka, Terumasa Ikeda, Takasuke Fukuhara, Kei Sato

Cell Host & Microbe, 30(11), 1540–1555.e15. https://doi.org/10.1016/j.chom.2022.10.003

Smoking enhances the expression of angiotensin-converting enzyme 2 involved in the efficiency of severe acute respiratory syndrome coronavirus 2 infection

Rigel Suzuki, Yuki Ono, Koji Noshita, Kwang Su Kim, Hayato Ito, Yuhei Morioka, Tomokazu Tamura, Daisuke Okuzaki, Tetsuzo Tagawa, Tomoyoshi Takenaka, Tomoharu Yoshizumi, Teppei Shimamura, Shingo Iwami, Takasuke Fukuhara

Microbiology and Immunology, 67(1), 22–31. https://doi.org/10.1111/1348-0421.13034

Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5

Izumi Kimura, Daichi Yamasoba, Tomokazu Tamura, Naganori Nao, Tateki Suzuki, Yoshitaka Oda, Shuya Mitoma, Jumpei Ito, Hesham Nasser, Jiri Zahradnik, Keiya Uriu, Shigeru Fujita, Yusuke Kosugi, Lei Wang, Masumi Tsuda, Mai Kishimoto, Hayato Ito, Rigel Suzuki, Ryo Shimizu, Mst Monira Begum, Kumiko Yoshimatsu, Kanako Terakado Kimura, Jiei Sasaki, Kaori Sasaki-Tabata, Yuki Yamamoto, Tetsuharu Nagamoto, Jun Kanamune, Kouji Kobiyama, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Kotaro Shirakawa, Akifumi Takaori-Kondo, Jin Kuramochi, Gideon Schreiber, Ken J Ishii, Genotype to Phenotype Japan (G2P-Japan) Consortium, Takao Hashiguchi, Terumasa Ikeda, Akatsuki Saito, Takasuke Fukuhara, Shinya Tanaka, Keita Matsuno, Kei Sato

Cell, 185(21), 3992–4007.e16. https://doi.org/10.1016/j.cell.2022.09.018

SARS-CoV-2 Omicron detection by antigen tests using saliva

Kaoru Murakami, Sumio Iwasaki, Satoshi Oguri, Kumiko Tanaka, Rigel Suzuki, Kasumi Hayasaka, Shinichi Fujisawa, Chiaki Watanabe, Satoshi Konno, Isao Yokota, Takasuke Fukuhara, Masaaki Murakami, Takanori Teshima

Journal of Clinical Virology Plus, 2(4), 100109. https://doi.org/10.1016/j.jcvp.2022.100109

Impact of JMJD6 on intrahepatic cholangiocarcinoma

Yukiko Kosai-Fujimoto, Shinji Itoh, Kyohei Yugawa, Takasuke Fukuhara, Daisuke Okuzaki, Takeo Toshima, Noboru Harada, Yoshinao Oda, Tomoharu Yoshizumi, Masaki Mori

Molecular and Clinical Oncology, 17(2), 131. https://doi.org/10.3892/mco.2022.2564

Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike

Daichi Yamasoba, Izumi Kimura, Hesham Nasser, Yuhei Morioka, Naganori Nao, Jumpei Ito, Keiya Uriu, Masumi Tsuda, Jiri Zahradnik, Kotaro Shirakawa, Rigel Suzuki, Mai Kishimoto, Yusuke Kosugi, Kouji Kobiyama, Teppei Hara, Mako Toyoda, Yuri L Tanaka, Erika P Butlertanaka, Ryo Shimizu, Hayato Ito, Lei Wang, Yoshitaka Oda, Yasuko Orba, Michihito Sasaki, Kayoko Nagata, Kumiko Yoshimatsu, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Jin Kuramochi, Motoaki Seki, Ryoji Fujiki, Atsushi Kaneda, Tadanaga Shimada, Taka-Aki Nakada, Seiichiro Sakao, Takuji Suzuki, Takamasa Ueno, Akifumi Takaori-Kondo, Ken J Ishii, Gideon Schreiber, Genotype to Phenotype Japan (G2P-Japan) Consortium, Hirofumi Sawa, Akatsuki Saito, Takashi Irie, Shinya Tanaka, Keita Matsuno, Takasuke Fukuhara, Terumasa Ikeda, Kei Sato

Cell, 185(12), 2103–2115.e19. https://doi.org/10.1016/j.cell.2022.04.035

Secretory glycoprotein NS1 plays a crucial role in the particle formation of flaviviruses

PLoS Pathogens, 18(6), e1010593. https://doi.org/10.1371/journal.ppat.1010593

Antiviral activity of ciclesonide acetal derivatives blocking SARS-CoV-2 RNA replication

Genichiro Tsuji, Shogo Nakajima, Koichi Watashi, Shiho Torii, Rigel Suzuki, Takasuke Fukuhara, Nobumichi Ohoka, Takao Inoue, Yosuke Demizu

Journal of Pharmacological Sciences, 149(3), 81–84. https://doi.org/10.1016/j.jphs.2022.04.001

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

Nature, 603(7902), 700–705. https://doi.org/10.1038/s41586-022-04462-1

2021

Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

Akatsuki Saito, Takashi Irie, Rigel Suzuki, Tadashi Maemura, Hesham Nasser, Keiya Uriu, Yusuke Kosugi, Kotaro Shirakawa, Kenji Sadamasu, Izumi Kimura, Jumpei Ito, Jiaqi Wu, Kiyoko Iwatsuki-Horimoto, Mutsumi Ito, Seiya Yamayoshi, Samantha Loeber, Masumi Tsuda, Lei Wang, Seiya Ozono, Erika P Butlertanaka, Yuri L Tanaka, Ryo Shimizu, Kenta Shimizu, Kumiko Yoshimatsu, Ryoko Kawabata, Takemasa Sakaguchi, Kenzo Tokunaga, Isao Yoshida, Hiroyuki Asakura, Mami Nagashima, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Kazuhisa Yoshimura, Akifumi Takaori-Kondo, Masaki Imai, Genotype to Phenotype Japan (G2P-Japan) Consortium, Shinya Tanaka, So Nakagawa, Terumasa Ikeda, Takasuke Fukuhara, Yoshihiro Kawaoka, Kei Sato

