Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice
Miyauchi H, Ohta H, Nagaoka S, Nakaki F, Sasaki K, Hayashi K, Yabuta Y, Nakamura T, Yamamoto T, Saitou M. EMBO J. 2017 Nov 2;36(21):3100-3119. doi: 10.15252/embj.201796875. Epub 2017 Sep 19.
Reconstitution of mouse oogenesis in a dish from pluripotent stem cells
Hayashi K, Hikabe O, Obata Y, Hirao Y. Nat Protoc. 2017 Sep;12(9):1733-1744. doi: 10.1038/nprot.2017.070. Epub 2017 Aug 10.
Detection of Bidirectional Promoter-Derived lncRNAs from Small-Scale Samples Using Pre-Amplification-Free Directional RNA-seq Method
Hamazaki N, Nakashima K, Hayashi K, Imamura T. Methods Mol Biol. 2017;1605:83-103. doi: 10.1007/978-1-4939-6988-3_6.
PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes
Endoh M, Endo TA, Shinga J, Hayashi K, Farcas A, Ma KW, Ito S, Sharif J, Endoh T, Onaga N, Nakayama M, Ishikura T, Masui O, Kessler BM, Suda T, Ohara O, Okuda A, Klose R, Koseki H. Elife. 2017 Mar 17;6:e21064. doi: 10.7554/eLife.21064.
Software updates in the Illumina HiSeq platform affect whole-genome bisulfite sequencing
Toh H, Shirane K, Miura F, Kubo N, Ichiyanagi K, Hayashi K, Saitou M, Suyama M, Ito T, Sasaki H. BMC Genomics. 2017 Jan 5;18(1):31. doi: 10.1186/s12864-016-3392-9.
In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells
Ishikura Y, Yabuta Y, Ohta H, Hayashi K, Nakamura T, Okamoto I, Yamamoto T, Kurimoto K, Shirane K, Sasaki H, Saitou M. Cell Rep. 2016 Dec 6;17(10):2789-2804. doi: 10.1016/j.celrep.2016.11.026.
Reconstitution in vitro of the entire cycle of the mouse female germ line
Hikabe O, Hamazaki N, Nagamatsu G, Obata Y, Hirao Y, Hamada N, Shimamoto S, Imamura T, Nakashima K, Saitou M, Hayashi K.
Nature. 2016 Nov 10;539(7628):299-303. doi: 10.1038/nature20104. Epub 2016 Oct 17.
Complete in vitro generation of fertile oocytes from mouse primordial germ cells
Shirane K, Kurimoto K, Yabuta Y, Yamaji M, Satoh J, Ito S, Watanabe A, Hayashi K, Saitou M, Sasaki H
Dev Cell. 2016 Oct 10;39(1):87-103. doi: 10.1016/j.devcel.2016.08.008. Epub 2016 Sep 15.
PMID: 27642137
Complete in vitro generation of fertile oocytes from mouse primordial germ cells
Morohaku K, Tanimoto R, Sasaki K, Kawahara-Miki R, Kono T, Hayashi K, Hirao Y, Obata Y.
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9021-6. doi: 10.1073/pnas.1603817113. Epub 2016 Jul 25.
Rewinding the process of mammalian extinction
Saragusty J, Diecke S, Drukker M, Durrant B, Friedrich Ben-Nun I, Galli C, Göritz F, Hayashi K, Hermes R, Holtze S, Johnson S, Lazzari G, Loi P, Loring JF, Okita K, Renfree MB, Seet S, Voracek T, Stejskal J, Ryder OA, Hildebrandt TB.
Angiogenesis in the developing spinal cord: blood vessel exclusion from neural progenitor region is mediated by VEGF and its antagonists.
Takahashi T., Takase Y., Yoshino T., Saito D., Tadokoro R. & Takahashi Y.
PLoS One 10 (1):e0116119 (2015)
Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells.
Kurimoto K, Yabuta Y, Hayashi K, Ohta H, Kiyonari H, Mitani T, Moritoki Y, Kohri K, Kimura H, Yamamoto T, Katou Y, Shirahige K, Saitou M.
Cell Stem Cell. 2015; 16, 517-532.
Perspectives of germ cell development in vitro in mammals.
