論文

2023

Smooth Elongation of Pavement Cells Induced by RIC1 Overexpression Leads to Marginal Protrusions of the Cotyledon in Arabidopsis thaliana. Kikukawa K*, Takigawa-Imamura H*, Soga K, Kotake T, Higaki T. Plant Cell Physiol. 2023 Sep 18:pcad094. doi: 10.1093/pcp/pcad094. Online ahead of print. PMID: 37718531 *equal contribution

The SYP123-VAMP727 SNARE complex delivers secondary cell wall components for root hair shank hardening in Arabidopsis. Hirano T, Ebine K, Ueda T, Higaki T, Watanabe-Nakayama T, Konno H, Takigawa-Imamura H, Sato MH. Plant Cell. 2023 Sep 15:koad240. doi: 10.1093/plcell/koad240. Online ahead of print. PMID: 37713604

Analyzing the effect of cell rearrangement on Delta-Notch pattern formation. Oguma T, Takigawa-Imamura H, Shinoda T, Ogura S, Uemura A, Miyata T, Maini PK, Miura T. Physical Review E. 2023 Jun 14;107:064404. doi: 10.1103/PhysRevE.107.064404. PMID: 37464594

Aquaporin regulates cell rounding through vacuole formation during endothelial-to-hematopoietic transition. Sato Y, Shigematsu M, Shibata-Kanno M, Maejima S, Tamura C, Sakamoto H. Development. 2023 Jun 1;150(11):dev201275. doi: 10.1242/dev.201275. PMID: 37272531

Mechanism of interdigitation formation at apical boundary of MDCK cell. Miyazaki S, Otani T, Sugihara K, Fujimori T, Furuse M, Miura T. iScience. 2023 Apr 21;26(5):106594. doi: 10.1016/j.isci.2023.106594. PMID: 37250331

Pericytes and shear stress each alter the shape of a self-assembled vascular network. Fujimoto K, Erickson S, Nakayama M, Ihara H, Sugihara K, Nashimoto Y, Nishiyama K, Miura T, Yokokawa R. Lab Chip. 2023 Jan 17;23(2):306-317. doi: 10.1039/d2lc00605g. PMID: 36537555

Electrochemical sensing of oxygen metabolism for a three-dimensional cultured model with biomimetic vascular flow. Nashimoto Y, Mukomoto R, Imaizumi T, Terai T, Shishido S, Ino K, Yokokawa R, Miura T, Onuma K, Inoue M, Shiku H. Biosens Bioelectron. 2023 Jan 1;219:114808. doi: 10.1016/j.bios.2022.114808. PMID: 36327566

2022

Computational Model Exploring Characteristic Pattern Regulation in Periventricular Vessels. Takigawa-Imamura H, Hirano S, Watanabe C, Ohtaka-Maruyama C, Ema M, Mizutani K. Life. 2022 Dec 9;12(12):2069. doi: 10.3390/life12122069.

Tmsb10 triggers fetal Leydig differentiation by suppressing the RAS/ERK pathway. Inoue M, Baba T, Takahashi F, Terao M, Yanai S, Shima Y, Saito D, Sugihara K, Miura T, Takada S, Suyama M, Ohkawa Y, Morohashi KI. Commun Biol. 2022 Sep 15;5(1):974. doi: 10.1038/s42003-022-03941-5. PMID: 36109592

Stripe and spot selection in cusp patterning of mammalian molar formation. Morita W, Morimoto N, Otsu K, Miura T. Sci Rep. 2022 Jun 14;12(1):9149. doi: 10.1038/s41598-022-13539-w.　PMID: 35701484

A Novel Egg-In-Cube System Enables Long-Term Culture and Dynamic Imaging of Early Embryonic Development. Dave M, Levin J, Ruffins SW, Sato Y, Fraser S, Lansford R, Kawahara T. Front Physiol. 2022 May 12;13:893736. doi: 10.3389/fphys.2022.893736. eCollection 2022. PMID: 35634159

Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins. Yuge S, Nishiyama K, Arima Y, Hanada Y, Oguri-Nakamura E, Hanada S, Ishii T, Wakayama Y, Hasegawa U, Tsujita K, Yokokawa R, Miura T, Itoh T, Tsujita K, Mochizuki N, Fukuhara S. Nat Commun. 2022 May 12;13(1):2594. doi: 10.1038/s41467-022-30197-8. PMID: 35551172

Mechanical regulation of tissues that reproduces wrinkle patterns of gastrointestinal tracts. Kai Y. Phys Biol. 2022 Apr 19;19(3). doi: 10.1088/1478-3975/ac6042. PMID: 35320785

