{"id":860,"date":"2014-07-30T17:10:19","date_gmt":"2014-07-30T08:10:19","guid":{"rendered":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/?page_id=860"},"modified":"2026-02-09T07:45:33","modified_gmt":"2026-02-08T22:45:33","slug":"%e5%8e%9f%e8%91%97%e8%ab%96%e6%96%87","status":"publish","type":"page","link":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/%e5%8e%9f%e8%91%97%e8%ab%96%e6%96%87\/","title":{"rendered":"\u539f\u8457\u8ad6\u6587"},"content":{"rendered":"

2026\u5e74<\/h4>\n

Histone methyltransferase Setd8 preserves chromatin accessibility to safeguard retinal progenitor cell identity during development<\/strong><\/p>\n

\nSekiryu, H.; Shimokawa, S.; Matsuda-Ito, K.; Oda, H.; Murakami, Y.; Sonoda, K.-H.; Nakashima, K.; Matsuda, T.\n<\/p>\n

\nStem Cell Reports<\/i>, 2026. \u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\u3000<\/em>

\nhttps:\/\/doi.org\/10.1016\/j.stemcr.2025.102789<\/a>\n<\/p>\n

Turnover of NESTIN-Negative Neural Progenitors Into NESTIN-Positive State by the Lack of JMJD3<\/strong><\/p>\n

\nChen, J.; Iwamori, T.; Shima, S.; Yamaguchi, M.; Imayoshi, I.; Nakashima, K.; Iwamori, N.\n<\/p>\n

\nGenes to Cells<\/i>, 31(2), e70087 (2026).
\nhttps:\/\/doi.org\/10.1111\/gtc.70087<\/a>\n<\/p>\n

Akhirin Functions as an Innate Immune Barrier to Preserve Neurogenic Niche Homeostasis During Mouse Brain Development<\/strong><\/p>\n

\nKudo, M.; Ohkubo, T.; Sugawara, T.; Irie, T.; Hatakeyama, J.; Tamura, S.; Shimamura, K.; Wakayama, T.; Matsuo, N.; Nakashima, K.; et al.\n<\/p>\n

\nCells<\/i>, 15, 151 (2026).
\nhttps:\/\/doi.org\/10.3390\/cells15020151<\/a>\n<\/p>\n

2025\u5e74<\/h4>\n

Dormant viral pathways underlie space-induced neural senescence: a neuroprotective strategy for spaceflight and neurological diseases<\/strong><\/p>\n

\nAline M. A. Martins, Hideyuki Nakashima, Angela Macia, Taichi Umeyama, Satoshi Miyashita, Livia L. S. Nascimento, Luisa B. V. Coelho, Pinar Mesci, Erik Viirre, Nicole Suarez, Aurian Saleh, Alex Savchenko, Beatriz Freitas, Aline L. Leite, Diego M. Assis, Masataka Ishizu, Tomoo Owa, Mikio Hoshino, John R. Yates III, Kinichi Nakashima, Alysson R. Muotri\n<\/p>\n

\nbioRxiv<\/i>, 2025.11.02.686043.
\n https:\/\/doi.org\/10.1101\/2025.11.02.686043 <\/a>\n<\/p>\n

miR-199a functions downstream of MeCP2 in neurons of MECP2 duplication syndrome models<\/strong><\/p>\n

\nYuichi Akaba, Satoru Takahashi, Shota Adachi, Masatoshi Nishimura, Keiichiro Suzuki, Hideyuki Nakashima, Kinichi Nakashima, Ryutaro Kira, Pin Fee Chong, Yasunari Sakai, Yohei Hayashi, Itaru Kushima, Daisuke Mori, Yuko Arioka, Hiroki Okumura, Atsuo Nakayama, Seiji Mizuno, Toshiyuki Yamamoto, Fumitaka Osakada, Norio Ozaki, Keita Tsujimura\n<\/p>\n

\niScience<\/i>, vol. 28, Issue 11, 2025, Article number: 113789.
\nhttps:\/\/doi.org\/10.1016\/j.isci.2025.113789<\/a>\n<\/p>\n

Novel plasmalogen derivative KIT-13 restores neurological function in a mouse model of Rett syndrome by reducing neuroinflammation and restoring mitochondrial function<\/strong><\/p>\n

\nAkane Matsuda, Hideyuki Nakashima, Takehiko Fujino, Tatsuo Okauchi, Md Shamim Hossain, Yasunari Sakai, Shouichi Ohga, Kinichi Nakashima, Masanori Honsho\n<\/p>\n

\nbioRxiv<\/i>, 2025.06.11.656246.
\nhttps:\/\/doi.org\/10.1101\/2025.06.11.656246<\/a>\n<\/p>\n

Epigenetic regulation of neural stem cell aging in the mouse hippocampus by Setd8 downregulation<\/strong><\/p>\n

Shuzo Matsubara, Kanae Matsuda-Ito, Haruka Sekiryu, Hiroyoshi Doi , Takumi Nakagawa, Naoya Murao, Hisanobu Oda, Kinichi Nakashima, and Taito Matsuda<\/p>\n

EMBO Journal<\/i>., 2025, vol.44, Issue.11; 1-24<\/p>\n

E3 ubiquitin ligase RMND5A maintains the self-renewal state of human neural stem\/precursor cells by regulating Wnt and mTOR signaling pathways<\/strong><\/p>\n

Takumi Nakagawa,\u00a0Kosuke Hata,\u00a0Yoshihiro Izumi,\u00a0Hideyuki Nakashima,\u00a0Sayako Katada,\u00a0Taito Matsuda,\u00a0Takeshi Bamba,\u00a0Kinichi Nakashima<\/p>\n

FEBS Letters<\/i>., 2025, vol.599, Number.10<\/p>\n

2024\u5e74<\/h4>\n

Human microglial cells as a therapeutic target in a neurodevelopmental disease model<\/strong><\/p>\n

Pinar Mesci, Christopher N. LaRock, Jacob J. Jeziorski, Hideyuki Nakashima, Natalia Chermont, Adriano Ferrasa, Roberto H. Herai, Tomoka Ozaki, Aurian Saleh, Cedric E. Snethlage, Sandra Sanchez, Gabriela Goldberg, Cleber A. Trujillo, Kinichi Nakashima, Victor Nizet, and Alysson R. Muotri<\/p>\n

Stem Cell Rep<\/i>., 2024; vol.19, 1-18<\/p>\n

The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis<\/strong><\/p>\n

Naoya Murao, Taito Matsuda, Hisae Kadowaki, Yosuke Matsushita, Kousuke Tanimoto, Toyomasa Katagiri, Kinichi Nakashima, and Hideki Nishitoh<\/p>\n

EMBO Rep<\/i>., 2024, 1-29<\/p>\n

2023\u5e74<\/h4>\n

Direct neuronal conversion of microglia\/macrophages reinstates neurological function after stroke<\/strong><\/p>\n

Takashi Irie, Taito Matsuda ,Yoshinori Hayashi and Kinichi Nakashima<\/p>\n

PNAS<\/i>.,2023;vol.120, No.42 \u30d7\u30ec\u30ea\u30ea\u30fc\u30b9<\/a><\/p>\n

Reduced neuroinflammation via astrocytes and neutrophils promotes regeneration after spinal cord injury in neonatal mice<\/strong><\/p>\n

Kazuki Kitade, Kazu Kobayakawa, Hirokazu Saiwai, Yoshihiro Matsumoto, Kenichi Kawaguchi, Keiichiro Iida, Ken Kijima, Hirotaka Iura, Tetsuya Tamaru, Yohei Haruta, Gentaro Ono, Daijiro Konno, Takeshi Maeda, Seiji Okada, Kinichi Nakashima, Yasuharu Nakashima<\/p>\n

J Neurotrauma.,2023;vol.0,No.ja<\/p>\n

C4orf47 contributes to the dormancy of pancreatic cancer under hypoxic conditions<\/strong><\/p>\n

Shinjiro Nagao, Hideya Onishi, Makoto Kawamoto, Shogo Masuda, Lin Na, Shinji Morisaki, Naoya Iwamoto, Yutaka Yamada, Satoko Koga, Shu Ichimiya, Kazunori Nakayama, Akira Imaizumi, Kinichi Nakashima, Yoshinao Oda, Masafumi Nakamura<\/p>\n