Hayashi K,Saitou M
Anim Sci J. 2014; 85: 617-26.
Induction of Primordial Germ Cell-Like Cells from Mouse Embryonic Stem Cells by ERK Signal Inhibition.
Kimura T, Kaga Y, Ohta H, Odamoto M, Sekita Y, Li K, Yamano N, Fujikawa K, Isotani A, Sasaki N, Toyoda M, Hayashi K, Okabe M, Shinohara T, Saitou M, Nakano T.
Stem Cells. 2014l Jul 3. Online.
Interepithelial signaling with nephric duct is required for the formation of overlying coelomic epithelial cell sheet.
Yoshino T., Saito D., Atsuta U., 以下３名省略, & Takahashi Y.
Proc. Natl. Acad. Sci.USA 111(18):6660-6665 (2014)
2013年以前
A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants.
Aramaki S, Hayashi K, Kurimoto K, Ohta H, Yabuta Y, Iwanari H, Mochizuki Y, Hamakubo T, Kato Y, Shirahige K, Saitou M.
Dev Cell. 2013; 27: 516-529.
Tsix RNA and the Germline Factor, PRDM14, Link X Reactivation and Stem Cell Reprogramming.
Payer B, Rosenberg M, Yamaji M, Yabuta Y, Koyanagi-Aoi M, Hayashi K, Yamanaka S, Saitou M, Lee JT.
Mol Cell. 2013; 52: 805-818.
Stepwise differentiation from naïve state pluripotent stem cells to functional primordial germ cells through an epiblast-like state.
Hayashi K, Saitou M.
Methods Mol Biol. 2013; 1074: 175-183.
Induction of the mouse germ-cell fate by transcription factors in vitro.
Nakaki F, Hayashi K, Ohta H, Kurimoto K, Yabuta Y, Saitou M.
Nature 2013; 501: 222-226.
Generation of eggs from mouse embryonic stem cells and induced pluripotent stem cells.
Hayashi K and Saitou M.
Nature Protoc. 2013; 8: 1513-1524.
PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells.
Yamaji M, Ueda J, Hayashi K, Ohta H, Yabuta Y, Kurimoto K, Nakato R, Yamada Y, Shirahige K, Saitou M.
Cell Stem Cell. 2013; 12 : 368-382.
Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice.
Dual function for the adaptor MIST in IFN-gamma production by NK and CD4(+)NKT cells regulated by the Src kinase Fgr.
Sasanuma H, Tatsuno A, Hidano S, Ohshima K, Matsuzaki Y, Hayashi K, Lowell CA, Kitamura D, Goitsuka R.
Blood. 2006; 107: 3647-3655.
A Histone H3 methyltransferase controls epigenetic events required for meiotic prophase.
Hayashi K, Yoshida K, Matsui Y.
Nature. 2005; 438: 374-378.
Expression of Cre recombinase in the mouse developing chondrocytes driven by the mouse α2(XI) collagen promoter.
Fujimaki R, Hayashi K, Watanabe N, Yamada T, Toyama Y, Tezuka, K and Hozumi N.
J Bone Miner Metab 2005; 23: 270-273.
Mouse epiblasts change responsiveness to BMP4 signal required for PGC formation through functions of extraembryonic ectoderm.
Okamura D, Hayashi K, Matsui Y.
Mol Reprod Dev. 2005; 70: 20-29.
Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice.
Seki Y, Hayashi K, Itoh K, Mizugaki M, Saitou M, Matsui Y.
Dev Biol. 2005; 278: 440-458.
Impaired Receptor Editing in the Primary B Cell Repertoire of BASH-Deficient Mice.
Hayashi K, Nojima T, Goitsuka R and Kitamura D.
J Immunol. 2004; 173: 5980-5988.
IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiation.
Seki N, Miyazaki M, Suzuki W, Hayashi K, Arima K, Myburgh E, Izuhara K, Brombacher F, Kubo M.
J Immunol. 2004; 172: 6158-6166.
BASH-deficient mice: limited primary repertoire and antibody formation, but sufficient affinity maturation and memory B cell generation, in anti-NP response.
Yamamoto M, Nojima, T, Hayashi K, Goitsuka R, Furukawa K, Azuma T, Kitamura D.
Int Immunol. 2004; 16: 1161-1171.
Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors.
Hayashi K., Yamamoto M., Nojima T., Goitsuka R., Kitamura D.
Immunity 2003; 18: 825-836.
Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK.
Johmura S, Oh-hora M, Inabe K, Nishikawa Y, Hayashi K, Vigorito E, Kitamura D, Turner M, Shingu K, Hikida M, Kurosaki T.
Immunity 2003; 18: 777-787.
SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.
Seki Y, Inoue H, Nagata N, Hayashi K, Fukuyama S, Matsumoto K, Komine O, Hamano S, Himeno K, Inagaki-Ohara K, Cacalano N, O’Garra A, Oshida T, Saito H, Johnston JA, Yoshimura A, Kubo M.
Nature Med. 2003; 9: 1047-1054.
A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production.
Matsumoto A, Seki Y, Watanabe R, Hayashi K, Johnston JA, Harada Y, Abe R, Yoshimura A, Kubo M.
J Exp Med 2003; 197: 425-436.
SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast.
Hayashi K, Kobayashi T, Umino T, Goitsuka R, Matsui Y, Kitamura D.
Mech Dev. 2002; 118: 99-109.
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.
Seki Y, Hayashi K, Matsumoto A, Seki N, Tsukada J, Ransom J, Naka T, Kishimoto T, Yoshimura A, Kubo M.
PNAS. 2002; 99: 13003-13008.
Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo.
Harada Y, Tokushima M, Matsumoto Y, Ogawa S, Otsuka M, Hayashi K, Weiss BD, June CH, Abe R.
J Immunol. 2001; 166: 3797-3803.
A Pivotal Role for DNase I-Sensitive Regions 3b and/or 4 in the Induction of Somatic Hypermutation of IgH Genes.
Terauchi A, Hayashi K, Kitamura D, Kozono Y, Motoyama N, Azuma T.
J Immunol. 2001; 167: 811-820.
A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation.
Goitsuka R, Kanazashi H, Sasanuma H, Fujimura Yi, Hidaka Y, Tatsuno A, Ra C, Hayashi K, Kitamura D.
Int Immunol. 2000; 12: 573-580.
The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells.
Hayashi K, Nittono R, Okamoto N, Tsuji S, Hara Y, Goitsuka R, Kitamura D.
論文
2018年～
Dual role of Ovol2 on the germ cell lineage segregation during gastrulation in mouse embryogenesis
Yuki Naitou, Go Nagamatsu, Nobuhiko Hamazaki, Kenjiro Shirane, Masafumi Hayashi, Makoto Hayashi, Satoru Kobayashi, Katsuhiko Hayashi
Development. 2022 Jan 14;dev.200319. doi: 10.1242/dev.200319. Online ahead of print.
Generation of ovarian follicles from mouse pluripotent stem cells
Takashi Yoshino, Takahiro Suzuki, Go Nagamatsu, Haruka Yabukami, Mika Ikegaya, Mami Kishima, Haruka Kita, Takuya Imamura, Kinichi Nakashima, Ryuichi Nishinakamura, Makoto Tachibana, Miki Inoue, Yuichi Shima, Ken-ichirou Morohashi, Katsuhiko Hayashi
Science 16 Jul 2021:Vol. 373, Issue 6552, eabe0237 DOI: 10.1126/science.abe0237
Reconstitution of the oocyte transcriptional network with transcription factors
Hamazaki N, Kyogoku H, Araki H, Miura F, Horikawa C, Hamada N, Shimamoto S, Hikabe O, Nakashima K, Kitajima TS, Ito T, Leitch HG, Hayashi K.
Nature. 2021 Jan;589(7841):264-269. doi: 10.1038/s41586-020-3027-9. Epub 2020 Dec 16.
Germ cell-intrinsic effects of sex chromosomes on early oocyte differentiation in mice.
Hamada N, Hamazaki N, Shimamoto S, Hikabe O, Nagamatsu G, Takada Y, Kato K, Hayashi K.
PLoS Genet. 2020 Mar 26;16(3):e1008676. doi: 10.1371/journal.pgen.1008676. eCollection 2020 Mar.
Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells
Terada M, Kawamata M, Kimura R, Sekiya S, Nagamatsu G, Hayashi K, Horisawa K, Suzuki A.
