{"id":35,"date":"2014-07-11T11:47:16","date_gmt":"2014-07-11T02:47:16","guid":{"rendered":"https:\/\/www.lab.med.kyushu-u.ac.jp\/biochem1\/?page_id=35"},"modified":"2014-07-14T13:55:14","modified_gmt":"2014-07-14T04:55:14","slug":"reseach","status":"publish","type":"page","link":"https:\/\/www.lab.med.kyushu-u.ac.jp\/biochem1\/reseach\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"

\u79c1\u305f\u3061\u306f\u3001\u30b2\u30ce\u30e0\u79d1\u5b66\u306e\u7acb\u5834\u304b\u3089\u72ec\u81ea\u306e\u6226\u7565\u3092\u8003\u6848\u3057\u3066\u3001\u751f\u547d\u30b7\u30b9\u30c6\u30e0\u306e\u7406\u89e3\u306b\u30e6\u30cb\u30fc\u30af\u306a\u8ca2\u732e\u3092\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u7db2\u7f85\u6027\u3068\u5b9a\u91cf\u6027\u3092\u30ad\u30fc\u30ef\u30fc\u30c9\u306b\u3001\u72ec\u81ea\u6280\u8853\u306e\u958b\u767a\u3092\u57fa\u76e4\u3068\u3059\u308b\u7814\u7a76\u306e\u5c55\u958b\u3092\u5fc3\u304c\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30b2\u30ce\u30e0\u306e\u767a\u73fe<\/h3>\n

\u79c1\u305f\u3061\u306f\u3001\u5b8c\u5168\u9577cDNA\u306e\u5927\u898f\u6a21\u89e3\u6790\u306b\u3088\u3063\u3066\u51fa\u82bd\u9175\u6bcd\u306e\u8ee2\u5199\u958b\u59cb\u70b9\u306b\u95a2\u3059\u308b\u6700\u5927\u7d1a\u306e\u30c7\u30fc\u30bf\u3092\u5f97\u308b\u3068\u3068\u3082\u306b\u3001\u591a\u6570\u306e\u975e\u30b3\u30fc\u30c9\u6027RNA\u3092\u898b\u51fa\u3057\u3066\u3001\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u306e\u4e88\u60f3\u5916\u306e\u8907\u96d1\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f(Miura et al. 2006, UTGB Yeast)\u3002\u3053\u306e\u7d50\u679c\u306f\u3001\u9ad8\u7b49\u751f\u7269\u3067\u5927\u304d\u306a\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u304d\u305f\u5927\u91cf\u306e\u975e\u30b3\u30fc\u30c9RNA\u3084\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u306a\u8ee2\u5199\u304c\u3001\u771f\u6838\u751f\u7269\u306b\u5171\u901a\u306e\u6027\u8cea\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3060\u3068\u3059\u308c\u3070\u3001\u51fa\u82bd\u9175\u6bcd\u306f\u3053\u308c\u3089\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3082\u512a\u308c\u305f\u30e2\u30c7\u30eb\u751f\u7269\u306b\u306a\u308b\u7b48\u3067\u3059\u3002