Live imaging of avian epiblast and anterior mesendoderm grafting reveals the complexity of cell dynamics during early brain development. Yoshihi K, Kato K, Iida H, Teramoto M, Kawamura A, Watanabe Y, Nunome M, Nakano M, Matsuda Y, Sato Y, Mizuno H, Iwasato T, Ishii Y, Kondoh H. Development. 2022 Mar 15;149(6):dev199999. doi: 10.1242/dev.199999. Epub 2022 Mar 28. PMID: 35132990

2021

Quantitative modeling of regular retinal microglia distribution. Endo Y, Asanuma D, Namiki S, Sugihara K, Hirose K, Uemura A, Kubota Y, Miura T. Sci Rep. 2021 Nov 22;11(1):22671. doi: 10.1038/s41598-021-01820-3. PMID: 34811401

Mathematical modeling of palatal suture pattern formation: morphological differences between sagittal and palatal sutures. Shibusawa N, Endo Y, Morimoto N, Takahashi I, Miura T. Sci Rep. 2021 Apr 26;11(1):8995. doi: 10.1038/s41598-021-88255-y. PMID: 33903631

Mathematical modeling of dynamic cellular association patterns in seminiferous tubules. Kawamura M, Sugihara K, Takigawa-Imamura H, Ogawa T, Miura T. Bull Math Biol. 2021 Feb 17;83(4):33. doi: 10.1007/s11538-021-00863-x. PMID: 33594605

Intestinal villus structure contributes to even shedding of epithelial cells. Kai Y. Biophys J. 2021 Feb 16;120(4):699-710. doi: 10.1016/j.bpj.2021.01.003. PMID: 33453270

Mesenchymal glioblastoma-induced mature de-novo vessel formation of vascular endothelial cells in a microfluidic device. Amemiya T, Hata N, Mizoguchi M, Yokokawa R, Kawamura Y, Hatae R, Sangatsuda Y, Kuga D, Fujioka Y, Takigawa K, Akagi Y, Yoshimoto K, Iihara K, Miura T. Mol Biol Rep. 2021 Jan 2. doi: 10.1007/s11033-020-06061-7. Online ahead of print. PMID: 33387197

2020

Noise-induced scaling in skull suture interdigitation. Naroda Y, Endo Y, Yoshimura K, Ishii H, Ei S-I, Miura T. PLoS One. 2020 Dec 17;15(12):e0235802. doi: 10.1371/journal.pone.0235802. eCollection 2020. PMID: 33332349

Mechanism underlying dynamic scaling properties observed in the contour of spreading epithelial monolayer. Oguma T, Takigawa-Imamura H, Miura T. Phys Rev E. 2020 Dec 4;102:062408. doi: 10.1103/PhysRevE.102.062408. PMID: 33466041

A new perfusion culture method with a self-organized capillary network. Sugihara K, Yamaguchi Y, Usui S, Nashimoto Y, Hanada S, Kiyokawa E, Uemura A, Yokokawa R, Nishiyama K, Miura T. PLoS One. 2020 Oct 28;15(10):e02240552. doi: 10.1371/journal.pone.0240552. eCollection 2020. PMID: 33112918

Remodeling mechanisms determine size distributions in developing retinal vasculature. Iizuka O, Kawamura S, Tero A, Uemura A, Miura T. PLoS One. 2020 Oct 14;15(10):e0235373. doi: 10.1371/journal.pone.0235373. eCollection 2020. PMID: 33052908

Effective nonlocal kernels on Reaction-diffusion networks. Ei SI, Ishii H, Kondo S, Miura T, Tanaka Y. J Theor Biol. 2021 Jan 21;509:110496. doi: 10.1016/j.jtbi.2020.110496. Epub 2020 Sep 29. PMID: 33007272

Oxygen consumption rate of tumour spheroids during necrotic-like core formation. Mukomoto R, Nashimoto Y, Terai T, Imaizumi T, Hiramoto K, Ino K, Yokokawa R, Miura T, Shiku H. Analyst. 2020 Sep 28;145(19):6342-6348. doi: 10.1039/d0an00979b. PMID: 32716439

Excess Pyrophosphate Restrains Pavement Cell Morphogenesis and Alters Organ Flatness in Arabidopsis thaliana.　Gunji S, Oda Y, Takigawa-Imamura H, Tsukaya H, Ferjani A.　Front Plant Sci. 2020 Feb 21;11:31. doi: 10.3389/fpls.2020.00031. eCollection 2020.　PMID: 32153602