Genesis. 2019 Nov;57(11-12):e23334. doi: 10.1002/dvg.23334. Epub 2019 Sep 12.PMID: 31513343
Mechanical stress accompanied with nuclear rotation is involved in the dormant state of mouse oocytes.
Nagamatsu G, Shimamoto S, Hamazaki N, Nishimura Y, Hayashi K.
Sci Adv. 2019 Jun 26;5(6):eaav9960. doi: 10.1126/sciadv.aav9960. eCollection 2019 Jun.
Hypoxia induces the dormant state in oocytes through expression of Foxo3.
Shimamoto S, Nishimura Y, Nagamatsu G, Hamada N, Kita H, Hikabe O, Hamazaki N, Hayashi K.
Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12321-12326. doi: 10.1073/pnas.1817223116. Epub 2019 May 30.
Embryos and embryonic stem cells from the white rhinoceros.
Hildebrandt TB, Hermes R, Colleoni S, Diecke S, Holtze S, Renfree MB, Stejskal J, Hayashi K, Drukker M, Loi P, Goritz F, Lazzari G, Galli C.
Nat Commun. 2018 Jul 4;9(1):2589. doi: 10.1038/s41467-018-04959-2.
2014～2017年
Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice
Miyauchi H, Ohta H, Nagaoka S, Nakaki F, Sasaki K, Hayashi K, Yabuta Y, Nakamura T, Yamamoto T, Saitou M.
EMBO J. 2017 Nov 2;36(21):3100-3119. doi: 10.15252/embj.201796875. Epub 2017 Sep 19.
Reconstitution of mouse oogenesis in a dish from pluripotent stem cells
Hayashi K, Hikabe O, Obata Y, Hirao Y.
Nat Protoc. 2017 Sep;12(9):1733-1744. doi: 10.1038/nprot.2017.070. Epub 2017 Aug 10.
Detection of Bidirectional Promoter-Derived lncRNAs from Small-Scale Samples Using Pre-Amplification-Free Directional RNA-seq Method
Hamazaki N, Nakashima K, Hayashi K, Imamura T.
Methods Mol Biol. 2017;1605:83-103. doi: 10.1007/978-1-4939-6988-3_6.
PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes
Endoh M, Endo TA, Shinga J, Hayashi K, Farcas A, Ma KW, Ito S, Sharif J, Endoh T, Onaga N, Nakayama M, Ishikura T, Masui O, Kessler BM, Suda T, Ohara O, Okuda A, Klose R, Koseki H.
Elife. 2017 Mar 17;6:e21064. doi: 10.7554/eLife.21064.
Software updates in the Illumina HiSeq platform affect whole-genome bisulfite sequencing
Toh H, Shirane K, Miura F, Kubo N, Ichiyanagi K, Hayashi K, Saitou M, Suyama M, Ito T, Sasaki H.
BMC Genomics. 2017 Jan 5;18(1):31. doi: 10.1186/s12864-016-3392-9.
In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells
Ishikura Y, Yabuta Y, Ohta H, Hayashi K, Nakamura T, Okamoto I, Yamamoto T, Kurimoto K, Shirane K, Sasaki H, Saitou M.
Cell Rep. 2016 Dec 6;17(10):2789-2804. doi: 10.1016/j.celrep.2016.11.026.
Reconstitution in vitro of the entire cycle of the mouse female germ line
Hikabe O, Hamazaki N, Nagamatsu G, Obata Y, Hirao Y, Hamada N, Shimamoto S, Imamura T, Nakashima K, Saitou M, Hayashi K.
Nature. 2016 Nov 10;539(7628):299-303. doi: 10.1038/nature20104. Epub 2016 Oct 17.
Complete in vitro generation of fertile oocytes from mouse primordial germ cells
Shirane K, Kurimoto K, Yabuta Y, Yamaji M, Satoh J, Ito S, Watanabe A, Hayashi K, Saitou M, Sasaki H
Dev Cell. 2016 Oct 10;39(1):87-103. doi: 10.1016/j.devcel.2016.08.008. Epub 2016 Sep 15.
PMID: 27642137
Complete in vitro generation of fertile oocytes from mouse primordial germ cells
Morohaku K, Tanimoto R, Sasaki K, Kawahara-Miki R, Kono T, Hayashi K, Hirao Y, Obata Y.