Nature, 602(7896), 300–306. https://doi.org/10.1038/s41586-021-04266-9

SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity

Chihiro Motozono, Mako Toyoda, Jiri Zahradnik, Akatsuki Saito, Hesham Nasser, Toong Seng Tan, Isaac Ngare, Izumi Kimura, Keiya Uriu, Yusuke Kosugi, Yuan Yue, Ryo Shimizu, Jumpei Ito, Shiho Torii, Akiko Yonekawa, Nobuyuki Shimono, Yoji Nagasaki, Rumi Minami, Takashi Toya, Noritaka Sekiya, Takasuke Fukuhara, Yoshiharu Matsuura, Gideon Schreiber, Genotype to Phenotype Japan (G2P-Japan) Consortium, Terumasa Ikeda, So Nakagawa, Takamasa Ueno, Kei Sato

Cell Host & Microbe, 29(7), 1124–1136.e11. https://doi.org/10.1016/j.chom.2021.06.006

DsRNA Sequencing for RNA Virus Surveillance Using Human Clinical Samples

Takuma Izumi, Yuhei Morioka, Syun-Ichi Urayama, Daisuke Motooka, Tomokazu Tamura, Takahiro Kawagishi, Yuta Kanai, Takeshi Kobayashi, Chikako Ono, Akinari Morinaga, Takahiro Tomiyama, Norifumi Iseda, Yukiko Kosai, Shoichi Inokuchi, Shota Nakamura, Tomohisa Tanaka, Kohji Moriishi, Hiroaki Kariwa, Tomoharu Yoshizumi, Masaki Mori, Yoshiharu Matsuura, Takasuke Fukuhara

Viruses, 13(7), 1310. https://doi.org/10.3390/v13071310

Phenotypic Characterization by Single-Cell Mass Cytometry of Human Intrahepatic and Peripheral NK Cells in Patients with Hepatocellular Carcinoma

Yuichi Yoshida, Sachiyo Yoshio, Taiji Yamazoe, Taizo Mori, Yuriko Tsustui, Hironari Kawai, Shiori Yoshikawa, Takasuke Fukuhara, Toru Okamoto, Yoshihiro Ono, Yu Takahashi, Ryuki Hashida, Takumi Kawaguchi, Akinobu Taketomi, Tatsuya Kanto

Cells, 10(6), 1495. https://doi.org/10.3390/cells10061495

M Segment-Based Minigenome System of Severe Fever with Thrombocytopenia Syndrome Virus as a Tool for Antiviral Drug Screening

Hiroshi Yamada, Satoshi Taniguchi, Masayuki Shimojima, Long Tan, Miyuki Kimura, Yoshitomo Morinaga, Takasuke Fukuhara, Yoshiharu Matsuura, Takashi Komeno, Yousuke Furuta, Masayuki Saijo, Hideki Tani

Viruses, 13(6), 1061. https://doi.org/10.3390/v13061061

Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction

Shiho Torii, Chikako Ono, Rigel Suzuki, Yuhei Morioka, Itsuki Anzai, Yuzy Fauzyah, Yusuke Maeda, Wataru Kamitani, Takasuke Fukuhara, Yoshiharu Matsuura

Cell Reports, 35(3), 109014. https://doi.org/10.1016/j.celrep.2021.109014

Suppression of optineurin impairs the progression of hepatocellular carcinoma through regulating mitophagy

Shoichi Inokuchi, Tomoharu Yoshizumi, Takeo Toshima, Shinji Itoh, Kyohei Yugawa, Noboru Harada, Hiroyuki Mori, Takasuke Fukuhara, Yoshiharu Matsuura, Masaki Mori

Cancer Medicine, 10(5), 1501–1514. https://doi.org/10.1002/cam4.3519

2020

Establishment of a cell culture model permissive for infection by hepatitis B and C viruses

Teruhime Otoguro, Tomohisa Tanaka, Hirotake Kasai, Nobuhiro Kobayashi, Atsuya Yamashita, Takasuke Fukuhara, Akihide Ryo, Moto Fukai, Akinobu Taketomi, Yoshiharu Matsuura, Kohji Moriishi

Hepatology Communications, 5(4), 634–649. https://doi.org/10.1002/hep4.1653

Ponesimod suppresses hepatitis B virus infection by inhibiting endosome maturation

Yuzy Fauzyah, Chikako Ono, Shiho Torii, Itsuki Anzai, Rigel Suzuki, Takuma Izumi, Yuhei Morioka, Yusuke Maeda, Toru Okamoto, Takasuke Fukuhara, Yoshiharu Matsuura

Antiviral Research, 186, 104999. https://doi.org/10.1016/j.antiviral.2020.104999

ISGylation of hepatitis C virus NS5A protein promotes viral RNA replication via the recruitment of cyclophilin A

Takayuki Abe, Nanae Minami, Rheza Gandi Bawono, Chieko Matsui, Lin Deng, Takasuke Fukuhara, Yoshiharu Matsuura, Ikuo Shoji

Journal of Virology, 94(20), e00532-20. https://doi.org/10.1128/JVI.00532-20

De novo hepatocellular carcinoma developing in the living donor liver grafts: A Japanese multicenter experience

