{"id":30,"date":"2017-04-21T16:48:30","date_gmt":"2017-04-21T07:48:30","guid":{"rendered":"http:\/\/dn.wp.med.kyushu-u.ac.jp\/?page_id=30"},"modified":"2026-03-16T11:26:33","modified_gmt":"2026-03-16T02:26:33","slug":"research","status":"publish","type":"page","link":"https:\/\/www.lab.med.kyushu-u.ac.jp\/dn\/research\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"

\u7814\u7a76\u5185\u5bb9<\/h2>\n

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\"\"\u6211\u3005\u306e\u8133\u306f\u7d041000\u5104\u3082\u306e\u795e\u7d4c\u7d30\u80de\u304c\u8907\u96d1\u306a\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\uff08\u56de\u8def\uff09\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3067\u6210\u308a\u7acb\u3063\u3066\u304a\u308a\u3001\u304a\u305d\u3089\u304f\u3082\u3063\u3068\u3082\u8907\u96d1\u306a\u81d3\u5668\u3067\u3059\u3002\u8133\u306e\u672c\u8cea\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306f\u300121\u4e16\u7d00\u306e\u751f\u547d\u79d1\u5b66\u306b\u304a\u3051\u308b\u6700\u3082\u5927\u304d\u306a\u30c1\u30e3\u30ec\u30f3\u30b8<\/strong>\u306e\u4e00\u3064\u3067\u3042\u308b\u3068\u8a00\u3063\u3066\u826f\u3044\u3067\u3057\u3087\u3046\u3002\u3053\u308c\u306f\u5358\u306b\u751f\u7269\u5b66\u3068\u3057\u3066\u91cd\u8981\u306a\u8ab2\u984c\u3067\u3042\u308b\u3068\u3044\u3046\u3060\u3051\u3067\u306a\u304f\u3001\u591a\u304f\u306e\u7cbe\u795e\u75be\u60a3\u306e\u7406\u89e3\u3084\u514b\u670d\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u307b\u304b\u3001\u4eba\u5de5\u77e5\u80fd\u306e\u7814\u7a76\u306a\u3069\u3068\u76f8\u307e\u3063\u3066\u793e\u4f1a\u306e\u3042\u308a\u3088\u3046\u3092\u3082\u5909\u9769\u3057\u3066\u3044\u304f\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u795e\u7d4c\u79d1\u5b66\u306f\u3001\u4eba\u985e\u304c\u554f\u3046\u3066\u304d\u305f\u81ea\u8eab\u306e\u5b58\u5728\u306e\u6e90\u3092\u7406\u89e3\u3059\u308b\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308b\u3068\u3082\u8a00\u3048\u307e\u3059\u3002<\/p>\n

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\u307e\u305a\u306f\u3001\u8133\u6a5f\u80fd\u304c\u795e\u7d4c\u56de\u8def\u30ec\u30d9\u30eb\u3067\u3069\u306e\u3088\u3046\u306b\u6f14\u7b97\u3055\u308c\u3001\u8868\u51fa\u3059\u308b\u306e\u304b\uff08\u52d5\u4f5c\u539f\u7406<\/strong>\uff09\u3092\u7406\u89e3\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u5f53\u7814\u7a76\u5ba4\u3067\u306f2\u5149\u5b50\u52b1\u8d77\u9855\u5fae\u93e1\u306b\u3088\u308bin vivo\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6cd5\u3092\u7528\u3044\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u65b9\u6cd5\u3092\u7528\u3044\u308b\u3068\u3001\u751f\u304d\u305f\u52d5\u7269\u306e\u8133\u6df1\u90e8\u304b\u3089\u3001\u540c\u6642\u306b\u591a\u6570\u306e\u795e\u7d4c\u7d30\u80de\u306e\u6d3b\u52d5\u3092\u6349\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30b7\u30b9\u30c6\u30e0\u795e\u7d4c\u79d1\u5b66<\/strong>\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7528\u3044\u3066\u3001\u60c5\u5831\u51e6\u7406\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u7406\u89e3\u3057\u307e\u3059\u3002<\/p>\n

\u6b21\u306b\u3001\u3053\u3046\u3057\u305f\u56de\u8def\u6a5f\u80fd\u304c\u3069\u306e\u3088\u3046\u306a\u56de\u8def\u69cb\u9020\u57fa\u76e4<\/strong>\u306b\u3088\u3063\u3066\u751f\u307f\u51fa\u3055\u308c\u308b\u306e\u304b\u3092\u7406\u89e3\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u3001\u795e\u7d4c\u56de\u8def\u306e\u5168\u4f53\u50cf\u3092\u6349\u3048\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3057\u305f\u304c\u3001\u8fd1\u5e74\u3001\u6211\u3005\u304c\u72ec\u81ea\u306b\u958b\u767a\u3057\u305f\u900f\u660e\u5316\u306a\u3069\u306e\u65b0\u3057\u3044\u624b\u6cd5\u306b\u3088\u3063\u3066\u305d\u308c\u304c\u53ef\u80fd\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u4e16\u754c\u7684\u306b\u3082\u56de\u8def\u69cb\u9020\u306e\u5168\u4f53\u50cf\u3092\u7406\u89e3\u3057\u3088\u3046\u3068\u3044\u3046\u6a5f\u904b\u306f\u9ad8\u307e\u3063\u3066\u304a\u308a\u3001\u30b3\u30cd\u30af\u30c8\u30df\u30af\u30b9<\/strong>\uff08\u56de\u8def\u63a5\u7d9a\u306e\u7dcf\u4f53\uff1d\u30b3\u30cd\u30af\u30c8\u30fc\u30e0\u3092\u89e3\u6790\u3059\u308b\u5b66\u554f\uff09\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u6700\u5f8c\u306b\u3001\u56de\u8def\u69cb\u9020\u304c\u767a\u9054\u904e\u7a0b\u3067\u3069\u306e\u3088\u3046\u306a\u30ed\u30b8\u30c3\u30af\u3067\u4f5c\u3089\u308c\u308b\u306e\u304b\uff08\u5f62\u6210\u539f\u7406<\/strong>\uff09\u3092\u7406\u89e3\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u795e\u7d4c\u56de\u8def\u306f\u591a\u304f\u306e\u5834\u5408\u3001\u907a\u4f1d\u7684\u306b\u30d7\u30ed\u30b0\u30e9\u30e0\u3055\u308c\u305f\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u5225\u306e\u795e\u7d4c\u7d30\u80de\u304b\u3089\u306e\u60c5\u5831\u3084\u3001\u795e\u7d4c\u6d3b\u52d5\uff08\u611f\u899a\u5165\u529b\u3084\u81ea\u767a\u795e\u7d4c\u6d3b\u52d5\uff09\u306b\u57fa\u3065\u3044\u3066\u4f5c\u3089\u308c\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u907a\u4f1d\u5b66\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u6a5f\u80fd\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3084\u30e2\u30c7\u30ea\u30f3\u30b0\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3082\u7d44\u307f\u5408\u308f\u305b\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u73fe\u5728\u306e\u3068\u3053\u308d\u3001\u30e2\u30c7\u30eb\u3068\u3057\u3066\u306f\u30de\u30a6\u30b9\u306e\u55c5\u899a\u7cfb\uff08\u7279\u306b\u55c5\u7403\uff09<\/strong>\u3068\u5927\u8133\u76ae\u8cea\uff08\u4f53\u6027\u611f\u899a\u91ce\uff09<\/strong>\u3092\u4e3b\u306b\u7528\u3044\u3066\u3044\u307e\u3059\u3002\u55c5\u7403\u306f\u3001\u7570\u306a\u308b\u55c5\u899a\u53d7\u5bb9\u4f53\u3092\u767a\u73fe\u3059\u308b1,000\u7a2e\u985e\u3082\u306e\u55c5\u795e\u7d4c\u7d30\u80de\u304c\u5165\u529b\u3059\u308b\u9818\u57df\u3067\u3042\u308a\u306a\u304c\u3089\u3001\u56de\u8def\u69cb\u9020\u304c\u6bd4\u8f03\u7684\u660e\u5feb\u3067\u3001\u307e\u305fin vivo\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u7b49\u306e\u624b\u6cd5\u304c\u4f7f\u3044\u3084\u3059\u3044\u3068\u3044\u3063\u305f\u5229\u70b9\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u55c5\u899a\u7cfb\u306b\u304a\u3051\u308b\u5302\u3044\u60c5\u5831\u51e6\u7406\u3092\u652f\u3048\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u306f\u30013\u3064\u306e\u91cd\u8981\u306a\u30eb\u30fc\u30eb\u304c\u3042\u308a\u307e\u3059\u3002\u7b2c\u4e00\u306f“one OSN – one receptor rule”<\/strong>\u3067\u3059\u3002\u500b\u3005\u306e\u55c5\u795e\u7d4c\u7d30\u80de\uff08OSN\uff09\u306b\u306f1\u7a2e\u985e\u306e\u55c5\u899a\u53d7\u5bb9\u4f53\uff08OR\uff09\u306e\u307f\u304c\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u304c\u5302\u3044\u8b58\u5225\u306e\u57fa\u76e4\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u5742\u91ce\u7814\u7a76\u5ba4\u3084Lomvardas\u7814\u7a76\u5ba4\u306b\u3088\u3063\u3066\u660e\u3089\u304b\u306b\u3055\u308c\u307e\u3057\u305f\u3002\u7b2c\u4e8c\u306e\u30eb\u30fc\u30eb\u3068\u3057\u3066\u3001“one glomerulus – one receptor rule”<\/strong>\u304c\u3042\u308a\u307e\u3059\u3002\u540c\u7a2e\u306eOR\u3092\u767a\u73fe\u3059\u308b\u55c5\u795e\u7d4c\u7d30\u80de\u306f\u3001\u55c5\u7403\u306e\u540c\u4e00\u306e\u7cf8\u7403\u4f53\uff08glomerulus\uff09\u3078\u3068\u8ef8\u7d22\u3092\u53ce\u6582\u3055\u305b\u308b\u3068\u3044\u3046\u30eb\u30fc\u30eb\u3067\u3059\u3002\u4eca\u4e95\u306f\u5742\u91ce\u7814\u6642\u4ee3\u306b\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u8ca2\u732e\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u7b2c\u4e09\u306e\u30eb\u30fc\u30eb\u304c“one mitral cell – one glomerulus rule”<\/strong>\u3067\u3059\u3002\u4e8c\u6b21\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u3042\u308b\u50e7\u5e3d\u7d30\u80de\uff08mitral cell\uff09\u306f\u5358\u4e00\u306e\u7cf8\u7403\u4f53\u304b\u3089\u306e\u307f\u611f\u899a\u60c5\u5831\u3092\u53d7\u3051\u53d6\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u3063\u3066\u30011000\u7a2e\u985e\u306eOR\u306b\u3088\u3063\u3066\u53d7\u5bb9\u3055\u308c\u305f\u5302\u3044\u306e\u60c5\u5831\u304c\u6df7\u7dda\u3059\u308b\u3053\u3068\u7121\u304f\u60c5\u5831\u51e6\u7406\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u6211\u3005\u306e\u7814\u7a76\u5ba4\u3067\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\uff08Cell Reports<\/em>\u00a02021; Developmental Cell<\/em> 2023\uff09\u3002<\/p>\n