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9021-6. doi: 10.1073/pnas.1603817113. Epub 2016 Jul 25.
Rewinding the process of mammalian extinction
Saragusty J, Diecke S, Drukker M, Durrant B, Friedrich Ben-Nun I, Galli C, Göritz F, Hayashi K, Hermes R, Holtze S, Johnson S, Lazzari G, Loi P, Loring JF, Okita K, Renfree MB, Seet S, Voracek T, Stejskal J, Ryder OA, Hildebrandt TB.
Zoo Biol. 2016 Jul;35(4):280-92. doi: 10.1002/zoo.21284. Epub 2016 May 3.PMID: 27142508
Angiogenesis in the developing spinal cord: blood vessel exclusion from neural progenitor region is mediated by VEGF and its antagonists.
Takahashi T., Takase Y., Yoshino T., Saito D., Tadokoro R. & Takahashi Y.
PLoS One 10 (1):e0116119 (2015)
Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells.
Kurimoto K, Yabuta Y, Hayashi K, Ohta H, Kiyonari H, Mitani T, Moritoki Y, Kohri K, Kimura H, Yamamoto T, Katou Y, Shirahige K, Saitou M.
Cell Stem Cell. 2015; 16, 517-532.
Perspectives of germ cell development in vitro in mammals.
Hayashi K,Saitou M
Anim Sci J. 2014; 85: 617-26.
Induction of Primordial Germ Cell-Like Cells from Mouse Embryonic Stem Cells by ERK Signal Inhibition.
Kimura T, Kaga Y, Ohta H, Odamoto M, Sekita Y, Li K, Yamano N, Fujikawa K, Isotani A, Sasaki N, Toyoda M, Hayashi K, Okabe M, Shinohara T, Saitou M, Nakano T.
Stem Cells. 2014l Jul 3. Online.
Interepithelial signaling with nephric duct is required for the formation of overlying coelomic epithelial cell sheet.
Yoshino T., Saito D., Atsuta U., 以下３名省略, & Takahashi Y.
Proc. Natl. Acad. Sci.USA 111(18):6660-6665 (2014)
2013年以前
A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants.
Aramaki S, Hayashi K, Kurimoto K, Ohta H, Yabuta Y, Iwanari H, Mochizuki Y, Hamakubo T, Kato Y, Shirahige K, Saitou M.
Dev Cell. 2013; 27: 516-529.
Tsix RNA and the Germline Factor, PRDM14, Link X Reactivation and Stem Cell Reprogramming.
Payer B, Rosenberg M, Yamaji M, Yabuta Y, Koyanagi-Aoi M, Hayashi K, Yamanaka S, Saitou M, Lee JT.
Mol Cell. 2013; 52: 805-818.
Stepwise differentiation from naïve state pluripotent stem cells to functional primordial germ cells through an epiblast-like state.
Hayashi K, Saitou M.
Methods Mol Biol. 2013; 1074: 175-183.
Induction of the mouse germ-cell fate by transcription factors in vitro.
Nakaki F, Hayashi K, Ohta H, Kurimoto K, Yabuta Y, Saitou M.
Nature 2013; 501: 222-226.
Generation of eggs from mouse embryonic stem cells and induced pluripotent stem cells.
Hayashi K and Saitou M.
Nature Protoc. 2013; 8: 1513-1524.
PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells.
Yamaji M, Ueda J, Hayashi K, Ohta H, Yabuta Y, Kurimoto K, Nakato R, Yamada Y, Shirahige K, Saitou M.
Cell Stem Cell. 2013; 12 : 368-382.
Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice.
Hayashi K, Ogushi S, Kurimoto K, Shimamoto S, Ohta H, Saitou M.
Science. 2012; 338: 971-975.
Epiblast stem cell-based system reveals reprogramming synergy of germline factors.
Gillich A, Bao S, Grabole N, Hayashi K, Trotter MW, Pasque V, Magnúsdóttir E, Surani MA.
Cell Stem Cell. 2012; 10: 425-439.
In vivo gene manipulations of epithelial cell sheets: a novel model to study epithelial-to-mesenchymal transition.
Yoshino T., Saito D., Tadokoro R. & Takahashi, Y.