Ryoichi Goto, Yukiko Kosai-Fujimoto, Shintaro Yagi, Tsuyoshi Kobayashi, Nobuhisa Akamatsu, Tsuyoshi Shimamura, Satoru Imura, Satoshi Ogiso, Shugo Mizuno, Mitsuhisa Takatsuki, Takasuke Fukuhara, Tatsuya Kanto, Susumu Eguchi, Katsuhiko Yanaga, Yasuhiro Ogura, Takumi Fukumoto, Mitsuo Shimada, Kiyoshi Hasegawa, Hideki Ohdan, Shinji Uemoto, Yuji Soejima, Toru Ikegami, Tomoharu Yoshizumi, Akinobu Taketomi, Yoshihiko Maehara

Hepatology Research, 50(12), 1365–1374. https://doi.org/10.1111/hepr.13565

Various miRNAs compensate the role of miR-122 on HCV replication

Chikako Ono, Takasuke Fukuhara, Songling Li, Jian Wang, Asuka Sato, Takuma Izumi, Yuzy Fauzyah, Takuya Yamamoto, Yuhei Morioka, Nikolay V Dokholyan, Daron M Standley, Yoshiharu Matsuura

PLoS Pathogens, 16(6), e1008308. https://doi.org/10.1371/journal.ppat.1008308

Host ESCRT factors are recruited during chikungunya virus infection and are required for the intracellular viral replication cycle

Shiho Torii, Yasuko Orba, Michihito Sasaki, Koshiro Tabata, Yuji Wada, Michael Carr, Jody Hobson-Peters, Roy A Hall, Ayato Takada, Takasuke Fukuhara, Yoshiharu Matsuura, William W Hall, Hirofumi Sawa

The Journal of Biological Chemistry, 295(23), 7941–7957. https://doi.org/10.1074/jbc.RA119.012303

Development of a high-throughput serum neutralization test using recombinant pestiviruses possessing a small reporter tag

Madoka Tetsuo, Keita Matsuno, Tomokazu Tamura, Takasuke Fukuhara, Taksoo Kim, Masatoshi Okamatsu, Norbert Tautz, Yoshiharu Matsuura, Yoshihiro Sakoda

Pathogens, 9(3), 188. https://doi.org/10.3390/pathogens9030188

Rimonabant suppresses RNA transcription of hepatitis B virus by inhibiting hepatocyte nuclear factor 4α

Asuka Sato, Chikako Ono, Tomokazu Tamura, Hiroyuki Mori, Takuma Izumi, Shiho Torii, Yuzy Fauzyah, Takuya Yamamoto, Yuhei Morioka, Daisuke Okuzaki, Takasuke Fukuhara, Yoshiharu Matsuura

Microbiology and Immunology, 64(5), 345–355. https://doi.org/10.1111/1348-0421.12777

2019

In vivo dynamics of reporter Flaviviridae viruses

Journal of Virology, 93(22), e01191-19. https://doi.org/10.1128/JVI.01191-19

The evolution of surgical treatment for gastrointestinal cancers

Yoshihiko Maehara, Yuji Soejima, Tomoharu Yoshizumi, Naoyuki Kawahara, Eiji Oki, Hiroshi Saeki, Tomohiko Akahoshi, Toru Ikegami, Yo-Ichi Yamashita, Tadashi Furuyama, Keishi Sugimachi, Noboru Harada, Tetsuzo Tagawa, Norifumi Harimoto, Shinji Itoh, Hideto Sonoda, Koji Ando, Yuichiro Nakashima, Yoshihiro Nagao, Nami Yamashita, Yuta Kasagi, Takafumi Yukaya, Takeshi Kurihara, Ryosuke Tsutsumi, Shinkichi Takamori, Shun Sasaki, Tetsuo Ikeda, Yoshikazu Yonemitsu, Takasuke Fukuhara, Hiroyuki Kitao, Makoto Iimori, Yuki Kataoka, Takeshi Wakasa, Masami Suzuki, Koji Teraishi, Yasuto Yoshida, Masaki Mori

International Journal of Clinical Oncology, 24(11), 1333–1349. https://doi.org/10.1007/s10147-019-01499-7

Characterization of human pegivirus infection in liver transplantation recipients

Takuma Izumi, Kazuhito Sakata, Daisuke Okuzaki, Shoichi Inokuchi, Tomokazu Tamura, Daisuke Motooka, Shota Nakamura, Chikako Ono, Masahiro Shimokawa, Yoshiharu Matsuura, Masaki Mori, Takasuke Fukuhara, Tomoharu Yoshizumi

Journal of Medical Virology, 91(12), 2093–2100. https://doi.org/10.1002/jmv.25555

Roles of secretory glycoproteins in particle formation of Flaviviridae viruses

Takasuke Fukuhara, Yoshiharu Matsuura

Microbiology and Immunology, 63(10), 401–406. https://doi.org/10.1111/1348-0421.12733

Ectopic localization of autophagosome in fatty liver is a key factor for liver regeneration

Yoshihiro Matsumoto, Tomoharu Yoshizumi, Takeo Toshima, Kazuki Takeishi, Takasuke Fukuhara, Shinji Itoh, Toru Ikegami, Yuji Soejima, Masaki Mori

Organogenesis, 15(1), 24–34. https://doi.org/10.1080/15476278.2019.1633872

USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation

Shinji Kusakabe, Tatsuya Suzuki, Yukari Sugiyama, Saori Haga, Kanako Horike, Makoto Tokunaga, Junki Hirano, He Zhang, David Virya Chen, Hanako Ishiga, Yasumasa Komoda, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masahito Ikawa, Takashi Satoh, Shizuo Akira, Tomohisa Tanaka, Kohji Moriishi, Moto Fukai, Akinobu Taketomi, Sachiyo Yoshio, Tatsuya Kanto, Tetsuro Suzuki, Toru Okamoto, Yoshiharu Matsuura

