{"id":933,"date":"2024-09-18T14:09:41","date_gmt":"2024-09-18T05:09:41","guid":{"rendered":"http:\/\/labmed.local\/biochemistry\/?page_id=933"},"modified":"2024-10-04T09:56:28","modified_gmt":"2024-10-04T00:56:28","slug":"research","status":"publish","type":"page","link":"https:\/\/www.lab.med.kyushu-u.ac.jp\/biochemistry\/research\/","title":{"rendered":"\u3053\u308c\u307e\u3067\u306e\u7814\u7a76"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-text-align-center\">\u3053\u308c\u307e\u3067\u306e\u7814\u7a76<\/h2>\n\n\n\n<p>\u79c1\u305f\u3061\u306f\u3001\u3053\u308c\u307e\u3067\u7d30\u80de\u63a5\u7740\u69cb\u9020\u3084\u5fae\u7d68\u6bdb\u306a\u3069\u306e\u4e0a\u76ae\u7d30\u80de\u306b\u8a8d\u3081\u3089\u308c\u308b\u7d30\u80de\u819c\u69cb\u9020\u306e\u5f62\u6210\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u304d\u307e\u3057\u305f\u3010\u56f3\uff11\u3011\u3002\u7d30\u80de\u63a5\u7740\u69cb\u9020\u306f\u3001\u308f\u308c\u308f\u308c\u591a\u7d30\u80de\u751f\u7269\u306e\u6839\u5e79\u3092\u62c5\u3046\u69cb\u9020\u3067\u3042\u308a\u3001\u5fae\u7d68\u6bdb\u306f\u6804\u990a\u306e\u5438\u53ce\u306a\u3069\u751f\u547d\u306e\u7dad\u6301\u306b\u5fc5\u9808\u306e\u69cb\u9020\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" src=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/biochemistry\/wp-content\/uploads\/sites\/34\/2024\/10\/1.jpg\" alt=\"\u56f31 \u4e0a\u76ae\u7d30\u80de\u306b\u5b58\u5728\u3059\u308b\u5f62\u614b\u5b66\u7684\u306b\u7279\u5fb4\u7684\u306a\u819c\u69cb\u9020\" style=\"object-fit:cover\"\/><\/figure>\n\n\n\n<p>\u79c1\u305f\u3061\u306f\u4e0a\u76ae\u7d30\u80de\u306e\u7d30\u80de\u63a5\u7740\u69cb\u9020\u3067\u3042\u308b\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u3092\u69cb\u6210\u3059\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u540c\u5b9a\u3084\u30a2\u30d4\u30ab\u30eb\u819c\u3068\u30d0\u30bd\u30e9\u30c6\u30e9\u30eb\u819c\u3092\u5206\u96e2\u3059\u308b\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u7d30\u80de\u819c\u306e\u8102\u8cea\u306b\u7740\u76ee\u3057\u3066\u7814\u7a76\u3092\u5c55\u958b\u3057\u3001\u7d30\u80de\u819c\u8102\u8cea\u7d44\u6210\u306e\u89e3\u6790\u624b\u6cd5\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u307f\u3001\u4e0a\u76ae\u7d30\u80de\u306e\u30a2\u30d4\u30ab\u30eb\u819c\u306b\u5b58\u5728\u3057\u7d30\u80de\u5185\u3078\u306e\u7269\u8cea\u306e\u5438\u53ce\u306b\u5fc5\u9808\u306e\u6a5f\u80fd\u3092\u679c\u305f\u3059\u5fae\u7d68\u6bdb\u306e\u69cb\u7bc9\u539f\u7406\u3092\u8102\u8cea\u30fb\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u53cc\u65b9\u306e\u89b3\u70b9\u304b\u3089\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" style=\"margin-top:var(--wp--preset--spacing--70);margin-bottom:var(--wp--preset--spacing--70)\"\/>\n\n\n\n<p>\u4ee5\u4e0b\u3067\u306f\u3001\u79c1\uff08\u6c60\u30ce\u5185\u9806\u4e00\uff09\u306e\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u306e\u7d4c\u7def\u306b\u3064\u3044\u3066\u3001\u8aac\u660e\u3057\u3066\u3044\u307e\u3059\u3002\u4eac\u90fd\u5927\u5b66\u533b\u5316\u5b66\u7b2c\u4e8c\u6559\u5ba4\uff08\u6708\u7530\u627f\u4e00\u90ce\u6559\u6388\