{"id":2244,"date":"2023-11-02T14:12:31","date_gmt":"2023-11-02T05:12:31","guid":{"rendered":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/?p=2244"},"modified":"2023-11-27T14:45:23","modified_gmt":"2023-11-27T05:45:23","slug":"matsunami2023","status":"publish","type":"post","link":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/matsunami2023\/","title":{"rendered":"2023\u5e7411\u670824\u65e5\u677e\u6ce2\u5b8f\u660e\u535a\u58eb\u30bb\u30df\u30ca\u30fc"},"content":{"rendered":"

\u7c73\u56fdDuke\u5927\u5b66\u6559\u6388\u306e\u677e\u6ce2\u5b8f\u660e\u5148\u751f\u3092\u304a\u8fce\u3048\u3057\u3066\u30bb\u30df\u30ca\u30fc\u3092\u958b\u50ac\u3044\u305f\u3057\u307e\u3059\u3002\u677e\u6ce2\u535a\u58eb\u306f\u4eac\u90fd\u5927\u5b66\uff08\u7af9\u5e02\u7814\uff09\u3067\u5b66\u4f4d\u3092\u53d6\u5f97\u5f8c\u3001Linda B. Buck\u535a\u58eb\uff082004\u5e74\u30ce\u30fc\u30d9\u30eb\u8cde\uff09\u306e\u3082\u3068\u3067\u30dd\u30b9\u30c9\u30af\u3092\u3057\u305f\u306e\u3061\u3001Duke\u5927\u5b66\u3067\u72ec\u7acb\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u306f\u3001\u4e00\u8cab\u3057\u3066\u5316\u5b66\u611f\u899a\uff08\u55c5\u899a\u304a\u3088\u3073\u5473\u899a\uff09\u7814\u7a76\u306e\u30c8\u30c3\u30d7\u30e9\u30f3\u30ca\u30fc\u3068\u3057\u3066\u3054\u6d3b\u8e8d\u3067\u3059\u3002\u7279\u306b\u3001\u55c5\u899a\u53d7\u5bb9\u4f53\u306e\u6a5f\u80fd\u89e3\u6790\u3092\u901a\u3057\u3066\u3001\u30d2\u30c8\u306e\u55c5\u899a\u306e\u5206\u5b50\u57fa\u76e4\u89e3\u660e\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u3067\u30de\u30a4\u30eb\u30b9\u30c8\u30f3\u3068\u306a\u308b\u304a\u4ed5\u4e8b\u3092\u3055\u308c\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u6700\u8fd1\u306f\u3001CryoEM\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u521d\u3081\u3066\u55c5\u899a\u53d7\u5bb9\u4f53\u306e\u7acb\u4f53\u69cb\u9020\u89e3\u6790\u306b\u3082\u6210\u529f\u3055\u308c\u307e\u3057\u305f\u3002\u672c\u30bb\u30df\u30ca\u30fc\u3067\u306f\u3001\u55c5\u899a\u53d7\u5bb9\u4f53\u306b\u3088\u308b\u591a\u69d8\u306a\u5302\u3044\u5206\u5b50\u306e\u8b58\u5225\u6a5f\u69cb\u306b\u3064\u3044\u3066\u3054\u8b1b\u6f14\u3044\u305f\u3060\u304d\u307e\u3059\u3002\u672c\u30bb\u30df\u30ca\u30fc\u306f\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u5f62\u5f0f\u3067\u65e5\u672c\u8a9e\u306b\u3066\u958b\u50ac\u3057\u307e\u3059\u3002<\/p>\n

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\u6f14\u8005\uff1a\u3000\u677e\u6ce2\u3000\u5b8f\u660e\u3000\u535a\u58eb<\/div>\n
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\u6240\u5c5e\uff1a\u3000Department of Molecular Genetics and Microbiology, Duke University Medical Center<\/div>\n
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\u65e5\u6642\uff1a\u30002023\u5e7411\u670824\u65e5\uff08\u91d1\uff0917:00-18:00<\/div>\n
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Zoom\u53c2\u52a0\u3092\u5e0c\u671b\u3055\u308c\u308b\u65b9\u306f\u4e0b\u8a18\u3088\u308a\u767b\u9332\u3092\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/div>\n
https:\/\/forms.gle\/uUgoA3WbvEEtR2wf7<\/a><\/div>\n

