{"id":878,"date":"2014-07-30T17:18:30","date_gmt":"2014-07-30T08:18:30","guid":{"rendered":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/?page_id=878"},"modified":"2025-12-12T07:37:56","modified_gmt":"2025-12-11T22:37:56","slug":"%e8%8b%b1%e6%96%87%e7%b7%8f%e8%aa%ac","status":"publish","type":"page","link":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/%e8%8b%b1%e6%96%87%e7%b7%8f%e8%aa%ac\/","title":{"rendered":"\u82f1\u6587\u7dcf\u8aac\u30fb\u66f8\u7c4d\u7ae0"},"content":{"rendered":"<p><!-- Tripartite Interaction... (2025) --><\/p>\n<p>\n  <strong>Direct Reprogramming of Microglia into Neurons<\/strong><br \/>\n  Kanae Matsuda-Ito, Eri Hatai, Tomohiko Irie, Taito Matsuda, Kinichi Nakashima<br \/>\n  <em>Methods in Molecular Biology<\/em>, vol. 2974, Lentiviral Vectors. Humana Press, New York, NY (2026).<br \/>\n  <a href=\"https:\/\/doi.org\/10.1007\/978-1-0716-4807-0_13\" target=\"_blank\">https:\/\/doi.org\/10.1007\/978-1-0716-4807-0_13<\/a>\n<\/p>\n<table style=\"border-collapse:collapse;margin-bottom:16px\">\n<tr>\n    <!-- Coluna do texto --><\/p>\n<td style=\"vertical-align:top;padding-right:4px\">\n<p>\n        <strong>Tripartite Interaction of Epigenetic Regulation, Brain Aging, and Neuroinflammation: Mechanistic Insights and Therapeutic Implications<\/strong><br \/>\n        Shenghui Mi, Hideyuki Nakashima, Kinichi Nakashima<br \/>\n        <em>Epigenomes<\/em>, 9(4), Article number: 38 (2025).<br \/>\n        <a href=\"https:\/\/doi.org\/10.3390\/epigenomes9040038\" target=\"_blank\">https:\/\/doi.org\/10.3390\/epigenomes9040038<\/a><br \/>\n        <a href=\"https:\/\/www.mdpi.com\/2075-4655\/9\/4\" target=\"_blank\">https:\/\/www.mdpi.com\/2075-4655\/9\/4<\/a>\uff08\u8868\u7d19\u306b\u9078\u51fa\u3055\u308c\u307e\u3057\u305f\uff09\n      <\/p>\n<\/td>\n<p>    <!-- Coluna da imagem --><\/p>\n<td style=\"vertical-align:top\">\n      <img decoding=\"async\" src=\"https:\/\/mdpi-res.com\/data\/covers\/epigenomes\/big_cover-epigenomes-v9-i4.png\" alt=\"Epigenomes 9(4) cover\" style=\"width:130px;height:auto\">\n    <\/td>\n<\/tr>\n<\/table>\n<p>  <strong>The influence of the choroid plexus on brain function: beyond its role in cerebrospinal fluid production<\/strong><br \/>\n  Sayako Katada, Kelren S. Rodrigues, Kinichi Nakashima<br \/>\n  <em>Inflammation and Regeneration<\/em>, 45, Article number: 20 (2025).<br \/>\n  <a href=\"https:\/\/doi.org\/10.1186\/s41232-025-00386-1\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s41232-025-00386-1<\/a>\n<\/p>\n<p><!-- Epigenetic Regulation of Neural Stem Cells... (2024) --><\/p>\n<p>\n  <strong>Epigenetic Regulation of Neural Stem Cells in Developmental and Adult Stages<\/strong><br \/>\n  Shu Kunoh, Hideyuki Nakashima, Kinichi Nakashima<br \/>\n  <em>Epigenomes<\/em>, 8(2) (2024).<br \/>\n  <a href=\"https:\/\/doi.org\/10.3390\/epigenomes8020022\" target=\"_blank\">https:\/\/doi.org\/10.3390\/epigenomes8020022<\/a>\n<\/p>\n<p><!-- Lineage Reprogramming... (2024) --><\/p>\n<p>\n  <strong>Lineage Reprogramming: Genetic, Chemical, and Physical Cues for Cell Fate Conversion with a Focus on Neuronal Direct Reprogramming and Pluripotency Reprogramming<\/strong><br \/>\n  Taichi Umeyama, Taito Matsuda, Kinichi Nakashima<br \/>\n  <em>Cells<\/em>, 13(8) (2024).