{"id":351,"date":"2017-10-04T19:17:26","date_gmt":"2017-10-04T10:17:26","guid":{"rendered":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/?page_id=351"},"modified":"2025-04-08T18:29:56","modified_gmt":"2025-04-08T09:29:56","slug":"%e7%a0%94%e7%a9%b6%e5%86%85%e5%ae%b9","status":"publish","type":"page","link":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/research\/%e7%a0%94%e7%a9%b6%e5%86%85%e5%ae%b9\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9\uff1a\u5e79\u7d30\u80de\u518d\u751f\u4fee\u5fa9\u533b\u5b66\u5206\u91ce\uff08\u5e79\u7d30\u80de\u751f\u7269\u5b66\u30fb\u518d\u751f\u533b\u5b66\uff09"},"content":{"rendered":"<p>\u5e79\u7d30\u80de\u518d\u751f\u4fee\u5fa9\u533b\u5b66\u5206\u91ce\u3067\u306f\u3001\u8840\u6db2\u7d30\u80de\u306e\u3082\u3068\u306b\u306a\u308b\u9020\u8840\u5e79\u7d30\u80de\u306e\u81ea\u5df1\u8907\u88fd\u3068\u5206\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u6a19\u3068\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u307e\u305f\u3001\u540c\u3058\u9aa8\u9ac4\u306b\u3044\u308b\u3001\u9aa8\u30fb\u8102\u80aa\u30fb\u8edf\u9aa8\u306a\u3069\u306e\u3082\u3068\u306b\u306a\u308a\u3001\u9020\u8840\u5e79\u7d30\u80de\u306e\u30b5\u30dd\u30fc\u30c8\u3082\u3059\u308b\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u306b\u3088\u308b\u518d\u751f\u533b\u7642\u3078\u306e\u5fdc\u7528\u7814\u7a76\u3082\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u9aa8\u9ac4\u30cb\u30c3\u30c1\u306f\u3001\u30cb\u30c3\u30c1\u7d30\u80de(\u652f\u6301\u7d30\u80de)\u3001\u304a\u3088\u3073\u30cb\u30c3\u30c1\u7d30\u80de\u304b\u3089\u7523\u751f\u3055\u308c\u308b\u5206\u5b50(\u30cb\u30c3\u30c1\u5206\u5b50)\u304b\u3089\u6210\u308a\u307e\u3059\u3002\u9020\u8840\u5e79\u7d30\u80de\u306e\u30cb\u30c3\u30c1\u3068\u3057\u3066\u306f\u3001\u9aa8\u5185\u819c\u8868\u9762\u3001\u7d30\u52d5\u8108\u3001\u9aa8\u9ac4\u6d1e\u306e\u30cb\u30c3\u30c1\u304c\u540c\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u30cb\u30c3\u30c1\u306f\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u30fb\u8840\u7ba1\u30fb\u9aa8\u82bd\u7d30\u80de\u30fb\u795e\u7d4c\u3092\u542b\u3080\u591a\u304f\u306e\u7a2e\u985e\u306e\u7d30\u80de\u306b\u3088\u308a\u69cb\u6210\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2>1. \u30cb\u30c3\u30c1\u5206\u5b50\u306e\u6a5f\u80fd\u89e3\u6790<\/h2>\n<p>\u5e79\u7d30\u80de\u306f\u5e79\u7d30\u80de\u30922\u500b\u751f\u307f\u51fa\u3059\u5bfe\u79f0\u5206\u88c2\u3001\u5e79\u7d30\u80de\u3068\u5206\u5316\u3057\u305f\u524d\u99c6\u7d30\u80de\u30921\u500b\u305a\u3064\u751f\u307f\u51fa\u3059\u975e\u5bfe\u79f0\u5206\u88c2\u3001\u3055\u3089\u306b2\u500b\u306e\u524d\u99c6\u7d30\u80de\u3092\u751f\u307f\u51fa\u3059\u5bfe\u79f0\u5206\u88c2\u3092\u884c\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d30\u80de\u5206\u88c2\u30d1\u30bf\u30fc\u30f3\u306e\u5236\u5fa1\u306f\u3001\u7d44\u7e54\u4e2d\u306e\u5e79\u7d30\u80de\u306e\u6570\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u4e0a\u3067\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002\u6211\u3005\u306f\u3001\u9020\u8840\u5e79\u7d30\u80de\u306e\u5bfe\u79f0\u5206\u88c2\u30fb\u975e\u5bfe\u79f0\u5206\u88c2\u306e\u5236\u5fa1\u306b\u95a