Journal of Virology, 93(6), e01708-18. https://doi.org/10.1128/JVI.01708-18

2018

Induction of selective autophagy in cells replicating hepatitis C virus genome

Hiroyuki Mori, Takasuke Fukuhara, Chikako Ono, Tomokazu Tamura, Asuka Sato, Yuzy Fauzyah, Masami Wada, Toru Okamoto, Takeshi Noda, Tamotsu Yoshimori, Yoshiharu Matsuura

The Journal of General Virology, 99(12), 1643–1657. https://doi.org/10.1099/jgv.0.001161

CEACAM1 is associated with the suppression of natural killer cell function in patients with chronic hepatitis C

Takahiro Suda, Tomohide Tatsumi, Akira Nishio, Tadashi Kegasawa, Teppei Yoshioka, Ryoko Yamada, Kunimaro Furuta, Takahiro Kodama, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Takasuke Fukuhara, Yoshiharu Matsuura, Tetsuo Takehara

Hepatology Communications, 2(10), 1247–1258. https://doi.org/10.1002/hep4.1240

Infection with flaviviruses requires BCLXL for cell survival

Tatsuya Suzuki, Toru Okamoto, Hiroshi Katoh, Yukari Sugiyama, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Takasuke Fukuhara, Masahito Ikawa, Takashi Satoh, Sachiyo Yoshio, Ryosuke Suzuki, Masayuki Saijo, David C S Huang, Tatsuya Kanto, Shizuo Akira, Yoshiharu Matsuura

PLoS Pathogens, 14(9), e1007299. https://doi.org/10.1371/journal.ppat.1007299

Serum Asunaprevir and Daclatasvir concentrations and outcomes in patients with recurrent hepatitis C who have undergone living donor liver transplantation

Noboru Harada, Tomoharu Yoshizumi, Toru Ikegami, Shinji Itoh, Norihiro Furusho, Masaki Kato, Shinji Shimoda, Takasuke Fukuhara, Yuji Soejima, Yoshihiko Maehara

Anticancer Research, 38(9), 5513–5520. https://doi.org/10.21873/anticanres.12885

A novel occludin-targeting monoclonal antibody prevents hepatitis C virus infection in vitro

Ken Okai, Naoki Ichikawa-Tomikawa, Akira C Saito, Tetsuya Watabe, Kotaro Sugimoto, Daiki Fujita, Chikako Ono, Takasuke Fukuhara, Yoshiharu Matsuura, Hiromasa Ohira, Hideki Chiba

Oncotarget, 9(24), 16588–16598. https://doi.org/10.18632/oncotarget.24742

Roles of the 5' untranslated region of nonprimate hepacivirus in translation initiation and viral replication

Tomohisa Tanaka, Teruhime Otoguro, Atsuya Yamashita, Hirotake Kasai, Takasuke Fukuhara, Yoshiharu Matsuura, Kohji Moriishi

Journal of Virology, 92(7), e01997-17. https://doi.org/10.1128/JVI.01997-17

Characterization of recombinant Flaviviridae viruses possessing a small reporter tag

Tomokazu Tamura, Takasuke Fukuhara, Takuro Uchida, Chikako Ono, Hiroyuki Mori, Asuka Sato, Yuzy Fauzyah, Toru Okamoto, Takeshi Kurosu, Yin Xiang Setoh, Michio Imamura, Norbert Tautz, Yoshihiro Sakoda, Alexander A Khromykh, Kazuaki Chayama, Yoshiharu Matsuura

Journal of Virology, 92(2), e01582-17. https://doi.org/10.1128/JVI.01582-17

2017

Characterization of SPP inhibitors suppressing propagation of HCV and protozoa

Junki Hirano, Toru Okamoto, Yukari Sugiyama, Tatsuya Suzuki, Shinji Kusakabe, Makoto Tokunaga, Takasuke Fukuhara, Miwa Sasai, Takahiro Tougan, Yasue Matsunaga, Kazuo Yamashita, Yusuke Sakai, Masahiro Yamamoto, Toshihiro Horii, Daron M Standley, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike, Yoshiharu Matsuura

Proceedings of the National Academy of Sciences, 114(50), E10782–E10791. https://doi.org/10.1073/pnas.1712484114

Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9

Scientific Reports, 7(1), 6122. https://doi.org/10.1038/s41598-017-05905-w

Development of hepatoma-derived, bidirectional oval-like cells as a model to study host interactions with hepatitis C virus during differentiation

Masahiko Ito, Suofeng Sun, Takasuke Fukuhara, Ryosuke Suzuki, Miho Tamai, Toyohiko Yamauchi, Kenji Nakashima, Yoh-Ichi Tagawa, Shigetoshi Okazaki, Yoshiharu Matsuura, Takaji Wakita, Tetsuro Suzuki

Oncotarget, 8(33), 53899–53915. https://doi.org/10.18632/oncotarget.19108

Host-derived apolipoproteins play comparable roles with viral secretory proteins Erns and NS1 in the infectious particle formation of Flaviviridae

PLoS Pathogens, 13(6), e1006475. https://doi.org/10.1371/journal.ppat.1006475

Characterization of miR-122-independent propagation of HCV

Chikako Ono, Takasuke Fukuhara, Daisuke Motooka, Shota Nakamura, Daisuke Okuzaki, Satomi Yamamoto, Tomokazu Tamura, Hiroyuki Mori, Asuka Sato, Kentaro Uemura, Yuzy Fauzyah, Takeshi Kurihara, Takahiro Suda, Akira Nishio, Su Su Hmwe, Toru Okamoto, Tomohide Tatsumi, Tetsuo Takehara, Kazuaki Chayama, Takaji Wakita, Kazuhiko Koike, Yoshiharu Matsuura