\"\"<\/p>\n

\u5927\u8133\u76ae\u8cea\u3067\u306f\u3001\u7279\u306b\u601d\u6625\u671f\u306b\u7279\u6709\u306a\u56de\u8def\u518d\u7de8\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u7cbe\u795e\u75be\u60a3\u306e\u95a2\u9023\u306b\u8208\u5473\u3092\u3082\u3063\u3066\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u5c06\u6765\u7684\u306b\u306f\u3001\u52d5\u4f5c\u539f\u7406\u30fb\u56de\u8def\u69cb\u9020\u57fa\u76e4\u30fb\u5f62\u6210\u539f\u7406\u306e\u7406\u89e3\u3092\u7d71\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u30b3\u30cd\u30af\u30c8\u30fc\u30e0\u304b\u3089\u8a18\u61b6\u3092\u8aad\u307f\u51fa\u3059<\/strong>\u3053\u3068\u3084\u3001\u751f\u7269\u306e\u8133\u3092\u8d8a\u3048\u308b\u3088\u3046\u306a\u4eba\u5de5\uff08\u5408\u6210\uff09\u795e\u7d4c\u56de\u8def\u3092\u5275\u51fa\u3059\u308b<\/strong>\u3053\u3068\u306b\u3082\u53d6\u308a\u7d44\u307f\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u55c5\u7403\u306e\u8aac\u660e\u306f\u8133\u79d1\u5b66\u8f9e\u5178\u30fb\u55c5\u7403\u306e\u9801\uff08\u4eca\u4e95\u57f7\u7b46\uff09<\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002\u55c5\u899a\u7cfb\u306e\u5165\u9580\u66f8\u3068\u3057\u3066\u306f\u68ee\u61b2\u4f5c\u5148\u751f\u304c\u66f8\u304b\u308c\u305f\u65b0\u66f8<\/a>\u3082\u304a\u3059\u3059\u3081\u3067\u3059\u3002\u307e\u305f\u3001\u55c5\u7403\u304c\u3069\u306e\u3088\u3046\u306a\u56de\u8def\u6a5f\u80fd\u3092\u62c5\u3063\u3066\u3044\u3066\u3001\u56de\u8def\u5f62\u6210\u306b\u95a2\u3057\u3066\u3069\u306e\u3088\u3046\u306aquestion\u304c\u3042\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u3053\u3061\u3089\u306e\u82f1\u6587\u7dcf\u8aac<\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n

\u5927\u8133\u76ae\u8cea\u306f\u3001\u80ce\u5150\u671f\u30fb\u5e7c\u5150\u671f\u306e\u307f\u306a\u3089\u305a\u3001\u601d\u6625\u671f\u306b\u304b\u3051\u3066\u767a\u9054\u304c\u7d9a\u304f\u3053\u3068\u304c\u7279\u5fb4\u7684\u3067\u3059\u3002\u73fe\u5728\u3001\u601d\u6625\u671f\u306e\u5927\u8133\u76ae\u8cea\u306b\u304a\u3051\u308b\u30b7\u30ca\u30d7\u30b9\u5206\u5e03\u306e\u7814\u7a76\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u307b\u304b\uff08\u4e3b\u306b\u4f53\u6027\u611f\u899a\u91ce\uff09\u3001\u9ad8\u7b49\u307b\u4e73\u985e\u306e\u56de\u8def\u767a\u9054\u3084\u7cbe\u795e\u75be\u60a3\u306e\u7814\u7a76\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n

\u7814\u7a76\u5ba4\u3067\u306f\u7279\u306b\u30012\u5149\u5b50\u52b1\u8d77\u9855\u5fae\u93e1\u3084\u8d85\u89e3\u50cf\u9855\u5fae\u93e1\u3068\u3044\u3063\u305f\u5149\u5b66\u9855\u5fae\u93e1\u6280\u8853\u3092\u99c6\u4f7f\u3057\u3066\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6d3b\u52d5\u3084\u5f62\u614b\u306e\u8a08\u6e2c\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u5206\u91ce\u306e\u767a\u5c55\u306b\u5bc4\u4e0e\u3059\u308b\u6280\u8853\u958b\u767a\u3082\u72ec\u81ea\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u7814\u7a76\u30c6\u30fc\u30de\u306f\u672c\u4eba\u306e\u610f\u5411\u3092\u6700\u512a\u5148\u3057\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u5185\u5bb9\u306b\u8208\u5473\u306e\u3042\u308b\u65b9\u306f\u3001\u307e\u305a\u306f\u4eca\u4e95\u307e\u3067\u30b3\u30f3\u30bf\u30af\u30c8\u3057\u3066\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n

\u4ee5\u4e0b\u3001\u73fe\u5728\u9032\u884c\u4e2d\uff0b\u6700\u8fd1\u306e\u7814\u7a76\u7d39\u4ecb\u3067\u3059\u3002<\/p>\n

 <\/p>\n

1) \u56de\u8def\u6a5f\u80fd\uff1a\u611f\u899a\u60c5\u5831\u51e6\u7406\u306e\u539f\u7406\uff08\u4e3b\u306b\u55c5\u899a\uff09<\/h3>\n