2\u3057\u3066\u3001\u30cb\u30c3\u30c1\u304b\u3089\u306e\u30b7\u30b0\u30ca\u30eb\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u3082\u3064\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u9020\u8840\u5e79\u7d30\u80de\u306e\u81ea\u5df1\u8907\u88fd\u306e\u5206\u5b50\u6a5f\u69cb\u3092\u7406\u89e3\u3057\u3001\u3053\u308c\u3092\u5e79\u7d30\u80de\u5897\u5e45\u306b\u7e4b\u3052\u308b\u305f\u3081\u306b\u306f\u3001\u5e79\u7d30\u80de\u306e\u7d30\u80de\u5206\u88c2\u5236\u5fa1\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u3001\u9020\u8840\u5e79\u7d30\u80de\u3068\u30cb\u30c3\u30c1\u7d30\u80de\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u7d30\u80de\u5206\u88c2\u306e\u5236\u5fa1\u306b\u3044\u304b\u306b\u3057\u3066\u95a2\u308f\u3063\u3066\u3044\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u306f\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\n\u305d\u3053\u3067\u6211\u3005\u306f\u30011\u500b\u306e\u5e79\u7d30\u80de\u304b\u3089\u751f\u3058\u308b2\u500b\u306e\u5a18\u7d30\u80de (paired daughter cell: PDC) \u306b\u3064\u3044\u3066\u30011\u7d30\u80de\u30ec\u30d9\u30eb\u306e\u7db2\u7f85\u7684\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u3092\u884c\u3044\u3001\u6570\u5b66\u8005\u3068\u9023\u643a\u3057\u3001\u6a5f\u68b0\u5b66\u7fd2\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u30d1\u30bf\u30fc\u30f3\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5bfe\u79f0\u30fb\u975e\u5bfe\u79f0\u5206\u88c2\u3092\u8b58\u5225\u30fb\u5206\u985e\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306a\u89e3\u6790\u7cfb\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3092\u7528\u3044\u3001Angpt1\u3092\u4ecb\u3057\u305f\u9020\u8840\u5e79\u7d30\u80de\u306e\u7d30\u80de\u5206\u88c2\u5236\u5fa1\u6a5f\u69cb\u306e\u4e00\u7aef\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405471220304555?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">Arai F, 2020<\/a>; <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1934590921000096?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">Stumpf PS, 2021<\/a>\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1073\" src=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-content\/uploads\/sites\/21\/2024\/01\/1-s2.0-S2405471220304555-fx1_lrg-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-content\/uploads\/sites\/21\/2024\/01\/1-s2.0-S2405471220304555-fx1_lrg-300x300.jpg 300w, https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-content\/uploads\/sites\/21\/2024\/01\/1-s2.0-S2405471220304555-fx1_lrg-150x150.jpg 150w, https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-content\/uploads\/sites\/21\/2024\/01\/1-s2.0-S2405471220304555-fx1_lrg-768x768.jpg 768w, https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-content\/uploads\/sites\/21\/2024\/01\/1-s2.0-S2405471220304555-fx1_lrg-250x250.jpg 250w, https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-content\/uploads\/sites\/21\/2024\/01\/1-s2.0-S2405471220304555-fx1_lrg.jpg 996w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\n<strong>\u56f31.