PLoS Pathogens, 13(5), e1006374. https://doi.org/10.1371/journal.ppat.1006374

Quasispecies of Hepatitis C Virus Participate in Cell-Specific Infectivity

Takasuke Fukuhara, Satomi Yamamoto, Chikako Ono, Shota Nakamura, Daisuke Motooka, Hiroyuki Mori, Takeshi Kurihara, Asuka Sato, Tomokazu Tamura, Takashi Motomura, Toru Okamoto, Michio Imamura, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Yoshihiko Maehara, Kazuaki Chayama, Yoshiharu Matsuura

Scientific Reports, 7, 45228. https://doi.org/10.1038/srep45228

CD14+ monocyte-derived galectin-9 induces natural killer cell cytotoxicity in chronic hepatitis C

Akira Nishio, Tomohide Tatsumi, Takatoshi Nawa, Takahiro Suda, Teppei Yoshioka, Yoshiki Onishi, Satoshi Aono, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Daisuke Okuzaki, Takasuke Fukuhara, Yoshiharu Matsuura, Naoki Hiramatsu, Tetsuo Takehara

Hepatology, 65(1), 18–31. https://doi.org/10.1002/hep.28847

2016

Human catholicidin compensate for the role of apolipoproteins in the infections particle formation

Francesc Puig-Basagoiti, Takasuke Fukuhara, Tomokazu Tamura, Chikako Ono, Kentaro Uemura, Yukako Kawachi, Satomi Yamamoto, Hiroyuki Mori, Takeshi Kurihara, Toru Okamoto, Hideki Aizaki, Yoshiharu Matsuura

Journal of Virology, 90(19), 8464–8477. https://doi.org/10.1128/JVI.00471-16

Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus

Satomi Yamamoto, Takasuke Fukuhara, Chikako Ono, Kentaro Uemura, Yukako Kawachi, Mai Shiokawa, Hiroyuki Mori, Masami Wada, Ryoichi Shima, Toru Okamoto, Nobuhiko Hiraga, Ryosuke Suzuki, Kazuaki Chayama, Takaji Wakita, Yoshiharu Matsuura

PLoS Pathogens, 12(5), e1005610. https://doi.org/10.1371/journal.ppat.1005610

TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis

Sayaka Aizawa, Toru Okamoto, Yukari Sugiyama, Takahisa Kouwaki, Ayano Ito, Tatsuya Suzuki, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masayasu Okochi, Nobuhiko Hiraga, Michio Imamura, Kazuaki Chayama, Ryosuke Suzuki, Ikuo Shoji, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike, Yoshiharu Matsuura

Nature Communications, 7, 11379. https://doi.org/10.1038/ncomms11379

Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx

Takahisa Kouwaki, Toru Okamoto, Ayano Ito, Yukari Sugiyama, Kazuo Yamashita, Tatsuya Suzuki, Shinji Kusakabe, Junki Hirano, Takasuke Fukuhara, Atsuya Yamashita, Kazunobu Saito, Daisuke Okuzaki, Koichi Watashi, Masaya Sugiyama, Sachiyo Yoshio, Daron M Standley, Tatsuya Kanto, Masashi Mizokami, Kohji Moriishi, Yoshiharu Matsuura

Journal of Virology, 90(7), 3530–3542. https://doi.org/10.1128/JVI.02776-15

2015

Roles of Lipoproteins and Apolipoproteins in Particle Formation of Hepatitis C Virus

Takasuke Fukuhara, Chikako Ono, Francesc Puig-Basagoiti, Yoshiharu Matsuura

Trends in Microbiology, 23(10), 618–629. https://doi.org/10.1016/j.tim.2015.07.007

Telaprevir versus simeprevir for the treatment of recurrent hepatitis C after living donor liver transplantation

Toru Ikegami, Tomoharu Yoshizumi, Yoshihro Yoshida, Takeshi Kurihara, Norifumi Harimoto, Shinji Itoh, Masahiro Shimokawa, Takasuke Fukuhara, Ken Shirabe, Yoshihiko Maehara

Hepatology Research, 46(3), E136–E145. https://doi.org/10.1111/hepr.12546

2014

Amphipathic a-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles

PLoS Pathogens, 10(12), e1004534. https://doi.org/10.1371/journal.ppat.1004534

Reduced-dose telaprevir-based triple antiviral therapy for recurrent hepatitis C after living donor liver transplantation

Toru Ikegami, Tomoharu Yoshizumi, Masaki Kato, Satomi Yamamoto, Takasuke Fukuhara, Yoshiharu Matsuura, Shota Nakamura, Shinji Itoh, Ken Shirabe, Yoshihiko Maehara

Transplantation, 98(9), 994–999. https://doi.org/10.1097/TP.0000000000000166

Interferon-lambda4 genetic polymorphism is associated with the therapy respomse for hepatitis C virus rexurrence after living donor liver transplant

H Konishi, T Motomura, Y Matsumoto, N Harimoto, T Ikegami, T Yoshizumi, Y Soejima, K Shirabe, T Fukuhara, Y Maehara

Journal of Viral Hepatitis, 21(6), 397–404. https://doi.org/10.1111/jvh.12154

Novel permissive cell lines for complete propagation of hepatitis C virus

Mai Shiokawa, Takasuke Fukuhara, Chikako Ono, Satomi Yamamoto, Toru Okamoto, Noriyuki Watanabe, Takaji Wakita, Yoshiharu Matsuura

Journal of Virology, 88(10), 5578–5594. https://doi.org/10.1128/JVI.03839-13

Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice

Takeo Toshima, Ken Shirabe, Takasuke Fukuhara, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Tetsuo Ikeda, Shinji Okano, Yoshihiko Maehara, Okano S and Maehara Y.