<br \/>\n  <a href=\"https:\/\/doi.org\/10.3390\/cells13080707\" target=\"_blank\">https:\/\/doi.org\/10.3390\/cells13080707<\/a>\n<\/p>\n<p><!-- Multifaceted Regulation... (2024) --><\/p>\n<p>\n  <strong>Multifaceted Regulation of Neural Stem Cell Fate in the Developing Brain<\/strong><br \/>\n  Takanobu Uotsu, Kinichi Nakashima, Sayako Katada<br \/>\n  <em>Medical Research Archives<\/em>, 12(3) (2024). <br \/>\n <a href=\"https:\/\/doi.org\/10.18103\/mra.v12i3\" target=\"_blank\">https:\/\/doi.org\/10.18103\/mra.v12i3 <\/a>\n<\/p>\n<p><!-- Epigenetic memory of drug exposure history... (2024) --><\/p>\n<p>\n  <strong>Epigenetic memory of drug exposure history controls neural stem cell quiescence in the adult brain<\/strong><br \/>\n  Masakazu Iwamoto, Taito Matsuda<br \/>\n  <em>Neural Regen Res<\/em>, 4 (2024). <br \/>\n  <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37843197\/\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37843197\/ <\/a>\n<\/p>\n<p><!-- Seizure-induced hilar ectopic granule cells... (2023) --><\/p>\n<p>\n  <strong>Seizure-induced hilar ectopic granule cells in the adult dentate gyrus<\/strong><br \/>\n  Yuka Kasahara, Hideyuki Nakashima, Kinichi Nakashima<br \/>\n  <em>Front Neurosci<\/em>, 17, 1150283 (2023). <br \/>\n  <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36937666\/\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36937666\/ <\/a>\n<\/p>\n<p><!-- Regulation of Adult Mammalian Neural Stem Cells... (2021) --><\/p>\n<p>\n  <strong>Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis by Cell Extrinsic and Intrinsic Factors<\/strong><br \/>\n  Shuzo Matsubara, Taito Matsuda*, Kinichi Nakashima*<br \/>\n  <em>Cells<\/em>, 10, 1145 (2021).<br \/>\n  <a href=\"https:\/\/doi.org\/10.3390\/cells10051145\" target=\"_blank\">https:\/\/doi.org\/10.3390\/cells10051145<\/a>\n<\/p>\n<p><!-- In vivo direct reprogramming... (2021) --><\/p>\n<p>\n  <strong>In vivo direct reprogramming as a therapeutic strategy for brain and retina repair<\/strong><br \/>\n  Sekiryu H., Matsuda T.<br \/>\n  <em>Neural Regen Res<\/em>, 10, 1998\u20131999 (2021). <br \/>\n  <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33642376\/\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33642376\/<\/a>\n<\/p>\n<p><!-- Natural and forced neurogenesis... (2021) --><\/p>\n<p>\n  <strong>Natural and forced neurogenesis in the adult brain: Mechanisms and their possible application to treat neurological disorders<\/strong><br \/>\n  Matsuda T., Nakashima K.<br \/>\n  <em>Neurosci Res<\/em>, 166, 1\u201311 (2021).<br \/>\n  <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32497571\/\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32497571\/<\/a>\n<\/p>\n<p><!-- Epigenetic Regulation for Acquiring Glial Identity... (2020) --><\/p>\n<p>\n  <strong>Epigenetic Regulation for Acquiring Glial Identity by Neural Stem Cells during Cortical Development<\/strong><br \/>\n  Nakagawa T., Yoshikuni W., Sayako K., Yusuke K.<br \/>\n  <em>Glia<\/em>, 68(8), 1554\u20131567 (2020).\n<\/p>\n<p><!-- New aspects of glioblastoma multiforme... (2018) --><\/p>\n<p>\n  <strong>New aspects of glioblastoma multiforme revealed by similarities between neural and glioblastoma stem cells<\/strong><br \/>\n  Kawamura Y., Takouda J., Yoshimoto K., Nakashima K.<br \/>\n  <em>Cell Biol Toxicol<\/em>, Epub ahead of print (2018).