uff09\u306b\u6240\u5c5e\u3057\u3066\u3044\u305f\u3001\u5f53\u6642\u5b66\u90e8\u751f\u3060\u3063\u305f\u79c1\u306f\u3001\u7d30\u80de\u540c\u58eb\u304c\u63a5\u7740\u3059\u308b\u4e0a\u76ae\u7d30\u80de\u306b\u8ee2\u5199\u56e0\u5b50Snail\u3092\u767a\u73fe\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u540c\u58eb\u304c\u63a5\u7740\u3057\u306a\u3044\u9593\u8449\u7d30\u80de\u306b\u8ee2\u63db\u3059\u308b\u3068\u3044\u3046\u8ad6\u6587\u306b\u51fa\u4f1a\u3044\u975e\u5e38\u306b\u5927\u304d\u306a\u885d\u6483\u3092\u53d7\u3051\u307e\u3057\u305f\uff08Nieto MA. Nat Rev Mol Cell Biol. 2002\uff09\u3002\u3059\u3050\u3055\u307e\u8ffd\u8a66\u3092\u884c\u3044\u3001\u57f9\u990a\u4e0a\u76ae\u7d30\u80de\u306bSnail\u3092\u767a\u73fe\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u78ba\u304b\u306b\u9593\u8449\u7d30\u80de\u306b\u8ee2\u63db\u3059\u308b\u3053\u3068\u3092\u78ba\u304b\u3081\u307e\u3057\u305f\u3002Snail\u306f\u8ee2\u5199\u6291\u5236\u56e0\u5b50\u3067\u3001\u4e0a\u76ae\u7d30\u80de\u306e\u4e3b\u8981\u306a\u7d30\u80de\u63a5\u7740\u56e0\u5b50\u3067\u3042\u308bE-\u30ab\u30c9\u30d8\u30ea\u30f3\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092Nieto MA\u3089\u304c\u65e2\u306b\u793a\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u79c1\u306f\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u3092\u69cb\u6210\u3059\u308b\u30af\u30ed\u30fc\u30c7\u30a3\u30f3\u3084\u30aa\u30af\u30eb\u30fc\u30c7\u30a3\u30f3\u306e\u767a\u73fe\u3082Snail\u306b\u3088\u3063\u3066\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3010<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12668723\" target=\"_blank\" rel=\"noreferrer noopener\">\u53c2\u8003\u6587\u732e<\/a>\u3011\u3010\u56f3\uff12\u3011\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" src=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/biochemistry\/wp-content\/uploads\/sites\/34\/2024\/10\/2.jpg\" alt=\"\u56f32 1\u7a2e\u985e\u306e\u8ee2\u5199\u6291\u5236\u56e0\u5b50\u3092\u5f37\u5236\u767a\u73fe\u3059\u308b\u3060\u3051\u3067\u4e0a\u76ae\u7d30\u80de\u304c\u63a5\u7740\u3057\u306a\u304f\u306a\u308b\u73fe\u8c61\u306b\u7740\u76ee\u3057\u3066\u3001\u7d30\u80de\u63a5\u7740\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u306e\u7d5e\u308a\u8fbc\u307f\u3092\u884c\u3063\u305f\" style=\"object-fit:cover\"\/><\/figure>\n\n\n\n<p>\u305d\u3053\u3067\u3001\u4e0a\u76ae\u7d30\u80de\u3068Snail\u3092\u767a\u73fe\u3059\u308b\u3053\u3068\u3067\u9593\u8449\u7d30\u80de\u306b\u8ee2\u63db\u3057\u305f\u7d30\u80de\u306e\u4e21\u8005\u3067\u3001\u767a\u73fe\u91cf\u306e\u7570\u306a\u308b\u907a\u4f1d\u5b50\u3092\u6bd4\u8f03\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u7d30\u80de\u63a5\u7740\u306b\u95a2\u4e0e\u3059\u308b\u65b0\u3057\u3044\u907a\u4f1d\u5b50\u3092\u898b\u3064\u3051\u3089\u308c\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u7740\u60f3\u3092\u5f97\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u4e0a\u76ae\u7d30\u80de\u3068Snail\u306b\u3088\u3063\u3066\u9593\u8449\u5316\u3057\u305f\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092Gene