\"\"\u611f\u899a\u5668\u306b\u306f\u611f\u899a\u60c5\u5831\u4ee5\u5916\u306b\u3082\u96d1\u591a\u306a\u30ce\u30a4\u30ba\u3082\u4e00\u7dd2\u306b\u5165\u529b\u3057\u3066\u304a\u308a\u305d\u308c\u3089\u306e\u4e2d\u304b\u3089\u5fc5\u8981\u306a\u611f\u899a\u60c5\u5831\u306e\u307f\u3092\u62bd\u51fa\u3059\u308b\u306e\u306f\u7c21\u5358\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u611f\u899a\u60c5\u5831\u304c\u79fb\u308d\u3044\u3086\u304f\u4e2d\u3001\u540c\u3058\u60c5\u5831\u3068\u7570\u306a\u308b\u60c5\u5831\u3092\u533a\u5225\u3059\u308b\u3068\u3044\u3046\u306e\u3082\u5bb9\u6613\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u6211\u3005\u306e\u7814\u7a76\u5ba4\u3067\u306f\u672b\u68a2\uff08\u55c5\u4e0a\u76ae\uff09\uff5e\u4e00\u6b21\u4e2d\u67a2\u306e\u55c5\u7403\u306b\u7740\u76ee\u3057\u3066\u3001\u300c\u751f\u4f53\u5185\u300d\u306b\u304a\u3051\u308b\u55c5\u899a\u60c5\u5831\u51e6\u7406\u306e\u3057\u304f\u307f\u3092\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u6211\u3005\u306f\u3001\u4e16\u754c\u3067\u521d\u3081\u3066\u3001\u55c5\u899a\u7cfb\u306e\u672b\u68a2\u5668\u5b98\u3067\u3042\u308b\u55c5\u4e0a\u76ae\u306b\u304a\u3051\u308b\u5302\u3044\u5fdc\u7b54\u3092in vivo\u8a08\u6e2c\u3059\u308b\u7cfb\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002\u55c5\u899a\u7814\u7a76\u3067\u306f\u3001\u3057\u3070\u3057\u3070\u5358\u7269\u8cea\u306b\u5bfe\u3059\u308b\u5fdc\u7b54\u304c\u7814\u7a76\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u81ea\u7136\u754c\u306e\u5302\u3044\u306f\u3001\u591a\u304f\u306e\u5834\u5408\u591a\u6570\u306e\u5302\u3044\u5206\u5b50\u306e\u6df7\u5408\u7269\u3067\u3059\u3002\u305d\u3053\u3067\u3001\u6df7\u5408\u81ed\u306b\u5bfe\u3059\u308b\u5fdc\u7b54\u3092in vivo\u8a08\u6e2c\u3057\u305f\u3068\u3053\u308d\u3001\u3057\u3070\u3057\u3070\u305d\u306e\u5fdc\u7b54\u306f\u5358\u7269\u8cea\u306e\u5fdc\u7b54\u306e\u8db3\u3057\u7b97\u3088\u308a\u3082\u5c0f\u3055\u304f\u306a\u3063\u305f\u308a\uff08\u62ee\u6297\u4f5c\u7528\uff09\u3001\u5927\u304d\u304f\u306a\u3063\u305f\u308a\uff08\u76f8\u4e57\u52b9\u679c\uff09\u3059\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\uff08Cell Reports<\/em> 2020\u3001\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\uff09\u3002\u7279\u306b\u3001\u76f8\u4e57\u52b9\u679c\u306b\u3064\u3044\u3066\u306f\u55c5\u899a\u53d7\u5bb9\u4f53\u306e\u30a2\u30ed\u30b9\u30c6\u30ea\u30c3\u30af\u52b9\u679c\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u304a\u308a\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u55c5\u7403\u3067\u306f\u3001\u5f93\u6765\u3001\u7cf8\u7403\u4f53\u306e\u7a7a\u9593\u7684\u306a\u6d3b\u52d5\u30de\u30c3\u30d7\uff08\u7cf8\u7403\u4f53\u30de\u30c3\u30d7\uff09\u304c\u5302\u3044\u8b58\u5225\u306e\u57fa\u76e4\u306b\u306a\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u8aac\u304c\u4fe1\u3058\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u8fd1\u5e74\u3001\u6642\u9593\u7684\u306a\u6d3b\u52d5\u30d1\u30bf\u30fc\u30f3\u306e\u91cd\u8981\u6027\u304c\u7740\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6700\u8fd1\u3001\u6211\u3005\u306f\u55c5\u7403\u50e7\u5e3d\u7d30\u80de\u306e2\u5149\u5b50\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u884c\u3044\u3001\u50e7\u5e3d\u7d30\u80de\u3067\u306f\u795e\u7d4c\u6d3b\u52d5\u306e\u6642\u9593\u30d1\u30bf\u30fc\u30f3\u304c\u5302\u3044\u60c5\u5831\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u308b\u3053\u3068\u3001\u3053\u308c\u304cconcentration invariant\u3067\u3042\u308b\u3053\u3068\u3001\u795e\u7d4c\u6d3b\u52d5\u306e\u201c\u632f\u52d5\u201d\u73fe\u8c61\u304c\u305d\u306e\u57fa\u76e4\u3068\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08Neuron<\/em> 2017\uff09\u3002\u5302\u3044\u60c5\u5831\u304c\u632f\u52d5\u4f4d\u76f8\u306b\u30b3\u30fc\u30c9\u3055\u308c\u308b\u3053\u3068\u304b\u3089\u3001\u4f4d\u76f8\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0\u3068\u547c\u3093\u3067\u3044\u307e\u3059\u3002\u65e5\u672c\u8a9e\u306e\u7dcf\u8aac\u306f\u3053\u3061\u3089<\/a>\u3002\u73fe\u5728\u306f\u3001\u3069\u3046\u3057\u3066\u3053\u3093\u306a\u60c5\u5831\u51e6\u7406\u304c\u53ef\u80fd\u306a\u306e\u304b\u3092\u7d30\u80de\u30ec\u30d9\u30eb\u3001\u56de\u8def\u30ec\u30d9\u30eb\u3067\u7406\u89e3\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u4f3c\u305f\u3088\u3046\u306a\u73fe\u8c61\u306f\u6d77\u99ac\u306e\u5834\u6240\u7d30\u80de\u7b49\u3067\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u56de\u8def\u57fa\u76e4\u306f\u5168\u304f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u6b21\u306b\u8ff0\u3079\u308b\u30b3\u30cd\u30af\u30c8\u30df\u30af\u30b9\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7d44\u307f\u5408\u308f\u305b\u3001\u6570\u7406\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u3063\u3066\u4f4d\u76f8\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0\u306e\u52d5\u4f5c\u539f\u7406\u30fb\u56de\u8def\u57fa\u76e4\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u6700\u8fd1\u306f\u3001\u55c5\u899a\u7cfb\u4ee5\u5916\u3067\u306e\u5316\u5b66\u53d7\u5bb9\uff08\u8ff7\u8d70\u795e\u7d4c\u3084\u4e09\u53c9\u795e\u7d4c\uff09\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e\u3092\u76ee\u6307\u3057\u305fin vivo\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n

2)\u00a0\u56de\u8def\u69cb\u9020\uff1a\u5149\u5b66\u9855\u5fae\u93e1\u3092\u7528\u3044\u305f\u30b3\u30cd\u30af\u30c8\u30df\u30af\u30b9<\/h3>\n

1)\u3067\u8ff0\u3079\u305f\u3088\u3046\u306b\u3001\u73fe\u5728\u591a\u304f\u306e\u795e\u7d4c\u7d30\u80de\u304b\u3089\u540c\u6642\u306b\u795e\u7d4c\u6d3b\u52d5\u3092\u8a18\u9332\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u305d\u306e\u3088\u3046\u306a\u6f14\u7b97\u304c\u53ef\u80fd\u306a\u306e\u304b\u3092\u7406\u89e3\u3059\u308b\u306b\u306f\u3001\u56de\u8def\u69cb\u9020\u306e\u7406\u89e3\u304c\u5fc5\u9808\u3067\u3059\u3002\u305d\u3053\u3067\u3001\u6211\u3005\u306f\u56de\u8def\u306e\u5168\u4f53\u50cf\u3092\u6349\u3048\u308b\u305f\u3081\u306e\u65b0\u3057\u3044\u6280\u8853\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n

\"\"\u6211\u3005\u306f\u3001\u539a\u307f\u306e\u3042\u308b\u8133\u7d44\u7e54\u306e\u69cb\u9020\u3092\u7dad\u6301\u3057\u3064\u3064\u3001\u56de\u8def\u306e\u5168\u4f53\u50cf\u3092\u6349\u3048\u308b\u3079\u304f\u30012013\u5e74\u306b\u7d44\u7e54\u900f\u660e\u5316\u6cd5SeeDB\u3092\u958b\u767a\u3057\u307e\u3057\u305f\uff08Nature Neuroscience<\/em> 2013\uff09\u3002\u3053\u306e\u65b9\u6cd5\u3092\u7528\u3044\u308b\u3068\u30012\u5149\u5b50\u52b1\u8d77\u9855\u5fae\u93e1\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u6570mm\u306e\u6df1\u3055\u307e\u3067\u56de\u8def\u3092\u6349\u3048\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u30011\u500b1\u500b\u306e\u30b7\u30ca\u30d7\u30b9\u307e\u3067\u9ad8\u89e3\u50cf\u5ea6\u3067\u6349\u3048\u308b\u305f\u3081\u306e\u900f\u660e\u5316\u8a66\u85acSeeDB2\u3082\u958b\u767a\u3057\u307e\u3057\u305f\uff08Cell Reports<\/em> 2016\uff09\u3002SeeDB2\u3068\u8d85\u89e3\u50cf\u9855\u5fae\u93e1\u3092\u7528\u3044\u308b\u3068\u3001\u96fb\u5b50\u9855\u5fae\u93e1\u3088\u308a\u3082\u77ed\u6642\u9593\u3067\u30b7\u30ca\u30d7\u30b9\u5206\u5e03\u306e\u89e3\u6790\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u900f\u660e\u5316\u6280\u8853\u306e\u8a73\u7d30\u306fSeeDB Resources<\/a>\u306b\u516c\u958b\u3057\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u591a\u8272\u6a19\u8b58\u6cd5\uff08Sakaguchi et al., 2017\uff09\u3092\u66f4\u306b\u62e1\u5f35\u3057\u305f\u300c\u8d85\u591a\u8272\u6a19\u8b58\u6cd5\u300d\u3092\u958b\u767a\u3057\u3001\u9855\u5fae\u93e1\u753b\u50cf\u304b\u3089\u56de\u8def\u69cb\u9020\u3092\u81ea\u52d5\u518d\u69cb\u7bc9\u3059\u308b\u305f\u3081\u306e\u65b0\u3057\u3044\u30c4\u30fc\u30eb\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059\uff08bioRxiv<\/em> 2022; \u672a\u767a\u8868\uff09\u3002\u307e\u305f\u3001\u30b7\u30ca\u30d7\u30b9\u30ec\u30d9\u30eb\u306e\u30b3\u30cd\u30af\u30c8\u30df\u30af\u30b9\u89e3\u6790\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u306e\u69cb\u7bc9\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\uff08AMED\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\uff09\u3002\u3068\u308a\u308f\u3051\u3001\u6a5f\u68b0\u5b66\u7fd2\u306e\u6d3b\u7528\u306f\u91cd\u8981\u306a\u8ab2\u984c\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u3063\u3066\u5149\u5b66\u9855\u5fae\u93e1\u3092\u7528\u3044\u305f\u30b3\u30cd\u30af\u30c8\u30fc\u30e0\u89e3\u6790\u306e\u52b9\u7387\u304c\u5287\u7684\u306b\u5411\u4e0a\u3057\u3001\u8907\u96d1\u306a\u795e\u7d4c\u56de\u8def\u69cb\u9020\u306e\u7814\u7a76\u304c\u5927\u304d\u304f\u9032\u5c55\u3059\u308b\u3082\u306e\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n