\u5206\u88c2\u69d8\u5f0f\u304b\u3089\u898b\u305f\u30cb\u30c3\u30c1\u56e0\u5b50\u306b\u5bfe\u3059\u308bHSC\u306e\u6a5f\u80fd\u5909\u5316<\/strong><br \/>\n\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u9020\u8840\u5e79\/\u524d\u99c6\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u3092\u4eba\u5de5\u30cb\u30e5\u30fc\u30e9\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\uff08ANN\uff09\u306b\u5b66\u7fd2\u3055\u305b\u3001\u7d30\u80de\u306e\u7a2e\u985e\u3092\u6b63\u78ba\u306b\u8b58\u5225\u3057\u3001\u7d30\u80de\u306e\u5e74\u9f62\u3092\u4e88\u6e2c\u3059\u308b\u6570\u5b66\u7684\u30e2\u30c7\u30eb\u3092\u4f5c\u308a\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3001HSC\u306e\u5206\u88c2\u76f4\u5f8c\u306e\u5a18\u7d30\u80de\u3092\u6bd4\u8f03\u3057\u3001\u500b\u3005\u306eHSC\u306e\u81ea\u5df1\u8907\u88fd\u80fd\u529b\u304c\u5e74\u9f62\u3068\u3068\u3082\u306b\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001HSC\u306e\u7d30\u80de\u5206\u88c2\u306f\u5e74\u9f62\u306b\u3088\u3063\u3066\u6027\u8cea\u304c\u5909\u5316\u3057\u3001\u4e2d\u5e74\u671f\u3067\u306f\u7279\u306b\u30cb\u30c3\u30c1\u56e0\u5b50\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u5909\u5316\u3059\u308b\u50be\u5411\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u5e79\u7d30\u80de\u6d3b\u6027\u306e\u5185\u56e0\u6027\u8abf\u7bc0\u3068\u5916\u56e0\u6027\u8abf\u7bc0\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5e74\u9f62\u3068\u5171\u306b\u5909\u5316\u3057\u3001\u5e79\u7d30\u80de\u6570\u306f\u5897\u3048\u308b\u4e00\u65b9\u3067\u518d\u751f\u80fd\u529b\u304c\u4f4e\u4e0b\u3059\u308b\u7406\u7531\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<br \/>\n\uff08<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405471220304555?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">Arai F et al., Cell Syst. 2020<\/a>\uff09<\/p>\n<p>\u9ad8\u5ea6\u306b\u7d14\u5316\u3057\u3001\u4e00\u898b\u5747\u4e00\u306b\u898b\u3048\u308b\u5e79\u7d30\u80de\u3067\u3042\u3063\u3066\u3082\u3001\u5b9f\u969b\u306b\u306f\u30d8\u30c6\u30ed\u306a\u96c6\u56e3\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u306e\u305f\u3081\u3001\u5e79\u7d30\u80de\u3092\u96c6\u56e3\u3068\u3057\u3066\u6271\u3046\u306e\u3067\u306f\u306a\u304f\u3001\u500b\u3005\u306e\u7d30\u80de\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u30cb\u30c3\u30c1\u306e\u6a5f\u80fd\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u30011\u7d30\u80de\u30ec\u30d9\u30eb\u306e\u6a5f\u80fd\u89e3\u6790\u306f\u3001\u5f93\u6765\u306e\u624b\u6cd5\u3067\u306f\u6349\u3048\u308b\u3053\u3068\u304c\u96e3\u3057\u3044\u3001\u500b\u3005\u306e\u7d30\u80de\u306e\u632f\u308b\u821e\u3044\u3092\u77e5\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u305d\u306e\u7d50\u679c\u3001\u30cb\u30c3\u30c1\u5168\u4f53\u306e\u6a5f\u80fd\u5236\u5fa1\u3092\u660e\u3089\u304b\u306b\u51fa\u6765\u308b\u3068\u8003\u3048\u3066\u304a\u308a\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u3067\u57f9\u308f\u308c\u305f\u9020\u8840\u5e79\u7d30\u80de\u30cb\u30c3\u30c1\u306e1\u7d30\u80de\u89e3\u6790\u306f\u4ed6\u306e\u5e79\u7d30\u80de\u30cb\u30c3\u30c1\u7814\u7a76\u306e\u30e2\u30c7\u30eb\u306b\u3082\u6210\u308a\u5f97\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2>2. \u9020\u8840\u5e79\u7d30