\n<\/p>\n<p><!-- Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration (2018) --><\/p>\n<p>\n  <strong>Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration<\/strong><br \/>\n  Kameda T., Imamura T., Nakashima K.<br \/>\n  <em>Cell Tissue Res<\/em>, 371, 189\u2013199 (2018).\n<\/p>\n<p><!-- Neural stem cell therapy aiming at better functional recovery... (2018) --><\/p>\n<p>\n  <strong>Neural stem cell therapy aiming at better functional recovery after spinal cord injury<\/strong><br \/>\n  Zhu Y., Uezono N., Yasui T., Nakashima K.<br \/>\n  <em>Dev Dyn<\/em>, 247, 75\u201384 (2018).\n<\/p>\n<p><!-- Emerging mechanisms underlying astrogenesis... (2017) --><\/p>\n<p>\n  <strong>Emerging mechanisms underlying astrogenesis in the developing mammalian brain<\/strong><br \/>\n  Takouda J., Katada S., Nakashima K.<br \/>\n  <em>Proc Jpn Acad Ser B Phys Biol Sci<\/em>, 93, 386\u2013398 (2017).\n<\/p>\n<p><!-- Detection of bidirectional promoter-derived lncRNAs... (2017) --><\/p>\n<p>\n  <strong>Detection of bidirectional promoter-derived lncRNAs from small-scale samples using pre-amplification-free directional RNA-seq method<\/strong><br \/>\n  Hamazaki N., Nakashima K., Hayashi K., Imamura T.<br \/>\n  <em>Methods Mol Biol<\/em>, 1605, 83\u2013103 (2017).\n<\/p>\n<p><!-- Manipulation of promoter-associated noncoding RNA... (2017) --><\/p>\n<p>\n  <strong>Manipulation of promoter-associated noncoding RNA in mouse early embryos for controlling sequence-specific epigenetic status<\/strong><br \/>\n  Hamazaki N., Nakashima K., Imamura T.<br \/>\n  <em>Methods Mol Biol<\/em>, 1543, 271\u2013282 (2017).\n<\/p>\n<p><!-- Emerging roles for miRNA-based post-transcriptional regulation... (2016) --><\/p>\n<p>\n  <strong>Emerging roles for miRNA-based post-transcriptional regulation in neuronal morphogenesis and neurodevelopmental disorders<\/strong><br \/>\n  Tsujimura K., Nakashima H., Irie K., Nakashima K.<br \/>\n  <em>RNA Dis<\/em>, 5, e1375 (2016).\n<\/p>\n<p><!-- Epigenetic regulation of neural stem cell property from embryo to adult (2016) --><\/p>\n<p>\n  <strong>Epigenetic regulation of neural stem cell property from embryo to adult<\/strong><br \/>\n  Murao N., Noguchi H., Nakashima K.<br \/>\n  <em>Neuroepigenetics<\/em>, 3, 1\u201310 (2016).\n<\/p>\n<p><!-- Bidirectional communication between the innate immune and nervous systems... (2015) --><\/p>\n<p>\n  <strong>Bidirectional communication between the innate immune and nervous systems for homeostatic neurogenesis in the adult hippocampus<\/strong><br \/>\n  Matsuda T., Nakashima K.<br \/>\n  <em>Neurogenesis<\/em>, 2 (2015).\n<\/p>\n<p><!-- Epigenetic mechanisms regulating differentiation of neural stem\/precursor cells (2014) --><\/p>\n<p>\n  <strong>Epigenetic mechanisms regulating differentiation of neural stem\/precursor cells<\/strong><br \/>\n  Adefuin A.M., Kimura A., Noguchi H., Nakashima K., Namihira M.<br \/>\n  <em>Epigenomics<\/em>, 6, 637\u2013649 (2014).\n<\/p>\n<p><!-- Epigenetic setting and reprogramming for neural cell fate determination... (2014) --><\/p>\n<p>\n  <strong>Epigenetic setting and reprogramming for neural cell fate determination and differentiation<\/strong><br \/>\n  Imamura T., Uesaka M., Nakashima K.<br \/>\n  <em>Philos Trans R Soc Lond B Biol Sci<\/em>, 369, 1652 (2014).