Hepatology, 60(1), 290–300. https://doi.org/10.1002/hep.27140

Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells

Chikako Ono, Akinori Ninomiya, Satomi Yamamoto, Takayuki Abe, Xiauyu Wen, Takasuke Fukuhara, Miwa Sasai, Masahiro Yamamoto, Tatsuya Saitoh, Takashi Satoh, Taro Kawai, Ken J Ishii, Shizuo Akira, Toru Okamoto, Yoshiharu Matsuura

Journal of virology, 88(4), 2157–2167. https://doi.org/10.1128/JVI.03055-13

2013

Strategies to treat interferon-induced graft dysfunction after living donor liver transplantation for hepatitis C

Toru Ikegami, Huanlin Wang, Tomoharu Yoshizumi, Takeo Toshima, Shinichi Aishima, Takasuke Fukuhara, Norihiro Furusyo, Kazuhiro Kotoh, Shinji Shimoda, Ken Shirabe, Yoshihiko Maehara

Hepatology International, 8(2), 285–292. https://doi.org/10.1007/s12072-013-9496-2

Decreased roundabout 1 expression promotes development of intrahepatic cholangiocarcinoma

Yohei Mano, Shinichi Aishima, Takasuke Fukuhara, Yuki Tanaka, Yuichiro Kubo, Takashi Motomura, Takeo Toshima, Tomohiro Iguchi, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda

Human Pathology, 44(11), 2419–2426. https://doi.org/10.1016/j.humpath.2013.03.022

Impact of conversion from pegylated interferon-a2b to interferon-a2a for treating recurrent hepatitis C after liver transplantation

Toru Ikegami, Ken Shirabe, Tomoharu Yoshizumi, Norihiro Furusyo, Kazuhiro Kotoh, Masaki Kato, Shinji Shimoda, Yuji Soejima, Takashi Motomura, Takasuke Fukuhara, Yoshihiko Maehara

Transplantation, 95(6), e38–e42. https://doi.org/10.1097/TP.0b013e318283a82e

Human blood dendritic cell antigen 3 (BDCA3)(+) dendritic cells are a potent producer of interferon-lambda in response to hepatitis C virus

Sachiyo Yoshio, Tatsuya Kanto, Shoko Kuroda, Tokuhiro Matsubara, Koyo Higashitani, Naruyasu Kakita, Hisashi Ishida, Naoki Hiramatsu, Hiroaki Nagano, Masaya Sugiyama, Kazumoto Murata, Takasuke Fukuhara, Yoshiharu Matsuura, Norio Hayashi, Masashi Mizokami, Tetsuo Takehara

Hepatology, 57(5), 1705–1715. https://doi.org/10.1002/hep.26182

Hepatic interferon-gamma-induced protein-10 expression is more strongly associated with liver fibrosis than interleukin-28B single nucleotide polymorohisms in hepatocellular carcinoma resected patients with chronic hepatitis C

Hideyuki Konishi, Ken Shirabe, Shohei Yoshiya, Tetsuo Ikeda, Toru Ikegami, Tomoharu Yoshizumi, Ayae Ikawa-Yoshida, Takashi Motomura, Takasuke Fukuhara, Yoshihiko Maehara

Hepatology Research, 43(11), 1139–1147. https://doi.org/10.1111/hepr.12070

Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation

Hiroshi Katoh, Toru Okamoto, Takasuke Fukuhara, Hiroto Kambara, Eiji Morita, Yoshio Mori, Wataru Kamitani, Yoshiharu Matsuura

Journal of Virology, 87(1), 489–502. https://doi.org/10.1128/JVI.02186-12

Role of miR-122 and lipid metabolism in HCV infection

Takasuke Fukuhara, Yoshiharu Matsuura

Journal of Gastroenterology, 48(2), 169–176. https://doi.org/10.1007/s00535-012-0661-5

2012

Effect of laparoscopic splenectomy in patients with hepatitis C and cirrhosis carrying IL28B minor genotype

Takashi Motomura, Ken Shirabe, Norihiro Furusyo, Tomoharu Yoshizumi, Toru Ikegami, Yuji Soejima, Tomohiko Akahoshi, Morimasa Tomikawa, Takasuke Fukuhara, Jun Hayashi, Yoshihiko Maehara

BMC Gastroenterology, 12, 158. https://doi.org/10.1186/1471-230X-12-158

Early extensive viremia, but not rs8099917 genotype, is the only predictor for cholestatic hepatitis C after living-donor liver transplantation

Toru Ikegami, Ken Shirabe, Takasuke Fukuhara, Norihiro Furusyo, Kazuhiro Kotoh, Masaki Kato, Shinji Shimoda, Shinichi Aishima, Yuji Soejima, Tomoharu Yoshizumi, Yoshihiko Maehara

Hepatology Research, 43(6), 621–629. https://doi.org/10.1111/hepr.12003

Neither MICA nor DEPDC5 genetic polymorphisms correlate with hepatocellular carcinoma recurrence following hepatectomy

Takashi Motomura, Yuki Ono, Ken Shirabe, Takasuke Fukuhara, Hideyuki Konishi, Yohei Mano, Takeo Toshima, Shohei Yoshiya, Jun Muto, Toru Ikegami, Tomoharu Yoshizumi, Yoshihiko Maehara

HPB Surgery, 2012, 185496. https://doi.org/10.1155/2012/185496

Neutrophil-lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment

Takashi Motomura, Ken Shirabe, Yohei Mano, Jun Muto, Takeo Toshima, Yuichiro Umemoto, Takasuke Fukuhara, Hideaki Uchiyama, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Yoshihiko Maehara

Journal of Hepatology, 58(1), 58–64. https://doi.org/10.1016/j.jhep.2012.08.017

Expression of microRNA miR-122 facilitates an efficient replication in nonhepatic cells upon infection with hepatitis C virus