Mechanisms of endothelial cell coverage by pericytes: computational modelling of cell wrapping and in vitro experiments. Sugihara K, Sasaki S, Uemura A, Kidoaki S, Miura T. J R Soc Interface. 2020 Jan;17(162):20190739. doi: 10.1098/rsif.2019.0739. Epub 2020 Jan 29. PMID: 31992164

Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid. Nashimoto Y, Okada R, Hanada S, Arima Y, Nishiyama K, Miura T, Yokokawa R. Biomaterials. 2020 Jan;229:119547. doi: 10.1016/j.biomaterials.2019.119547. Epub 2019 Oct 17. PMID: 31710953

2019

Mark1 regulates distal airspace expansion through type I pneumocyte flattening in lung development. Fumoto K, Takigawa-Imamura H, Sumiyama K, Yoshimura SH, Maehara N, Kikuchi A. J Cell Sci. 2019 Dec 13;132(24):jcs235556. doi: 10.1242/jcs.235556. PMID: 31719161

Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity. Otani T, Nguyen TP, Tokuda S, Sugihara K, Sugawara T, Furuse K, Miura T, Ebnet K, Furuse M. J Cell Biol. 2019 Oct 7;218(10):3372-3396. doi: 10.1083/jcb.201812157. Epub 2019 Aug 29. PMID: 31467165

Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice. Acebedo AR, Suzuki K, Hino S, Alcantara MC, Sato Y, Haga H, Matsumoto KI, Nakao M, Shimamura K, Takeo T, Nakagata N, Miyagawa S, Nishinakamura R, Adelstein RS, Yamada G. Commun Biol. 2019 Mar 8;2:95. doi: 10.1038/s42003-019-0336-3. eCollection 2019. PMID: 30886905

2018

PtdIns(3,5)P2 mediates root hair shank hardening in Arabidopsis. Hirano T, Konno H, Takeda S, Dolan L, Kato M, Aoyama T, Higaki T, Takigawa-Imamura H, Sato MH. Nat Plants. 2018 Nov;4(11):888-897. doi: 10.1038/s41477-018-0277-8. Epub 2018 Nov 2. PMID: 30390081

MUTE Directly Orchestrates Cell-State Switch and the Single Symmetric Division to Create Stomata. Han SK, Qi X, Sugihara K, Dang JH, Endo TA, Miller KL, Kim ED, Miura T, Torii KU. Dev Cell. 2018 May 7;45(3):303-315.e5. doi: 10.1016/j.devcel.2018.04.010. PMID: 29738710

Elasticity-based boosting of neuroepithelial nucleokinesis via indirect energy transfer from mother to daughter. Shinoda T, Nagasaka A, Inoue Y, Higuchi R, Minami Y, Kato K, Suzuki M, Kondo T, Kawaue T, Saito K, Ueno N, Fukazawa Y, Nagayama M, Miura T, Adachi T, Miyata T. PLoS Biol. 2018 Apr 20;16(4):e2004426. doi: 10.1371/journal.pbio.2004426. eCollection 2018 Apr. PMID: 29677184

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device. Nashimoto Y, Teraoka Y, Banan Sadeghian R, Nakamasu A, Arima Y, Hanada S, Kotera H, Nishiyama K, Miura T, Yokokawa R. J Vis Exp. 2018 Apr 4;(134):57242. doi: 10.3791/57242. PMID: 29683439

Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching. Okuda S, Miura T, Inoue Y, Adachi T, Eiraku M. Sci Rep. 2018 Feb 5;8(1):2386. doi: 10.1038/s41598-018-20678-6. PMID: 29402913

2017

Nakamasu A, Suematsu NJ, Kimura S. Asymmetries in leaf branch are associated with differential speeds along growth axes: A theoretical prediction. Dev Dyn. 2017 Sep 2. doi: 10.1002/dvdy.24587.

Sasaki D, Nakajima H, Yamaguchi Y, Yokokawa R, Ei SI, Miura T. Mathematical modeling for meshwork formation of endothelial cells in fibrin gels. J Theor Biol. 2017 Sep 21;429:95-104. doi: 10.1016/j.jtbi.2017.06.012.

Nashimoto Y, Hayashi T, Kunita I, Nakamasu A, Torisawa YS, Nakayama M, Takigawa-Imamura H, Kotera H, Nishiyama K, Miura T, Yokokawa R. Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device. Integr Biol (Camb). 2017 Jun 19;9(6):506-518. doi: 10.1039/c7ib00024c.

Sato Y, Nagatoshi K, Hamano A, Imamura Y, Huss D, Uchida S, Lansford R. Basal filopodia and vascular mechanical stress organize fibronectin into pillars bridging the mesoderm-endoderm gap. Development. 2017 Jan 15;144(2):281-291. doi: 10.1242/dev.141259.