\n\u305d\u3053\u3067\u79c1\u305f\u3061\u306f\u3001\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u306b\u3088\u308b\u7db2\u7f85\u7684\u8a08\u6e2c\u3068\u30e2\u30c7\u30eb\u751f\u7269\u3068\u3057\u3066\u306e\u51fa\u82bd\u9175\u6bcd\u306e\u69d8\u3005\u306a\u5229\u70b9\u3092\u6d3b\u304b\u3057\u305f\u72ec\u81ea\u306e\u53d6\u308a\u7d44\u307f\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u975e\u30b3\u30fc\u30c9RNA\u306b\u95a2\u3057\u3066\u306f\u3001\u6a5f\u80fd\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u305f\u5206\u5b50\u304c\u5831\u544a\u3055\u308c\u308b\u4e00\u65b9\u3067\u3001\u305d\u306e\u5927\u534a\u306f\u6a5f\u80fd\u7684\u306b\u4e2d\u7acb\u306a\u8ee2\u5199\u30ce\u30a4\u30ba\u306e\u7523\u7269\u3067\u3042\u308b\u3068\u3082\u4e91\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3053\u3067\u79c1\u305f\u3061\u306f\u3001\u8ee2\u5199\u5bb9\u91cf\u3092\u907a\u4f1d\u5b66\u7684\u306b\u5236\u9650\u3057\u305f\u5834\u5408\u306e\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u3084\u3001\u6216\u3044\u306f\u9006\u306b\u9175\u6bcd\u5185\u3067\u306f\u6a5f\u80fd\u3092\u6301\u305f\u306a\u3044\u7570\u7a2e\u30b2\u30ce\u30e0\u304b\u3089\u306a\u308b\u4eba\u5de5\u67d3\u8272\u4f53\u306e\u8ee2\u5199\u3092\u8abf\u3079\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u4e2d\u7acb\u306a\u8ee2\u5199\u30ce\u30a4\u30ba\u306e\u983b\u5ea6\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u30b2\u30ce\u30e0\u306e\u767a\u73fe\u306b\u95a2\u3059\u308b\u65b0\u3057\u3044\u30a4\u30e1\u30fc\u30b8\u3092\u63cf\u304d\u51fa\u305d\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e00\u65b9\u3067\u3001\u751f\u7406\u7684\u30d7\u30ed\u30bb\u30b9\u3068\u3057\u3066\u6e1b\u6570\u5206\u88c2\u671f\u306b\u304a\u3051\u308b\u975e\u30b3\u30fc\u30c9RNA\u767a\u73fe\u3092\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u69cb\u9020\u5909\u63db\u3068\u95a2\u9023\u3065\u3051\u306a\u304c\u3089\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8fd1\u7e01\u7a2e\u3068\u306e\u6bd4\u8f03\u89e3\u6790\u3082\u5c55\u958b\u3057\u3066\u3001\u6a5f\u80fd\u6027\u975e\u30b3\u30fc\u30c9RNA\u3082\u542b\u3081\u305f\u767a\u73fe\u5236\u5fa1\u7cfb\u306e\u666e\u904d\u6027\u3068\u591a\u69d8\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3001\u305d\u306e\u9032\u5316\u306e\u7406\u89e3\u306b\u8feb\u308a\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"reseach01\"<\/a>
\n\u56f3\uff11\uff1a\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u306a\u8ee2\u5199\u306b\u3088\u308b\u975e\u30b3\u30fc\u30c9RNA\u306e\u751f\u6210\u306e\u7db2\u7f85\u7684\u89e3\u6790<\/p>\n