Takasuke Fukuhara, Hiroto Kambara, Mai Shiokawa, Chikako Ono, Hiroshi Katoh, Eiji Morita, Daisuke Okuzaki, Yoshihiko Maehara, Kazuhiko Koike, Yoshiharu Matsuura

Journal of Virology, 86(15), 7918–7933. https://doi.org/10.1128/JVI.00567-12

CD44 participates in IP-10 induction in cells in which hepatitis C virus RNA is replicating, through an interaction with Toll-like receptor 2 and hyaluronan

Takayuki Abe, Takasuke Fukuhara, Xiauyu Wen, Akinori Ninomiya, Kohji Moriishi, Yoshihiko Maehara, Osamu Takeuchi, Taro Kawai, Shizuo Akira, Yoshiharu Matsuura

Journal of Virology, 86(11), 6159–6170. https://doi.org/10.1128/JVI.06872-11

V5-drainage-preserved right lobe grafts improve graft congestion for liver transplantation

Takeo Toshima, Akinobu Taketomi, Toru Ikegami, Takasuke Fukuhara, Hiroto Kayashima, Tomoharu Yoshizumi, Yuji Soejima, Ken Shirabe, Yoshihiko Maehara

Transplantation, 93(9), 929–935. https://doi.org/10.1097/TP.0b013e3182488bd8

Baculovirus GP64-mediated entry into mammalian cells

Chikako Kataoka, Yuuki Kaname, Shuhei Taguwa, Takayuki Abe, Takasuke Fukuhara, Hideki Tani, Kohji Moriishi, Yoshiharu Matsuura

Journal of Virology, 86(5), 2610–2620. https://doi.org/10.1128/JVI.06704-11

Establishment of a novel permissive cell line for the propagation of hepatitis C virus by expression of microRNA miR122

Hiroto Kambara, Takasuke Fukuhara, Mai Shiokawa, Chikako Ono, Yuri Ohara, Wataru Kamitani, Yoshiharu Matsuura

Journal of Virology, 86(3), 1382–1393. https://doi.org/10.1128/JVI.06242-11

2011

Efficacy of splenectomy in preventing anemia in patients with recurrent hepatitis C following liver transplantation is not dependent on inosine triphosphate pyrophosphatase genotype

Takashi Motomura, Erina Koga, Akinobu Taketomi, Takasuke Fukuhara, Yohei Mano, Jun Muto, Hideyuki Konishi, Takeo Toshima, Hideaki Uchiyama, Tomoharu Yoshizumi, Ken Shirabe, Yoshihiko Maehara

Hepatology Research, 42(3), 288–295. https://doi.org/10.1111/j.1872-034X.2011.00927.x

Heterogeneous nuclear ribonucleoprotein A2 participates in the replication of Japanese encephalitis virus through an interaction with viral proteins and RNA

Hiroshi Katoh, Yoshio Mori, Hiroto Kambara, Takayuki Abe, Takasuke Fukuhara, Eiji Morita, Kohji Moriishi, Wataru Kamitani, Yoshiharu Matsuura

Journal of Virology, 85(21), 10976–10988. https://doi.org/10.1128/JVI.00846-11

The impact of IL28B genetic variants on recurrent hepatitis C in liver transplantation: significant lessons from a dual graft case

T Motomura, A Taketomi, T Fukuhara, Y Mano, K Takeishi, T Toshima, N Harada, H Uchiyama, T Yoshizumi, Y Soejima, K Shirabe, Y Matsuura, Y Maehara

American Journal of Transplantation, 11(6), 1325–1329. https://doi.org/10.1111/j.1600-6143.2011.03537.x

Involvement of cyclophilin B in the replication of Japanese encephalitis virus

Hiroto Kambara, Hideki Tani, Yoshio Mori, Takayuki Abe, Hiroshi Katoh, Takasuke Fukuhara, Shuhei Taguwa, Kohji Moriishi, Yoshiharu Matsuura

Virology, 412(1), 211–219. https://doi.org/10.1016/j.virol.2011.01.011

Intracellular delivery of serum-derived hepatitis C virus

Takasuke Fukuhara, Hideki Tani, Mai Shiokawa, Yukinori Goto, Takayuki Abe, Akinobu Taketomi, Ken Shirabe, Yoshihiko Maehara, Yoshiharu Matsuura

Microbes and Infection, 13(4), 405–412. https://doi.org/10.1016/j.micinf.2011.01.005

2010

Variants in IL28B in liver recipients and donors correlate with response to peg-interferon and ribavirin therapy for recurrent hepatitis C

Takasuke Fukuhara, Akinobu Taketomi, Takashi Motomura, Shinji Okano, Akinori Ninomiya, Takayuki Abe, Hideaki Uchiyama, Yuji Soejima, Ken Shirabe, Yoshiharu Matsuura, Yoshihiko Maehara

Gastroenterology, 139(5), 1577–1585.e15853. https://doi.org/10.1053/j.gastro.2010.07.058

Evolving strategies to prevent bilary strictures after living donor liver transplantation

T Ikegami, Y Soejima, K Shirabe, A Taketomi, T Yoshizumi, H Uchiyama, T Fukuhara, T Ikeda, Y Maehara

Transplantation Proceedings, 42(9), 3624–3629. https://doi.org/10.1016/j.transproceed.2010.07.091

Impact of preoperative serum sodium concentration in living donor liver transplantation

Takasuke Fukuhara, Toru Ikegami, Kazutoyo Morita, Kenji Umeda, Shigeru Ueda, Shigeyuki Nagata, Keishi Sugimachi, Tomonobu Gion, Tomoharu Yoshizumi, Yuji Soejima, Akinobu Taketomi, Yoshihiko Maehara

Journal of Gastroenterology and Hepatology, 25(5), 978–984. https://doi.org/10.1111/j.1440-1746.2009.06162.x