Matsunaga Y, Noda M, Murakawa H, Hayashi K, Nagasaka A, Inoue S, Miyata T, Miura T, Kubo KI, Nakajima K. Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2048-2053. doi: 10.1073/pnas.1615215114.

Higaki T, Takigawa-Imamura H, Akita K, Kutsuna N, Kobayashi R, Hasezawa S, Miura T. Exogenous Cellulase Switches Cell Interdigitation to Cell Elongation in an RIC1-dependent Manner in Arabidopsis thaliana Cotyledon Pavement Cells. Plant Cell Physiol. 2017 Jan 1;58(1):106-119. doi: 10.1093/pcp/pcw183.

Fumoto K, Takigawa-Imamura H, Sumiyama K, Kaneiwa T, Kikuchi A. Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition. Development. 2017 Jan 1;144(1):151-162. doi: 10.1242/dev.141325.

2016

Yoshimura K, Kobayashi R, Ohmura T, Kajimoto Y, Miura T. A new mathematical model for pattern formation by cranial sutures. J Theor Biol. 2016 Nov 7;408:66-74. doi: 10.1016/j.jtbi.2016.08.003.

Sato M, Yasugi T, Minami Y, Miura T, Nagayama M. Notch-mediated lateral inhibition regulates proneural wave propagation when combined with EGF-mediated reaction diffusion. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5153-62. doi: 10.1073/pnas.1602739113.

A Theoretical Model of Jigsaw-Puzzle Pattern Formation by Plant Leaf Epidermal Cells.
Higaki T, Kutsuna N, Akita K, Takigawa-Imamura H, Yoshimura K, Miura T.
PLoS Comput Biol. 2016 Apr 7;12(4):e1004833. doi: 10.1371/journal.pcbi.1004833.

Köhn-Luque A, de Back W, Yamaguchi Y, Yoshimura K, Herrero MA, Miura T. Dynamics of VEGF matrix-retention in vascular network patterning. Phys Biol. 2013 Dec;10(6):066007. doi: 10.1088/1478-3975/10/6/066007.

Miura T. Modeling lung branching morphogenesis. Biological Theory. 2013 Jun 28;8(3):265-273.

Miura T. Turing and Wolpert work together during limb development. Sci Signal. 2013 Apr 9;6(270):pe14. doi: 10.1126/scisignal.2004038.

Modeling Periodic Aspect of Limb Pattern Formation, Takashi Miura, Forma 27, S33-37 (2012)

“Fiber components of the shoulder superior labrum”, Ryuzo Arai, Masahiko Kobayashi, Yoshinobu Toda, Shinichiro Nakamura, Takashi Miura, Takashi Nakamura. Surgical and Radiologic Anatomy: Volume 34, Issue 1 (2012), Page 49-56.

発生における細胞外シグナル因子の拡散ダイナミクス　三浦　岳、数理研講究録1789, 5-6(2012)

How well does Turing’s theory of morphogenesis work? 三浦　岳、数理研講究録1796, 31-38 (2012)

“上皮細胞の極性を用いた in vitro における三次元組織構造形成” 三浦　岳、数理研講究録1748, 125-133 (2011)

Modeling lung branching morphogenesis via epithelial–mesenchymal interaction. Developmental Biology, Volume 356, Issue 1, 1 August 2011, Page 143. Takashi Miura, Hiraga Kennichi, Tsuyoshi Hirashima

“Reaction-Diffusion model as a Framework for Understanding Biological Pattern Formation”, S. Kondo and T. Miura, Science, 329, 1616-20

三浦　岳・長山雅晴. 反応拡散系の生物のパターン形成現象への応用 蛋白質　核酸　酵素　55(1), 114-122, 2010

Lanying Zhao,Hirotomo Saitsu,Xiangnan Sun,Kohei Shiota,Makoto Ishibashi. Sonic hedgehog is involved in formation of the ventral optic up by limiting Bmp4 expression to the dorsal domain, MOD Volume 127(1-2), 62-72 (2010)

FGF-induced collective cell migration during lung branching morphogenesis. Developmental Biology, Volume 344, Issue 1, 1 August 2010, Page 432. Takashi Miura

三浦　岳、肺の枝分かれの形成機構、数理研講究録1663, 52-58 (2009)

Takashi Miura, Chad A. Perlyn, Masato Kinboshi, Naomichi Ogihara, Mikiko Kobayashi-Miura, Gillian M. Morriss-Kay, and Kohei Shiota. Mechanism of skull suture maintenance and interdigitation, J Anat 215(6), 642-655(2009)

Miura T., Tanaka R., In vitro vasculogenesis models revisited – Measurement of VEGF’s diffusion in Matrigel. Mathematical Modelling of Natural Phenomena, 4(4), 118-130 (2009).