Dev. Growth Differ.53 (3):377-388 (2011)
Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells.
Hayashi K, Ohta H, Kurimoto K, Aramaki S, Saitou M.
Cell. 2011; 146: 519-532.
Dissecting ensemble networks in ES cell populations reveals micro-heterogeneity underlying pluripotency.
Trott J, Hayashi K, Surani A, Babu MM, Martinez-Arias.A.
Mol Biosyst. 2012; 8: 744-752.
Antagonistic crosstalk of Wnt/-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation.
Villacorte M, Suzuki K, Hayashi K, de Sousa Lopes SC, Haraguchi R, Taketo MM, Nakagata N, Yamada G.
Biochem Biophys Res Commun. 2010; 391: 1653-1657.
Genome-wide identification of targets and function of individual MicroRNAs in mouse embryonic stem cells.
Hanina SA, Mifsud W, Down TA, Hayashi K, O’Carroll D, Lao K, Miska EA, Surani MA.
PLoS Genet. 2010; 6: e1001163.
Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells.
Bao S, Tang F, Li X, Hayashi K, Gillich A, Lao K, Surani MA.
Nature. 2009; 461: 1292-1295.
Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro.
Hayashi K and Surani MA.
Development. 2009; 136: 3549-3556.
ERG-associated protein with SET domain (ESET)-Oct4 interaction regulates pluripotency and represses the trophectoderm lineage.
Yeap LS, Hayashi K, Surani MA.
Epigenetics Chromatin. 2009; 2: 12
BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
Nakayama J, Yamamoto M, Hayashi K, Satoh H, Bundo K, Kubo M, Goitsuka R, Farrar MA, Kitamura D.
Blood. 2009; 113: 1483-1492.
Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states.
Hayashi K, Chuva de Sousa Lopes SM, Tang F, Surani MA.
Cell Stem Cell. 2008; 3: 391-401.
Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses.
Watanabe M, Takagi Y, Kotani M, Hara Y, Inamine A, Hayashi K, Ogawa S, Takeda K, Tanabe K, Abe R.
J Immunol. 2008; 180: 5222-5234.
A sensitive multiplex assay for piRNA expression.
Tang F, Hayashi K, Kaneda M, Lao K, Surani MA.
Biochem Biophys Res Commun. 2008; 369: 1190-1194.
MicroRNA. Biogenesis Is Required for Mouse Primordial Germ Cell Development and Spermatogenesis.
Hayashi K, Chuva de Sousa Lopes SM, Kaneda M, Tang F, Hajkova P, Lao K, O’Carroll D, Das PP, Tarakhovsky A, Miska EA, Surani MA.
PLoS ONE. 2008; 3: e1738.
X Chromosome Activity in Mouse XX Primordial Germ Cells.
Chuva de Sousa Lopes SM, Hayashi K, Shovlin TC, Mifsud W, Surani MA, McLaren A.
PLoS Genet. 2008; 4: e30
Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-gamma production.
Hidano S, Sasanuma H, Ohshima K, Seino K, Kumar L, Hayashi K, Hikida M, Kurosaki T, Taniguchi M, Geha RS, Kitamura D, Goitsuka R.
Int Immunol. 2008; 20: 345-352.
Proximal visceral endoderm and extraembryonic ectoderm regulate the formation of primordial germ cell precursors.
Chuva de Sousa Lopes SM, Hayashi K, Surani MA.
BMC Dev Biol. 2007; 7: 140
BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces κ gene rearrangement.
Yamamoto M, Hayashi K, Nojima T, Matsuzaki Y, Kawano Y, Karasuyama H, Goitsuka R, Kitamura D.
Blood. 2006; 108: 2703-2711.
The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.
Tanaka S, Tsukada J, Suzuki W, Hayashi K, Tanigaki K, Tsuji M, Inoue H, Honjo T, Kubo M.
Immunity. 2006; 24: 689-701.
Double knockout mice show BASH and PKC delta have different epistatic relationships in B cell maturation and CD40-mediated activation.
Nojima T, Hayashi K, Goitsuka R, Nakayama K, Nakayama K, Kitamura D.
Immunol Lett. 2006; 105: 48-54.
