{"id":2700,"date":"2025-09-14T21:26:10","date_gmt":"2025-09-14T12:26:10","guid":{"rendered":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/?p=2700"},"modified":"2025-09-14T21:52:31","modified_gmt":"2025-09-14T12:52:31","slug":"ueda_seminar","status":"publish","type":"post","link":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/ueda_seminar\/","title":{"rendered":"\u4e0a\u7530\u6cf0\u5df1\u5148\u751f\u30bb\u30df\u30ca\u30fc"},"content":{"rendered":"<p>\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u6559\u6388\u30fb\u4e45\u7559\u7c73\u5927\u5b66\u5206\u5b50\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u6559\u6388\u306e\u4e0a\u7530\u6cf0\u5df1\u5148\u751f\u3092\u304a\u8fce\u3048\u3057\u3066\u30bb\u30df\u30ca\u30fc\u3092\u958b\u50ac\u3044\u305f\u3057\u307e\u3059\u3002\u672c\u8b1b\u6f14\u3067\u306f\u3001\u7761\u7720\u5236\u5fa1\u306e\u5206\u5b50\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u3054\u7814\u7a76\u3084\u3001\u793e\u4f1a\u5b9f\u88c5\u306e\u305f\u3081\u306e\u53d6\u308a\u7d44\u307f\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3044\u305f\u3060\u304d\u307e\u3059\u3002\u591a\u6570\u306e\u7686\u69d8\u306e\u3054\u53c2\u52a0\u3092\u304a\u5f85\u3061\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n<div>\n<div>\u6f14\u8005\uff1a\u3000\u4e0a\u7530\u6cf0\u5df1\u3000\u535a\u58eb<\/div>\n<div><\/div>\n<div>\u6240\u5c5e\uff1a<\/div>\n<div>\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u30b7\u30b9\u30c6\u30e0\u30ba\u85ac\u7406\u5b66\u5206\u91ce\u30fb\u6559\u6388<\/div>\n<div>\u4e45\u7559\u7c73\u5927\u5b66\u5206\u5b50\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u30fb\u6559\u6388<\/div>\n<div><\/div>\n<div>\u65e5\u6642\uff1a\u30002025\u5e7410\u67087\u65e5\uff08\u706b\uff0911:00-12:00<\/div>\n<div><\/div>\n<div>\u5834\u6240\uff1a\u3000\u533b\u5b66\u90e8\u57fa\u790e\u7814\u7a76A\u68df1\u968e\u3000\u7b2c2\u8b1b\u7fa9\u5ba4\uff08\u751f\u5354\u5411\u304b\u3044\uff09<\/div>\n<div><\/div>\n<div><\/div>\n<div>\u8b1b\u6f14\u30bf\u30a4\u30c8\u30eb\uff1a\u3000\u7761\u7720\u306e\u4ed5\u7d44\u307f\u3068\u610f\u7fa9\u306b\u3064\u3044\u3066<\/div>\n<div><\/div>\n<\/div>\n<div><\/div>\n<p>&nbsp;<\/p>\n<div>\u8981\u65e8\uff1a<\/div>\n<div>\n<p>\u672c\u8b1b\u6f14\u3067\u306f\u3001\u7761\u7720\u6052\u5e38\u6027\u306b\u304a\u3051\u308b\u30ab\u30eb\u30b7\u30a6\u30e0\u304a\u3088\u3073\u30ab\u30eb\u30b7\u30a6\u30e0\u4f9d\u5b58\u7684\u306a\u30ea\u30f3\u9178\u5316\u6a5f\u69cb\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u3001\u6211\u3005\u306e\u7814\u7a76\u6210\u679c\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002\u5f93\u6765\u3001\u7761\u7720\u7269\u8cea\u306e\u63a2\u7d22\u304c\u4e3b\u6d41\u3067\u3057\u305f\u304c\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3067\u9855\u8457\u306a\u52b9\u679c\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u6211\u3005\u306f\u300c\u899a\u9192\u7269\u8cea\u306e\u5c65\u6b74\u3092\u7a4d\u5206\u3059\u308b\u6a5f\u69cb\u300d\u3078\u3068\u8996\u70b9\u3092\u8ee2\u63db\u3057\u3001\u899a\u9192\u7269\u8cea\u3067\u3042\u308b\u30ab\u30eb\u30b7\u30a6\u30e0\u306b\u7740\u76ee\u3057\u307e\u3057\u305f\u3002\u6211\u3005\u306f25\u7a2e\u985e\u4ee5\u4e0a\u3082\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u95a2\u9023\u907a\u4f1d\u5b50\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3059\u308b\u305f\u3081\u306b\u300c\u30c8\u30ea\u30d7\u30eb\u30af\u30ea\u30b9\u30d1\u30fc\u6cd5\u300d\u3092\u958b\u767a\u3057\u3001\u30de\u30a6\u30b9\u306e95%\u4ee5\u4e0a\u3067\u52b9\u7387\u7684\u306a\u907a\u4f1d\u5b50\u7834\u58ca\u3092\u5b9f\u73fe\u3057\u307e\u3057\u305f (Sunagawa et al. 2016)\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u7761\u7720\u4fc3\u9032\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f (Tatsuki et al. 2016)\u3002\u3055\u3089\u306b\u3001\u7d44\u7e54\u900f\u660e\u5316\u6280\u8853CUBIC (Susaki et al. 2014; Tainaka et al. 