 <\/p>\n

\u30bf\u30f3\u30d1\u30af\u8cea\u30cd\u30c3\u30c8\u30ef\u30fc\u30af<\/h3>\n

\u79c1\u305f\u3061\u306f\u3001\uff12\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u6cd5\u3092\u7528\u3044\u3066\u51fa\u82bd\u9175\u6bcd\u306b\u304a\u3051\u308b\u86cb\u767d\u8cea\u9593\u76f8\u4e92\u4f5c\u7528\u306e\u7db2\u7f85\u7684\u89e3\u6790\u3092\u884c\u306a\u3044\u3001\u30a4\u30f3\u30bf\u30e9\u30af\u30c8\u30fc\u30e0\u89e3\u6790\u306e\u5148\u99c6\u3051\u3068\u306a\u308a\u307e\u3057\u305f(Ito et al. 2001<\/a>, Hot Paper Comment<\/a>)\u3002\u73fe\u5728\u306e\u30a4\u30f3\u30bf\u30e9\u30af\u30c8\u30fc\u30e0\u30c7\u30fc\u30bf\u306e\u9650\u754c\u306f\u3001\u300c\u86cb\u767d\u8ceaA\u3068\u86cb\u767d\u8ceaB\u304c\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u300d\u3068\u3044\u3046\u5358\u7d14\u306a\u4e8c\u9805\u95a2\u4fc2\u306e\u60c5\u5831\u306b\u7559\u307e\u308a\u3001\u300c\u3044\u3064\u3001\u3069\u3053\u3067\u3001\u3069\u308c\u3060\u3051\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u300d\u3068\u3044\u3046\u6642\u9593\u7a7a\u9593\u5206\u89e3\u80fd\u3068\u5b9a\u91cf\u6027\u3092\u6b20\u3044\u3066\u3044\u308b\u3068\u3053\u308d\u306b\u3042\u308a\u307e\u3059\u3002
\n\u305d\u3053\u3067\u79c1\u305f\u3061\u306f\u3001\u540c\u4f4d\u5143\u7d20\u6a19\u8b58\u3068\u8cea\u91cf\u5206\u6790\u3092\u99c6\u4f7f\u3057\u305f\u65b0\u898f\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u6280\u8853\u3092\u958b\u767a\u3057\u3001\u5b9a\u91cf\u7684\u306a\u76f8\u4e92\u4f5c\u7528\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u89e3\u6790\u3092\u9032\u3081\u3066\u304d\u307e\u3057\u305f(Kito et al. 2007<\/a>)\u3002\u66f4\u306b\u3001\u69d8\u3005\u306a\u7d30\u80de\u6a5f\u80fd\u306e\u5236\u5fa1\u306b\u95a2\u308f\u308b\u91cd\u8981\u306a\u7ffb\u8a33\u5f8c\u4fee\u98fe\u3067\u3042\u308b\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u95a2\u3057\u3066\u3082\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u52b9\u7387\u7684\u306b\u7cbe\u88fd\u3059\u308b\u72ec\u81ea\u306e\u624b\u6cd5\u3068\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u6280\u8853\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u89e3\u6790\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f(Ota et al. 2008<\/a>)\u3002\u3053\u306e\u65b9\u6cd5\u3092\u51fa\u82bd\u9175\u6bcd\u306e\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u9175\u7d20\u30fb\u8131\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u9175\u7d20\u5909\u7570\u4f53\u306e\u89e3\u6790\u306b\u5fdc\u7528\u3057\u3001\u9175\u7d20\u3068\u57fa\u8cea\u306e\u5bfe\u5fdc\u95a2\u4fc2\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u672a\u77e5\u306e\u90e8\u5206\u304c\u591a\u3044\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"research02\"<\/a>
\n\u56f3\uff12\uff1a\u5b9a\u91cf\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u306b\u3088\u308b\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u89e3\u660e<\/p>\n