Dual function for the adaptor MIST in IFN-gamma production by NK and CD4(+)NKT cells regulated by the Src kinase Fgr.
Sasanuma H, Tatsuno A, Hidano S, Ohshima K, Matsuzaki Y, Hayashi K, Lowell CA, Kitamura D, Goitsuka R.
Blood. 2006; 107: 3647-3655.
A Histone H3 methyltransferase controls epigenetic events required for meiotic prophase.
Hayashi K, Yoshida K, Matsui Y.
Nature. 2005; 438: 374-378.
Expression of Cre recombinase in the mouse developing chondrocytes driven by the mouse α2(XI) collagen promoter.
Fujimaki R, Hayashi K, Watanabe N, Yamada T, Toyama Y, Tezuka, K and Hozumi N.
J Bone Miner Metab 2005; 23: 270-273.
Mouse epiblasts change responsiveness to BMP4 signal required for PGC formation through functions of extraembryonic ectoderm.
Okamura D, Hayashi K, Matsui Y.
Mol Reprod Dev. 2005; 70: 20-29.
Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice.
Seki Y, Hayashi K, Itoh K, Mizugaki M, Saitou M, Matsui Y.
Dev Biol. 2005; 278: 440-458.
Impaired Receptor Editing in the Primary B Cell Repertoire of BASH-Deficient Mice.
Hayashi K, Nojima T, Goitsuka R and Kitamura D.
J Immunol. 2004; 173: 5980-5988.
IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiation.
Seki N, Miyazaki M, Suzuki W, Hayashi K, Arima K, Myburgh E, Izuhara K, Brombacher F, Kubo M.
J Immunol. 2004; 172: 6158-6166.
BASH-deficient mice: limited primary repertoire and antibody formation, but sufficient affinity maturation and memory B cell generation, in anti-NP response.
Yamamoto M, Nojima, T, Hayashi K, Goitsuka R, Furukawa K, Azuma T, Kitamura D.
Int Immunol. 2004; 16: 1161-1171.
Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors.
Hayashi K., Yamamoto M., Nojima T., Goitsuka R., Kitamura D.
Immunity 2003; 18: 825-836.
Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK.
Johmura S, Oh-hora M, Inabe K, Nishikawa Y, Hayashi K, Vigorito E, Kitamura D, Turner M, Shingu K, Hikida M, Kurosaki T.
Immunity 2003; 18: 777-787.
SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.
Seki Y, Inoue H, Nagata N, Hayashi K, Fukuyama S, Matsumoto K, Komine O, Hamano S, Himeno K, Inagaki-Ohara K, Cacalano N, O’Garra A, Oshida T, Saito H, Johnston JA, Yoshimura A, Kubo M.
Nature Med. 2003; 9: 1047-1054.
A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production.
Matsumoto A, Seki Y, Watanabe R, Hayashi K, Johnston JA, Harada Y, Abe R, Yoshimura A, Kubo M.
J Exp Med 2003; 197: 425-436.
SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast.
Hayashi K, Kobayashi T, Umino T, Goitsuka R, Matsui Y, Kitamura D.
Mech Dev. 2002; 118: 99-109.
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.
Seki Y, Hayashi K, Matsumoto A, Seki N, Tsukada J, Ransom J, Naka T, Kishimoto T, Yoshimura A, Kubo M.
PNAS. 2002; 99: 13003-13008.
Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo.
Harada Y, Tokushima M, Matsumoto Y, Ogawa S, Otsuka M, Hayashi K, Weiss BD, June CH, Abe R.
J Immunol. 2001; 166: 3797-3803.
A Pivotal Role for DNase I-Sensitive Regions 3b and/or 4 in the Induction of Somatic Hypermutation of IgH Genes.
Terauchi A, Hayashi K, Kitamura D, Kozono Y, Motoyama N, Azuma T.
J Immunol. 2001; 167: 811-820.
A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation.
Goitsuka R, Kanazashi H, Sasanuma H, Fujimura Yi, Hidaka Y, Tatsuno A, Ra C, Hayashi K, Kitamura D.
Int Immunol. 2000; 12: 573-580.
The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells.
Hayashi K, Nittono R, Okamoto N, Tsuji S, Hara Y, Goitsuka R, Kitamura D.
PNAS 2000; 97: 2755-2760.