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\u8b1b\u6f14\u30bf\u30a4\u30c8\u30eb\uff1a<\/div>\n
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\u8981\u65e8\uff1a<\/div>\n
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\n\u55c5\u899a\u306b\u304a\u3051\u308b\u6700\u3082\u91cd\u8981\u306a\u8ab2\u984c\u306e\u4e00\u3064\u306f\u3001\u5302\u3044\u5206\u5b50\u304c\u539f\u5b50\u30ec\u30d9\u30eb\u3067\u3069\u306e\u3088\u3046\u306b\u5302\u3044\u53d7\u5bb9\u4f53\u3068\u7d50\u5408\u3059\u308b\u306e\u304b\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1\u3001\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30fc\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3001\u90e8\u4f4d\u7279\u7570\u7684\u5909\u7570\u5c0e\u5165\u6280\u8853\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001\u6d3b\u6027\u5316\u72b6\u614b\u306e\u5302\u3044\u5206\u5b50\u304c\u3069\u306e\u3088\u3046\u306b\u5302\u3044\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3057\u3066\u6d3b\u6027\u5316\u3055\u305b\u3066\u3044\u308b\u306e\u304b\u3092\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002\u5302\u3044\u5206\u5b50\u306f\u3001\u5302\u3044\u53d7\u5bb9\u4f53\u306e\u30ea\u30ac\u30f3\u30c9\u7d50\u5408\u90e8\u4f4d\u5185\u3067\u30a4\u30aa\u30f3\u7d50\u5408\u3001\u6c34\u7d20\u7d50\u5408\u3001\u30d5\u30a1\u30f3\u30c7\u30eb\u30ef\u30fc\u30eb\u30b9\u7d50\u5408\u3092\u5f62\u6210\u3057\u3001\u3053\u308c\u306b\u3088\u3063\u3066\u53d7\u5bb9\u4f53\u3092\u6d3b\u6027\u72b6\u614b\u306b\u5b89\u5b9a\u5316\u3055\u305b\u308b\u91cd\u8981\u306a\u76f8\u4e92\u4f5c\u7528\u3092\u3057\u3066\u3044\u304a\u308a\u3001\u305d\u306e\u7d50\u679c\u5302\u3044\u53d7\u5bb9\u4f53\u3068G\u30bf\u30f3\u30d1\u30af\u3068\u306e\u5171\u5f79\u304c\u306a\u3055\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u7d50\u5408\u90e8\u4f4d\u5185\u306e\u7279\u5b9a\u306e\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u306b\u5909\u7570\u3092\u5c0e\u5165\u3059\u308b\u3068\u3001\u305d\u306e\u5909\u7570\u306e\u4f4d\u7f6e\u306b\u5fdc\u3058\u3066\u5302\u3044\u5206\u5b50\u306e\u8a8d\u8b58\u7bc4\u56f2\u304c\u5909\u5316\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u5302\u3044\u5206\u5b50\u306e\u9078\u629e\u6027\u304c\u5302\u3044\u5206\u5b50\u3068\u305d\u306e\u53d7\u5bb9\u4f53\u3068\u306e\u9593\u306e\u5bc6\u63a5\u306a\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002
\n\u3053\u308c\u3089\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u5302\u3044\u306b\u53cd\u5fdc\u3059\u308b\u53d7\u5bb9\u4f53\u306b\u95a2\u3059\u308b\u57fa\u790e\u7684\u306a\u77e5\u8b58\u3092\u63d0\u4f9b\u3057\u3001\u5302\u3044\u306e\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0\u306b\u95a2\u3059\u308b\u3055\u3089\u306a\u308b\u63a2\u6c42\u306e\u57fa\u76e4\u3092\u7bc9\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n
References:<\/div>\n
Billesb\u00f8lle, et al. \u201cStructural basis of odorant recognition by a human odorant receptor.\u201d Nature 615: 742\u201349 (2023). https:\/\/doi.org\/10.1038\/s41586-023-05798-y.<\/div>\n
Yoshikawa, et al. \u201cAn odorant receptor that senses four classes of musk compounds.\u201d Curr Biol 32: 5172-5179.e5 (2022). https:\/\/doi.org\/10.1016\/j.cub.2022.10.038.
\nZhu, et al. \u201cDecoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli.\u201d Nat Commun 13: 5137 (2022). https:\/\/doi.org\/10.1038\/s41467-022-32267-3.<\/div>\n
Kida et al., \u201cVapor detection and discrimination with a panel of odorant receptors.\u201d Nat Commun 9: 4556 (2018). https:\/\/doi.org\/10.1038\/s41467-018-06806-w.<\/div>\n
Jiang et al., \u201cMolecular profiling of activated olfactory neurons identifies odorant receptors for odors in vivo.\u201d Nat Neurosci 18: 1446-1454 (2015). https:\/\/www.nature.com\/articles\/nn.4104
\nMainland et al., \u201cThe missense of smell: functional variability in the human odorant receptor repertoire.\u201d Nat Neurosci 17: 114-120 (2014). https:\/\/www.nature.com\/articles\/nn.3598<\/div>\n
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\u4e16\u8a71\u4eba\uff1a\u3000\u533b\u5b66\u7814\u7a76\u9662\u30fb\u75be\u60a3\u60c5\u5831\u7814\u7a76\u5206\u91ce\u3000\u4eca\u4e95\u3000\u731b<\/div>\n
#\u7b2c20\u56de\u75be\u60a3\u60c5\u5831\u7814\u7a76\u5206\u91ce\u4e3b\u50ac\uff08\u7b2c24\u56de\u4eca\u4e95\u7814\u4e3b\u50ac\uff09\u516c\u958b\u30bb\u30df\u30ca\u30fc<\/div>\n
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\n\u30bb\u30df\u30ca\u30fc\u3092\u958b\u50ac\u3057\u307e\u3057\u305f\u3002\u5927\u5909exciting\u306a\u3054\u8b1b\u6f14\u3067\u3001\u5b66\u751f\u3055\u3093\u3082\u5927\u5909\u523a\u6fc0\u3092\u53d7\u3051\u3066\u3044\u307e\u3057\u305f\u3002<\/div>\n
\"\"<\/div>\n","protected":false},"excerpt":{"rendered":"

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