J Cancer.,<\/em>2023;14(2):306-317<\/p>\n

Lineage tracing identifies in vitro microglia-to-neuron conversion by NeuroD1 expression<\/strong><\/p>\n

Takashi Irie*, Kanae Matsuda-Ito*, Taito Matsuda#, Takahiro Masuda, Marco Prinz, Noriko Isobe, Kinichi Nakashima<\/p>\n

Genes Cells.,2023;1-9<\/i><\/p>\n

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2022\u5e74<\/h4>\n

Expression level of the reprogramming factor NeuroD1 is critical for neuronal conversion efficiency from different cell types<\/strong><\/p>\n

Kanae Matsuda-Ito*, Taito Matsuda*#, and Kinichi Nakashima#<\/p>\n

Scientific Reports.2022;12:17980<\/em><\/p>\n

2021\u5e74<\/h4>\n

Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration<\/strong><\/p>\n

\n

Takahiro Wakizono, Hideyuki Nakashima, Tetsuro Yasui, Teppei Noda, Kei Aoyagi, Kanako Okada, Yasuhiro Yamada, Takashi Nakagawa, and Kinichi Nakashima<\/p>\n

JCI Insight. 2021;6(22):e139171., 2021\u00a0 \u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\u3000<\/em><\/p>\n<\/div>\n

SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem\/precursor cells downstream of Nfia<\/strong><\/p>\n

\n

Jun Takouda, Sayako Katada, Takuya Imamura, Tsukasa Sanosaka, Kinichi Nakashima<\/p>\n<\/div>\n

Pharmacol. Res. Perspect., 9(6):e00749., 2021<\/em><\/p>\n

Neural stem\/precursor cells dynamically change their epigenetic landscape\"\" to\u00a0differentially respond to BMP signaling for fate switching during brain development<\/strong><\/p>\n

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Sayako Katada, Jun Takouda, Takumi Nakagawa, Mizuki Honda, Katsuhide Igarashi, Takuya Imamura, Yasuyuki Ohkawa, Shoko Sato, Hitoshi Kurumizaka, and Kinichi Nakashima<\/p>\n<\/div>\n

Genes Dev.,35(21-22):1431-1444., 2021<\/em>\u00a0\u00a0\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\u3000<\/em><\/p>\n

2021\u5e7411\u6708\u53f7\u306eCover Article \u306b\u9078\u3070\u308c\u307e\u3057\u305f\u3002<\/p>\n

Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through\u00a0de novo<\/i>\u00a0DNA methylation<\/strong><\/p>\n

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Tomonori KAMEDA, Hideyuki NAKASHIMA, Takumi TAKIZAWA, Fumihito MIURA, Takashi ITO, Kinichi NAKASHIMA, Takuya IMAMURA<\/p>\n<\/div>\n

J Reprod Dev., 2021<\/em>, 67(6):369-379<\/p>\n

Early-life midazolam exposure persistently changes chromatin accessibility to impair adult hippocampal neurogenesis and cognition<\/strong><\/p>\n

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Hiroyoshi Doi*, Taito Matsuda*#, Atsuhiko Sakai, Shuzo Matsubara, Sumio Hoka, Ken Yamaura, and Kinichi Nakashima#<\/p>\n<\/div>\n

Proc Natl Acad Sci USA, 118(38):e2107596118., 2021<\/em>\u00a0\u00a0\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a><\/p>\n

scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse<\/strong><\/p>\n

Marie-Theres Wittmann, Sayako Katada, Elisabeth Sock, Philipp Kirchner, Arif B Ekici, Michael Wegner, Kinichi Nakashima, Dieter Chichung Lie, Andr\u00e9 Reis<\/p>\n

Development, 15;148(14):dev196022, 2021<\/em><\/p>\n

Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice<\/strong><\/p>\n

Bijay Parajuli, Hiroki Saito, Youichi Shinozaki, Eiji Shigetomi, Hiroto Miwa, Sosuke Yoneda, Miki Tanimura, Shigeki Omachi, Toshiyuki Asaki, Koji Takahashi, Masahide Fujita, Kinichi Nakashima, Schuichi Koizumi<\/p>\n

Glia, 69(10), 2332-2348, 2021\u3000<\/em>\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a><\/p>\n

Generation of ovarian follicles from mouse pluripotent stem cells<\/strong><\/p>\n

Takashi Yoshino1, Takahiro Suzuki, Go Nagamatsu, Haruka Yabukami, Mika Ikegaya, Mami Kishima, Haruka Kita, Takuya Imamura, Kinichi Nakashima, Ryuichi Nishinakamura, Makoto Tachibana, Miki Inoue, Yuichi Shima, Ken-ichirou Morohashi, Katsuhiko Hayashi<\/p>\n

Science, 373, 298, 2021<\/em><\/p>\n

CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Acting in cis<\/strong><\/p>\n

Yuta Shirogane, Ryuichi Takemoto, Tateki Suzuki, Tomonori Kameda, Kinichi Nakashima, Takao Hashiguchi, and Yusuke Yanagi<\/p>\n

J Virol, 24;95(14):e0052821, 2021<\/em><\/p>\n

MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP\u2013Smad signaling<\/strong><\/p>\n

Hideyuki Nakashima, Keita Tsujimura, Koichiro Irie, Takuya Imamura, Cleber A. Trujillo, Masataka Ishizu, Masahiro Uesaka, Miao Pan, Hirofumi Noguchi, Kanako Okada, Kei Aoyagi, Tomoko Andoh-Noda, Hideyuki Okano, Alysson R. Muotri, Kinichi Nakashima<\/p>\n

Cell Reports, 35, 109124, 2021\u3000<\/em>\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u00b9<\/a>\u3001\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u00b2 <\/a>\u3001\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u00b3<\/a><\/p>\n

Combinatrial treatment of anti-High Mobility Group Box-1 monoclonal antibody and epothilone B improves functional recovery after spinal cord contusion injury<\/strong><\/p>\n

Yicheng Zhu, Naohiro Uezono, Tetsuro Yasui, Masahide Nakajo, Tatsuya Nagai, Dengli Wang, Masahiro Nishibori, KinichiNakashima<\/p>\n

Neurosci Res, 172, 17-25, 2021<\/em><\/p>\n

Reconstitution of the oocyte transcriptional network with transcription factors<\/strong><\/p>\n

Nobuhiko Hamazaki, Hirohisa Kyogoku, Hiromitsu Araki, Fumihito Miura, Chisako Horikawa, Norio Hamada, So Shimamoto, Orie Hikabe, Kinichi Nakashima, Tomoya S. Kitajima, Takashi Ito, Harry G. Leitch & Katsuhiko Hayashi<\/p>\n

Nature, 589(7841):264-269, 2021<\/em><\/em><\/p>\n

2020\u5e74<\/h4>\n

NF\u03baB and TGF\u03b2 contribute to the expression of PTPN3 in activated human lymphocytes <\/strong><\/p>\n

Kazunori Nakayama, Hideya Onishi, Akiko Fujimura, Akira Imaizumi, Makoto Kawamoto, Yasuhiro Oyama, Shu Ichimiya, Satoko Koga, Yuichi Fujimoto, Kinichi Nakashima, Masafumi Nakamura<\/p>\n

Cell Immunol, 358:104237, 2020<\/em><\/p>\n

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Identification of Qk as a glial precursor cell marker that governs the fate specification of neural stem cells to a glial cell lineage.<\/strong><\/p>\n

Takeuchi A., Takahashi Y., Iida K., Hosokawa M., Irie K., Ito M., Brown BJ., Ohno K., Nakashima K. & Hagiwara M.<\/p>\n

Stem Cell Rep,15(4):883-897<\/em><\/p>\n

Modeling of early neural development in vitro by direct neurosphere formation culture of chimpanzee induced pluripotent stem cells.<\/strong><\/p>\n

Kitajima R., Nakai R., Imamura T., Kameda T., Kozuka D., Hirai H., Ito H., Imai H., Imamura M.<\/p>\n

Stem Cell Rep<\/em>, 44: 101749, 2020<\/em><\/p>\n

Enhanced processivity of Dnmt1 by monoubiquitinated Histone H3.<\/strong><\/p>\n

Mishima Y.,Brueckner L., Takahashi S., Kawakami T., Otani J., Shinohara A., Takeshita K.,Garvilles RG., Watanabe M., Sakai N., Takeshima H., Nachtegael C., Nishiyama A.,Nakanishi M., Arita K., Nakashima K., Hojo H., Suetake I.<\/p>\n