\u80de\u306e\u4f53\u5916\u7dad\u6301<\/h2>\n<p>\u9020\u8840\u5e79\u7d30\u80de\u306f\u7d44\u7e54\u5e79\u7d30\u80de\u306e\u4e2d\u3067\u6700\u3082\u89e3\u6790\u306e\u9032\u3093\u3060\u3082\u306e\u306e1\u3064\u3067\u3042\u308a\u3001\u305d\u306e\u7dad\u6301\u306b\u95a2\u308f\u308b\u5206\u5b50\u7fa4\u306e\u540c\u5b9a\u304a\u3088\u3073\u6a5f\u80fd\u89e3\u6790\u3082\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u8a66\u9a13\u7ba1\u306e\u4e2d\u3067\u6a5f\u80fd\u7684\u306a\u9020\u8840\u5e79\u7d30\u80de\u3068\u3057\u3066\u7dad\u6301\u3057\u306a\u304c\u3089\u907a\u4f1d\u5b50\u64cd\u4f5c\u3059\u308b\u3053\u3068\u306f\u672a\u3060\u96e3\u3057\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u30cb\u30c3\u30c1\u30b7\u30b0\u30ca\u30eb\u306e\u64cd\u4f5c\u3001\u30cb\u30c3\u30c1\u3092\u8a66\u9a13\u7ba1\u5185\u306b\u518d\u69cb\u7bc9\u3059\u308b\u3053\u3068\u3001\u907a\u4f1d\u5b50\u64cd\u4f5c\u65b9\u6cd5\u306e\u6700\u9069\u5316\u304c\u91cd\u8981\u306a\u8ab2\u984c\u3068\u3044\u3048\u307e\u3059\u3002<br \/>\n\u3053\u306e\u3088\u3046\u306a\u8ab2\u984c\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u533b\u5b66\u751f\u7269\u5b66\u306e\u307f\u306a\u3089\u305a\u3001\u7d44\u7e54\u5de5\u5b66\u306a\u3069\u4ed6\u5206\u91ce\u3068\u306e\u7dca\u5bc6\u306a\u9023\u643a\u304c\u809d\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u307e\u3059\u3002\u6211\u3005\u306f\u3001\u751f\u4f53\u5de5\u5b66\u9818\u57df\u306e\u7814\u7a76\u8005\u3068\u306e\u56fd\u969b\u5171\u540c\u7814\u7a76\u306b\u3088\u308a\u3001\u4eba\u5de5\u30cb\u30c3\u30c1\u306e\u4f5c\u88fd\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u3001\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u30fb\u30cf\u30a4\u30c9\u30ed\u30b2\u30eb\u3092\u7528\u3044\u3066\u4f5c\u88fd\u3057\u305f\u4eba\u5de5\u30cb\u30c3\u30c1\u4e0a\u3067\u9020\u8840\u5e79\u7d30\u80de\u306e\u57f9\u990a\u3092\u884c\u3044\u3001\u9020\u8840\u5e79\u7d30\u80de\u6570\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u51fa\u6765\u308b\u3053\u3068\u3092\u7d30\u80de\u5206\u88c2\u89e3\u6790\u306b\u3088\u3063\u3066\u78ba\u8a8d\u3057\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u30cb\u30c3\u30c1\u5206\u5b50\u3067\u4eba\u5de5\u30cb\u30c3\u30c1\u3092\u4fee\u98fe\u3059\u308b\u3053\u3068\u3067\u3001\u751f\u4f53\u306e\u9020\u8840\u74b0\u5883\u3092\u518d\u73fe\u3057\u3001\u9020\u8840\u5e79\u7d30\u80de\u306e\u5897\u5e45\u3092\u9054\u6210\u3057\u305f\u3044\u3068\u8003\u3048\u3001\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u6211\u3005\u306f\u9020\u8840\u5e79\u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u30cb\u30c3\u30c1\u5206\u5b50\u306e1\u3064\u3067\u3042\u308bAngpt1\u306e\u523a\u6fc0\u306b\u3088\u308a\u3001Shelterin\u8907\u5408\u4f53\u69cb\u6210\u56e0\u5b50\u306e1\u3064\u3001Protection of telomere 1a (Pot1a) \u306e\u767a\u73fe\u304c\u4ea2\u9032\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002Pot1a\u306f\u9020\u8840\u5e79\u7d30\u80de\u306e\u30c6\u30ed\u30e1\u30a2\u9818\u57df\u306b\u304a\u3051\u308bDNA\u30c0\u30e1\u30fc\u30b8\u306e\u6291\u5236\u3001\u81ea\u5df1\u8907\u88fd\u80fd\u306e\u7dad\u6301\u3001\u8001\u5316\u5236\u5fa1\u306b\u95a2\u308f\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u7d30\u80de\u819c\u900f\u904e\u6027Pot1a\u86cb\u767d\u3092\u7528\u3044\u3066\u9020\u8840\u5e79\u7d30\u80de\u306bPot1a\/POT1\u30bf\u30f3\u30d1\u30af\u3092\u9020\u8840\u5e79\u7d30\u80de\u306b\u5c0e\u5165\u3059\u308b\u7cfb\u3092\u78ba\u7acb\u3057\u3001Pot1a\/POT\u306e\u5c0e\u5165\u306b\u3088\u308a\u3001\u6a5f\u80fd\u7684\u306a\u30de\u30a6\u30b9\u304a\u3088\u3073\u30d2\u30c8\u9020\u8840\u5e79\u7d30\u80de\u3092\u7dad\u6301\u3067\u304d\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41467-017-00935-4\" target=\"_blank\" rel=\"noopener noreferrer\">Hosokawa K, 2017<\/a>\uff09\u3002<\/p>\n<p><img decoding=\"async\" class=\"alignleft size-medium wp-image-1073\" src=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-content\/uploads\/sites\/21\/2024\/01\/pot1a-HSC.jpg\" alt=\"\" width=\"300\" height=\"\" \/><br \/>\n<strong>\u56f32.HSC\u306e\u7dad\u6301\u306b\u5bfe\u3059\u308b\u5916\u56e0\u6027Pot1a\u306e\u6a5f\u80fd<\/strong><br \/>\n\u5b9a\u5e38\u72b6\u614b\u306b\u304a\u3044\u3066\u3001HSC\u306f\u3086\u3063\u304f\u308a\u3068\u5206\u88c2\u3068\u81ea\u5df1\u8907\u88fd\u3092\u7e70\u308a\u8fd4\u3057\u307e\u3059\u304c\u3001\u8001\u5316\u304c\u9032\u3080\u306b\u3064\u308c\u3066\u3001HSC\u3067\u306f\u30c6\u30ed\u30e1\u30a2DDR\u306e\u84c4\u7a4d\u3068BM\u306e\u518d\u69cb\u6210\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u540c\u69d8\u306e\u554f\u984c\u306f\u3001HSC\u306e\u5897\u6b96\u4e2d\u306b\u3082\u767a\u751f\u3057\u307e\u3059\u3002HSC\u5185\u306ePot1a\u30ec\u30d9\u30eb\u306f\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u3088\u3063\u3066\u4f4e\u4e0b\u3057\u307e\u3059\u304c\u3001\u5916\u56e0\u6027\u306ePOT1a\u6dfb\u52a0\u306b\u3088\u3063\u3066\u56de\u5fa9\u3057\u3001HSC\u306e\u6d3b\u6027\u306e\u55aa\u5931\u304b\u3089\u4fdd\u8b77\u3055\u308c\u307e\u3059\u3002<br \/>\n(<a href=\"https:\/\/www.nature.com\/articles\/s41467-017-00935-4\" target=\"_blank\" rel=\"noopener noreferrer\">Hosokawa K et al., Nat Commun. 2017<\/a>)<br \/>\n(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29550946\/\" target=\"_blank\" rel=\"noopener noreferrer\">Hosokawa K et al., Int J Hematol. 2018<\/a>)<\/p>\n<p>&nbsp;<br \/>\n&nbsp;<\/p>\n<h2>3. \u9020\u8840\u5e79\u7d30\u80de\u30cb\u30c3\u30c1\u30fb\u30cb\u30c3\u30c1\u5206\u5b50\u306e\u540c\u5b9a<\/h2>\n<p>\u6211\u3005\u306f\u3001\u9020\u8840\u5e79\u7d30\u80de\u307e\u305f\u306f\u30cb\u30c3\u30c1\u7d30\u80de\u7279\u7570\u7684\u5206\u5b50\u306e\u30ec\u30dd\u30fc\u30bf\u30fc\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u4e09\u6b21\u5143\u9aa8\u9ac4\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u884c\u3044\u3001\u9020\u8840\u5e79\u7d30\u80de\u3068\u5468\u56f2\u306e\u7d30\u80de\u3068\u306e\u7acb\u4f53\u7684\u4f4d\u7f6e\u95a2\u4fc2\u304b\u3089\u3001\u6d3b\u6027\u5316\u3057\u305f\u5e79\u7d30\u80de\u3068\u9759\u6b62\u9020\u8840\u5e79\u7d30\u80de\u306b\u3064\u3044\u3066\u3001\u305d\u308c\u305e\u308c\u7279\u7570\u7684\u306a\u30cb\u30c3\u30c1\u3092\u540c\u5b9a\u3057\u3001\u3055\u3089\u306b\u3001\u305d\u306e\u30cb\u30c3\u30c1\u69cb\u6210\u7d30\u80de\u3092\u5206\u96e2\u3057\u3066\u3001\u305d\u306e\u7279\u6027\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u9020\u8840\u5e79\u7d30\u80de\u306e\u6d3b\u6027\u5316(\u5897\u6b96)\u21d4\u9759\u6b62\u5316\u3092\u5236\u5fa1\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img