Miura T, Hartmann D, Kinboshi M, Komada M, Ishibashi M, Shiota K, The cyst-branch difference in developing chick lung results from a different morphogen diffusion coefficient, Mech. Dev. 126, 160-72 (2009)

Miura, T. (2008). Modeling lung branching morphogenesis. Curr Top Dev Biol, 81, 291-310.

Visualizing morphogen distribution in lumen. Developmental Biology, Volume 319, Issue 2, 15 July 2008, Page 506. Takashi Miura

Hartmann, D. & Miura, T. Mathematical analysis of a free-boundary model for lung branching morphogenesis.”, , Math Med Biol, 24, 209-224 (2007).

Miura, T (2007). Modulation of activator diffusion by extracellular matrix in Turing system. RIMS kokyuroku Bessatsu B3 2007, 165-176.

三浦　岳. それ，ほんとにチューリングパターンですか？：理論モデルの実験的検証に必要なこと。　細胞工学　26(7)

Miura, T.; Shiota, K.; Morriss-Kay, G. & Maini, P. K., Mixed-mode pattern in Doublefoot mutant mouse limb–Turing reaction-diffusion model on a growing domain during limb development. J Theor Biol, 2006, 240, 562-573 (2006).

Hartmann, D. & Miura, T.. Modelling in vitro lung branching morphogenesis during development., J Theor Biol, 242: 862-872, 2006.

Hinoue, A.; Takigawa, T.; Miura, T., Nishimura, Y.; Suzuki, S. & Shiota, K. Disruption of actin cytoskeleton and anchorage-dependent cell spreading induces apoptotic death of mouse neural crest cells cultured in vitro. Anat Rec A Discov Mol Cell Evol Biol, 282: 130-137, 2005.

三浦 岳. 発生生物学におけるチューリング系の応用. 蛋白質　核酸　酵素 50(15): 1955-1961, 2005.

Miura, T., K. Shiota, et al. A mesenchyme-free culture system to elucidate the mechanism of otic vesicle morphogenesis. J Anat 205(4): 297-312, 2004.

Miura, T. and P. K. Maini. Speed of pattern appearance in reaction-diffusion models: implications in the pattern formation of limb bud mesenchyme cells. Bull Math Biol 66(4): 627-49, 2004.

Miura, T. and P. K. Maini. Periodic pattern formation in reaction-diffusion systems: An introduction for numerical simulation. Anat Sci Int 79(1): 112-123, 2004.

Miura, T. and K. Shiota. ,Depletion of FGF acts as a lateral inhibitory factor in lung branching morphogenesis in vitro. Mech Dev 116(1-2): 29-38, 2002.

Miura, T. and K. Shiota Extracellular matrix environment influences chondrogenic pattern formation in limb bud micromass culture: experimental verification of theoretical models of morphogenesis. Anat Rec 258: 100-107, 2000.

Miura, T., M. Komori, et al. A novel method for analysis of the periodicity of chondrogenic patterns in limb bud cell culture: correlation of in vitro pattern formation with theoretical models. Anat Embryol 201: 419-428, 2000.

Miura, T. and K. Shiota Time-lapse observation of branching morphogenesis of the lung bud epithelium in mesenchyme-free culture and its relationship with the localization of actin filaments. Int J Dev Biol 44(8): 899-902, 2000.

Miura, T. and K. Shiota TGFb2 acts as an “activator” molecule in reaction diffusion model and is involved in cell sorting phenomenon in mouse limb micromass culture. Dev Dyn 217: 241-249, 2000.

Miura, T. , Mechanisms of Pattern Formation in Limb Bud Micromass Culture: Possible Relationship with in vivo Pattern Formation. Congenital Anomalies 40 (Suppl): S2, 2000.

Komori M, Miura T, Shiota K, Minato K, Takahashi T. Virtual embryology: a 3D library reconstructed from human embryo sections and animation of development process. Medinfo.8 Pt 2:1229-30

Miura T, Komori M, Takahashi T & Shiota K. Computerized three-dimensional reconstruction of human embryos and their organs using the “NIH image” software. 解剖学雑誌. 70:353-61, 1995.

書　籍

発生の数理 (京都大学出版会(2015/12/28)）

再生医療製品の許認可と組織工学の新しい試み（シーエムシー出版(2012/5)）

生命科学の新しい潮流 理論生物学（共立出版 (2011/1/22)）

形の科学百科事典（朝倉書店(2004/09/01) 2005年毎日出版文化賞受賞）