Genes Cells<\/em>, 25: 22-32, 2020<\/em><\/p>\n

2019\u5e74<\/h4>\n
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Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice.<\/strong><\/p>\n

Saito H., Hara K., Tominaga T., Nakashima K. & Tanemura K.<\/p>\n

J Appl Toxicol<\/em>, 39:1651-1662, 2019<\/em><\/p>\n

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells.<\/strong><\/p>\n

Noguchi H., Castillo J.G., Nakashima K. & Pleasure S.J.<\/p>\n

eLIFE<\/em>, 8:e42918, 2019<\/em><\/p>\n

Pioneer factor NeuroD1 rearranges transcriptional and epigenetic profiles to execute microglia-neuron conversion. <\/strong><\/p>\n

#Matsuda T.\uff0cIrie T.\uff0cKatsurabayashi S.\uff0cHayashi T.\uff0cNagai T.\uff0cHamazaki N.\uff0cAdefuin AM.\uff0cMiura F.\uff0cIto T.\uff0cKimura H.\uff0cShirahige K.\uff0cTakeda T.\uff0cIwasaki K.\uff0cImamura T. & #Nakashima K.<\/p>\n

Neuron<\/em>, 101, 472-485, 2019<\/em><\/p>\n

Nox4 promotes neural stem\/precursor cell proliferation and neurogenesis in the hippocampus and restores memory function following trimethyltin-induced Injury.<\/strong><\/p>\n

Yoshikawa Y.\uff0c*Ago T.\uff0cKuroda J.\uff0cWakisaka Y.\uff0cTachibana M.\uff0cKomori M.\uff0cShibahara T.\uff0cNakashima H.\uff0cNakashima K. & Kitazono T.<\/p>\n

Neuroscience<\/em>, 398, 193-205, 2019<\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\u00a02018\u5e74<\/h4>\n
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Canonical TGF-\u03b2 signaling negatively regulates neuronal morphogenesis through TGIF\/Smad complex-mediated CRMP2 suppression<\/strong><\/p>\n

Nakashima\u00a0H.,\u00a0Tsujimura\u00a0K.*,\u00a0Irie\u00a0K.,\u00a0Ishizu\u00a0M.,\u00a0Pan\u00a0M.,\u00a0Kameda\u00a0T. &\u00a0Nakashima K.*<\/p>\n

J Neurosci<\/em>,\u00a038: 4791-4810, 2018<\/em><\/p>\n

Np95\/Uhrf1 regulates tumor suppressor gene expression of neural stem\/precursor cells, contributing to neurogenesis in the adult mouse brain<\/strong><\/p>\n

Murao\u00a0N., Matsubara S., Matsuda T., Noguchi H., Mutoh T., Mutoh M., Koseki H., Namihira M. &\u00a0Nakashima K.*<\/p>\n

Neurosci Res<\/em>,\u00a0Epub ahead of print,\u00a0May\u00a031, 2018<\/em><\/p>\n

Ectopic neurogenesis induced by prenatal antiepileptic drug exposure augments seizure susceptibility in adult mice<\/strong><\/p>\n

Sakai A., Matsuda T., Doi H., Nagaishi Y., Kato K.\u00a0& Nakashima K.*<\/p>\n

Proc Natl Acad Sci USA<\/em>,\u00a0Epub ahead of print,\u00a0Apr\u00a02, 2018<\/em>\u3000\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306f\u3053\u3061\u3089<\/a><\/p>\n

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Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury<\/strong><\/p>\n

Nakajo M., Uezono N., Nakashima H., Wake H., Komiya S., Nishibori M.\u00a0&\u00a0Nakashima K.*<\/p>\n

Neurosci Res<\/em>, Epub ahead of print,\u00a0Mar\u00a028, 2018\u00a0<\/em><\/p>\n

Prior treatment with anti-High Mobility Group Box-1 antibody boosts human neural stem cell transplantation-mediated functional recovery after spinal cord injury<\/strong><\/p>\n

Uezono N., Zhu Y., Fujimoto Y., Yasui T., Matsuda T., Nakajo M., Abematsu M., Setoguchi T., Mori S., Takahashi H.K., Komiya S., Nishibori M. &\u00a0Nakashima K.*<\/p>\n

Stem Cells<\/em>,\u00a036, 737-750, 2018<\/em>\u3000\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306f\u3053\u3061\u3089<\/a><\/p>\n

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HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells<\/strong><\/p>\n

Kimura A., Matsuda T.*, Sakai A., Murao N.\u00a0& Nakashima K.* (*Corresponding authors)<\/p>\n

Dev Dyn<\/em>, 247, 229-238, 2018<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\u00a02017\u5e74<\/h4>\n
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Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain<\/strong><\/p>\n

Kawamura Y., Katada S., Noguchi H., Yamamoto H., Sanosaka T., Iihara K. & Nakashima K.*<\/p>\n

FEBS Lett<\/em>,\u00a0591, 3709-3720<\/p>\n

DNA methylome analysis identifies transcription factor-based epigenomic signatures of multilineage competence in neural stem\/progenitor cells<\/strong><\/p>\n

Sanosaka T.\u25ca*, Imamura T.\u25ca*, Hamazaki N., Chai M.C., Igarashi K., Ideta-Otsuka M., Miura F., Ito T., Fujii N., Ikeo K. & Nakashima K.* (\u25ca<\/sup>Co-first authors,\u00a0*<\/sup>Co-corresponding authors)<\/p>\n

Cell Reports<\/em>, 20, 2992\u20133003, 2017\u3000\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306f\u3053\u3061\u3089<\/a><\/p>\n

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PRMT1 regulates astrocytic differentiation of embryonic neural stem\/precursor cells<\/strong><\/p>\n

Honda\u00a0M., Nakashima\u00a0K. & Katada S.*<\/p>\n

J Neurochem<\/em>,\u00a0142, 901-907, 2017<\/p>\n

Hypoxia epigenetically confers astrocytic differentiation potential on human pluripotent cell-derived neural precursor cells<\/strong><\/p>\n

Yasui\u00a0T., Uezono N., Nakashima H, Noguchi H., Matsuda T., Noda-Andoh T., Okano H. & Nakashima K.*<\/p>\n

Stem Cell Reports<\/em>, 8, 1743\u20131756, 2017\u3000\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306f\u3053\u3061\u3089<\/a><\/p>\n

NEUROD1 instructs neuronal conversion in non-reactive astrocytes<\/strong><\/p>\n

Brulet R., Matsuda T., Zhang L., Miranda C., Giacca M., Kaspar B.K., Nakashima K. & Hsieh J.*<\/p>\n

Stem Cell Reports<\/em>, 8, 1506\u20131515, 2017<\/p>\n

Evolutionary acquisition of promoter-associated non-coding RNA (pancRNA) repertoires diversifies species-dependent gene activation mechanisms in mammals<\/strong><\/p>\n

Uesaka M., Agata\u00a0K., Oishi T., Nakashima\u00a0K. & Imamura\u00a0T.*<\/p>\n

BMC Genomics<\/em>,\u00a018, 285, 2017<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

2016\u5e74<\/h4>\n
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Prenatal deletion of\u00a0DNA methyltransferase 1<\/i>\u00a0in neural stem cells impairs neurogenesis and causes anxiety-like behavior in adulthood<\/strong><\/p>\n

Noguchi H., Kimura A., Murao N., Namihira M. & Nakashima K.*<\/p>\n

Neurogenesis,<\/em> 3,\u00a02016<\/p>\n

Targeted DNA demethylation in vivo using dCas9\u2013peptide repeat and scFv\u2013tet1 catalytic domain fusions<\/strong><\/p>\n

Morita S., Noguchi H., Horii T., Nakabayashi K., Kimura M., Okamura K., Sakai A., Nakashima H., Hata K., Nakashima K. & Hatada I.*<\/p>\n

Nat Biotechnol,<\/em> 34, 1060\u20131065, 2016<\/p>\n

MicroRNA-214 promotes dendritic development by targeting the schizophrenia-associated gene Quaking (Qki<\/em>)<\/strong><\/p>\n

Irie\u00a0K., Tsujimura\u00a0K.*, Nakashima\u00a0H. & Nakashima K.* (*Corresponding authors)<\/p>\n

