第３４回生命医科学セミナー （Biomedical Science Seminar

演 題：Studies of Leading and Lagging Strand DNA

Replication Fidelity in Yeast

演 者：　 Dr. Thomas A. Kunkel

Genome Integrity and Structural Biology Laboratory,

National Institute of Environmental Health Sciences,

NIH, DHHS, USA

日 時：平成２７年１１月２５日（水）

１７：３０～１９：００

場 所：病院地区総合研究棟１階　１０２講義室

Coordinated replication of the two undamaged DNA strands of the eukaryotic nuclear genome is normally catalyzed by DNA polymerases a, d and e. These replicases are related, but they differ in protein partnerships and physical and biochemical properties, including fidelity. This talk will focus on their roles in leading and lagging strand DNA replication fidelity in budding yeast. Emphasis will be on recent studies in which deep sequence has been used to define the genome-wide rates of ribonucleotide incorporation by the three polymerases during leading and lagging strand replication. This will be followed by a discussion of the processes by which replication errors are corrected, and the consequences of defects in these processes.

日本学術振興会の外国人招へい研究者として、11月27日に開催予定の日本環境変異原学会第44回大会での特別講演や関連研究者達との研究討議他のために来日されます。多くの方の参加を歓迎致します。

共　催：福岡医学会

問合せ：九州大学大学院 医学研究院 基礎放射線医学分野　續　輝久・中津可道

（内線６１４１、６１４２）

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