decoding=\"async\" class=\"alignleft size-full wp-image-37\" title=\"270404_01\" src=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/wp-content\/uploads\/sites\/21\/2015\/04\/270404_01.jpg\" alt=\"\" width=\"300\" height=\"\" border=\"0\" srcset=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-content\/uploads\/sites\/21\/2015\/04\/270404_01.jpg 388w, https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-content\/uploads\/sites\/21\/2015\/04\/270404_01-300x201.jpg 300w, https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-content\/uploads\/sites\/21\/2015\/04\/270404_01-250x167.jpg 250w\" sizes=\"(max-width: 388px) 100vw, 388px\" \/><strong>\u56f33.\u30de\u30a6\u30b9\u80f8\u9aa8\u9aa8\u9ac4\u7d44\u7e54\u306e3D\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/strong><br \/>\n\u9752:VE-carherin,<br \/>\n\u8d64\uff1aCD150,<br \/>\n\u9ec4\uff1aLineage\/CD41\/CD48,<br \/>\n\u7dd1\uff1aGFP<br \/>\n\u672a\u5206\u5316\u9020\u8840\u5e79\u7d30\u80de\u306e\u751f\u4f53\u7d44\u7e54\u5185\u3067\u306e\u5c40\u5728\u3092\u30b9\u30d4\u30cb\u30f3\u30b0\u30c7\u30a3\u30b9\u30af\u5171\u7126\u9855\u5fae\u93e1\u306b\u3088\u308a\u9bae\u660e\u306b\u53ef\u8996\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u5e79\u7d30\u80de-\u30cb\u30c3\u30c1\u7d30\u80de\u306e3\u6b21\u5143\u89e3\u6790\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/drive.google.com\/file\/d\/1dU9chjpRufv8KgSiRzqYxZtCTpEMBNpb\/view?usp=sharing\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignleft size-full wp-image-37\" title=\"270404_01\" src=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/wp-content\/uploads\/sites\/21\/2015\/04\/270404_02.jpg\" alt=\"\" width=\"300\" height=\"\" border=\"0\" \/><\/a><strong>\u56f34.\u30de\u30a6\u30b9\u982d\u84cb\u9aa8\u9aa8\u9ac4\u5185\u306e\u86cd\u5149\u751f\u4f53\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/strong><br \/>\n\u9752:VE-carherin,<br \/>\n\u767d\uff1aGFP<br \/>\n\u751f\u304d\u305f\u500b\u4f53\u306e\u4e2d\u3067\u3001\u751f\u304d\u305f\u7d30\u80de\u3084\u5206\u5b50\u306e\u80f4\u4f53\u3092\u5358\u4e00\u7d30\u80de\u5358\u4f4d\u3067\u53ef\u8996\u5316\u3059\u308b\u3053\u3068\u306e\u3067\u304d\u308b\u300c\u86cd\u5149\u751f\u4f53\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u300d\u306f\u975e\u5e38\u306b\u5f37\u529b\u306a\u7814\u7a76\u30c4\u30fc\u30eb\u3067\u3059\u30023\u6b21\u5143\u7684\u89e3\u6790\u306b\u52a0\u3048\u3001\u6642\u9593\u8ef8\u3092\u52a0\u3048\u305f4\u6b21\u5143\u7684\u306a\u89e3\u6790\u3092\u884c\u3044\u307e\u3059\u3002<br \/>\n\u8840\u7ba1\u5185\u3092\u79fb\u52d5\u3057\u3066\u3044\u304fGFP\u967d\u6027\u306e\u8840\u7403\u7d30\u80de\u3092\u78ba\u8a8d\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<br \/>\n\uff08\u5225\u30a6\u30a4\u30f3\u30c9\u30a6\u3067\u52d5\u753b\u304c\u3054\u89a7\u306b\u306a\u308c\u307e\u3059\uff09<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\u6700\u8fd1\u6211\u3005\u306f\u3001\u9aa8\u9ac4\u30cb\u30c3\u30c1\u7d30\u80de\u3067\u3042\u308b\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08MSC\uff09\u306e\u30b7\u30a7\u30eb\u30bf\u30ea\u30f3\u56e0\u5b50Pot1a\u306e\u5f79\u5272\u306b\u95a2\u3057\u3066\u7814\u7a76\u3092\u9032\u3081\u305f\u3068\u3053\u308d\u3001MSC\u306e\u6a5f\u80fd\u7dad\u6301\u306b\u304a\u3051\u308b\u91cd\u8981\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.nature.com\/articles\/s42003-023-05374-0\" target=\"_blank\" rel=\"noopener noreferrer\">Nakashima K 2023<\/a>\uff09\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u9020\u8840\u7cfb\u3060\u3051\u3067\u306a\u304f\u3001\u4ed6\u306e\u7d44\u7e54\u5e79\u7d30\u80de\u306b\u304a\u3044\u3066\u3082\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img decoding=\"async\" class=\"alignleft size-full wp-image-37\" title=\"\" src=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-content\/uploads\/sites\/21\/2024\/01\/Pot1a-KO_NG2_mouse.jpg\" alt=\"\" width=\"300\" height=\"\" border=\"0\" \/><br \/>\n<strong>\u56f35.NG2\u967d\u6027\u7d30\u80de\u3067Pot1a\u3092\u6b20\u640d\u3057\u305f\u30de\u30a6\u30b9<\/strong><br \/>\n\u5de6\uff09Pot1a\u6b20\u640d\u30de\u30a6\u30b9\u3001<br \/>\n\u53f3\uff09\u540c\u8179Control\u30de\u30a6\u30b9<br \/>\nNG2+MSC\u306b\u304a\u3051\u308bPot1a\u304c\u3001MSC\u306e\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u91cd\u8981\u3067\u3042\u308b\u4ed6\u3001B\u7d30\u80de\u5206\u5316\u5236\u5fa1\u3001\u9aa8\u5f62\u6210\u5236\u5fa1\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<br \/>\n(<a href=\"https:\/\/www.nature.com\/articles\/s42003-023-05374-0\" target=\"_blank\" rel=\"noopener noreferrer\">Nakashima K et al., Commun Biol. 2023<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5e79\u7d30\u80de\u518d\u751f\u4fee\u5fa9\u533b\u5b66\u5206\u91ce\u3067\u306f\u3001\u8840\u6db2\u7d30\u80de\u306e\u3082\u3068\u306b\u306a\u308b\u9020\u8840\u5e79\u7d30\u80de\u306e\u81ea\u5df1\u8907\u88fd\u3068\u5206\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u6a19\u3068\u3057\u3066\u3044\u307e\u3059\u3002 \u307e\u305f\u3001\u540c\u3058\u9aa8\u9ac4\u306b\u3044\u308b\u3001\u9aa8\u30fb\u8102\u80aa\u30fb\u8edf\u9aa8\u306a\u3069\u306e\u3082\u3068\u306b\u306a\u308a\u3001\u9020\u8840\u5e79\u7d30\u80de\u306e\u30b5\u30dd\u30fc\u30c8\u3082\u3059\u308b\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u306b [&hellip;]<\/p>\n","protected":false},"author":26,"featured_media":0,"parent":31,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-351","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-json\/wp\/v2\/pages\/351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-json\/wp\/v2\/comments?post=351"}],"version-history":[{"count":39,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-json\/wp\/v2\/pages\/351\/revisions"}],"predecessor-version":[{"id":1276,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-json\/wp\/v2\/pages\/351\/revisions\/1276"}],"up":[{"embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-json\/wp\/v2\/pages\/31"}],"wp:attachment":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scr\/wp-json\/wp\/v2\/media?parent=351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}