J Biol Chem,<\/em>\u00a0291, 13891\u201313904, 2016<\/p>\n

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\"1<\/strong><\/p>\n

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DNA methyltransferase 1 is indispensable for development of the hippocampal dentate gyrus
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Noguchi H., Murao N., Kimura A., Matsuda T., Namihira M. & Nakashima K.*<\/p>\n

J Neurosci,<\/em> 36, 6050\u20136068, 2016<\/p>\n

Cover Article \u306b\u9078\u3070\u308c\u307e\u3057\u305f\u3002<\/p>\n

Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation<\/strong><\/p>\n

Ito K., Sanosaka T., Igarashi K., Otsuka I.M., Aizawa A., Uosaki Y., Noguchi A., Arakawa H., Nakashima K. & Takizawa T.*<\/p>\n

Sci Rep,<\/em> 6, 23903, 2016<\/p>\n

Bidirectional promoters link cAMP signaling with irreversible differentiation through promoter-associated non-coding RNA (pancRNA) expression in PC12 cells<\/strong><\/p>\n

Yamamoto N., Agata K., Nakashima K. & Imamura T.*<\/span><\/p>\n

Nucleic Acids Res, 44, 5105-5122,<\/em>\u00a02016\u3000\u3000\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306f\u3053\u3061\u3089<\/a>\u00a0\u3068 \u3053\u3061\u3089<\/a><\/p>\n<\/div>\n

2015\u5e74<\/h4>\n
\n

Reduced adult hippocampal neurogenesis and cognitive impairments following prenatal treatment of the antiepileptic drug valproic acid<\/strong><\/p>\n

Juliandi B.\u25ca, Tanemura K.\u25ca, Igarashi K., Tominaga T., Furukawa Y., Otsuka M., Moriyama N., Ikegami D., Abematsu M., Sanosaka T., Tsujimura K., Narita M., Kanno J. &\u00a0Nakashima K.*\u00a0(\u25ca<\/sup>Co-first authors)<\/p>\n

Stem Cell Reports,<\/em> 5, 1-14, 2015\u3000\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306f\u3053\u3061\u3089<\/a><\/p>\n

miR-199a links MeCP2 with mTOR signaling and its dysregulation leads to Rett Syndrome phenotypes<\/strong><\/p>\n

Tsujimura K., Irie K., Nakashima H., Egashira Y., Fukao Y., Fujiwara M., Itoh M., Uesaka M., Imamura T., Nakahata Y., Yamashita Y., Abe T.,\u00a0Takamori S. &\u00a0Nakashima K.*<\/p>\n

Cell Rep,<\/em> 12, 1-15, 2015\u3000\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306f\u3053\u3061\u3089<\/a><\/p>\n

Recommended by Faculty of 1000<\/a><\/p>\n

Low-cost three-dimensional gait analysis system for mice with an infrared depth sensor<\/strong><\/p>\n

Nakamura A., Funaya H., Uezono N., Nakashima K., Ishida Y., Suzuki T., Wakana S. & Shibata T.*<\/p>\n

Neurosci Res,<\/em> 100, 55-62,<\/span>\u00a02015<\/p>\n

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage<\/strong><\/p>\n

Andoh-Noda T., Akamatsu W., Miyake K., Matsumoto T., Yamaguchi R., Sanosaka T., Okada Y., Kobayashi T., Ohyama M., Nakashima K., Kurosawa H., Kubota T. & Okano H.*<\/p>\n

Mol Brain,<\/em> 8, 2015<\/p>\n

TLR9\u00a0signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus<\/strong><\/p>\n

Matsuda T., Murao N., Katano Y.,\u00a0Juliandi B., Kohyama J., Akira S., Kawai T. & Nakashima K.*<\/p>\n

Nat commun,\u00a0<\/em>6, 6514, 2015\u3000\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306f\u3053\u3061\u3089<\/a><\/p>\n

Recommended by Faculty of 1000<\/a><\/p>\n

Expression of DNMT1 in neural stem\/precursor cells is critical for survival of newly generated neurons in the adult hippocampus<\/strong><\/p>\n

Noguchi H., Kimura A., Murao N., Matsuda T., Namihira M. & Nakashima K.*<\/p>\n

Neurosci Res,\u00a0<\/em>95, 1-11,\u00a0<\/em>2015<\/p>\n

Gene activation-associated long noncoding RNAs function in mouse preimplantation development<\/strong><\/p>\n

Hamazaki N., Uesaka M., Nakashima K., Agata K. & Imamura T.*<\/p>\n

Development,<\/em>\u00a0142, 910-920, 2015\u3000\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306f\u3053\u3061\u3089<\/a><\/p>\n<\/div>\n

2014\u5e74<\/h4>\n
\n

Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem\/precursor cells<\/strong><\/p>\n

Murao N., Matsuda T., Noguchi H., Koseki H., Namihira M*<\/sup>. & Nakashima K*<\/sup>. (*<\/sup>Co-corresponding authors)<\/p>\n

Neurogenesis,<\/em> 1, 1-11, 2014<\/p>\n<\/div>\n

VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome<\/strong><\/p>\n

Guo W\u25ca<\/sup>., Tsujimura K\u25ca<\/sup>., Otsuka I.M., Irie K., Igarashi K*<\/sup>., Nakashima K*<\/sup>. & Zhao X*<\/sup>. (\u25ca<\/sup>Co-first authors, *<\/sup>Co-corresponding authors)<\/p>\n

PLoS ONE,<\/em>\u00a09, e100215, 2014<\/p>\n

Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation<\/strong><\/p>\n

Yi S.H., He X.B., Rhee Y.H., Park C.H., Takizawa T., Nakashima K. & Lee S.H.*<\/p>\n

Development,<\/em>\u00a0141, 761-772, 2014<\/p>\n

Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals<\/strong><\/p>\n

Uesaka M., Nishimura O., Go Y., Nakashima K., Agata K. & Imamura T.*<\/p>\n

BMC Genomics,\u00a0<\/em>15,\u00a0<\/em>35, 2014<\/p>\n

2013\u5e74<\/h4>\n

Prenatal exposure to suberoylanilide hydroxamic acid perturbs corticogenesis<\/strong><\/p>\n

Yuniarti N., Juliandi B., Muhchyi C., Noguchi H., Sanosaka T. & Nakashima K.<\/p>\n

Neurosci Res,<\/em>\u00a077, 42-49, 2013<\/p>\n

Chromatin accessibility at a STAT3 target site is altered prior to astrocyte differentiation<\/strong><\/p>\n

Urayama S., Semi K., Sanosaka T., Hori Y., Namihira M., Kohyama J., Takizawa T. & Nakashima K.<\/p>\n

Cell Struct Func,<\/em>\u00a038, 55-66, 2013<\/p>\n

2012\u5e74<\/h4>\n

Unfolded protein response activated by OASIS family transcription factors promotes astrocyte differentiation<\/strong><\/p>\n

Saito A., Kanemoto S., Kawasaki N., Asada R., Iwamoto H., Oki M., Miyagi H., Izumi S., Sanosaka T., Nakashima K. & Imaizumi K.<\/p>\n

Nat Commun,<\/em>\u00a03, 967, 2012<\/p>\n

Treatment of a mouse model of spinal cord injury by transplantation of human iPS cell-derived long-term self-renewing neuroepithelial-like stem cells<\/strong><\/p>\n

Fujimoto Y., Abematsu M., Falk A., Tsujimura K., Sanosaka T., Juliandi B., Semi K., Namihira M., Komiya S., Smith A., & Nakashima K.<\/p>\n

Stem Cells,<\/em>\u00a030, 1163-1173, 2012<\/p>\n

Oxygen Levels Epigenetically Regulate Fate Switching of Neural Precursor Cells via Hypoxia-Inducible Factor 1alpha-Notch Signal Interaction in the Developing Brain<\/strong><\/p>\n

Mutoh T., Sanosaka T., Ito K. & Nakashima K.<\/p>\n

Stem Cells,<\/em>\u00a030, 561-569, 2012.<\/p>\n

Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid<\/strong><\/p>\n

Juliandi B., Abematsu M., Sanosaka T., Tsujimura K., Smith A. & Nakashima K.<\/p>\n

Neurosci Res,\u00a0<\/em>72, 23-31, 2012<\/p>\n

2011\u5e74<\/h4>\n

Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb<\/strong><\/p>\n

Kuwabara T., Kagalwala M.N., Onuma Y., Ito Y., Warashina M., Terashima K., Sanosaka T., Nakashima K., Gage F.H. & Asashima M.<\/p>\n