chip\u3067\u6bd4\u8f03\u3057\u3066\u3001\u4e0a\u76ae\u7d30\u80de\u306b\u306e\u307f\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\u306e\u7d5e\u308a\u8fbc\u307f\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u5927\u5b66\u9662\u306e\u671f\u9593\u3001\u4e0a\u76ae\u7d30\u80de\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u6a5f\u80fd\u672a\u77e5\u306e\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3092\u7247\u3063\u7aef\u304b\u3089\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3057\u3066\u3001\u305d\u306e\u5c40\u5728\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u3066\u3044\u304d\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\uff13\u3064\u306e\u4e0a\u76ae\u7d30\u80de\u304c\u63a5\u7740\u3057\u3066\u5f62\u6210\u3059\u308b\uff13\u7d30\u80de\u7d50\u5408\u3092\u69cb\u6210\u3059\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u30c8\u30ea\u30bb\u30eb\u30ea\u30f3\uff08Tricellulin\uff09\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u540c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3010<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16365161\" target=\"_blank\" rel=\"noreferrer noopener\">\u53c2\u8003\u6587\u732e<\/a>\u3011\u3010\u56f3\uff13\u3011\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" src=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/biochemistry\/wp-content\/uploads\/sites\/34\/2024\/10\/3.jpg\" alt=\"\u56f33 \u4e16\u754c\u3067\u521d\u3081\u3066\u898b\u3064\u304b\u3063\u305f3\u3064\u306e\u4e0a\u76ae\u7d30\u80de\u306e\u9593\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u3092\u62c5\u3046\u5206\u5b50\u30c8\u30ea\u30bb\u30eb\u30ea\u30f3(Tricellulin)\" style=\"object-fit:cover\"\/><\/figure>\n\n\n\n<p>\u3053\u306e\u4e0a\u76ae\u7d30\u80de\u306b\u306e\u307f\u306b\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\u7fa4\u3092\u773a\u3081\u3066\u3044\u307e\u3059\u3068\u3001\u591a\u6570\u306e\u8102\u8cea\u4ee3\u8b1d\u9175\u7d20\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u306b\u6c17\u304c\u4ed8\u304d\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u63a5\u7740\u3059\u308b\u4e0a\u76ae\u7d30\u80de\u3068\u63a5\u7740\u3057\u306a\u3044\u9593\u8449\u7d30\u80de\u3067\u306f\u3001\u7d30\u80de\u819c\u3092\u69cb\u6210\u3059\u308b\u8102\u8cea\u5206\u5b50\u306e\u7d44\u6210\u304c\u7570\u306a\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3001\u3068\u3044\u3046\u6b21\u306a\u308b\u7740\u60f3\u3092\u5f97\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u7d30\u80de\u819c\u306e\u4e3b\u305f\u308b\u69cb\u6210\u6210\u5206\u306f\u3001\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u8102\u8cea\u5206\u5b50\u3067\u3059\u3002\u7d30\u80de\u819c\u3092\u69cb\u6210\u3059\u308b\u8102\u8cea\u5206\u5b50\u306f\u6570\u5343\u7a2e\u985e\u306b\u3082\u53ca\u3076\u591a\u69d8\u6027\u3092\u6709\u3057\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u305d\u308c\u305e\u308c\u306e\u751f\u7406\u5b66\u7684\u610f\u7fa9\u306f\u307b\u3068\u3093\u3069\u660e\u3089\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u306e\u539f\u56e0\u306e\u4e00\u3064\u3068\u3057\u3066\u3001\u8102\u8cea\u5206\u5b50\u306e\u89e3\u6790\u306e\u56f0\u96