\u795e\u7d4c\u751f\u7406\u5b66\u306e\u7814\u7a76\u8005\u3067\u3042\u308b\u52a0\u85e4\u7d18\u4e4b\u535a\u58eb\uff08\u30ce\u30fc\u30b9\u30ab\u30ed\u30e9\u30a4\u30ca\u5927\u5b66\u30c1\u30e3\u30da\u30eb\u30d2\u30eb\u6821
\n\u795e\u7d4c\u79d1\u5b66\u30bb\u30f3\u30bf\u30fc\u30fb\u51c6\u6559\u6388\uff09\u3092\u304a\u62db\u304d\u3057\u3001\u30bb\u30df\u30ca\u30fc\u3092\u958b\u50ac\u3044\u305f\u3057\u307e\u3059\u30022\u5149\u5b50\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3084\u5149\u907a\u4f1d\u5b66\u3092\u99c6\u4f7f\u3057\u305f\u5927\u8133\u76ae\u8cea\u8074\u899a\u91ce\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\u3054\u8b1b\u6f14\u9802\u304d\u307e\u3059\u3002\u3069\u306a\u305f\u3067\u3082\u53c2\u52a0\u53ef\u80fd\u3067\u3059\u3002\u3075\u308b\u3063\u3066\u3054\u53c2\u52a0\u4e0b\u3055\u3044\u3002
\n\u6d77\u5916\u7559\u5b66\u3084\u6d77\u5916\u3067\u306e\u72ec\u7acb\u306e\u3054\u7d4c\u9a13\u306b\u3064\u3044\u3066\u3082\u304a\u8a71\u3044\u305f\u3060\u3051\u308b\u4e88\u5b9a\uff08\u65e5\u672c\u8a9e\uff09\u3067\u3059\u306e\u3067\u3001\u5b66\u90e8\u5b66\u751f\u30fb\u5927\u5b66\u9662\u751f\u306e\u53c2\u52a0\u3082\u6b53\u8fce\u3057\u307e\u3059\u3002<\/p>\n
\u6f14\u8005\uff1a\u3000\u52a0\u85e4\u3000\u7d18\u4e4b\u3000\u5148\u751f
\n\u6240\u5c5e\uff1a\u3000\u30ce\u30fc\u30b9\u30ab\u30ed\u30e9\u30a4\u30ca\u5927\u5b66\u30c1\u30e3\u30da\u30eb\u30d2\u30eb\u6821\u51c6\u6559\u6388
\nhttps:\/\/katolab-unc.org\/<\/p>\n
\u30bf\u30a4\u30c8\u30eb\uff1a
\n\u5927\u8133\u76ae\u8cea\u8074\u899a\u91ce\u306b\u304a\u3051\u308b\u611f\u899a\u30c1\u30e5\u30fc\u30cb\u30f3\u30b0
\nInhibitory circuits underlying sensory tuning of cortical neurons<\/p>\n
\u65e5\u6642\uff1a\u30002018\u5e748\u67083\u65e5\uff08\u91d1\uff0917:00\uff5e18:00
\n\u5834\u6240\uff1a\u3000\u57fa\u790e\u7814\u7a76A\u68df1\u968e\u3000\u7b2c2\u8b1b\u7fa9\u5ba4\uff08\u751f\u5354\u524d\uff09<\/p>\n
\u8981\u65e8\uff1a
\nLateral inhibition is a fundamental circuit operation that sharpens
\nthe tuning properties of cortical neurons. This operation is
\nclassically attributed to an increase in GABAergic synaptic input
\ntriggered by non-preferred stimuli. Here we use in vivo whole-cell
\nrecording and two-photon Ca2+ imaging in awake mice to show that
\nlateral inhibition shapes frequency tuning in primary auditory cortex
\nvia an unconventional mechanism: non-preferred tones suppress both
\nexcitatory and inhibitory synaptic inputs onto layer 2\/3 cells
\n(“network suppression”). Moreover, optogenetic inactivation of
\ninhibitory interneurons elicits a paradoxical increase in inhibitory
\nsynaptic input. These results indicate that GABAergic interneurons
\nregulate cortical activity indirectly via the suppression of recurrent
\nexcitation (inhibition-stabilized network model), rather than via the
\ndirect inhibition. Furthermore, the network suppression underlying
\nlateral inhibition was blocked by inactivation of
\nsomatostatin-expressing interneurons (SOM cells), but not
\nparvalbumin-expressing interneurons (PV cells). These findings reveal
\nthat SOM cells govern lateral inhibition and control cortical
\nfrequency tuning through the regulation of reverberating recurrent
\ncircuits. Together with our previous finding that SOM cell activity is
\nregulated by the behavioral relevance attached to sounds, these
\nresults demonstrate a dynamic nature of sensory tuning that is enabled
\nby cortical inhibitory circuits.<\/p>\n
\u53c2\u8003\u6587\u732e\uff1a
\n1. Kato HK, Asinof SK, Isaacson JS. (2017) Network-level control of
\nfrequency tuning in auditory cortex. Neuron 95: 412-423.
\n2. Kato HK, Gillet SN, Isaacson JS. (2015) Flexible sensory
\nrepresentations in auditory cortex driven by behavioral relevance.
\nNeuron 88: 1027-1039.
\n3. Kato HK, Gillet SN, Peters AJ, Isaacson JS, Komiyama T. (2013)
\nParvalbumin-Expressing Interneurons Linearly Control Olfactory Bulb
\nOutput. Neuron 80:1218-1231.
\n4. Kato HK, Chu MW, Isaacson JS, Komiyama T. (2012) Dynamic sensory
\nrepresentations in the olfactory bulb: modulation by wakefulness and
\nexperience. Neuron 76:962-75.<\/p>\n
\u7814\u7a76\u30bb\u30df\u30ca\u30fc\u306f\u82f1\u8a9e\u3067\u306e\u767a\u8868\u3068\u306a\u308a\u307e\u3059\u304c\u3001\u65e5\u672c\u8a9e\u3067\u306e\u8cea\u7591\u3082\u6b53\u8fce\u3067\u3059\u3002<\/p>\n
\u4e16\u8a71\u4eba\uff1a\u3000\u533b\u5b66\u7814\u7a76\u9662\u30fb\u75be\u60a3\u60c5\u5831\u7814\u7a76\u5206\u91ce\u3000\u4eca\u4e95\u3000\u731b<\/p>\n","protected":false},"excerpt":{"rendered":"
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