2014) \u306b\u3088\u308a\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u795e\u7d4c\u8208\u596e\u6027\u3092\u6291\u5236\u3059\u308b\u300c\u30d6\u30ec\u30fc\u30ad\u300d\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u3082\u793a\u3057\u307e\u3057\u305f\u3002\u52a0\u3048\u3066\u3001CaMKII\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u89e3\u6790\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u30ea\u30f3\u9178\u5316\u30b9\u30a4\u30c3\u30c1\u304c\u7761\u7720\u5236\u5fa1\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f (Tatsuki et al. 2016; Tone et al. 2022)\u3002\u307e\u305f\u30ab\u30eb\u30b7\u30cb\u30e5\u30fc\u30ea\u30f3\u3084PP1\u3084\u305d\u308c\u3089\u3068\u62ee\u6297\u3059\u308bPKA\u306e\u5f79\u5272\u3082\u89e3\u660e\u3057\u3001\u7761\u7720\u5236\u5fa1\u306e\u7cbe\u7dfb\u306a\u5206\u5b50\u6a5f\u69cb\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f (Wang et al. 2024)\u3002\u3055\u3089\u306b\u3001\u30ea\u30a2\u30ce\u30b8\u30f3\u53d7\u5bb9\u4f53\u304c\u5438\u5165\u9ebb\u9154\u85ac\u306e\u6a19\u7684\u3067\u3042\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u307e\u3057\u305f (Kanaya et al. 2025)\u3002\u7761\u7720\u306e\u6a5f\u80fd\u306b\u3064\u3044\u3066\u3082\u3001\u5f93\u6765\u306e\u4eee\u8aac\u3068\u306f\u9006\u306b\u3001\u899a\u9192\u4e2d\u306b\u30b7\u30ca\u30d7\u30b9\u5f37\u5ea6\u304c\u4f4e\u4e0b\u3057\u3001\u7761\u7720\u4e2d\u306b\u56de\u5fa9\u3059\u308b\u300cWISE\u4eee\u8aac\u300d\u3092\u63d0\u5531\u3057\u307e\u3057\u305f (Kinoshita et al. 2025)\u3002\u3053\u306e\u7406\u8ad6\u306f\u3001\u9577\u671f\u899a\u9192\u304c\u30b7\u30ca\u30d7\u30b9\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u3046\u3064\u75c5\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u3092\u8aac\u660e\u3057\u3001\u7761\u7720\u306e\u6297\u3046\u3064\u52b9\u679c\u3082\u793a\u5506\u3057\u307e\u3059\u3002<br \/>\n\u3053\u308c\u3089\u306e\u77e5\u898b\u3092\u4eba\u3005\u306e\u751f\u6d3b\u306b\u9084\u5143\u3059\u3079\u304f\u3001ACCEL\u3068\u3044\u3046\u7761\u7720\u6e2c\u5b9a\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u958b\u767a\u3057 (Ode et al. 2022; Katori et al. 2022)\u30012020\u5e74\u3088\u308a\u300c\u7761\u7720\u5065\u8a3a\u300d\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u7761\u7720\u3092\u5f53\u305f\u308a\u524d\u306e\u6a29\u5229\u3068\u3059\u308b\u793e\u4f1a\u904b\u52d5\u3067\u3059\u3002\u672c\u8b1b\u6f14\u3067\u306f\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u304b\u3089\u793e\u4f1a\u5b9f\u88c5\u307e\u3067\u3092\u542b\u3081\u305f\u3001\u7761\u7720\u7814\u7a76\u306e\u6700\u524d\u7dda\u3092\u5c55\u671b\u3057\u307e\u3059\u3002<\/p>\n<div>References:<\/div>\n<div>Kanaya et al., <em>PLoS Biology<\/em> 2025; Wang et al., <em>Nature<\/em> 2024; Kinoshita et al., <em>PLoS Biology<\/em> 2025; Katori et al., <em>PNAS<\/em> 2022; Tone et al., <em>PLoS Biology<\/em> 2022; Ode et al., <em>iScience<\/em> 2022; Tatsuki et al., <em>Neuron<\/em> 2016; Sunagawa et al., <em>Cell Reports<\/em> 2016; Tainaka et al., <em>Cell<\/em> 2014; Susaki et al., <em>Cell<\/em> 2014.<\/div>\n<div><\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<div>\u4e16\u8a71\u4eba\uff1a\u3000\u533b\u5b66\u7814\u7a76\u9662\u30fb\u75be\u60a3\u60c5\u5831\u7814\u7a76\u5206\u91ce\u3000\u4eca\u4e95\u3000\u731b<\/div>\n<div>#\u7b2c22\u56de\u75be\u60a3\u60c5\u5831\u7814\u7a76\u5206\u91ce\u4e3b\u50ac\uff08\u7b2c26\u56de\u4eca\u4e95\u7814\u4e3b\u50ac\uff09\u516c\u958b\u30bb\u30df\u30ca\u30fc<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u6559\u6388\u30fb\u4e45\u7559\u7c73\u5927\u5b66\u5206\u5b50\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u6559\u6388\u306e\u4e0a\u7530\u6cf0\u5df1\u5148\u751f\u3092\u304a\u8fce\u3048\u3057\u3066\u30bb\u30df\u30ca\u30fc\u3092\u958b\u50ac\u3044\u305f\u3057\u307e\u3059\u3002\u672c\u8b1b\u6f14\u3067\u306f\u3001\u7761\u7720\u5236\u5fa1\u306e\u5206\u5b50\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u3054\u7814\u7a76\u3084\u3001\u793e\u4f1a\u5b9f\u88c5\u306e\u305f\u3081\u306e\u53d6\u308a\u7d44\u307f\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3044\u305f\u3060\u304d\u307e\u3059\u3002\u591a\u6570&hellip; 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