\u30d5\u30e9\u30f3\u30b9Institut du Cerveau et de la Moelle Epini\u00e8re\uff08ICM\uff09\u306eClaire Wyart\u7814\u7a76\u5ba4\u7814\u7a76\u54e1\u306eAdna Dumitrescu\u535a\u58eb\u306b\u3088\u308b\u30bb\u30df\u30ca\u30fc\u3092\u958b\u50ac\u81f4\u3057\u307e\u3059\u3002\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3092\u7528\u3044\u305f\u5149\u907a\u4f1d\u5b66\u30c4\u30fc\u30eb\u3084\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\u3054\u8b1b\u6f14\u3044\u305f\u3060\u304d\u307e\u3059\u3002\u3075\u308b\u3063\u3066\u3054\u53c2\u52a0\u4e0b\u3055\u3044\u3002\u5b66\u90e8\u5b66\u751f\u30fb\u5927\u5b66\u9662\u751f\u306e\u53c2\u52a0\u3082\u6b53\u8fce\u3067\u3059\u3002<\/p>\n
\u6f14\u8005\uff1a\u3000\u3000Adna Dumitrescu\u535a\u58eb<\/p>\n
\u6240\u5c5e\uff1a\u3000\u30d5\u30e9\u30f3\u30b9Institut du Cerveau et de la Moelle Epini\u00e8re (ICM), Claire Wyart Lab<\/p>\n
\u30bf\u30a4\u30c8\u30eb\uff1a\u3000In vivo optogenetic control of neuronal activity: ground-truth electrophysiological calibration of zebrafish opsin transgenic lines<\/p>\n
\u65e5\u6642\uff1a\u30002019\u5e747\u670812\u65e5\uff08\u91d1\uff0914:00\uff5e15:00
\n\u5834\u6240\uff1a\u3000\u533b\u5b66\u90e8\u57fa\u790e\u7814\u7a76A\u68df1\u968e\u3000\u7b2c2\u8b1b\u7fa9\u5ba4\uff08\u751f\u5354\u5411\u304b\u3044\uff09<\/p>\n
Abstract: Fifteen years after the publication of the original Channelrhodopsin-2 proof of principle paper using cultured neurons, we now have available an array of several excitatory and inhibitory opsins. Despite these advancements, the field is currently facing several challenges such as: the availability of stable transgenic lines, somewhat limited spectral properties, and poor kinetics in terms of achieving neural control within a millisecond range precision. We have addressed these issues by taking advantage of the transparent zebrafish larva model to calibrate the performance of the 10 best-expressing opsin transgenic lines available via electrophysiological recordings in vivo in motor neurons.<\/p>\n
<\/p>\n
\u4e16\u8a71\u4eba\uff1a\u3000\u533b\u5b66\u7814\u7a76\u9662\u30fb\u75be\u60a3\u60c5\u5831\u7814\u7a76\u5206\u91ce\u3000\u4eca\u4e95\u3000\u731b<\/p>\n","protected":false},"excerpt":{"rendered":"
\u30d5\u30e9\u30f3\u30b9Institut du Cerveau et de la Moelle Epini\u00e8re\uff08ICM\uff09\u306eClaire Wyart\u7814\u7a76\u5ba4\u7814\u7a76\u54e1\u306eAdna Dumitrescu\u535a\u58eb\u306b\u3088\u308b\u30bb\u30df\u30ca\u30fc\u3092\u958b\u50ac\u81f4\u3057\u307e\u3059\u3002\u30bc\u30d6\u30e9\u30d5\u30a3… <\/p>\n","protected":false},"author":22,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,6],"tags":[],"class_list":["post-1154","post","type-post","status-publish","format-standard","hentry","category-news","category-seminar","clearfix"],"_links":{"self":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/wp-json\/wp\/v2\/posts\/1154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/wp-json\/wp\/v2\/users\/22"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/wp-json\/wp\/v2\/comments?post=1154"}],"version-history":[{"count":8,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/wp-json\/wp\/v2\/posts\/1154\/revisions"}],"predecessor-version":[{"id":1164,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/wp-json\/wp\/v2\/posts\/1154\/revisions\/1164"}],"wp:attachment":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/wp-json\/wp\/v2\/media?parent=1154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/wp-json\/wp\/v2\/categories?post=1154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/wp-json\/wp\/v2\/tags?post=1154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}