\n<\/p>\n<p><!-- Roles of Epigenetics in the Neural Stem Cell and Neuron (2014) --><\/p>\n<p>\n  <strong>Roles of Epigenetics in the Neural Stem Cell and Neuron<\/strong><br \/>\n  Yamamoto N., Uesaka M., Imamura T., Nakashima K.<br \/>\n  <em>Epigenetics in Psychiatry<\/em>, 51\u201378 (2014).\n<\/p>\n<p><!-- Mechanisms of astrocytogenesis in the mammalian brain (2013) --><\/p>\n<p>\n  <strong>Mechanisms of astrocytogenesis in the mammalian brain<\/strong><br \/>\n  Namihira M., Nakashima K.<br \/>\n  <em>Curr Opin Neurobiol<\/em>, 23, 921\u2013927 (2013).\n<\/p>\n<p><!-- Epigenetic regulation of neural stem cell fate during corticogenesis (2013) --><\/p>\n<p>\n  <strong>Epigenetic regulation of neural stem cell fate during corticogenesis<\/strong><br \/>\n  MuhChyi C., Juliandi B., Matsuda T., Nakashima K.<br \/>\n  <em>Int J Dev Neurosci<\/em>, 31, 424\u2013433 (2013).\n<\/p>\n<p><!-- Epigenetic regulation in neural stem cell differentiation (2010) --><\/p>\n<p>\n  <strong>Epigenetic regulation in neural stem cell differentiation<\/strong><br \/>\n  Juliandi B., Abematsu M., Nakashima K.<br \/>\n  <em>Dev Growth Differ<\/em>, 52, 493\u2013504 (2010).\n<\/p>\n<p><!-- Epigenetic mechanisms in sequential differentiation of neural stem cells (2009) --><\/p>\n<p>\n  <strong>Epigenetic mechanisms in sequential differentiation of neural stem cells<\/strong><br \/>\n  Sanosaka T., Namihira M., Nakashima K.<br \/>\n  <em>Epigenetics<\/em>, 4, 89\u201392 (2009).\n<\/p>\n<p><!-- Epigenetic mechanisms regulating fate specification of neural stem cells (2008) --><\/p>\n<p>\n  <strong>Epigenetic mechanisms regulating fate specification of neural stem cells<\/strong><br \/>\n  Namihira M., Kohyama J., Abematsu M., Nakashima K.<br \/>\n  <em>Philos Trans R Soc Lond B Biol Sci<\/em>, 363, 2099\u20132109 (2008).\n<\/p>\n<p><!-- Mechanisms of neural stem cell fate determination... (2006) --><\/p>\n<p>\n  <strong>Mechanisms of neural stem cell fate determination: extracellular cues and intracellular programs<\/strong><br \/>\n  Abematsu M., Smith I., Nakashima K.<br \/>\n  <em>Curr Stem Cell Res Ther<\/em>, 1, 267\u2013277 (2006).\n<\/p>\n<p><!-- Mechanisms underlying cytokine-mediated cell-fate regulation... (2002) --><\/p>\n<p>\n  <strong>Mechanisms underlying cytokine-mediated cell-fate regulation in the nervous system<\/strong><br \/>\n  Nakashima K., Taga T.<br \/>\n  <em>Mol Neurobiol<\/em>, 25, 233\u2013244 (2002).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Direct Reprogramming of Microglia into Neurons Kanae Matsuda-Ito, Eri Hatai, Tomohiko Irie, Taito Matsuda, Kin&#8230;<a href=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/%e8%8b%b1%e6%96%87%e7%b7%8f%e8%aa%ac\/\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-878","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/pages\/878","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/comments?post=878"}],"version-history":[{"count":60,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/pages\/878\/revisions"}],"predecessor-version":[{"id":2417,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/pages\/878\/revisions\/2417"}],"wp:attachment":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/media?parent=878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}