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 <\/p>\n

3)\u00a0\u56de\u8def\u5f62\u6210\uff1a\u56de\u8def\u6a5f\u80fd\u306e\u8d77\u6e90\u306b\u8feb\u308b<\/h3>\n

1000\u7a2e\u985e\u3042\u308b\u55c5\u795e\u7d4c\u7d30\u80de\u304c\u3001\u767a\u73fe\u3059\u308b\u55c5\u899a\u53d7\u5bb9\u4f53\u306e\u7a2e\u985e\u306b\u5fdc\u3058\u3066\u6b63\u3057\u3044\u7cf8\u7403\u4f53\u3078\u3068\u6295\u5c04\u3059\u308b\u4ed5\u7d44\u307f\u306b\u3064\u3044\u3066\u306f\u3001\u6211\u3005\u304c10\u5e74\u304b\u3051\u3066\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\uff08Science<\/em> 2006; Science<\/em> 2009; Cell<\/em> 2013\uff09\u3002\u4e00\u65b9\u3067\u3001\u55c5\u7403\u5185\u306e\u56de\u8def\u304c\u3069\u306e\u3088\u3046\u306b\u3064\u304f\u3089\u308c\u308b\u306e\u304b\u306f\u4f9d\u7136\u3068\u3057\u3066\u3088\u304f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

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\"\"
\n\u6211\u3005\u304c\u7279\u306b\u91cd\u8981\u3060\u3068\u8003\u3048\u3066\u3044\u308b\u306e\u306f\u3001”one mitral cell – one glomerulus rule”\u3067\u3059\u3002\u50e7\u5e3d\u7d30\u80de\u306f\u3001\u751f\u5f8c\u76f4\u5f8c\u306b\u306f\u591a\u6570\u306e\u6a39\u72b6\u7a81\u8d77\u304c\u3042\u308a\u3001\u8907\u6570\u306e\u7cf8\u7403\u4f53\u304b\u3089\u5302\u3044\u60c5\u5831\u3092\u53d7\u3051\u53d6\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3084\u304c\u3066\u305d\u308c\u3089\u306f\u5208\u308a\u8fbc\u307e\u308c\u3001\u6700\u7d42\u7684\u306b\u306f\u5358\u4e00\u306e\u6a39\u72b6\u7a81\u8d77\u3092\u5358\u4e00\u306e\u7cf8\u7403\u4f53\u306b\u306e\u307f\u63a5\u7d9a\u3059\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u6a39\u72b6\u7a81\u8d77\u3092\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3059\u308b\u3053\u3068\u3067\u3001\u53d7\u3051\u53d6\u308b\u611f\u899a\u60c5\u5831\uff08\u53d7\u5bb9\u91ce\uff09\u3092\u7cbe\u7dfb\u306b\u3057\u3066\u3044\u304f\u73fe\u8c61\u306f\u3001\u8996\u899a\u91ce\u3084\u4f53\u6027\u611f\u899a\u91ce\u306a\u3069\u3001\u591a\u304f\u306e\u8133\u9818\u57df\u3067\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u4ed5\u7d44\u307f\u306f\u5341\u5206\u306b\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u6700\u8fd1\u3001\u6211\u3005\u306f\u3001\u30b7\u30ca\u30d7\u30b9\u5165\u529b\u306b\u4f9d\u5b58\u3057\u305f\u300c\u5074\u65b9\u6291\u5236\u300d\u304c\u53d7\u5bb9\u91ce\u5f62\u6210\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\uff08Developmental Cell<\/em> 2023\uff09\u3002\u73fe\u5728\u3001\u305d\u306e\u8a73\u7d30\u306a\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

 <\/p>\n

4) \u55c5\u899a\u7cfb\u306e\u56de\u8def\u5f62\u6210\u3068\u75be\u60a3<\/h3>\n

\"\"\u55c5\u795e\u7d4c\u7d30\u80de\u306f\u751f\u6daf\u306b\u4e98\u3063\u3066\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3057\u3001\u8ef8\u7d22\u3092\u518d\u751f\u3057\u3066\u3044\u307e\u3059\u3002\u80ce\u5150\u671f\u306b\u51fa\u6765\u4e0a\u304c\u3063\u305f\u55c5\u899a\u5730\u56f3\u306b\u518d\u751f\u8ef8\u7d22\u304c\u53b3\u5bc6\u306b\u63a5\u7d9a \u3059\u308b\u3053\u3068\u306f\u3001\u5302\u3044\u60c5\u5831\u3092\u751f\u6daf\u306b\u4e98\u3063\u3066\u7dad\u6301\u3059\u308b\u4e0a\u3067\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002\u5b9f\u969b\u3001\u982d\u90e8\u3078\u306e\u7269\u7406\u7684\u30c0\u30e1\u30fc\u30b8\u7b49\u3067\u55c5\u795e\u7d4c\u7d30\u80de\u8ef8\u7d22\u304c\u3072\u3068\u305f\u3073\u5207\u65ad\u3055\u308c\u3066\u3057\u307e\u3046\u3068\u3001\u305d\u306e\u5f8c \u518d\u751f\u8ef8\u7d22\u304c\u6b63\u3057\u304f\u55c5\u7403\u306b\u63a5\u7d9a\u305b\u305a\u3001\u5302\u3044\u304c\u6b63\u3057\u304f\u55c5\u3052\u306a\u304f\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\uff08\u7570\u81ed\u75c7\uff09\u3002\u5302\u3044\u306f\u751f\u5b58\u306b\u5fc5\u9808\u306a\u611f\u899a\u60c5\u5831\u3067\u306f\u306a\u3044\u3068\u306f\u3044\u3048\u3001\u4e0d\u5feb\u306a\u5302\u3044\u306b\u3088\u3063\u3066\u304a\u3044\u3057\u304f\u3054\u98ef\u304c\u98df\u3079\u3089\u308c\u306a\u304f\u306a\u308b\u306a\u3069\u3001QOL\u3078\u306e\u5f71\u97ff\u306f\u751a\u5927\u3067\u3059\u3002\u3057\u304b\u3082\u3001\u7570\u81ed\u75c7\u306f\u4e88\u5f8c\u304c\u60aa\u304f\u3001\u73fe\u5728\u306e\u3068\u3053\u308d\u6cbb\u7642\u306e\u624b\u6bb5\u306f\u3042\u308a\u307e\u305b\u3093\u3002 \u6211\u3005\u306f\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u55c5\u795e\u7d4c\u7d30\u80de\u8ef8\u7d22\u5207\u65ad\u306b\u3088\u308b\u7570\u81ed\u75c7\u30e2\u30c7\u30eb\u3092\u4f5c\u6210\u3057\u3001\u305d\u306e\u75c5\u614b\u306e\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u6211\u3005\u304c\u3053\u308c\u307e\u3067\u306b\u884c\u3063\u3066\u304d\u305f\u55c5\u795e\u7d4c\u7d30\u80de\u8ef8\u7d22\u6295\u5c04\u306e\u77e5\u8b58\u3092\u7528\u3044\u3066\u3001\u305d\u306e\u539f\u56e0\u306b\u3064\u3044\u3066\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u306f\u5ca1\u5c71\u5927\u5b66\u8033\u9f3b\u79d1\u3068\u306e\u5171\u540c\u7814\u7a76\u3068\u3057\u3066\u884c\u3044\u307e\u3057\u305f\u3002
\nMurai et al., eNeuro<\/em><\/strong> (2016)
\n\u65b0\u805e\u8a18\u4e8b\u306f\u3053\u3061\u3089<\/a><\/p>\n