EMBO Mol Med,<\/em>\u00a03, 742-754, 2011<\/p>\n

Role of GLI2 in the growth of human osteosarcoma<\/strong><\/p>\n

Nagao H., Ijiri K., Hirotsu M., Ishidou Y., Yamamoto T., Nagano S., Takizawa T., Nakashima K., Komiya S. & Setoguchi T.<\/p>\n

J Pathol,<\/em>\u00a0224, 169-179, 2011<\/p>\n

2010\u5e74<\/h4>\n

Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury<\/strong><\/p>\n

Abematsu M., Tsujimura K., Yamano M., Saito M., Kohno K., Kohyama J., Namihira M., Komiya S. & Nakashima K.<\/p>\n

J Clin Invest,<\/em>\u00a0120, 3255-3266, 2010<\/p>\n

BMP-induced REST regulates the establishment and maintenance of astrocytic identity<\/strong><\/p>\n

Kohyama J., Sanosaka T., Tokunaga A., Takatsuka E., Tsujimura K., Okano H. & Nakashima K.<\/p>\n

J Cell Biol,\u00a0<\/em>189, 159-170, 2010<\/p>\n

Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus<\/strong><\/p>\n

Mira H., Andreu Z., Suh H., Lie D.C., Jessberger S., Consiglio A., San Emeterio J., Hortiguela R., Marques-Torrejon M.A., Nakashima K., Colak D., Gotz M., Farinas I. & Gage F.H.<\/p>\n

Cell Stem Cell,<\/em>\u00a07, 78-89, 2010<\/p>\n

L1 retrotransposition in neurons is modulated by MeCP2<\/strong><\/p>\n

Muotri A.R., Marchetto M.C., Coufal N.G., Oefner R., Yeo G., Nakashima K. & Gage F.H.<\/p>\n

Nature,<\/em>\u00a0468, 443-446, 2010<\/p>\n

2009\u5e74<\/h4>\n

Astrocyte Differentiation of Neural Precursor Cells is Enhanced by Retinoic Acid Through a Change in Epigenetic Modification<\/strong><\/p>\n

Asano H., Aonuma M., Sanosaka T., Kohyama J., Namihira M. & Nakashima K.<\/p>\n

Stem Cells,<\/em>\u00a027, 2744-2752, 2009<\/p>\n

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis<\/strong><\/p>\n

Kuwabara T., Hsieh J., Muotri A., Yeo G., Warashina M., Lie D.C., Moore L., Nakashima K.,\u00a0 Asashima M. & Gage F.H.<\/p>\n

Nat Neurosci,<\/em>\u00a012, 1097-1105, 2009<\/p>\n

Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells<\/strong><\/p>\n

\u3000\u3000Namihira M., Kohyama J., Semi K., Sanosaka T., Deneen B., Taga T. & Nakashima K.<\/p>\n

\u3000\u3000Dev Cell,<\/em>\u00a016, 245-255, 2009<\/p>\n

Periventricular notch activation and asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cells<\/strong><\/p>\n

\u3000\u3000Ochiai W., Nakatani S., Takahara T., Kainuma M., Masaoka M., Minobe S., Namihira M., Nakashima K., Sakakibara A., Ogawa M. & Miyata T.<\/p>\n

\u3000\u3000Mol Cell Neurosci,<\/em>\u00a040, 225-233, 2009<\/p>\n

Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2<\/strong><\/p>\n

\u3000\u3000Tsujimura K., Abematsu M., Kohyama J., Namihira M. & Nakashima K.<\/p>\n

\u3000\u3000Exp Neurol,\u00a0<\/em>219, 104-111, 2009<\/p>\n

2008\u5e74<\/h4>\n

Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation<\/strong><\/p>\n

\u3000\u3000Hatada I., Namihira M., Morita S., Kimura M., Horii T. & Nakashima K.<\/p>\n

\u3000\u3000PLoS ONE.<\/em>\u00a03, e3189, 2008<\/p>\n

Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain<\/strong><\/p>\n

\u3000\u3000Kohyama J., Kojima T., Takatsuka E., Yamashita T., Namiki J., Hsieh J., Gage F.H., Namihira M., Okano H., Sawamoto K. & Nakashima K.<\/p>\n

\u3000\u3000Proc Natl Acad Sci USA,<\/em>\u00a0105, 18012-18017, 2008<\/p>\n

Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain<\/strong><\/p>\n

\u3000\u3000Li W., Sun G., Yang S., Qu Q., Nakashima K. & Shi Y.<\/p>\n

\u3000\u3000Mol Endocrinol,<\/em>\u00a022, 56-64, 2008<\/p>\n

Identification of genes that restrict astrocyte differentiation of midgestational neural precursor cells<\/strong><\/p>\n

\u3000\u3000Sanosaka T., Namihira M., Asano H., Kohyama J., Aisaki K., Igarashi K., Kanno J. & Nakashima K.<\/p>\n

\u3000\u3000Neuroscience,<\/em>\u00a0155, 780-788, 2008<\/p>\n

2007\u5e74<\/h4>\n

Bcl-XL\/Bax Proteins Direct the Fate of Embryonic Cortical Precursor Cells<\/strong><\/p>\n

\u3000\u3000Chang M.Y., Sun W., Ochiai W., Nakashima K., Kim S.Y., Park C.H., Kang J.S., Shim J.W., Jo A.Y., Kang C.S., Lee Y.S., Kim J.S. & Lee S.H.<\/p>\n

\u3000\u3000Mol Cell Biol,\u00a0<\/em>27, 4293-4305, 2007<\/p>\n

Potentiation of astrogliogenesis by STAT3-mediated activation of bone morphogenetic protein-Smad signaling in neural stem cells<\/strong><\/p>\n

\u3000\u3000Fukuda S., Abematsu M., Mori H., Yanagisawa M., Kagawa T., Nakashima K., Yoshimura A. & Taga T.<\/p>\n

\u3000\u3000Mol Cell Biol,<\/em>\u00a027, 4931-4937, 2007<\/p>\n

Epigenetic modulation of seizure-induced neurogenesis and cognitive decline<\/strong><\/p>\n

\u3000\u3000Jessberger S., Nakashima K., Clemenson G.D., Jr., Mejia E., Mathews E., Ure K., Ogawa S., Sinton C.M., Gage F.H. & Hsieh J.<\/p>\n

\u3000\u3000J Neurosci,<\/em>\u00a027, 5967-5975, 2007<\/p>\n

2006\u5e74<\/h4>\n

Identification of astrocyte-expressed factors that modulate neural stem\/progenitor cell differentiation<\/strong><\/p>\n

\u3000\u3000Barkho B.Z., Song H., Aimone J.B., Smrt R.D., Kuwabara T., Nakashima K., Gage F.H. & Zhao X.<\/p>\n

\u3000\u3000Stem Cells Dev,<\/em>\u00a015, 407-421, 2006<\/p>\n

Conversion of mammalian Muller glial cells into a neuronal lineage by in vitro aggregate-culture<\/strong><\/p>\n

\u3000\u3000Kubota A., Nishida K., Nakashima K. & Tano Y.<\/p>\n

\u3000\u3000Biochem Biophys Res Commun,<\/em>\u00a0351, 514-520, 2006<\/p>\n

Neuropoietin induces neuroepithelial cells to differentiate into astrocytes via activation of STAT3<\/strong><\/p>\n

\u3000\u3000Ohno M., Kohyama J., Namihira M., Sanosaka T., Takahashi J.A., Hashimoto N. & Nakashima K.<\/p>\n

\u3000\u3000Cytokine,<\/em>\u00a036, 17-22, 2006<\/p>\n

Methyl-CpG binding proteins are involved in restricting differentiation plasticity in neurons<\/strong><\/p>\n

\u3000\u3000Setoguchi H., Namihira M., Kohyama J., Asano H., Sanosaka T. & Nakashima K.<\/p>\n

\u3000\u3000J Neurosci Res,<\/em>\u00a084, 969-979, 2006<\/p>\n

Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification<\/strong><\/p>\n

\u3000\u3000Suzuki A., Raya A., Kawakami Y., Morita M., Matsui T., Nakashima K., Gage F.H., Rodriguez-Esteban C. & Belmonte J.C.<\/p>\n

\u3000\u3000Nat Clin Pract Cardiovasc Med,<\/em>\u00a03 Suppl 1, S114-S122, 2006<\/p>\n

Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells<\/strong><\/p>\n

\u3000\u3000Suzuki A., Raya A., Kawakami Y., Morita M., Matsui T., Nakashima K., Gage F.H., Rodriguez-Esteban C. & Izpisua Belmonte J.C.<\/p>\n

\u3000\u3000Proc Natl Acad Sci USA,\u00a0<\/em>103, 10294-10299, 2006<\/p>\n

2005\u5e74<\/h4>\n

Development of functional human embryonic stem cell-derived neurons in mouse brain<\/strong><\/p>\n

\u3000\u3000Muotri A.R., Nakashima K., Toni N., Sandler V.M. & Gage F.H.<\/p>\n

\u3000\u3000Proc Natl Acad Sci USA,<\/em>\u00a0102, 18644-18648, 2005<\/p>\n

Stage- and site-specific DNA demethylation during neural cell development from embryonic stem cells<\/strong><\/p>\n

\u3000\u3000Shimozaki K., Namihira M., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000J Neurochem,<\/em>\u00a093, 432-439, 2005<\/p>\n

Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture.<\/strong><\/p>\n

\u3000\u3000Yanagisawa M., Nakashima K., Ochiai W., Takizawa T., Setoguchi T., Uemura A., Takizawa M., Nobuhisa I. & Taga T.<\/p>\n

\u3000\u3000Neurosci Res,\u00a0<\/em>53, 176-182, 2005<\/p>\n

2004\u5e74<\/h4>\n

IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes<\/strong><\/p>\n

\u3000\u3000Hsieh J., Aimone J.B., Kaspar B.K., Kuwabara T., Nakashima K. & Gage F.H.<\/p>\n

\u3000\u3000J Cell Biol,\u00a0<\/em>164, 111-122, 2004<\/p>\n

Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells<\/strong><\/p>\n

\u3000\u3000Hsieh J., Nakashima K., Kuwabara T., Mejia E. & Gage F.H.<\/p>\n

\u3000\u3000Proc Natl Acad Sci USA,<\/em>\u00a0101, 16659-16664, 2004<\/p>\n

A small modulatory dsRNA specifies the fate of adult neural stem cells<\/strong><\/p>\n

\u3000\u3000Kuwabara T., Hsieh J., Nakashima K., Taira K. & Gage F.H.<\/p>\n

\u3000\u3000Cell,\u00a0<\/em>116, 779-793, 2004<\/p>\n

Developmental stage dependent regulation of DNA methylation and chromatin modification in a immature astrocyte specific gene promoter<\/strong><\/p>\n

\u3000\u3000Namihira M., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000FEBS Lett,<\/em>\u00a0572, 184-188, 2004<\/p>\n

Treatment of spinal cord injury by transplantation of fetal neural precursor cells engineered to express BMP inhibitor<\/strong><\/p>\n

\u3000\u3000Setoguchi T., Nakashima K., Takizawa T., Yanagisawa M., Ochiai W., Okabe M., Yone K., Komiya S. & Taga T.<\/p>\n

\u3000\u3000Exp Neurol,\u00a0<\/em>189, 33-44, 2004<\/p>\n

Expression and function of orphan nuclear receptor TLX in adult neural stem cells<\/strong><\/p>\n

\u3000\u3000Shi Y., Chichung Lie D., Taupin P., Nakashima K., Ray J., Yu R.T., Gage F.H. & Evans R.M.<\/p>\n

\u3000\u3000Nature,<\/em>\u00a0427, 78-83, 2004<\/p>\n

Cell fusion-independent differentiation of neural stem cells to the endothelial lineage<\/strong><\/p>\n

\u3000\u3000Wurmser A.E., Nakashima K., Summers R.G., Toni N., D\u2019Amour K.A., Lie D.C. & Gage F.H.<\/p>\n

\u3000\u3000Nature,<\/em>\u00a0430, 350-356, 2004<\/p>\n

2003\u5e74<\/h4>\n

Interisland evolution of Trimeresurus flavoviridis venom phospholipase A2<\/sub>\u00a0isozymes<\/strong><\/p>\n

\u3000\u3000Chijiwa T., Yamaguchi Y., Ogawa T., Deshimaru M., Nobuhisa I., Nakashima K., Oda-Ueda N., Fukumaki Y., Hattori S. & Ohno M.<\/p>\n

\u3000\u3000J Mol Evol,\u00a0<\/em>56, 286-293, 2003<\/p>\n

Involvement of Oct3\/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures<\/strong><\/p>\n

\u3000\u3000Shimozaki K., Nakashima K., Niwa H. & Taga T.<\/p>\n

\u3000\u3000Development,<\/em>\u00a0130, 2505-2512, 2003<\/p>\n

Requirement of gp130 signaling for the AGM hematopoiesis<\/strong><\/p>\n

\u3000\u3000Takizawa M., Nobuhisa I., Igarashi K., Ueno M., Nakashima K., Kitamura T. & Taga T.<\/p>\n

\u3000\u3000Exp Hematol,<\/em>\u00a031, 283-289, 2003<\/p>\n

Enhanced gene activation by Notch and BMP signaling cross-talk<\/strong><\/p>\n

\u3000\u3000Takizawa T., Ochiai W., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000Nucleic Acids Res,<\/em>\u00a031, 5723-5731, 2003<\/p>\n

Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function<\/strong><\/p>\n

\u3000\u3000Zhao X., Ueba T., Christie B.R., Barkho B., McConnell M.J., Nakashima K., Lein E.S., Eadie B.D., Willhoite A.R., Muotri A.R., Summers R.G., Chun J., Lee K.F. & Gage F.H.<\/p>\n

\u3000\u3000Proc Natl Acad Sci USA,<\/em>\u00a0100, 6777-6782, 2003<\/p>\n

2002\u5e74<\/h4>\n

The Role of gp130 in Cerebral Cortical Development: In Vivo Functional Analysis in a Mouse Exo Utero System<\/strong><\/p>\n

\u3000\u3000Hatta T., Moriyama K., Nakashima K., Taga T. & Otani H.<\/p>\n

\u3000\u3000J Neurosci,\u00a0<\/em>22, 5516-5524, 2002<\/p>\n

Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues<\/strong><\/p>\n

\u3000\u3000Kimura N., Takizawa M., Okita K., Natori O., Igarashi K., Ueno M., Nakashima K., Nobuhisa I. & Taga T.<\/p>\n

\u3000\u3000Genes Cells,\u00a0<\/em>7, 435-446, 2002<\/p>\n

Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of stat3<\/strong><\/p>\n

\u3000\u3000Uemura A., Takizawa T., Ochiai W., Yanagisawa M., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000Cytokine,<\/em>\u00a018, 1-7, 2002<\/p>\n

2001\u5e74<\/h4>\n

Ligand recognition by the vitamin D receptor.<\/strong><\/p>\n

\u3000\u3000Choi M., Yamamoto K., Masuno H., Nakashima K., Taga T. & Yamada S.<\/p>\n

\u3000\u3000Bioorg Med Chem,\u00a0<\/em>9, 1721-1730, 2001<\/p>\n

Brain from bone: efficient \u201cmeta-differentiation\u201d of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent<\/strong><\/p>\n

\u3000\u3000Kohyama J., Abe H., Shimazaki T., Koizumi A., Nakashima K., Gojo S., Taga T., Okano H., Hata J. & Umezawa A.<\/p>\n

\u3000\u3000Differentiation,<\/em>\u00a068, 235-244, 2001<\/p>\n

A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody<\/strong><\/p>\n

\u3000\u3000Matsuo R., Ochiai W., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000J Immunol Methods,<\/em>\u00a0247, 141-151, 2001<\/p>\n

BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis<\/strong><\/p>\n

\u3000\u3000Nakashima K., Takizawa T., Ochiai W., Yanagisawa M., Hisatsune T., Nakafuku M., Miyazono K., Kishimoto T., Kageyama R. & Taga T.<\/p>\n

\u3000\u3000Proc Natl Acad Sci USA,\u00a0<\/em>98, 5868-5873, 2001<\/p>\n

Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3<\/strong><\/p>\n

\u3000\u3000Ochiai W., Yanagisawa M., Takizawa T., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000Cytokine,<\/em>\u00a014, 264-271, 2001<\/p>\n

Traumatic injury-induced BMP7 expression in the adult rat spinal cord<\/strong><\/p>\n