Improved results for a surgical resection for the recurrence of hepatocellular carcinoma after living donor liver transplantation

Akinobu Taketomi, Takasuke Fukuhara, Kazutoyo Morita, Hiroto Kayashima, Mizuki Ninomiya, Yoichi Yamashita, Toru Ikegami, Hideaki Uchiyama, Tomoharu Yoshizumi, Yuji Soejima, Ken Shirabe, Yoshihko Maehara

Annals of Surgical Oncology, 17(9), 2283–2289. https://doi.org/10.1245/s10434-010-0999-y

Mutations in hepatitis C virus genotype 1b and the sensitivity of interferon-ribavirin therapy after liver transplantation

Takasuke Fukuhara, Akinobu Taketomi, Shinji Okano, Toru Ikegami, Yuji Soejima, Ken Shirabe, Yoshihiko Maehara

Journal of Hepatology, 52(5), 672–680. https://doi.org/10.1016/j.jhep.2009.10.034

Impact of amino acid substitutions in the core region of HCV on multistep hepatocarcinogenesis

Takasuke Fukuhara, Kazuki Takeishi, Takeo Toshima, Kazutoyo Morita, Shigeru Ueda, Tomohiro Iguchi, Shigeyuki Nagata, Keishi Sugimachi, Toru Ikegami, Tomonobu Gion, Yuji Soejima, Akinobu Taketomi, Yoshihiko Maehara

Hepatology Research, 40(2), 171–178. https://doi.org/10.1111/j.1872-034X.2009.00575.x

2009

The benefits of interferon treatment in patients without sustained viral response after living donor liver transplantation for hepatitis C

T Ikegami, A Taketomi, Y Soejima, T Yoshizumi, T Fukuhara, K Kotoh, S Shimoda, M Kato, Y Maehara

Transplantation Proceedings, 41(10), 4246–4252. https://doi.org/10.1016/j.transproceed.2009.08.070

De novo hepatocellular carcinoma in a liver graft with sustained hepatitis C virus clearance after living donor liver transplantation

Kazutoyo Morita, Akinobu Taketomi, Yuji Soejima, Toru Ikegami, Takasuke Fukuhara, Tomohiro Iguchi, Shigeyuki Nagata, Keishi Sugimachi, Tomonobu Gion, Ken Shirabe, Yoshihiko Maehara

Liver Transplantation, 15(11), 1412–1416. https://doi.org/10.1002/lt.21894

Human VAP-C negatively regulates hepatitis C virus propagation

Hiroshi Kukihara, Kohji Moriishi, Shuhei Taguwa, Hideki Tani, Takayuki Abe, Yoshio Mori, Tetsuro Suzuki, Takasuke Fukuhara, Akinobu Taketomi, Yoshihiko Maehara, Yoshiharu Matsuura

Journal of Virology, 83(16), 7959–7969. https://doi.org/10.1128/JVI.00889-09

Congestion of the donor remnant right liver after extended left lobe donation.

Takasuke Fukuhara, Kenji Umeda, Takeo Toshima, Kazuki Takeishi, Kazutoyo Morita, Shigeyuki Nagata, Keishi Sugimachi, Toru Ikegami, Tomonobu Gion, Yuji Soejima, Akinobu Taketomi, Yoshihiko Maehara

Transplant International, 22(8), 837–844. https://doi.org/10.1111/j.1432-2277.2009.00880.x

Phase1/2 study of the lipiodolization using DDP-H (CDDP powder; IA-call) in patients with unresectable hepatocellular carcinoma

Yo-ichi Yamashita, Akinobu Taketomi, Shinji Itoh, Norifumi Harimoto, Kazutoyo Morita, Takasuke Fukuhara, Shigeru Ueda, Kensaku Sanefuji, Keishi Sugimachi, Tsuyoshi Tajima, Yoshihiko Maehara

Cancer Chemotherapy and Pharmacology, 65(2), 301–307. https://doi.org/10.1007/s00280-009-1034-5

Rapid normalization of portopulmonary hypertension after living donor liver transplantation

K Sugimachi, Y Soejima, K Morita, S Ueda, T Fukuhara, S Nagata, T Ikegami, A Taketomi, Y Maehara

Transplantation Proceedings, 41(5), 1976–1978. https://doi.org/10.1016/j.transproceed.2009.02.095

2008

A simple hilar dissection technique preserving maximum blood supply to the bile duct in living donor liver transplantation

Yuji Soejima, Takasuke Fukuhara, Kazutoyo Morita, Tomoharu Yoshizumi, Toru Ikegami, Yoichi Yamashita, Keishi Sugimachi, Akinobu Taketomi, Yoshihiko Maehara

Transplantation, 86(10), 1468–1469. https://doi.org/10.1097/TP.0b013e318188d4dc

The impact of surgical treatment and poor prognostic factors for patients with intrahepatic cholangiocarcinoma: retrospective analysis of 60 patients

Yo-ichi Yamashita, Akinobu Taketomi, Kazutoyo Morita, Takasuke Fukuhara, Shigeru Ueda, Kensaku Sanefuji, Tomohiro Iguchi, Hiroto Kayashima, Keishi Sugimachi, Yoshihiko Maehara

Anticancer Research, 28(4C), 2353–2359 https://ar.iiarjournals.org/content/28/4C/2353.long

One-step venous reconstruction for a right lobe graft with multiple venous orifices in living donor liver transplantation

Yuji Soejima, Naoyuki Ueda, Takasuke Fukuhara, Tomoharu Yoshizumi, Toru Ikegami, Yoichi Yamashita, Keishi Sugimachi, Akinobu Taketomi, Yoshihiko Maehara

Liver Transplantation, 14(5), 706–708. https://doi.org/10.1002/lt.21401