 <\/p>\n

5) \u7cbe\u795e\u75be\u60a3\u306e\u7406\u89e3\u3078\u5411\u3051\u3066<\/h3>\n

\"\"
\n\u73fe\u5728\u3001\u7d71\u5408\u5931\u8abf\u75c7\u3001\u81ea\u9589\u75c7\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u3001\u591a\u304f\u306e\u795e\u7d4c\u75be\u60a3\u306f\u30b7\u30ca\u30d7\u30b9\u306e\u5f62\u6210\u3084\u52d5\u614b\u306b\u7570\u5e38\u304c\u3042\u308b\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u30b7\u30ca\u30d7\u30b9\u7570\u5e38\u306e\u5168\u4f53\u50cf\u3068\u795e\u7d4c\u56de\u8def\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u3088\u304f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u3082\u305d\u3082\u3001\u767a\u9054\u671f\u306b\u30b7\u30ca\u30d7\u30b9\u5206\u5e03\u304c\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3057\u3001\u7cbe\u795e\u75be\u60a3\u3067\u306f\u3069\u3053\u304c\u3069\u306e\u3088\u3046\u306b\u304a\u304b\u3057\u304f\u306a\u308b\u306e\u304b\u3082\u5341\u5206\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u73fe\u5728\u6211\u3005\u306f\u72ec\u81ea\u306e\u900f\u660e\u5316\u6280\u8853\u3092\u7528\u3044\u3066\u5927\u898f\u6a21\u30b7\u30ca\u30d7\u30b9\u30de\u30c3\u30d4\u30f3\u30b0\u3092\u884c\u3044\u3001\u767a\u9054\u671f\u3084\u75c5\u614b\u306b\u304a\u3051\u308b\u30b7\u30ca\u30d7\u30b9\u7570\u5e38\u306e\u89e3\u6790\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u6700\u8fd1\u3001\u601d\u6625\u671f\u306e\u5927\u8133\u76ae\u8cea\u3067\u30b9\u30d1\u30a4\u30f3\u5206\u5e03\u304c\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u3066\u304a\u308a\u3001\u601d\u6625\u671f\u306e\u30b7\u30ca\u30d7\u30b9\u5f62\u6210\u3068\u7d71\u5408\u5931\u8abf\u75c7\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u3001\u907a\u4f1d\u5b50\u3001\u5f62\u614b\uff08\u900f\u660e\u5316\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\uff09\u3001\u6a5f\u80fd\uff082\u5149\u5b50\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\uff09\u306e\u9762\u304b\u3089\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3068\u3044\u3063\u305f\u591a\u304f\u306e\u7cbe\u795e\u75be\u60a3\u3067\u306f\u3001\u767a\u75c7\u306b\u5148\u7acb\u3063\u3066\u55c5\u899a\u7570\u5e38\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u598a\u5a20\u671f\u306e\u55c5\u899a\u904e\u654f\u3084\u7d71\u5408\u5931\u8abf\u75c7\u306b\u304a\u3051\u308b\u55c5\u899a\u306e\u5e7b\u899a\u3082\u9762\u767d\u3044\u554f\u984c\u3067\u3059\u3002\u6211\u3005\u306f\u3055\u307e\u3056\u307e\u306a\u30e9\u30a4\u30d5\u30a4\u30d9\u30f3\u30c8\u3084\u7cbe\u795e\u75be\u60a3\u3068\u55c5\u899a\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u3082\u8208\u5473\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

 <\/p>\n

6) \u8178-\u8133\u30b3\u30cd\u30af\u30c8\u30df\u30af\u30b9\u30d7\u30ed\u30b8\u30a7\u30af\u30c8<\/h3>\n

\u73fe\u5728\u3001JST CREST\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3068\u3057\u3066\u3001\u8178\u8133\u30b3\u30cd\u30af\u30c8\u30df\u30af\u30b9\u306e\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u8178\u7ba1\u4e0a\u76ae\u306b\u5b58\u5728\u3059\u308b\u8178\u5185\u5206\u6ccc\u7d30\u80de\uff08EEC\uff09\u306f\u69d8\u3005\u306a\u5316\u5b66\u53d7\u5bb9\u3092\u884c\u3044\u3001\u6d88\u5316\u7ba1\u30db\u30eb\u30e2\u30f3\u3092\u5206\u6ccc\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u3001\u3053\u308c\u306b\u52a0\u3048\u3066\u3001EEC\u306f\u6c42\u5fc3\u6027\u8ff7\u8d70\u795e\u7d4c\u306b\u795e\u7d4c\u63a5\u7d9a\u3057\u3001\u305d\u306e\u60c5\u5831\u3092\u76f4\u63a5\u8133\u306b\u4f1d\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\uff08\u81d3\u5668\u611f\u899a\u306e\u4e00\u7a2e\uff09\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u55c5\u899a\u7cfb\u3084\u5473\u899a\u7cfb\u3068\u7570\u306a\u308a\u3001\u8178\u7ba1\u306b\u304a\u3051\u308b\u5316\u5b66\u53d7\u5bb9\u306e\u30ed\u30b8\u30c3\u30af\u3084\u8133\u306b\u304a\u3051\u308b\u51e6\u7406\u6a5f\u69cb\u306f\u307b\u3068\u3093\u3069\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u73fe\u5728\u9032\u884c\u5f62\u306e\u7814\u7a76\u3067\u306f\u3001\u8178\u7ba1\u306e\u5316\u5b66\u53d7\u5bb9\u306f\u304b\u306a\u308a\u7d30\u5206\u5316\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u3066\u304a\u308a\u3001\u7570\u306a\u308b\u6804\u990a\u7d20\u3054\u3068\u306b\u69d8\u3005\u306a\u751f\u4f53\u53cd\u5fdc\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u3042\u307e\u308a\u7740\u76ee\u3055\u308c\u3066\u3053\u306a\u304b\u3063\u305f\u8178\u7ba1\u306b\u304a\u3051\u308b\u5316\u5b66\u611f\u899a\u30fb\u81d3\u5668\u611f\u899a\u306e\u4ed5\u7d44\u307f\u306e\u89e3\u660e\u306b\u53d6\u308a\u7d44\u307f\u307e\u3059\u3002<\/p>\n

 <\/p>\n

7) \u30b3\u30cd\u30af\u30c8\u30fc\u30e0\u304b\u3089\u8a18\u61b6\u3092\u8aad\u307f\u51fa\u3059\u3053\u3068\u306f\u3067\u304d\u308b\u304b\uff1f<\/h3>\n

\u6211\u3005\u306e\u8133\u306b\u306f\u3001\u305d\u308c\u307e\u3067\u306e\u4eba\u751f\u306e\u3042\u3089\u3086\u308b\u7d4c\u9a13\u304c\u8a18\u61b6\u3068\u3057\u3066\u66f8\u304d\u8fbc\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8a18\u61b6\u306f\u3001\u30b7\u30ca\u30d7\u30b9\u7d50\u5408\u306e\u5909\u5316\u3068\u3057\u3066\u4fdd\u6301\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3067\u306f\u3001\u30b7\u30ca\u30d7\u30b9\u7d50\u5408\u306e\u5168\u4f53\u50cf\u3092\u6349\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308c\u3070\u3001\u8a18\u61b6\u3092\u8aad\u307f\u51fa\u3059\u3053\u3068\u306f\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u304b\uff1f\u6211\u3005\u306f\u3001\u30b3\u30cd\u30af\u30c8\u30fc\u30e0\u89e3\u6790\u306e\u305f\u3081\u306e\u69d8\u3005\u306a\u624b\u6cd5\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u304c\u3001\u7a76\u6975\u7684\u306b\u306f\u3001\u30b3\u30cd\u30af\u30c8\u30fc\u30e0\u3092\u8aad\u307f\u53d6\u308b\u3053\u3068\u3067\u305d\u3053\u306b\u66f8\u304d\u8fbc\u307e\u308c\u305f\u8a18\u61b6\u3092\u8aad\u307f\u51fa\u3057\u3001\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u306b\u79fb\u690d\u3067\u304d\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u58ee\u5927\u306a\u76ee\u6a19\u306b\u5411\u3051\u305f\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u30d2\u30c8\u3084\u30de\u30a6\u30b9\u306e\u5168\u8133\u306e\u30b3\u30cd\u30af\u30c8\u30fc\u30e0\u3092\u8aad\u307f\u51fa\u3059\u306e\u306f\u73fe\u6642\u70b9\u3067\u306f\u4e0d\u53ef\u80fd\u306a\u306e\u3067\u3001\u57f9\u990a\u795e\u7d4c\u7d30\u80de\u306e\u795e\u7d4c\u56de\u8def\u304b\u3089\u8a18\u61b6\u3092\u8aad\u307f\u51fa\u3059\u3053\u3068\u3092\u6700\u521d\u306e\u76ee\u6a19\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u8a73\u3057\u304f\u306f\u3053\u3061\u3089\u3002<\/p>\n