\u3000\u3000Setoguchi T., Yone K., Matsuoka E., Takenouchi H., Nakashima K., Sakou T., Komiya S. & Izumo S<\/p>\n

\u3000\u3000Brain Res,<\/em>\u00a0921, 219-225, 2001.<\/p>\n

DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain<\/strong><\/p>\n

\u3000\u3000Takizawa T., Nakashima K., Namihira M., Ochiai W., Uemura A., Yanagisawa M., Fujita N., Nakao M. & Taga T<\/p>\n

\u3000\u3000Dev Cell,\u00a0<\/em>1, 749-758, 2001.<\/p>\n

Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3<\/strong><\/p>\n

\u3000\u3000Takizawa T., Yanagisawa M., Ochiai W., Yasukawa K., Ishiguro T., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000Cytokine,<\/em>\u00a013, 272-279, 2001<\/p>\n

Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion<\/strong><\/p>\n

\u3000\u3000Ueno M., Igarashi K., Kimura N., Okita K., Takizawa M., Nobuhisa I., Kojima T., Kitamura T., Samulowitz U., Vestweber D., Shimomura T., Suda T., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000Biochem Biophys Res Commun,\u00a0<\/em>287, 501-506, 2001<\/p>\n

Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7<\/strong><\/p>\n

\u3000\u3000Yanagisawa M., Nakashima K., Takeda K., Ochiai W., Takizawa T., Ueno M., Takizawa M., Shibuya H. & Taga T.<\/p>\n

\u3000\u3000Genes Cells,<\/em>\u00a06, 1091-1099, 2001<\/p>\n

Signaling crosstalk underlying synergistic induction of astrocyte differentiation by BMPs and IL-6 family of cytokines<\/strong><\/p>\n

\u3000\u3000Yanagisawa M., Nakashima K., Takizawa T., Ochiai W., Arakawa H. & Taga T.<\/p>\n

\u3000\u3000FEBS Lett,<\/em>\u00a0489, 139-143, 2001<\/p>\n

Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins<\/strong><\/p>\n

\u3000\u3000Yanagisawa M., Takizawa T., Ochiai W., Uemura A., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000Neurosci Res,<\/em>\u00a041, 391-396, 2001<\/p>\n

2000\u5e74<\/h4>\n

Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan<\/strong><\/p>\n

\u3000\u3000Chijiwa T., Deshimaru M., Nobuhisa I., Nakai M., Ogawa T., Oda N., Nakashima K., Fukumaki Y., Shimohigashi Y., Hattori S. & Ohno M.<\/p>\n

\u3000\u3000Biochem J,\u00a0<\/em>347, 491-499, 2000<\/p>\n

Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons<\/strong><\/p>\n

\u3000\u3000Kato H., Chen S., Kiyama H., Ikeda K., Kimura N., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000\u00a0J Biochem,\u00a0<\/em>128, 923-932, 2000<\/p>\n

BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6<\/strong><\/p>\n

\u3000\u3000Kimura N., Matsuo R., Shibuya H., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000J Biol Chem,<\/em>\u00a0275, 17647-17652, 2000<\/p>\n

Cell density-dependent regulation of hepatic development by a gp130-independent pathway<\/strong><\/p>\n

\u3000\u3000Kojima N., Kinoshita T., Kamiya A., Nakamura K., Nakashima K., Taga T., Miyajima A..<\/p>\n

\u3000\u3000Biochem Biophys Res Commun,<\/em>\u00a0277, 152-158, 2000<\/p>\n

Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1<\/strong><\/p>\n

\u3000\u3000Ueno M., Kimura N., Nakashima K., Saito-Ohara F., Inazawa J. & Taga T.<\/p>\n

\u3000\u3000Gene,<\/em>\u00a0254, 29-35, 2000<\/p>\n

Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain<\/strong><\/p>\n

\u3000\u3000Yamamoto K., Masuno H., Choi M., Nakashima K., Taga T., Ooizumi H., Umesono K., Sicinska W., VanHooke J., DeLuca H.F. & Yamada S.<\/p>\n

\u3000\u3000Proc Natl Acad Sci USA,<\/em>\u00a097, 1467-1472, 2000<\/p>\n

Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3<\/strong><\/p>\n

\u3000\u3000Yanagisawa M., Nakashima K., Arakawa H., Ikenaka K., Yoshida K., Kishimoto T., Hisatsune T. & Taga T.<\/p>\n

\u3000\u3000J Neurochem,<\/em>\u00a074, 1498-1504, 2000<\/p>\n

1999\u5e74<\/h4>\n

Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer.<\/strong><\/p>\n

\u3000\u3000Kamiya A., Kinoshita T., Ito Y., Matsui T., Morikawa Y., Senba E., Nakashima K., Taga T., Yoshida K., Kishimoto T. & Miyajima A.<\/p>\n

\u3000\u3000EMBO J,\u00a0<\/em>18, 2127-2136, 1999<\/p>\n

A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain<\/strong><\/p>\n

\u3000\u3000Kimura N., Nakashima K., Ueno M., Kiyama H. & Taga T.<\/p>\n

\u3000\u3000Brain Res Dev Brain Res,<\/em>\u00a0115, 183-193, 1999<\/p>\n

A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains<\/strong><\/p>\n

\u3000\u3000Kimura N., Ueno M., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000J Biochem,<\/em>\u00a0126, 180-187, 1999<\/p>\n

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300<\/strong><\/p>\n

\u3000\u3000Nakashima K., Yanagisawa M., Arakawa H., Kimura N., Hisatsune T., Kawabata M., Miyazono K. & Taga T.<\/p>\n

\u3000\u3000Science,<\/em>\u00a0284, 479-482, 1999<\/p>\n

Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation<\/strong><\/p>\n

\u3000\u3000Nakashima K., Wiese S., Yanagisawa M., Arakawa H., Kimura N., Hisatsune T., Yoshida K., Kishimoto T., Sendtner M. & Taga T.<\/p>\n

\u3000\u3000J Neurosci,<\/em>\u00a019, 5429-5434, 1999<\/p>\n

Astrocyte differentiation mediated by LIF in cooperation with BMP2<\/strong><\/p>\n

\u3000\u3000Nakashima K., Yanagisawa M., Arakawa H. & Taga T.<\/p>\n

\u3000\u3000FEBS Lett,\u00a0<\/em>457, 43-46, 1999<\/p>\n

STAT3-mediated astrocyte differentiation from mouse fetal neuroepithelial cells by mouse oncostatin M<\/strong><\/p>\n

\u3000\u3000Yanagisawa M., Nakashima K. & Taga T.<\/p>\n

\u3000\u3000Neurosci Lett,<\/em>\u00a0269, 169-172, 1999<\/p>\n

1998\u5e74<\/h4>\n

Molecular cloning of mouse choline kinase and choline\/ethanolamine kinase: their sequence comparison to the respective rat homologs<\/strong><\/p>\n

\u3000\u3000Aoyama C., Nakashima K. & Ishidate K.<\/p>\n

\u3000\u3000Biochim Biophys Acta,<\/em>\u00a01393, 179-185, 1998<\/p>\n

Complementary DNA sequence for a 42 kDa rat kidney choline\/ethanolamine kinase<\/strong><\/p>\n

\u3000\u3000Aoyama C., Nakashima K., Matsui M. & Ishidate K.<\/p>\n

\u3000\u3000Biochim Biophys Acta,<\/em>\u00a01390, 1-7, 1998<\/p>\n

Retrotransposable CR1-like elements in crotalinae snake genomes<\/strong><\/p>\n

\u3000\u3000Nobuhisa I., Ogawa T., Deshimaru M., Chijiwa T., Nakashima K.I., Chuman Y., Shimohigashi Y., Fukumaki Y., Hattori S. & Ohno M.<\/p>\n

\u3000\u3000Toxicon,<\/em>\u00a036, 915-920, 1998<\/p>\n

1997\u5e74<\/h4>\n

Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130<\/strong><\/p>\n

\u3000\u3000Nakashima K., Narazaki M. & Taga T.<\/p>\n

\u3000\u3000FEBS Lett,<\/em>\u00a0403, 79-82, 1997<\/p>\n

Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130<\/strong><\/p>\n

\u3000\u3000Nakashima K., Narazaki M. & Taga T.<\/p>\n

\u3000\u3000FEBS Lett,<\/em>\u00a0401, 49-52, 1997<\/p>\n

Structures of genes encoding phospholipase A2 inhibitors from the serum of Trimeresurus flavoviridis snake<\/strong><\/p>\n

