{"id":9,"date":"2020-09-28T10:18:25","date_gmt":"2020-09-28T01:18:25","guid":{"rendered":"https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/?page_id=9"},"modified":"2020-09-28T10:19:20","modified_gmt":"2020-09-28T01:19:20","slug":"research","status":"publish","type":"page","link":"https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/research\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"<ul id=\"menu-global\" class=\"menu\">\n<li id=\"menu-item-30\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-30\">\n<div class=\"wt04 tit\">\u7814\u7a76\u30ad\u30fc\u30ef\u30fc\u30c9<\/div>\n<div class=\"wt08\">\u6297\u75c5\u6027\u52d5\u7269\u3001\u62b5\u6297\u6027\u907a\u4f1d\u5b50\u3001 \u53ef\u6eb6\u578b\u30ec\u30bb\u30d7\u30bf\u30fc\u3001intracellular immunization\u3001\u907a\u4f1d\u5b50\u6539\u5909\u52d5\u7269\u3001\u7cbe\u795e\u795e\u7d4c\u75be\u60a3\u30e2\u30c7\u30eb\u52d5\u7269<\/div>\n<div class=\"wt04 tit\">\u7814\u7a76\u30c6\u30fc\u30de<\/div>\n<div class=\"wt08\">1) \u6297\u75c5\u6027\u52d5\u7269\u306e\u958b\u767a\uff081990\uff5e\u3000\uff09<br \/>\n2) \u7cbe\u795e\u795e\u7d4c\u75be\u60a3\u306e\u767a\u75c7\u75c5\u614b\u30e2\u30c7\u30eb\u52d5\u7269\u306e\u958b\u767a\u3068\u767a\u75c5\u75c5\u7406\u306e\u89e3\u660e\uff081995\uff5e\uff09<\/div>\n<div><\/div>\n<hr \/>\n<div class=\"wt12\">\uff11\uff09\u30aa\u30fc\u30a8\u30b9\u30ad\u30fc\u75c5\u62b5\u6297\u6027\u52d5\u7269\u306e\u958b\u767a<br \/>\n\u30aa\u30fc\u30a8\u30b9\u30ad\u30fc\u75c5\u306a\u3069\u306e\u795e\u7d4c\u7d30\u80de\u5185\u306b\u6f5c\u4f0f\u611f\u67d3\u3092\u5f15\u304d\u8d77\u3053\u3059\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306a\u3069\u306e\u96e3\u6cbb\u6027\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u5236\u5727\u65b9\u6cd5\u3068\u3057\u3066\u3001\u6211\u3005\u306f\u6297\u75c5\u6027\u52d5\u7269\u306e\u958b\u767a\u306b\u7740\u76ee\u3057\u7814\u7a76\u3092\u9032\u3081\u3066\u304d\u305f\u3002\u6211\u3005\u306f\u30a6\u30a4\u30eb\u30b9\u30ec\u30bb\u30d7\u30bf\u30fc\u306b\u7740\u76ee\u3057\u3001\u30aa\u30fc\u30a8\u30b9\u30ad\u30fc\u75c5\u30a6\u30a4\u30eb\u30b9\u306e\u30ec\u30bb\u30d7\u30bf\u30fc\u306e\uff11\u3064\u3067\u3042\u308b\u30d6\u30bf\u30cd\u30af\u30c1\u30f3-\uff11\u306e\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u3068\u30d2\u30c8IgG\u306eFc\u9818\u57df\u3068\u306e\u53ef\u6eb6\u578b\u30ad\u30e1\u30e9\u5206\u5b50\u3092\u767a\u73fe\u3059\u308b\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u3001\u3053\u308c\u3089\u306e\u30de\u30a6\u30b9\u304c\u3001\u30aa\u30fc\u30a8\u30b9\u30ad\u30fc\u75c5\u30a6\u30a4\u30eb\u30b9\u306e\u653b\u6483\u306b\u5bfe\u3057\u3066\u660e\u3089\u304b\u306b\u611f\u67d3\u62b5\u6297\u6027\u3092\u793a\u3057\u3001\u4e14\u3064\u3001\u4e00\u822c\u72b6\u614b\u306e\u89b3\u5bdf\u3084\u75c5\u7406\u7d44\u7e54\u5b66\u7684\u89e3\u6790\u304b\u3089\u306f\u3001\u5168\u304f\u7570\u5e38\u304c\u8a8d\u3081\u3089\u308c\u306a\u3044\u3053\u3068\u3092\u5831\u544a\u3057\u305f\uff08Ono et