\u305f\u307e\u3054\u3063\u3061\u8a08\u753b\uff08Neuro2022\u30e9\u30f3\u30c1\u30e7\u30f3\u5927\u8a0e\u8ad6\u4f1a\uff09<\/a><\/p>\n

 <\/p>\n

8) \u7814\u7a76\u5ba4\u306e\u7814\u7a76\u65bd\u8a2d\u30fb\u5b9f\u9a13\u6a5f\u5668\u30fb\u5b9f\u9a13\u624b\u6cd5\u306e\u7d39\u4ecb<\/h3>\n

\u5206\u5b50\u751f\u7269\u5b66\u30fb\u751f\u5316\u5b66\u30fb\u5206\u5149\u5b9f\u9a13<\/strong>\uff1a \u4e00\u901a\u308a\u306e\u5206\u5b50\u751f\u7269\u5b66\u3084\u751f\u5316\u5b66\u5b9f\u9a13\u304c\u53ef\u80fd\u3067\u3059\u3002\u86cd\u5149\u30fb\u767a\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u30c4\u30fc\u30eb\u306e\u958b\u767a\u3082\u884c\u3046\u305f\u3081\u3001\u305d\u306e\u305f\u3081\u306e\u5438\u5149\u30fb\u86cd\u5149\u5206\u5149\u6a5f\u5668\u3082\u63c3\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u7d30\u80de\u57f9\u990a<\/strong>\uff1a \u4e00\u822c\u7684\u306a\u7d30\u80de\u57f9\u990a\u3084\u3001\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\uff08AAV\u306a\u3069\uff09\u306e\u4f5c\u88fd\u3082\u30e9\u30dc\u5185\u3067\u4e00\u901a\u308a\u5168\u3066\u884c\u3048\u307e\u3059\u3002\u30d7\u30ec\u30fc\u30c8\u30ea\u30fc\u30c0\u30fc\u3092\u4f7f\u3063\u3066\u3001\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u305f\u30eb\u30b7\u30d5\u30a7\u30e9\u30fc\u30bc\u30ec\u30dd\u30fc\u30bf\u30fc\u30a2\u30c3\u30bb\u30a4\u3082\u884c\u3048\u307e\u3059\u3002<\/p>\n

\u7d44\u7e54\u5316\u5b66\u5b9f\u9a13<\/strong>\uff1a \u51cd\u7d50\u5207\u7247\uff08\u30af\u30e9\u30a4\u30aa\u30b9\u30bf\u30c3\u30c8\uff09\u3001\u30d3\u30d6\u30e9\u30c8\u30fc\u30e0\u5207\u7247\u306e\u4f5c\u88fd\u3068\u3001\u6297\u4f53\u67d3\u8272\u3001in situ hybridization\u306a\u3069\u306f\u4e00\u901a\u308a\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n

\u900f\u660e\u5316<\/strong>\uff1a \u8133\u900f\u660e\u5316\u6280\u8853\u306f\u3046\u3061\u306e\u7814\u7a76\u5ba4\u3067\u72ec\u81ea\u306b\u958b\u767a\u3057\u3066\u304d\u305f\u3053\u3068\u3082\u3042\u308a\u3001\u30ce\u30a6\u30cf\u30a6\u306f\u968f\u4e00\u3068\u8a00\u3048\u307e\u3059\u3002\u7279\u306b\u30b7\u30ca\u30d7\u30b9\u30ec\u30d9\u30eb\u306e\u89e3\u6790\u306f\u4e16\u754c\u3067\u3069\u3053\u306b\u3082\u8ca0\u3051\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u3044\u304f\u3064\u304b\u306f\u7279\u8a31\u3092\u53d6\u5f97\u3057\u3066\u5546\u54c1\u3057\u3066\u3044\u307e\u3059\u3002\u30ea\u30bd\u30fc\u30b9\u30b5\u30a4\u30c8\u306f\u3053\u3061\u3089<\/a>\u3002<\/p>\n

\u5171\u7126\u70b9\u9855\u5fae\u93e1\u30fb\u8d85\u89e3\u50cf\u9855\u5fae\u93e1<\/strong>\uff1a Leica\u306e\u5171\u7126\u70b9\u9855\u5fae\u93e1\u3068\u8d85\u89e3\u50cf\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30e6\u30cb\u30c3\u30c8\uff08Lightning\u30b7\u30b9\u30c6\u30e0\u3001x-y\u5206\u89e3\u80fd120nm, z\u5206\u89e3\u80fd200nm\uff09\u3092\u4fdd\u6709\u3057\u3066\u3044\u307e\u3059\u3002\u72ec\u81ea\u306b\u958b\u767a\u3057\u305f\u900f\u660e\u5316\u6cd5\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u30b7\u30ca\u30d7\u30b9\u30ec\u30d9\u30eb\u306e\u5b9a\u91cf\u89e3\u6790\u3084\u30b3\u30cd\u30af\u30c8\u30fc\u30e0\u89e3\u6790\u304c\u53ef\u80fd\u3067\u3059\u3002\u53d6\u5f97\u3057\u305f\u86cd\u5149\u753b\u50cf\u306f\u3001Neurolucida\uff08\u795e\u7d4c\u30c8\u30ec\u30fc\u30b7\u30f3\u30b0\u30bd\u30d5\u30c8\uff09\u3084Matlab\u3092\u4f7f\u3063\u3066\u89e3\u6790\u3057\u307e\u3059\u3002\u3053\u306e\u89e3\u6790\u30ce\u30a6\u30cf\u30a6\u3082\u4e16\u754c\u3067\u3082\u968f\u4e00\u3068\u3044\u3048\u307e\u3059\u30027\u91cd\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u3084\u3063\u3066\u3044\u308b\u306e\u3082\u4e16\u754c\u3067\u3046\u3061\u304f\u3089\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u30e9\u30a4\u30c8\u30b7\u30fc\u30c8\u9855\u5fae\u93e1<\/strong>\uff1a \u30df\u30eb\u30c6\u30cb\u30fc\u793e\u306e\u30e9\u30a4\u30c8\u30b7\u30fc\u30c8\u9855\u5fae\u93e1\uff08Ultramicroscope Blaze\uff09\u304c\u5c0e\u5165\u3055\u308c\u307e\u3057\u305f\uff08\u4e5d\u5927\u5171\u901a\u6a5f\u5668\u3068\u3057\u3066\u7ba1\u7406\uff09\u3002\u3053\u308c\u306b\u3088\u3063\u3066\u3001\u30de\u30a6\u30b9\u5168\u8133\u306e\u86cd\u5149\u753b\u50cf\u3092\u308f\u305a\u304b\u6570\u6642\u9593\u3067\u53d6\u5f97\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u5168\u8133\u753b\u50cf\u306e\u81ea\u52d5\u89e3\u6790\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u3082\u69cb\u7bc9\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u52d5\u7269\u98fc\u80b2<\/strong>\uff1a \u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3082\u3063\u3071\u3089\u30de\u30a6\u30b9\u3092\u4f7f\u3063\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u5ba4\u5185\u306b\u72ec\u81ea\u306e\u52d5\u7269\u98fc\u80b2\u65bd\u8a2d\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u30a4\u30ce\u30e9\u30c3\u30af\u3068\u547c\u3070\u308c\u308b\u500b\u5225\u63db\u6c17\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u3066\u3001\u5fae\u751f\u7269\u5b66\u7684\u306b\u6e05\u6d44\u306a\u74b0\u5883\u3067\u30de\u30a6\u30b9\u3092\u7ba1\u7406\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u30e9\u30dc\u5185\u306e2\u5149\u5b50\u9855\u5fae\u93e1\u3092\u7528\u3044\u305fin vivo imaging\u3084\u30a6\u30a4\u30eb\u30b9\u5b9f\u9a13\uff08P1A, P2A\uff09\u3092\u52b9\u7387\u3088\u304f\u884c\u3048\u308b\u4f53\u5236\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30a6\u30a4\u30eb\u30b9\u5b9f\u9a13<\/strong>\uff1a \u4e3b\u306bAAV\uff08P1\uff09\u3092\u4f7f\u3063\u3066\u3044\u307e\u3059\u304c\u3001P2\u306e\u30a6\u30a4\u30eb\u30b9\u5b9f\u9a13\u3082\u53ef\u80fd\u3067\u3059\u3002\u8133\u306b\u30a4\u30f3\u30b8\u30a7\u30af\u30b7\u30e7\u30f3\u3059\u308b\u305f\u3081\u306e\u88c5\u7f6e\u3084\u30ce\u30a6\u30cf\u30a6\u306f\u4e00\u901a\u308a\u63c3\u3063\u3066\u3044\u307e\u3059\u3002\u751f\u5f8c\u306e\u8133\u6a5f\u80fd\u3092\u8abf\u3079\u308b\u5834\u5408\u306b\u306fAAV\u3092\u4f7f\u3046\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002AAV\u306fDNA\u304b\u3089\u81ea\u5728\u306b\u81ea\u4f5c\u3067\u304d\u308b\u306e\u3067\u6bd4\u8f03\u7684\u65e9\u304f\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u5b50\u5bae\u5185\u96fb\u6c17\u7a7f\u5b54\u6cd5\uff08in utero electroporation\uff09<\/strong>\uff1a \u5f93\u6765\u306f\u907a\u4f1d\u5b50\u6a5f\u80fd\u306e\u89e3\u6790\u306b\u306f\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\u3084\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3092\u4f7f\u3046\u3053\u3068\u304c\u591a\u304b\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u73fe\u5728\u306fAAV\u306e\u4ed6\u3001in utero electroporation\u3067\u884c\u3046\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u30de\u30a6\u30b9\u80ce\u4ed4\u306e\u8133\u5ba4\u306b\u30d7\u30e9\u30b9\u30df\u30c9DNA\u3092\u6ce8\u5165\u3057\u3066\u96fb\u6c17\u523a\u6fc0\u3092\u884c\u3046\u3053\u3068\u3067\u52b9\u7387\u3088\u304f\u907a\u4f1d\u5b50\u5c0e\u5165\u3067\u304d\u308b\u305f\u3081\u3001\u77ed\u671f\u9593\u306e\u3046\u3061\u306b\u907a\u4f1d\u5b50\u6a5f\u80fd\u89e3\u6790\u304c\u53ef\u80fd\u3067\u3059\u3002CRISPR\/Cas9\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3082\u78ba\u7acb\u3067\u304d\u3066\u304a\u308a\u3001\u80ce\u5150\u671f\uff5e\u751f\u5f8c\u521d\u671f\u306e\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u306e\u89e3\u6790\u306f\u975e\u5e38\u306b\u52b9\u7387\u3088\u304f\u884c\u3048\u307e\u3059\u3002<\/p>\n