\u3000\u3000Nobuhisa I., Deshimaru M., Chijiwa T., Nakashima K., Ogawa T., Shimohigashi Y., Fukumaki Y., Hattori S., Kihara H. & Ohno M.<\/p>\n

\u3000\u3000Gene,<\/em>\u00a0191, 31-37, 1997<\/p>\n

1996\u5e74<\/h4>\n

Accelerated evolution of crotalinae snake venom gland serine proteases<\/strong><\/p>\n

\u3000\u3000Deshimaru M., Ogawa T., Nakashima K., Nobuhisa I., Chijiwa T., Shimohigashi Y., Fukumaki Y., Niwa M., Yamashina I., Hattori S. & Ohno M.<\/p>\n

\u3000\u3000FEBS Lett,<\/em>\u00a0397, 83-88, 1996<\/p>\n

Roles of lysine-69 in dimerization and activity of Trimeresurus flavoviridis venom aspartate-49-phospholipase A2<\/strong><\/p>\n

\u3000\u3000Nakamura S., Nakai M., Nakashima K., Ogawa T., Shimohigashi Y., Ohno M., Kihara H., Yamane T. & Ashida T.<\/p>\n

\u3000\u3000J Mol Recognit,<\/em>\u00a09, 23-30, 1996<\/p>\n

Accelerated evolution of Trimeresurus okinavensis venom gland phospholipase A2 isozyme-encoding genes<\/strong><\/p>\n

\u3000\u3000Nobuhisa I., Nakashima K., Deshimaru M., Ogawa T., Shimohigashi Y., Fukumaki Y., Sakaki Y., Hattori S., Kihara H. & Ohno M.<\/p>\n

\u3000\u3000Gene,<\/em>\u00a0172, 267-272, 1996<\/p>\n

Accelerated evolution of snake venom phospholipase A2 isozymes for acquisition of diverse physiological functions<\/strong><\/p>\n

\u3000\u3000Ogawa T., Nakashima K., Nobuhisa I., Deshimaru M., Shimohigashi Y., Fukumaki Y., Sakaki Y., Hattori S. & Ohno M.<\/p>\n

\u3000\u3000Toxicon,<\/em>\u00a034, 1229-1236, 1996<\/p>\n

1995\u5e74<\/h4>\n

Purification and primary structure of a myotoxic lysine-49 phospholipase A2 with low lipolytic activity from Trimeresurus gramineus venom<\/strong><\/p>\n

\u3000\u3000Nakai M., Nakashima K.I., Ogawa T., Shimohigashi Y., Hattori S., Chang C.C. & Ohno M.<\/p>\n

\u3000\u3000Toxicon,<\/em>\u00a033, 1469-1478, 1995<\/p>\n

Accelerated evolution in the protein-coding regions is universal in crotalinae snake venom gland phospholipase A2 isozyme genes<\/strong><\/p>\n

\u3000\u3000Nakashima K., Nobuhisa I., Deshimaru M., Nakai M., Ogawa T., Shimohigashi Y., Fukumaki Y., Hattori M., Sakaki Y., Hattori S. & Ohno M.<\/p>\n

\u3000\u3000Proc Natl Acad Sci USA,<\/em>\u00a092, 5605-5609, 1995<\/p>\n

Structures of genes encoding TATA box-binding proteins from Trimeresurus gramineus and T. flavoviridis snakes<\/strong><\/p>\n

\u3000\u3000Nakashima K., Nobuhisa I., Deshimaru M., Ogawa T., Shimohigashi Y., Fukumaki Y., Hattori M., Sakaki Y., Hattori S. & Ohno M.<\/p>\n

\u3000\u3000Gene,<\/em>\u00a0152, 209-213, 1995<\/p>\n

Molecular evolution of group II phospholipases A2<\/strong><\/p>\n

\u3000\u3000Ogawa T., Kitajima M., Nakashima K., Sakaki Y. & Ohno M.<\/p>\n

\u3000\u3000J Mol Evol,<\/em>\u00a041, 867-877, 1995<\/p>\n

Trimeresurus flavoviridis venom gland phospholipase A2 isozymes genes have evolved via accelerated substitutions<\/strong><\/p>\n

\u3000\u3000Ogawa T., Nakashima K., Oda N., Shimohigashi Y., Ohno M., Hattori S., Hattori M., Sakaki Y. & Kihara H.<\/p>\n

\u3000\u3000J Mol Recognit,<\/em>\u00a08, 40-46 1995<\/p>\n

Lysine-49-Phospholipase A2 from Trimeresurus flavoviridis venom are membrane-acting enzymes<\/strong><\/p>\n

\u3000\u3000Shimohigashi Y., Tani A., Matsumoto H., Nakashima K., Yamaguchi Y., Oda N., Takano Y., Kamiya H., Kishino J., Arita H. & Ohno M.<\/p>\n

\u3000\u3000J Biochem,<\/em>\u00a0118, 1037-1044, 1995<\/p>\n

1994\u5e74<\/h4>\n

Polymorphisms of Trimeresurus flavoviridis venom gland phospholipase A2 isozyme genes<\/strong><\/p>\n

\u3000\u3000Nakashima K., Nobuhisa I., Ogawa T., Hattori M., Sakaki Y., Kihara H. & Ohno M<\/p>\n

\u3000\u3000Biosci Biotechnol Biochem,<\/em>\u00a058, 1510-1511, 1994.<\/p>\n

Darwinian evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes<\/strong><\/p>\n

\u3000\u3000Nakashima K., Ogawa T., Oda N., Shimohigashi Y., Hattori M., Sakaki Y., Kihara H. & Ohno M.<\/p>\n

\u3000\u3000Pure & Appl Chem,<\/em>\u00a066, 715-720, 1994<\/p>\n

1993\u5e74<\/h4>\n

Purification, sequencing and characterization of single amino acid-substituted phospholipase A2 isozymes from Trimeresurus gramineus (green habu snake) venom<\/strong><\/p>\n

\u3000\u3000Fukagawa T., Nose T., Shimohigashi Y., Ogawa T., Oda N., Nakashima K., Chang C.C. & Ohno M.<\/p>\n

\u3000\u3000Toxicon,<\/em>\u00a031, 957-967, 1993<\/p>\n

Accelerated evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes<\/strong><\/p>\n

\u3000\u3000Nakashima K., Ogawa T., Oda N., Hattori M., Sakaki Y., Kihara H. & Ohno M.<\/p>\n

\u3000\u3000Proc Natl Acad Sci USA,<\/em>\u00a090, 5964-5968, 1993<\/p>\n

Chymotrypsin inhibitory conformation of dipeptides constructed by side chain-side chain hydrophobic interactions<\/strong><\/p>\n

\u3000\u3000Sakamoto H., Shimohigashi Y., Maeda I., Nose T., Nakashima K., Nakamura I., Ogawa T., Kawano K. & Ohno M.<\/p>\n

\u3000\u3000Mol Recognit,<\/em>\u00a06, 95-100, 1993<\/p>\n

1992\u5e74<\/h4>\n

Refolding of Trimeresurus flavoviridis phospholipase A2<\/strong><\/p>\n

\u3000\u3000Tsuno S., Ogawa T., Nakashima K., Oda N., Lee S., Shimohigashi Y., Aoyagi H. & Ohno M.<\/p>\n

\u3000\u3000Bull Chem Soc Jpn,<\/em>\u00a065, 2655-2659 1992<\/p>\n

Unusually high conservation of untranslated sequences in cDNAs for Trimeresurus flavoviridis phospholipase A2 isozymes<\/strong><\/p>\n

\u3000\u3000Ogawa T., Oda N., Nakashima K., Sasaki H., Hattori M., Sakaki Y., Kihara H. & Ohno M.<\/p>\n

\u3000\u3000Proc Natl Acad Sci USA,<\/em>\u00a089, 8557-8561, 1992<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

2026\u5e74 Histone methyltransferase Setd8 preserves chromatin accessibility to safeguard retinal progenitor cell i…\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-860","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/pages\/860","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/comments?post=860"}],"version-history":[{"count":156,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/pages\/860\/revisions"}],"predecessor-version":[{"id":2435,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/pages\/860\/revisions\/2435"}],"wp:attachment":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/scb\/wp-json\/wp\/v2\/media?parent=860"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}