e3\u3055\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u8102\u8cea\u306f\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7570\u306a\u308a\u3001\u6297\u4f53\u3092\u7528\u3044\u3066\u898b\u5206\u3051\u305f\u308a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u305f\u3081\u3001\u307e\u305a\u306f\u7d30\u80de\u819c\u306b\u542b\u307e\u308c\u308b\u8102\u8cea\u5206\u5b50\u3092\u3001\u8102\u8cea\u5206\u5b50\u7a2e\u4e00\u3064\u4e00\u3064\u306e\u30ec\u30d9\u30eb\u3067\u533a\u5225\u3067\u304d\u308b\u3088\u3046\u306a\u65b9\u6cd5\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u3080\u3053\u3068\u306b\u3057\u307e\u3057\u305f\u3002\u6570\u5e74\u306e\u8a66\u884c\u932f\u8aa4\u306e\u7d50\u679c\u3001\u30b3\u30ed\u30a4\u30c9\u72b6\u306e\u30b7\u30ea\u30ab\u7c92\u5b50\u3092\u7528\u3044\u3066\u4e0a\u76ae\u7d30\u80de\u306e\u7d30\u80de\u819c\u3092\u7269\u7406\u7684\u306b\u5358\u96e2\u3057\u3001\u7d30\u80de\u819c\u8102\u8cea\u306e\u7d44\u6210\u3092\u8cea\u91cf\u5206\u6790\u306b\u3088\u308a\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u8102\u8cea\u5206\u5b50\u7a2e\u306e\u7d44\u6210\u3092\u89e3\u6790\u3059\u308b\u624b\u6cd5\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3010<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22294698\" target=\"_blank\" rel=\"noreferrer noopener\">\u53c2\u8003\u6587\u732e<\/a>\u3011\u3010\u56f3\uff14\u3011\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" src=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/biochemistry\/wp-content\/uploads\/sites\/34\/2024\/10\/4.jpg\" alt=\"\u56f34 \u7d30\u80de\u819c\u306e\u8102\u8cea\u7d44\u6210\u89e3\u6790\u6cd5\u306e\u6982\u7565\"\/><\/figure>\n\n\n\n<p>\u3053\u306e\u624b\u6cd5\u3084\u3001\u5f53\u6642\u79c1\u304c\u6240\u5c5e\u3057\u3066\u3044\u307e\u3057\u305f\u4eac\u90fd\u5927\u5b66 \u6885\u7530\u771f\u90f7 \u7814\u7a76\u5ba4\u3067\u540c\u5b9a\u3055\u308c\u305f\u30b9\u30d5\u30a3\u30f3\u30b4\u30df\u30a8\u30ea\u30f3\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u4e0a\u76ae\u7d30\u80de\u306e\u5fae\u7d68\u6bdb\u306b\u304a\u3044\u3066\u306f\u30b9\u30d5\u30a3\u30f3\u30b4\u30df\u30a8\u30ea\u30f3\u3068\u547c\u3070\u308c\u308b\u8102\u8cea\u5206\u5b50\u304c\u96c6\u7a4d\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u66f4\u306b\u30b9\u30d5\u30a3\u30f3\u30b4\u30df\u30a8\u30ea\u30f3\u3068\u5171\u5f79\u3057\u3066\u50cd\u304f\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u540c\u5b9a\u3057\u3001\u5fae\u7d68\u6bdb\u306e\u5f62\u6210\u306b\u304a\u3044\u3066\u30b9\u30d5\u30a3\u30f3\u30b4\u30df\u30a8\u30ea\u30f3\u306e\u679c\u305f\u3059\u5f79\u5272\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3010<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23690544\" target=\"_blank\" rel=\"noreferrer noopener\">\u53c2\u8003\u6587\u732e<\/a>\u3011\u3010\u56f3\uff15\u3011\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" src=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/biochemistry\/wp-content\/uploads\/sites\/34\/2024\/10\/5.jpg\" alt=\"\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76 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