2\u5149\u5b50\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/strong>\uff1a 2\u5149\u5b50\u52b1\u8d77\u9855\u5fae\u93e1\u30922\u53f0\u4fdd\u6709\u3057\u3066\u3044\u307e\u3059\uff08\u8fd1\u65e5\u4e2d\u306b3\u53f0\u76ee\u3092\u5c0e\u5165\u4e88\u5b9a\uff09\u3002\u30aa\u30ea\u30f3\u30d1\u30b9\u30de\u30b7\u30f3\u306f2\u6ce2\u9577\u52b1\u8d77\u53ef\u80fd\u306aInSight Dual\u30ec\u30fc\u30b6\u30fc\u3092\u642d\u8f09\u3057\u3066\u3044\u307e\u3059\u3002\u65b0\u3057\u304f\u5c0e\u5165\u3057\u305fThorlabs\u30de\u30b7\u30f3\u306f920nm\u306e\u6ce2\u9577\u56fa\u5b9a\u30ec\u30fc\u30b6\u30fc\u3092\u642d\u8f09\u3057\u3066\u304a\u308a\u3001GCaMP\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5c02\u7528\u3067\u3059\u30022\u5149\u5b50\u52b1\u8d77\u9855\u5fae\u93e1\u3092\u7528\u3044\u308b\u3068\u3001\u751f\u304d\u305f\u52d5\u7269\u306e\u6df1\u90e8\u306e\u86cd\u5149\u30b7\u30b0\u30ca\u30eb\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u899a\u9192\u4e0b\u3001\u9ebb\u9154\u4e0b\u306ein vivo\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\uff08GCaMP\u306a\u3069\uff09\u306f\u3001\u6210\u4f53\u3060\u3051\u3067\u306a\u304f\u3001\u65b0\u751f\u4ed4\u306e\u30de\u30a6\u30b9\u3067\u3082\u884c\u3046\u305f\u3081\u306e\u30ce\u30a6\u30cf\u30a6\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u66f4\u306b\u3001\u8133\u30b9\u30e9\u30a4\u30b9\u3092\u4f7f\u3063\u3066\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3001FRET\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3001\u30a2\u30f3\u30b1\u30fc\u30b8\u30f3\u30b0\u306a\u3069\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u53d6\u5f97\u3057\u305f\u753b\u50cf\u30c7\u30fc\u30bf\u306f\u3001Matlab\u3092\u4f7f\u3063\u3066\u89e3\u6790\u3057\u307e\u3059\u3002<\/p>\n

\u8133\u30b9\u30e9\u30a4\u30b9\u751f\u7406\u5b66\u30fb\u85ac\u7406\u5b66<\/strong>\uff1a \u6025\u6027\u8133\u30b9\u30e9\u30a4\u30b9\u3092\u7528\u3044\u305f2\u5149\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\uff08\u30ab\u30eb\u30b7\u30a6\u30e0\u3001FRET\uff09\u3001\u85ac\u7406\u5b66\u5b9f\u9a13\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u753b\u50cf\u89e3\u6790<\/strong>\uff1a Matlab\u3084Python\u306e\u81ea\u4f5c\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u89e3\u6790\u3059\u308b\u4eba\u304c\u591a\u3044\u3067\u3059\u3002\u753b\u50cf\u89e3\u6790\u7528\u306b\u5927\u5bb9\u91cf\u306e\u753b\u50cf\u3092\u6271\u3048\u308b\u30ef\u30fc\u30af\u30b9\u30c6\u30fc\u30b7\u30e7\u30f3\u3092\u4f7f\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u307b\u304b\u30013D\u753b\u50cf\u306e\u89e3\u6790\u306b\u306fImaris\u3001\u795e\u7d4c\u56de\u8def\u30c8\u30ec\u30fc\u30b7\u30f3\u30b0\u306b\u306fNeurolucida\/Neurolucida360\u306a\u3069\u3092\u4f7f\u3063\u3066\u3044\u307e\u3059\u3002\u6df1\u5c64\u5b66\u7fd2\u3092\u7528\u3044\u305f\u9855\u5fae\u93e1\u753b\u50cf\u306e\u81ea\u52d5\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u308b\u4eba\u3082\u3044\u307e\u3059\u3002<\/p>\n

\u55c5\u899a\u5b9f\u9a13<\/strong>\uff1a \u55c5\u899a\u7cfb\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u5b9f\u9a13\u3067\u306f\u5302\u3044\u523a\u6fc0\u88c5\u7f6e\u3092\u5404\u81ea\u81ea\u4f5c\uff08\u96fb\u5b50\u5de5\u4f5c\uff09\u3057\u3066\u4f7f\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u884c\u52d5\u5b9f\u9a13<\/strong>\uff1a \u55c5\u899a\u884c\u52d5\u306e\u30a2\u30c3\u30bb\u30a4\u3084\u3001\u7cbe\u795e\u75be\u60a3\u30e2\u30c7\u30eb\u306e\u89e3\u6790\u3092\u884c\u3044\u307e\u3059\u3002DeepLabCut\u3092\u4f7f\u3063\u305f\u30c8\u30e9\u30c3\u30ad\u30f3\u30b0\u3092\u884c\u3063\u305f\u308a\u3001\u5c02\u7528\u306e\u89e3\u6790\u88c5\u7f6e\u3092\u4f7f\u3063\u3066\u89e3\u6790\u3057\u307e\u3059\u3002\u5149\u907a\u4f1d\u5b66\u306f\u81ea\u4f5c\u3057\u305f\u523a\u6fc0\u88c5\u7f6e\u3067\u5b9f\u9a13\u3057\u307e\u3059\u3002<\/p>\n

 <\/p>\n

9) \u904e\u53bb\u306e\u7814\u7a76\u6210\u679c\u306e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u30fb\u30cb\u30e5\u30fc\u30b9\u8a18\u4e8b<\/h3>\n

\u30fb\u751f\u304d\u305f\u307e\u307e\u7d44\u7e54\u3092\u900f\u660e\u5316\u3067\u304d\u308b\u8a66\u85ac\u306e\u958b\u767a
\n\uff5e\u6b63\u5e38\u6a5f\u80fd\u3092\u4fdd\u6301\u3057\u305f\u307e\u307e\u900f\u660e\u5316\u3057\u3066\u795e\u7d4c\u7d30\u80de\u306e\u6d3b\u52d5\u3092\u86cd\u5149\u89b3\u5bdf\u3059\u308b\u3053\u3068\u306b\u6210\u529f\uff5e
\n[\u4e5d\u5927 2026\/03\/12<\/a>] (Nature Methods<\/strong><\/em> 2026)<\/p>\n

\u30fb\u601d\u6625\u671f\u306b\u304a\u3051\u308b\u5927\u8133\u76ae\u8cea\u306e\u30b7\u30ca\u30d7\u30b9\u5f62\u6210\u304c\u9ad8\u6b21\u8133\u6a5f\u80fd\u767a\u9054\u306e\u9375
\n\uff5e\u7d71\u5408\u5931\u8abf\u75c7\u306e\u75c5\u614b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3082\u65b0\u8aac\uff5e
\n[\u4e5d\u5927 2026\/01\/15<\/a>] (Science Advances<\/strong><\/em> 2026)<\/p>\n