al., PNAS,2004\uff09\u3002\u3055\u3089\u306b\u3001\u3053\u308c\u3092\u5fdc\u7528\u3057\u3066\u3001\u30d5\u30e9\u30f3\u30b9\u3068\u306e\u56fd\u969b\u5171\u540c\u7814\u7a76\u3067\u5bb6\u755c\u30d6\u30bf\u3092\u7528\u3044\u3066\u53ef\u6eb6\u578b\u30d6\u30bf\u30cd\u30af\u30c1\u30f3-1\u767a\u73fe\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30d4\u30c3\u30b0\u3092\u4f5c\u88fd\u3057\u3001\u5b50\u30d6\u30bf\u306b\u304a\u3051\u308b\u611f\u67d3\u5b9f\u9a13\u306e\u7d50\u679c\u3001\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30d4\u30c3\u30b0\u306f\u611f\u67d3\u62b5\u6297\u6027\u3092\u793a\u3059\u3053\u3068\u3092\u8a3c\u660e\u3057\u305f\uff08\u672a\u767a\u8868\uff09\u3002<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-112\" src=\".\/\u7814\u7a76\u5185\u5bb9 \u2013 \u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u9662\u3000\u5b9f\u9a13\u52d5\u7269\u5b66\u5206\u91ce_files\/r_ono1.jpg\" sizes=\"auto, (max-width: 434px) 100vw, 434px\" srcset=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-content\/uploads\/sites\/1\/sites\/61\/2019\/02\/r_ono1.jpg 434w, https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-content\/uploads\/sites\/1\/sites\/61\/2019\/02\/r_ono1-300x150.jpg 300w, https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-content\/uploads\/sites\/1\/sites\/61\/2019\/02\/r_ono1-250x125.jpg 250w\" alt=\"\" width=\"434\" height=\"217\" \/><\/div>\n<div><\/div>\n<div class=\"wt12\">\uff12\uff09\u30aa\u30fc\u30a8\u30b9\u30ad\u30fc\u75c5\u30a6\u30a4\u30eb\u30b9\u524d\u521d\u671f\u86cb\u767dIE180\u767a\u73fe\u30de\u30a6\u30b9\u306e\u89e3\u6790<br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-113 alignright\" src=\".\/\u7814\u7a76\u5185\u5bb9 \u2013 \u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u9662\u3000\u5b9f\u9a13\u52d5\u7269\u5b66\u5206\u91ce_files\/r_ono2.jpg\" sizes=\"auto, (max-width: 397px) 100vw, 397px\" srcset=\"https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-content\/uploads\/sites\/1\/sites\/61\/2019\/02\/r_ono2.jpg 397w, https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-content\/uploads\/sites\/1\/sites\/61\/2019\/02\/r_ono2-224x300.jpg 224w, https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-content\/uploads\/sites\/1\/sites\/61\/2019\/02\/r_ono2-250x335.jpg 250w\" alt=\"\" width=\"397\" height=\"532\" \/>\u30aa\u30fc\u30a8\u30b9\u30ad\u30fc\u75c5\u30a6\u30a4\u30eb\u30b9\uff08ADV\uff09\u306f\u3001\u5225\u540d\u4eee\u6027\u72c2\u72ac\u75c5\u30a6\u30a4\u30eb\u30b9\u3068\u3082\u547c\u3070\u308c\u3001\u5358\u7d14\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\u3084\u6c34\u75d8-\u5e2f\u72b6\u75b1\u75b9\u30a6\u30a4\u30eb\u30b9\u3068\u540c\u3058\u30a2\u30eb\u30d5\u30a1\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\u3067\u3042\u308b\u3002ADV\u306f\u30d6\u30bf\u3092\u5bbf\u4e3b\u3068\u3059\u308b\u304c\u3001\u30d6\u30bf\u4ee5\u5916\u306e\u52d5\u7269\u306b\u611f\u67d3\u3057\u305f\u5834\u5408\u3001\u611f\u67d3\u52d5\u7269\u306f\u63bb\u75d2\u3092\u4e3b\u5fb4\u3068\u3059\u308b\u795e\u7d4c\u75c7\u72b6\u3092\u5448\u3057\u6025\u6027\u7d4c\u904e\u3067\u6b7b\u4ea1\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u30a6\u30a4\u30eb\u30b9\u5b66\u7814\u7a76\u8005\u306b\u306f\u3001\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\u7814\u7a76\u306e\u30e2\u30c7\u30eb\u3068\u3057\u3066\u3001\u307e\u305f\u3001\u795e\u7d4c\u751f\u7269\u5b66\u7814\u7a76\u8005\u306b\u306f\u795e\u7d4c\u7d4c\u8def\u306e\u201c\u751f\u304