 <\/p>\n

 <\/p>\n

DNA\u30e1\u30c1\u30ed\u30fc\u30e0<\/h3>\n

\u79c1\u305f\u3061\u306f\u3001\u30d2\u30c821\u756a\u67d3\u8272\u4f53\u4e0a\u306e\u5168CpG\u30a2\u30a4\u30e9\u30f3\u30c9\u306b\u3064\u3044\u3066\u72ec\u81ea\u306ePCR\u30a2\u30c3\u30bb\u30a4\u306b\u3088\u308b\u30a2\u30ec\u30eb\u5225DNA\u30e1\u30c1\u30eb\u5316\u306e\u89e3\u6790\u3092\u884c\u3044\u3001\u914d\u5217\u4f9d\u5b58\u7684\u306b\u7279\u5b9a\u306e\u30a2\u30ec\u30eb\u304c\u30e1\u30c1\u30eb\u5316\u3055\u308c\u308b\u3068\u3044\u3046\u73fe\u8c61\u3092\u767a\u898b\u3057\u307e\u3057\u305f(Yamada et al. 2004)\u3002\u30a4\u30f3\u30d7\u30ea\u30f3\u30c6\u30a3\u30f3\u30b0\u3084\uff38\u67d3\u8272\u4f53\u4e0d\u6d3b\u5316\u306b\u304a\u3051\u308b\u3082\u306e\u3068\u306f\u5168\u304f\u7570\u306a\u308b\u30a2\u30ec\u30eb\u5225\u30e1\u30c1\u30eb\u5316\u69d8\u5f0f\u306b\u3088\u308b\u3053\u306e\u73fe\u8c61\u306f\u3001\u6700\u8fd1\u3001\u4ed6\u306e\u30b2\u30ce\u30e0\u9818\u57df\u304b\u3089\u3082\u7d9a\u3005\u3068\u898b\u3064\u304b\u308a\u3001\u305d\u308c\u304c\u8fd1\u508d\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u4f8b\u3082\u898b\u51fa\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30e9\u30f3\u30c0\u30e0\u306a\u5358\u30a2\u30ec\u30eb\u6027\u30e1\u30c1\u30eb\u5316\u3092\u7591\u308f\u305b\u308b\u4f8b\u3082\u898b\u51fa\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3082\u8003\u3048\u5408\u308f\u305b\u308b\u3068\u3001\u65e2\u5b58\u77e5\u8b58\u306b\u56da\u308f\u308c\u305a\u306bDNA\u30e1\u30c1\u30eb\u5316\u306e\u52d5\u614b\u3068\u591a\u69d8\u6027\u3092\u6349\u3048\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002
\n\u305d\u3053\u3067\u79c1\u305f\u3061\u306f\u3001\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u3092\u7528\u3044\u3066DNA\u30e1\u30c1\u30eb\u5316\u72b6\u614b\u3092\u5358\u4e00\u5869\u57fa\u89e3\u50cf\u5ea6\u3067\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u306b\u89e3\u660e\u3059\u308b\u65b0\u6280\u8853\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u3093\u3067\u304d\u307e\u3057\u305f\u3002\u305d\u306e\u904e\u7a0b\u3067\u3001\u958b\u767a\u30e2\u30c7\u30eb\u306b\u7528\u3044\u305f\u30a2\u30ab\u30d1\u30f3\u30ab\u30d3\u306eDNA\u30e1\u30c1\u30eb\u5316\u306b\u95a2\u3057\u3066\u3001\u5358\u4e00\u5869\u57fa\u89e3\u50cf\u5ea6\u3068\u5b9a\u91cf\u6027\u3092\u5099\u3048\u305f\u30e1\u30c1\u30eb\u5316\u30c7\u30fc\u30bf\u304c\u3042\u3063\u3066\u521d\u3081\u3066\u767a\u898b\u53ef\u80fd\u306a\u65b0\u3057\u3044\u6cd5\u5247\u3092\u898b\u51fa\u3057\u3001\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u6709\u52b9\u6027\u3092\u5b9f\u8a3c\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u3057\u305f\u3002\u66f4\u306b\u6539\u826f\u3092\u91cd\u306d\u305f\u3053\u306e\u6280\u8853\u306e\u611f\u5ea6\u306f\u3001\u4eca\u3084\u3001\u4e16\u754c\u6700\u9ad8\u306e\u6c34\u6e96\u306b\u9054\u3057\u3066\u3044\u307e\u3059(Miura et al. 2012)\u3002\u79c1\u305f\u3061\u306f\u3053\u308c\u3092\u6b66\u5668\u306b\u3057\u3066\u3001\u533b\u5b66\u30fb\u751f\u7269\u5b66\u7684\u306b\u8208\u5473\u6df1\u3044\u306b\u3082\u95a2\u308f\u3089\u305a\u91cf\u7684\u306a\u554f\u984c\u3067\u7814\u7a76\u304c\u9032\u307e\u306a\u304b\u3063\u305f\u5e79\u7d30\u80de\u3084\u521d\u671f\u80da\u7b49\u306e\u30a8\u30d4\u30b2\u30ce\u30e0\u89e3\u6790\u306b\u7a81\u7834\u53e3\u3092\u958b\u304d\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3053\u3046\u3057\u3066\u5f97\u3089\u308c\u305f\u7db2\u7f85\u7684\u30c7\u30fc\u30bf\u306e\u60c5\u5831\u5b66\u7684\u89e3\u6790\u304b\u3089\u3001\u30e1\u30c1\u30eb\u5316\u30fb\u8131\u30e1\u30c1\u30eb\u5316\u306b\u95a2\u3059\u308b\u65b0\u3057\u3044\u6cd5\u5247\u3092\u898b\u51fa\u3059\u3053\u3068\u3067\u3001\u5206\u5b50\u6a5f\u69cb\u3084\u5236\u5fa1\u69d8\u5f0f\u306e\u89e3\u660e\u306b\u8feb\u3063\u3066\u3086\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002
\n\"research03\"<\/a>
\n\u56f3\uff13\uff1aDNA\u30e1\u30c1\u30eb\u5316\u306e\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u5358\u4e00\u5869\u57fa\u89e3\u50cf\u5ea6\u89e3\u6790<\/p>\n

 <\/p>\n

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