\u30fb\u795e\u7d4c\u7a81\u8d77\u306e\u914d\u7dda\u3092\u591a\u304f\u306e\u8272\u3067\u6a19\u8b58\u3057\u81ea\u52d5\u89e3\u6790\u3059\u308b\u624b\u6cd5\u3092\u958b\u767a
\n\uff5e\u30d2\u30c8\u306b\u306f\u898b\u3048\u306a\u30447\u539f\u8272\u306e\u4e16\u754c\u3092\u6a5f\u68b0\u3067\u8b58\u5225\uff5e
\n[\u4e5d\u5927 2024\/6\/26]<\/a>(Nature Communications<\/em><\/strong> 2024)<\/p>\n

\u30fb\u767a\u9054\u671f\u306b\u304a\u3051\u308b\u795e\u7d4c\u7a81\u8d77\u306e\u5208\u308a\u8fbc\u307f\u3092\u5236\u5fa1\u3059\u308b\u30b7\u30ca\u30d7\u30b9\u7af6\u5408\u306e\u57fa\u672c\u539f\u7406\u3092\u89e3\u660e
\n\uff5e\u96d1\u591a\u306a\u5165\u529b\u3092\u906e\u65ad\u3057\u3001\u7cbe\u7dfb\u306a\u56de\u8def\u3092\u3064\u304f\u308b\u305f\u3081\u306e\u4ed5\u7d44\u307f\u3092\u89e3\u660e\uff5e
\n[\u4e5d\u5927 2023\/6\/8]<\/a>[Neuroscience News<\/a>](Developmental Cell<\/em><\/strong> 2023)<\/p>\n

\u30fb\u767a\u9054\u671f\u306b\u7279\u5b9a\u306e\u6a39\u72b6\u7a81\u8d77\u304c\u9078\u629e\u7684\u306b\u5f37\u5316\u3055\u308c\u308b\u4ed5\u7d44\u307f\u3092\u89e3\u660e
\n\uff5e\u5206\u6ccc\u30bf\u30f3\u30d1\u30af\u8ceaBMP\u3068\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u5171\u5165\u529b\u304c\u9375\uff5e
\n[\u4e5d\u5927 2021\/6\/23]<\/a>(Cell Reports<\/em><\/strong> 2021)<\/p>\n

\u30fb\u5302\u3044\u306e\u30cf\u30fc\u30e2\u30cb\u30fc\u304c\u751f\u307f\u51fa\u3055\u308c\u308b\u4ed5\u7d44\u307f\u3092\u89e3\u660e
\n\u9f3b\u306e\u4e2d\u3067\u751f\u3058\u308b\u6291\u5236\u6027\u5fdc\u7b54\u3001\u62ee\u6297\u4f5c\u7528\u3001\u76f8\u4e57\u52b9\u679c\u3092\u751f\u304d\u305f\u52d5\u7269\u3067\u5b9f\u8a3c
\n[\u4e5d\u5927 2020\/7\/1]<\/a>(Cell Reports<\/em><\/strong>\u00a02020)<\/p>\n

\u30fb\u795e\u7d4c\u7d30\u80de\u3092\u660e\u308b\u304f\u30ab\u30e9\u30d5\u30eb\u306b\u67d3\u3081\u308b\u3053\u3068\u3067\u795e\u7d4c\u56de\u8def\u7814\u7a76\u3092\u52a0\u901f
\n[\u4e5d\u5927 2018\/11\/20]<\/a>(eLife<\/em><\/strong>\u00a02018)<\/p>\n

\u30fb\u767a\u706b\u30bf\u30a4\u30df\u30f3\u30b0\u306b\u57fa\u3065\u304f\u5302\u3044\u8b58\u5225\u306e\u4ed5\u7d44\u307f\u3092\u89e3\u660e
\n\uff0d\u5302\u3044\u306e\u6fc3\u5ea6\u304c\u5909\u308f\u3063\u3066\u3082\u611f\u3058\u308b\u5302\u3044\u304c\u5909\u308f\u3089\u306a\u3044\u306e\u306f\u306a\u305c\u304b\uff1f\uff0d
\n[\u7406\u7814 2017\/12\/7]<\/a>\u00a0[CDB\u30cb\u30e5\u30fc\u30b9]<\/a>(Neuron<\/em><\/strong>\u00a02017)<\/p>\n

\u30fb\u640d\u50b7\u5f8c\u306e\u8aa4\u3063\u305f\u8ef8\u7d22\u914d\u7dda\u304c\u55c5\u899a\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3059
\n[CDB\u30cb\u30e5\u30fc\u30b9 2016\/10\/26]<\/a>\u00a0(eNeuro<\/em><\/strong>\u00a02016)<\/p>\n

\u30fb\u30b7\u30ca\u30d7\u30b9\u306e\u5fae\u7d30\u69cb\u9020\u307e\u3067\u9bae\u660e\u306b
\n\uff0d\u9ad8\u5c48\u6298\u7387\u306e\u6539\u826f\u578b\u900f\u660e\u5316\u6db2\u3067\u6df1\u90e8\u8d85\u89e3\u50cf\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u5b9f\u73fe\uff0d
\n[\u7406\u7814 2016\/3\/11]<\/a>\u00a0[CDB\u30cb\u30e5\u30fc\u30b9]<\/a>\u00a0(Cell Reports<\/em><\/strong>\u00a02016)<\/p>\n

\u30fb\u7c21\u4fbf\u3067\u751f\u4f53\u8a66\u6599\u306b\u3084\u3055\u3057\u3044\u7d44\u7e54\u900f\u660e\u5316\u8a66\u85ac\u300cSeeDB\u300d\u3092\u958b\u767a
\n [\u7406\u7814 2013\/6\/24] <\/a>[CDB\u30cb\u30e5\u30fc\u30b9] <\/a>[\u30b5\u30a4\u30a8\u30f3\u30b9\u30c1\u30e3\u30f3\u30cd\u30eb(YouTube)]<\/a>\u00a0(Nat Neurosci.<\/strong><\/em> 2013)<\/p>\n

\u30fb\u9ad8\u7b49\u52d5\u7269\u306e\u8a8d\u77e5\u6a5f\u80fd\u306e\u57fa\u76e4\u3067\u3042\u308b\u300c\u795e\u7d4c\u5730\u56f3\u300d\u304c\u4f5c\u3089\u308c\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e
\n[\u6771\u5927 2009\/7\/10]<\/a>\u00a0(Science<\/em><\/strong>\u00a02009)<\/p>\n

\u30fb\u54fa\u4e73\u985e\u55c5\u899a\u7cfb\u3067\u55c5\u899a\u53d7\u5bb9\u4f53\u304c\u8ef8\u7d22\u6295\u5c04\u3092\u5236\u5fa1\u3059\u308b\u6a5f\u69cb\u306e\u89e3\u660e
\n[\u6771\u5927 2006\/10\/12]<\/a>\u00a0(Science<\/strong><\/em>\u00a02006)<\/p>\n

 <\/p>\n

10) YouTube\u52d5\u753b<\/h3>\n

\u30fb\u7814\u7a76\u5ba4\u7d39\u4ecb2020\u5e745\u6708\uff08\u4e5d\u5927\u30aa\u30f3\u30e9\u30a4\u30f3\u5927\u5b66\u9662\u8aac\u660e\u4f1a\uff09<\/a><\/p>\n

\u30fb\u5e02\u6c11\u516c\u958b\u8b1b\u5ea7\u300c\u8133\u79d1\u5b66\u306e\u9054\u4eba2018\u300d<\/a><\/p>\n

\u30fb\u7814\u7a76\u5ba4\u7d39\u4ecb2015\u5e744\u6708\uff08\u4eac\u5927\uff09<\/a><\/p>\n

\u30fb\u900f\u660e\u5316SeeDB: [YouTube(1)]<\/a>\u00a0[YouTube(2)]<\/a>\u00a0[YouTube(3)]<\/a> [\u30b5\u30a4\u30a8\u30f3\u30b9\u30c1\u30e3\u30f3\u30cd\u30eb(YouTube)]<\/a><\/p>\n

\u30fb\u900f\u660e\u5316\u8d85\u89e3\u50cf\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0SeeDB2: [YouTube(1)]<\/a>\u00a0[YouTube(2)]<\/a>[YouTube(3)]<\/a><\/p>\n

\u30fb\u30cb\u30e5\u30fc\u30ed\u30f3\u591a\u8272\u6a19\u8b58Tetbow:\u00a0[YouTube (1)]<\/a>\u00a0[YouTube (2)]<\/a>\u00a0[YouTube (3)]<\/a>\u00a0[YouTube (4)]<\/a><\/p>\n

\u30fb\u55c5\u74032\u5149\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0(Neuron 2017): [YouTube (1)]<\/a> [YouTube (2)]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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