d\u305f\u201d\u30c8\u30ec\u30fc\u30b5\u30fc\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u304d\u305f\u3002ADV\u306e\u6700\u3082\u91cd\u8981\u306a\u8ee2\u5199\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308bIE180\u3092\u767a\u73fe\u3059\u308b\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\u306f\u3001\u6b69\u884c\u4e2d\u306e\u3088\u308d\u3081\u304d\u3001\u6a2a\u8ee2\u3001\u5168\u8eab\u306e\u9707\u3048\u7b49\u306e\u795e\u7d4c\u75c7\u72b6\u3092\u5448\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u306e\u30de\u30a6\u30b9\u306e\u5c0f\u8133\u306f\u5bfe\u7167\u306e\u30de\u30a6\u30b9\u306b\u6bd4\u3079\u5c0f\u3055\u304f\u3001\u5c64\u69cb\u7bc9\u304c\u4e0d\u898f\u5247\u3067\u3001\u4e00\u90e8\u5206\u5b50\u5c64\u306a\u3089\u3073\u306b\u9846\u7c92\u5c64\u306e\u6b20\u5982\u304c\u89b3\u5bdf\u3055\u308c\u3001IE180\u306e\u767a\u73fe\u304c\u5c0f\u8133\u5f62\u6210\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u305f (Taharaguchi et al., Virology, 2003)\u3002\u3053\u306e\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u3001IE180\u304c\u661f\u72b6\u81a0\u7d30\u80de\u304a\u3088\u3073\u795e\u7d4c\u7d30\u80de\u3067\u767a\u73fe\u3057\u3001\u7d30\u80de\u79fb\u52d5\u3068\u914d\u5217\u3001\u7d30\u80de\u306e\u5206\u5316\u3001\u30b7\u30ca\u30d7\u30b9\u5f62\u6210\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u3001\u767a\u73fe\u7d30\u80de\u306b\u7d30\u80de\u6b7b\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f (Tomioka et al., Eur. J. Neurosci., 2008)\u3002\u307e\u305f\u3001\u30b9\u30da\u30a4\u30f3\u306eUniversidad Pablo de Olavide\u3068\u306e\u56fd\u969b\u5171\u540c\u7814\u7a76\u3067\u3001\u3053\u306e\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u3001\u5c0f\u8133\u304c\u5b66\u7fd2\u6a5f\u80fd\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u306b\u679c\u305f\u3059\u3053\u3068\u3092\u8a3c\u660e\u3057\u305f (Lopes-Ramos et al., Plos ONE, 2010)\u3002\u3055\u3089\u306b\u3001IE180\u306e\u767a\u73fe\u306f\u30de\u30a6\u30b9\u7cbe\u5b50\u306e\u767a\u751f\u3084\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u7e41\u6b96\u969c\u5bb3\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002(Tomioka et al., BBRC, 2013)\u3002<\/div>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u7814\u7a76\u30ad\u30fc\u30ef\u30fc\u30c9 \u6297\u75c5\u6027\u52d5\u7269\u3001\u62b5\u6297\u6027\u907a\u4f1d\u5b50\u3001 \u53ef\u6eb6\u578b\u30ec\u30bb\u30d7\u30bf\u30fc\u3001intracellular immunization\u3001\u907a\u4f1d\u5b50\u6539\u5909\u52d5\u7269\u3001\u7cbe\u795e\u795e\u7d4c\u75be\u60a3\u30e2\u30c7\u30eb\u52d5\u7269 \u7814\u7a76\u30c6\u30fc\u30de 1) \u6297\u75c5\u6027\u52d5\u7269\u306e\u958b\u767a\uff081990 &#8230; <\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-json\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-json\/wp\/v2\/comments?post=9"}],"version-history":[{"count":2,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-json\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":11,"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-json\/wp\/v2\/pages\/9\/revisions\/11"}],"wp:attachment":[{"href":"https:\/\/www.lab.med.kyushu-u.ac.jp\/anim\/wp-json\/wp\/v2\/media?parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}